• The HCV IRES initiates translation by directly binding to the small ribosomal subunit (40S), circumventing the need for many eukaryotic translation initiation factors required for mRNA scanning. (nih.gov)
  • Here we present the cryo-EM structure of the human 40S ribosomal subunit in complex with the HCV IRES at 3.9 Å resolution, determined by focused refinement of an 80S ribosome-HCV IRES complex. (nih.gov)
  • Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. (embl.de)
  • Together with eIF2 and GTP, the initiator tRNA binds the P site of the small ribosomal subunit forming the eukaryotic pre-initiation complex. (jove.com)
  • Upon codon-anticodon recognition, GTP is hydrolyzed and the initiation factors dissociate, allowing the large ribosomal subunit to join the complex and form an intact ribosome. (jove.com)
  • This consensus AGGAGGU sequence serves as the ribosomal binding site by base pairing with a complementary sequence on the 16S rRNA of the small ribosomal subunit. (jove.com)
  • Now, the 50S ribosomal subunit can bind to the initiation complex, with the complete ribosome ready to begin translation. (jove.com)
  • Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. (jove.com)
  • Next, the eIF2/GTP/Met-tRNAi ternary complex and other eIFs bind to the small ribosomal subunit to form a 43S preinitiation complex. (jove.com)
  • In bacterial ribosomes, the small (30S) ribosomal subunit is composed of 16S rRNA and 21 distinct proteins. (unboundmedicine.com)
  • Ribosomal protein S15 is of particular interest because it binds primarily to 16S rRNA and is required for assembly of the small subunit and for intersubunit association, thus representing a key element in the assembly of a whole ribosome. (unboundmedicine.com)
  • In starvation conditions, the reinitiating ribosomes bypass uORFs 2-4 and reinitiate at GCN4 instead, owing to lowered availability of the ternary complex (TC)-comprised of initiation factor 2 (eIF2), GTP, and initiator Met-tRNAi-which binds to the small (40S) ribosomal subunit to assemble a 43S preinitiation complex (PIC). (nih.gov)
  • LMU researchers have now structurally characterized late stages in the assembly of the human small ribosomal subunit, yielding detailed insights into their maturation principles. (uni-muenchen.de)
  • Their data reveals in detail how the ribosomal RNAs are progressively folded to provide the necessary binding sites for the cognate ribosomal proteins. (uni-muenchen.de)
  • We have used cryo-electron microscopy to determine the structures of intermediate forms of the small ribosomal subunit isolated from human cells. (uni-muenchen.de)
  • The succession of precursors reveals that maturation of the small ribosomal subunit proceeds in several defined steps. (uni-muenchen.de)
  • The GEN-PROBE TMA reaction replicates a specific region of the small ribosomal subunit from trichomonas vaginalis via DNA and RNA intermediates and generates RNA amplicon molecules. (cdc.gov)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing. (medlineplus.gov)
  • A shortage (deficiency) of functional integrin αIIbβ3 prevents sufficient binding of fibrinogen or other proteins, impairing the formation of blood clots. (medlineplus.gov)
  • The overactive integrin αIIbβ3 binds inappropriately to clotting proteins within the cell during the formation of platelets, causing the platelets to become misshapen and large. (medlineplus.gov)
  • Binding of mRNA requires extended mitoribosomal proteins of the small subunit, and movement of tRNA is realized through additional proteins of the large subunit. (nature.com)
  • Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). (fishersci.com)
  • KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. (fishersci.com)
  • This complex recognizes the mRNA by interacting with initiation factors eIF4E bound to the 5' cap, and eIF4G bound to the poly(A) tail-binding proteins. (jove.com)
  • Ribosomes are tiny particles made up of RNA and proteins that specialize in protein synthesis and are found free or bound to the endoplasmic reticulum within cells . (britannica.com)
  • Intriguingly, the overall fold of the bet3 and trs33 monomers was similar, although the proteins had little overall sequence identity. (proteopedia.org)
