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  • mRNA
  • MicroRNAs (miRNAs) and short interfering RNAs (siRNAs) are small noncoding RNAs that have recently emerged as important regulators of mRNA degradation, translational repression, and chromatin modification. (plantcell.org)
  • A core set of metatranscriptomic practices can now be identified, with key steps including RNA extraction, messenger RNA (mRNA) enrichment, synthesis of complementary DNA (cDNA), shotgun sequencing of cDNA, and bioinformatic analysis of sequence data. (asmscience.org)
  • Plant MPSS (Massively Parallel Signature Sequencing) databases [ 18 ] of Arabidopsis , rice, grape, and rice blast fungus ( Magnaporthe grisea ) were developed to provide an online resource for mRNA and small RNA analyses. (biomedcentral.com)
  • degradome sequenc
  • Integrated analysis of small RNAs and degradome sequencing reveals that miRNA-mediated SA signaling, ABA-dependent, and ROS response pathways are involved in sweetpotato root response to chilling stress during storage. (deepdyve.com)
  • High throughput deep degradome sequencing reveals microRNAs and their targets in response to drought stress in mulberry (Morus alba). (nih.gov)
  • Responses
  • Uncovering small RNA-mediated responses to cold stress in a wheat thermosensitive genic male-sterile line by deep sequencing. (nih.gov)
  • The researchers, led by molecular biologist Curt M. Horvath , are among the first to show the influenza virus can change the expression of microRNA to control immune responses in human lung cells. (healthcanal.com)
  • responsive
  • Furthermore, we showed both in vitro and in vivo that the transcription of MIR168a is directly regulated by four abscisic acid-responsive element (ABRE) binding factors, which bind to the ABRE cis-element within the MIR168a promoter. (plantphysiol.org)
  • Identification of chilling-responsive microRNAs and their targets in vegetable soybean (Glycine max L. (deepdyve.com)
  • Identification and characterization of cold-responsive microRNAs in tea plant (Camellia sinensis) and their targets using high-throughput sequencing and degradome analysis. (nih.gov)
  • The drought responsive miRNA/target pairs were confirmed by the presence of decay intermediates generated by miRNA-guided cleavages in Parallel Analysis of RNA Ends (PARE) libraries. (biomedcentral.com)
  • methylation
  • To understand the interactions of microRNAs with other epigenetic factors (altered methylation and acetylation) that influence lupus and inflammation. (vt.edu)
  • To understand how epigenetics (microRNA, altered methylation and acetylation) influences lupus and inflammation. (vt.edu)
  • sequences
  • We sequenced ~350000 small RNAs from soybean roots inoculated with B. japonicum and identified conserved miRNAs based on similarity to miRNAs known in other plant species and new miRNAs based on potential hairpin-forming precursors within soybean EST and shotgun genomic sequences. (biomedcentral.com)
  • CSRDB (Cereal Small RNA Database) [ 21 ] consists of maize and rice small RNA sequences generated by high-throughput pyrosequencing with the provided maps to the available rice and maize genomes. (biomedcentral.com)
  • strands
  • One of the strands, called mature miRNA, is incorporated into the RNA-induced silencing complex (RISC), whereas the other strand is usually degraded. (biomedcentral.com)
  • immune
  • Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)
  • To investigate microRNA regulation of the immune system in health and autoimmune diseases. (vt.edu)
  • Naturally occurring small RNAs (microRNAs) regulate the immune system in healthy and autoimmune individuals. (vt.edu)
  • The flu increases the expression of microRNA, which decreases the amount of protein and diminishes the immune response. (healthcanal.com)
  • known
  • In solid tumors, such as tummy, pancreatic and prostate cancers, amendment of the known amounts of a little amount Crenolanib of miRNAs, including miR-214, provides been discovered as a personal for these tumors (10,11). (healthandwellnesssource.org)
  • In addition, it is known that abnormal amounts of microRNA stimulate the onset and development of different diseases, such as cancer. (eurekalert.org)
  • analyses
  • Here RNA-seq analyses of leaves from drought stressed rice plants was performed, producing differential expression profiles of noncoding RNAs. (biomedcentral.com)
  • genomics
  • Along with different functional genomics strategies, how recent researches on microRNA (miRNA) revealed a new field in understanding as well as combating salt stress, have been discussed in this chapter. (springer.com)
  • found
  • New atypical precursor classes producing only specific 21- and 24-nucleotide small RNAs were found. (plantcell.org)
  • miRNAs are an abundant class of tiny RNAs that are often found to be conserved evolutionarily across species boundaries and are capable of regulating the expression of protein-coding genes in multicellular eukaryotes ( Bartel, 2004 ). (plantcell.org)
  • They found one, microRNA-668, consistently elevated in both patients with an acute kidney injury as well as animal models of the condition, which is common in patients in intensive care, particularly older patients. (eurekalert.org)
  • They found that ischemic acute kidney injury induces HIF-1, which upregulates microRNA-668, which suppresses MTP18 and the result is kidney cell protection. (eurekalert.org)
  • They focused on six microRNAs that were found to increase in abundance during flu infection. (healthcanal.com)
  • The researchers found the virus activated two microRNAs that turned on the genes IRAK1 and MAPK3. (healthcanal.com)
  • In addition, over-expression of miR-378a-5p was found to reduce the sensitivity of cancer cells to paclitaxel treatment and to activate certain cell surface receptors, which transmit signals regulating, for example, angiogenesis. (eurekalert.org)
  • identification
  • The identification of signature microRNA expression profile in autoimmune states is of prognostic, diagnostic and therapeutic importance. (vt.edu)