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  • benign
  • The vast majority of the tumors of the heart have a benign course and are not directly fatal. (wikipedia.org)
  • However, even the benign tumors of the heart can be lethal due to either direct extension into the electrical conduction system of the heart (causing complete heart block or a fatal dysrhythmia), or due to emboli from the tumor mass that may have lethal sequelae. (wikipedia.org)
  • typically
  • This is in contrast to secondary tumors of the heart, which are typically either metastatic from another part of the body, or infiltrate the heart via direct extension from the surrounding tissues. (wikipedia.org)
  • heterogeneity
  • The emerging picture is an extreme inter-tumor heterogeneity, characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. (biomedcentral.com)
  • Mesenchymal
  • On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase. (wikipedia.org)
  • Chromosome
  • Chromosome 22 is one of the 23 pairs of chromosomes in human cells. (wikipedia.org)
  • Humans normally have two copies of chromosome 22 in each cell. (wikipedia.org)
  • Chromosome 22 is the second smallest human chromosome (chromosome 21 being smaller), spanning about 49 million DNA base pairs and representing between 1.5 and 2% of the total DNA in cells. (wikipedia.org)
  • Chromosome 22 was originally identified as the smallest chromosome. (wikipedia.org)
  • After extensive research, however, researchers concluded that chromosome 21 was smaller. (wikipedia.org)
  • These changes include an extra piece of chromosome 22 in each cell (partial trisomy), a missing segment of the chromosome in each cell (partial monosomy), and a circular structure called ring chromosome 22 that is caused by the breakage and reattachment of both ends of the chromosome. (wikipedia.org)
  • A small extra chromosome is made up of genetic material from chromosome 22 that has been abnormally duplicated (copied). (wikipedia.org)
  • binds
  • This medicine is an antibody which binds to certain tumors, including DSCRT. (mskcc.org)
  • Bevacizumab binds to vascular endothelial growth factor (VEGF) and inhibits the interaction of VEGF to Flt1 and KDR receptors on the surface of endothelial cells. (aetna.com)