  • In eukaryotes, the mature small subunit contains one rRNA and about 30 proteins, while the large subunit is made up of three rRNAs and approximately 50 proteins. (uni-muenchen.de)
  • The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
  • Think of a ribosome as a small protein biosynthetic factory that translates the DNA genetic information into an amino acid sequence (the primary structure of proteins). (brighthub.com)
  • According to Alberts et al (2002) the 60S subunit is made of a 5S RNA (of 120 nucleotides), a 28S RNA (of 4700 nucleotides), a 5.8S subunit (of 160 nucleotides) and around 49 proteins. (brighthub.com)
  • The 40S subunit, on the contrary, has a 1900 nucleotide (18S) RNA and approximately 33 proteins. (brighthub.com)
  • The mRNA leaves the nucleus and travels to the endoplasmic reticulum (or the cytosol) where the two ribosome subunits assemble around it and start synthesizing proteins. (brighthub.com)
  • In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. (lu.se)
  • Regulated by guanine nucleotide exchange factors (GEFS) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (gaps) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. (lu.se)
  • The influenza virus's hemagglutinin (HA) surface proteins then bind to the sialic acid receptors on the surface of a human respiratory tract cell. (cdc.gov)
  • Following influenza infection or receipt of the influenza vaccine, the body's immune system develops antibodies that recognize and bind to "antigenic sites," which are regions found on an influenza virus' surface proteins. (cdc.gov)
  • The eukaryotic translation initiation factor EIF-2B is a complex made up of five different subunits, alpha, beta, gamma, delta and epsilon, and catalyses the exchange of EIF-2-bound GDP for GTP. (embl.de)
  • We show that renal cell carcinoma cells and normal renal cells express IL-15 mRNA and membrane-bound IL-15 (MbIL-15). (nih.gov)
  • However, how mRNA binds to its dedicated channel, and tRNA moves as the mitoribosomal subunit rotate with respect to each other is not understood. (nature.com)
  • The models of the active mitoribosome explain how mRNA binds through a dedicated protein platform on the small subunit, tRNA is translocated with the help of the protein mL108, bridging it with L1 stalk on the large subunit, and nascent polypeptide paths through a newly shaped exit tunnel involving a series of structural rearrangements. (nature.com)
  • Before the preinitiation complex binds the mRNA, to make sure that a correctly processed mRNA is translated, the cell uses initial recognition of the 5' cap of the mRNA by the eIF4E subunit of eIF4F. (jove.com)
  • Once the preinitiation complex is bound to the mRNA, the complex moves forward to search for the first AUG triplet, which is usually 50-100 nucleotides downstream of the 5′-terminal cap. (jove.com)
  • Levels of mRNA encoding the ADPGp large subunit and levels of starch were also higher in young fibers relative to older fibers. (usda.gov)
  • Early accomplishments of the SNCGE in this area include discovering the novel regulatory mechanism that induces translation of GCN4 mRNA via small upstream ORFs (uORFs) in the mRNA leader by phosphorylation and inhibition of eIF2 by the kinase Gcn2, now understood to regulate expression of key transcription factors (Atf4 and Atf5) in mammals and implicated in learning and memory. (nih.gov)
  • We have also investigated the roles of various eIFs, tRNAi and the 40S subunit in scanning the mRNA 5′ untranslated region and in accurately identifying the AUG initiation codon. (nih.gov)
  • Now, a new tRNA, carrying the second amino acid, can bind to the A-site on the ribosome and protein synthesis can begin. (jove.com)
  • A ribosome is made of two pieces (subunits). (brighthub.com)
  • A typical eukaryotic cell ribosome consists of two subunits named 60S (large subunit) and 40S (small). (brighthub.com)
  • A prokaryotic cell ribosome is a little smaller but it is made of two subunits too: a 50S and 30S subunit. (brighthub.com)
  • that bind to the 30S subunit of the ribosome, thus inhibiting bacterial protein synthesis. (msdmanuals.com)
  • Our data support the interaction of α-CTx RgIA at the α10/α9 rather than the α9/α10 nAChR subunit interface, and may facilitate the development of selective ligands with therapeutic potential. (aspetjournals.org)
  • The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. (medlineplus.gov)
  • To carry out these roles, the complex's p150-glued subunit attaches (binds) to a protein called dynein, which acts as a motor, and also binds to a track-like system of small tubes called microtubules. (medlineplus.gov)
  • Significant research is underway to examine how the receptor binding domain (RBD) at the tip of the club-shaped SARS-CoV-2 Spike protein attaches to an ACE2 receptor on a human cell, but little is known about the other changes that occur in the Spike protein as a result of this attachment," said Ganesh Anand, associate professor of chemistry, Penn State. (eurekalert.org)
  • We have determined structures of Sulfolobus solfataricus DNA ligase and heterotrimeric PCNA separately by X-ray diffraction and in complex by small-angle X-ray scattering (SAXS). (rcsb.org)
  • When complexed with heterotrimeric PCNA, the DNA ligase binds to the PCNA3 subunit and ligase retains an open, extended conformation. (rcsb.org)
  • Particularly in yeast, an organism where gluconeogenesis and glycolytic activity are intermittently coordinated, the multi-subunit GID E3 ligase complex specifically targets the surplus of gluconeogenic enzymes, including the conserved Fructose-1,6-bisphosphatase 1 (Fbp1), for proteasomal degradation. (elifesciences.org)
  • The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
  • Each multimeric subunit has binding sites for the receptor glycoprotein Ib on nonactivated platelets and the receptor glycoprotein IIb/IIIa on activated platelets. (medscape.com)
  • Insulin resistance, an important feature of type 2 diabetes, is manifested as attenuated insulin receptor (IR) signaling in response to insulin binding. (diabetesjournals.org)
  • Anand and his colleagues used a process, called amide hydrogen-deuterium exchange mass spectrometry (HDXMS), to visualize what happens when the SARS-CoV-2 Spike protein binds to an ACE2 receptor. (eurekalert.org)
  • Using this technique, the team determined that binding of the Spike protein and ACE2 receptor is necessary for furin-like proteases -- a family of human enzymes -- that act to snip off the tip, called the S1 subunit, of the Spike protein, which is the next step in the virus's infection of the cell. (eurekalert.org)
  • Anand noted that researchers have already learned much about how the Spike protein and ACE2 receptor bind together, but until now no one knew how this binding relayed the message to the furins to cut the protein. (eurekalert.org)
  • Our findings show ACE2 receptor binding to SARS-CoV-2 Spike protein causes long-range changes and allosterically enhances protease cutting at the distal S1/S2 cleavage site," he said. (eurekalert.org)
  • Anand said that researchers are currently focusing only on therapeutics that block the Spike protein from binding to the ACE2 receptor. (eurekalert.org)
  • Three distinct PCNA subunits assemble into a protein ring resembling the homotrimeric PCNA of humans but with three unique protein-binding sites. (rcsb.org)
  • Subsequently, we used the Gcd− selection to identify domains/residues in eIF2 and tRNAi, eIF1, eIF1A, eIF3, and residues of 18S rRNA located near the 'P' decoding site of the 40S subunit, that participate in rapid TC recruitment in vivo (Figure 1A). (nih.gov)
  • The mutations that cause this disorder occur in both copies of the gene in each cell and impair the production or activity of the beta3 subunit, which disrupts the formation of functional integrin αIIbβ3. (medlineplus.gov)
  • This study also may help in explaining how mutations in emerging variants might alter dynamics and allostery of ACE2 binding, potentially increasing infectiousness of the SARS-CoV-2 virus. (eurekalert.org)
  • We previously exploited this fact to isolate mutations in subunits of eIF2B that constitutively derepress GCN4 (Gcd− phenotype) by lowering TC assembly in the absence of eIF2 phosphorylation. (nih.gov)
  • However, mutations of these residues had little or no effect on toxin block of the α9α10 nAChR. (aspetjournals.org)
  • In contrast, mutations of homologous residues in the opposing nAChR subunits (α10 Ε197, P200 and α9 T61, D121) resulted in 19- to 1700-fold loss of toxin activity. (aspetjournals.org)
  • RFC1 has a binding region that interacts with PCNA, which has been linked to Hutchinson-Gilford progeria syndrome [HGPS]. (wikipedia.org)
  • A previous molecular modeling study, based on the structure of the homologous molluscan acetylcholine-binding protein, predicted that RgIA interacts with three residues on the α9(+) face and two residues on the α10(-) face of the α9α10 nAChR. (aspetjournals.org)
  • The potential mechanisms probably involved interfering Rac1 geranylgeranylation, inhibiting the assembly of NADPH oxidase cytosolic regulatory subunits, reducing oxidative injury, and decreasing ERK1/2 and JNK phosphorylation. (hindawi.com)
  • Bound at active site OR to substrate. (flashcardmachine.com)
  • The open reading frame (ORF) was very similar to other plant ADPGp small subunits including conserved sites associated enzyme activity, with allosteric regulation by phosphoglyceraldehyde and phosphate and with redox regulation and substrate binding. (usda.gov)
  • TLK16998 alone had no effect on IR signaling in mouse 3T3-L1 adipocytes but, at concentrations as low as 3.2 μmol/l, enhanced the effects of insulin on the phosphorylation of the IR β-subunit and IR substrate 1, and on the amount of phosphatidylinositol 3-kinase that coimmunoprecipitated with IRS-1. (diabetesjournals.org)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • 18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)
  • The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
  • During the hybridization step, the sequence specific regions of the capture oligomers bind to specific regions of the target molecules. (cdc.gov)
  • The work shows that mitoribosomes acquire cofactors and subunits associated with the respiratory complexes, such as NAD and IF 1 . (nature.com)
  • Transport protein particle (TRAPP) comprises a family of two highly related multiprotein complexes, with seven common subunits, that serve to target different classes of transport vesicles to their appropriate compartments. (proteopedia.org)
  • We propose that one of the roles of Trs33p is to facilitate the incorporation of the Bet3p subunit into assembling TRAPP complexes. (proteopedia.org)
  • Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. (bdbiosciences.com)
  • Ca 2+ channel β subunits regulate cell-surface expression and gating of voltage-dependent Ca 2+ channel α1 subunits. (jneurosci.org)
  • Here, we identified all subunits of the mammalian GID/CTLH complex and provide a comprehensive map of its hierarchical organization and step-wise assembly. (elifesciences.org)
  • These results suggest, therefore, that small nonpeptide molecules that directly sensitize the IR may be useful for treating type 2 diabetes. (diabetesjournals.org)
  • The microparticles, including the captured target molecules bound to them, are pulled to the side of the reaction vessel using magnets and the supernatant is aspirated. (cdc.gov)
  • Membrane-bound ribosomes are responsible for the characteristic roughness of the endoplasmic reticulum when seen under a microscope. (brighthub.com)
  • At Yale he worked in the laboratory of American molecular biophysicist and biochemist Peter Moore and learned to use a technique known as neutron scattering to investigate the structure of the small subunit of ribosomes in the bacterium Escherichia coli (ribosomes are composed of two distinct subunits, one large and one small). (britannica.com)
  • We identified the eIF2α phosphatases in yeast and made key contributions to elucidating the mechanism whereby phosphorylated eIF2 inhibits its GDP-GTP exchange factor, eIF2B, defining the catalytic and regulatory subcomplexes of eIF2B and their distinct roles in binding phosphorylated or nonphosphorylated eIF2. (nih.gov)
  • RFC Box 6 is different between the two subunits such as one large 6a and small 6b subunits. (wikipedia.org)
  • Nicotinamide adenine dinucleotide (NAD) is found in the central protuberance of the large subunit, and the ATPase inhibitory factor 1 (IF 1 ) in the small subunit. (nature.com)
  • An assembly intermediate is modeled with the maturation factor Atp25, providing insight into the biogenesis of the mitoribosomal large subunit and translation regulation. (nature.com)
  • Calpain , a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. (wikidoc.org)
  • This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. (wikidoc.org)
  • Ribosomes are made up of two subunits, the small and the large, which are assembled separately and interact to form a single functional unit only when needed. (uni-muenchen.de)
  • The mature small subunit can then bind to the large subunit, in association with a messenger RNA that provides the blueprint for protein synthesis. (uni-muenchen.de)
  • The structure of the oligomer with the S/T-rich region is a large step forward in the understanding of the function of DNAJB6 and how it can bind aggregation-prone peptides and prevent amyloid diseases. (lu.se)
  • After the initial steps in assembly, the immature subunits are transported from the nucleus into the cytoplasm. (uni-muenchen.de)
  • The prevailing hypothesis for the spread of CaMKII activity, involving shuffling of subunits between activated and naive holoenzymes, is broadly termed subunit exchange. (elifesciences.org)
  • The ligand binds at the major interface between the alphaV and beta3 subunits and makes extensive contacts with both. (rcsb.org)
  • Ligand binding induces small changes in the orientation of alphaV relative to beta3. (rcsb.org)
  • This report describes the effect of a small molecule IR sensitizer, TLK16998, on IR signaling. (diabetesjournals.org)
  • The bigger the number given to the subunit the bigger the molecule. (brighthub.com)
  • This manuscript reports the fundamental finding that an oligomeric protein kinase, CaMKII, can be phosphorylated by another molecule of the holoenzyme in a manner that does not involve subunit exchange. (elifesciences.org)
  • It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. (wikipedia.org)
  • During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. (medlineplus.gov)
  • Phosphopeptide mapping revealed that the effect of TLK16998 on the IR was associated with increased tyrosine phosphorylation of the activation loop of the β-subunit tyrosine kinase domain. (diabetesjournals.org)
  • These neurons are of small diameter and can be identified by the binding of the lectin IB4 and the expression of the enzyme thiamine monophosphatase (TMP). (jneurosci.org)
  • the 3-D cleft on enzyme where S binds and conversion to P occurs. (flashcardmachine.com)
  • What two things determine how much ligand is bound to a given enzyme? (flashcardmachine.com)
  • Geranylgeranyl transferase-I (GGTase-I) is an essential enzyme mediating posttranslational modification, especially the geranylgeranylation of small GTPase, Rac1. (hindawi.com)
  • RFC Boxes [1-8] are the amino acid sequences found in human replication factor C. RFC 1 is the largest RFC subunit, with 8RFC Boxes. (wikipedia.org)
  • Positive cases were further confirmed by PCR using primers of the small subunit RNA gene sequences. (cdc.gov)
  • The purified protein is well folded and composed of oligomers with a varying number of subunits according to small-angle X-ray scattering (SAXS). (lu.se)
  • 39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)
  • Such calculations can also be used to interpret the structures, e.g. to decide the protonation state of metal-bound ligands. (lu.se)
  • The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. (wikipedia.org)
  • von Willebrand factor is composed of dimeric subunits that are linked by disulfide bonds to form complex multimers of low, intermediate, and high molecular weights. (medscape.com)
  • in the complex, betaA acquires two cations, one of which contacts the ligand Asp directly and the other stabilizes the ligand-binding surface. (rcsb.org)
  • Altered topoisomerase I and II activity prevents drugs such as doxorubicin, etoposide and camptothecin from binding the topoisomerase-DNA complex, allowing the broken strands to be repaired. (nature.com)
  • The p150-glued version of dynactin-1 is the largest component (subunit) of the dynactin complex. (medlineplus.gov)
  • These genetic changes impair the ability of the p150-glued version of dynactin-1 to bind to the dynactin complex and to microtubules. (medlineplus.gov)
  • This mutation likely alters the 3-dimensional shape of dynactin-1, which may impair its binding with the dynactin complex and microtubules. (medlineplus.gov)
  • Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. (bdbiosciences.com)
  • Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. (proteopedia.org)
  • With this label in hand, we can move towards the use of biochemical research to visualize distances between protein subunits through the use of Forster Resonance Energy Transfer (FRET). (mtsu.edu)
  • Mixed isotope crosslinking showed that the oligomers are dynamic entities that exchange subunits. (lu.se)
  • Lysine-specific crosslinking mass spectrometry provided distance constraints to select a homology model of the DNAJB6 monomer, which was subsequently used in crosslink-assisted docking to generate a dimer model, revealing that a peptide-binding cleft lined with S/T-residues is formed at the monomer-monomer interface. (lu.se)
  • Small diameter DRG cells, in contrast, have unmyelinated axons and are principally nociceptors and thermoceptors. (jneurosci.org)
  • In contrast, only small effects were observed on IGF-1-stimulated 2-deoxy- d -glucose uptake. (diabetesjournals.org)
  • In contrast to the expectations of previous work, we found little evidence for subunit exchange upon activation, and no effect of restraining subunits to their parent holoenzymes. (elifesciences.org)
  • GDNF also prevents the slowing of conduction velocity that normally occurs after axotomy in a population of small diameter DRG cells and the A-fiber sprouting into lamina II of the dorsal horn. (jneurosci.org)
  • DNA sliding clamps encircle DNA and provide binding sites for many DNA-processing enzymes. (rcsb.org)
  • Geranylgeranyl transferase-I (GGTase-I) is one of the key enzymes mediating protein isoprenylation during the posttranslational modification, especially the geranylgeranylation of small GTPase, Rac1 [ 6 ]. (hindawi.com)
  • RFC box 1 has a 90 amino acid-long region, while RFC box 2 is a highly conserved subunit. (wikipedia.org)
  • This abnormally active protein is unable to reach the surface of the platelet where it is needed to bind to other platelets during clot formation. (medlineplus.gov)
  • In vitro experiments using yeast TRAPP subunits indicated that Bet3p binding to Trs33p facilitates the interaction between Bet3p and another TRAPP subunit, Bet5p. (proteopedia.org)
  • However, little information is available on their roles in vegetative tissues. (bvsalud.org)
  • The N-terminal A domain differs among the four subtypes of Ca 2+ channel β subunits (β 1 -β 4 ) primarily as the result of two duplications of an ancestral gene containing multiple alternatively spliced exons. (jneurosci.org)
  • High-molecular weight multimers have higher numbers of platelet-binding sites and greater adhesive properties. (medscape.com)
  • This binding sites where shown within 5.0 Angstroms radius around Zinc atom. (atomistry.com)
  • By binding to these antigenic sites, antibodies neutralize flu viruses, which prevents them from causing further infection. (cdc.gov)
  • gp41, the transmembrane subunit, mediates fusion of viral and cellular membranes [ 3 ]. (plos.org)
  • Silencing of IL-15Ralpha by specific small interfering RNA in renal cell carcinoma had no effect on MbIL-15 production, indicating that the cytokine is not cross-presented by IL-15Ralpha in renal cell carcinoma cells but anchored to the membrane. (nih.gov)
  • Genetic analyses in yeast suggested a specific interaction between the TRAPP subunits Bet3p and Trs33p. (proteopedia.org)
  • Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. (bdbiosciences.com)
  • Cholera Cholera is an acute infection of the small bowel by the gram-negative bacterium Vibrio cholerae , which secretes a toxin that causes copious watery diarrhea, leading to dehydration, oliguria. (msdmanuals.com)
  • Plasma membrane-associated small GTPase which cycles between an active GTP-bond and inactive GDP-bound state. (lu.se)
  • Belongs to the small GTPase superfamily. (lu.se)