Small molecule inhibitors of aurora kinases. Medical search. Frequent questions

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Anatomy21

Cell Line, Tumor Spindle Apparatus HeLa Cells Cell Line Kinetochores Cells, Cultured Microtubules Centrosome Tumor Cells, Cultured HEK293 Cells Blastodisc NIH 3T3 Cells Fibroblasts Jurkat Cells Centromere HCT116 Cells Sf9 Cells Microtubule-Organizing Center Cell Membrane Chromosomes CHO Cells

Organisms9

Mice, Nude Mice, SCID Mice, Inbred C57BL Potoroidae Mice, Knockout Cricetinae Mice, Inbred BALB C Mice, Transgenic Escherichia coli

Diseases6

Neoplasms Polyploidy Chondroma Cell Transformation, Neoplastic Disease Models, Animal Aneuploidy

Chemicals and Drugs128

Aurora Kinases Aurora Kinase A Aurora Kinase B Aurora Kinase C Small Molecule Libraries Protein-Serine-Threonine Kinases Protein Kinase Inhibitors Enzyme Inhibitors Phosphatidylinositol 3-Kinases Antineoplastic Agents Protein Kinases Piperazines Pyrimidines Benzamides Azepines Pyrazoles Indoles src-Family Kinases Cell Cycle Proteins RNA, Small Interfering Thiazoles Quinazolines Calcium-Calmodulin-Dependent Protein Kinases p38 Mitogen-Activated Protein Kinases Protein-Tyrosine Kinases Organophosphates Pyridines Histones Mitogen-Activated Protein Kinase Kinases Sulfonamides JNK Mitogen-Activated Protein Kinases Protein Kinase C Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Extracellular Signal-Regulated MAP Kinases Cyclic AMP-Dependent Protein Kinases Recombinant Proteins Cyclin-Dependent Kinases Microtubule-Associated Proteins Imidazoles Mitogen-Activated Protein Kinase 1 Ligands Receptor Protein-Tyrosine Kinases Nuclear Proteins Aneugens RNA, Messenger Pyrroles Gossypol Cell Adhesion Molecules Janus Kinase 2 CDC2 Protein Kinase p21-Activated Kinases Mitogen-Activated Protein Kinase 3 Heterocyclic Compounds, 3-Ring Intracellular Signaling Peptides and Proteins I-kappa B Kinase Glycogen Synthase Kinase 3 Mitogen-Activated Protein Kinases Hydrazones Quinazolinones Pyrones TOR Serine-Threonine Kinases Isoenzymes Chromosomal Proteins, Non-Histone Collagen Type XI Tumor Suppressor Protein p53 MAP Kinase Kinase Kinases Benzimidazoles Creatine Kinase Peptides Recombinant Fusion Proteins Quinolines Casein Kinase II Receptor, Epidermal Growth Factor Purines eIF-2 Kinase Thiones DNA-Binding Proteins Casein Kinases Focal Adhesion Protein-Tyrosine Kinases Ribosomal Protein S6 Kinases Pyruvate Kinase MAP Kinase Kinase 1 Transcription Factors Aniline Compounds para-Aminobenzoates Morpholines Neoplasm Proteins Carrier Proteins Membrane Proteins Thymidine Kinase Phenylurea Compounds Phosphotransferases (Alcohol Group Acceptor)Protease Inhibitors STAT3 Transcription Factor Nitrophenols MAP Kinase Kinase 4 Aminopyridines Dioxoles Proto-Oncogene Proteins c-pim-1 Acid Sensing Ion Channel Blockers NF-kappa B Pyrimidinones Thiadiazoles 1-Phosphatidylinositol 4-Kinase rho-Associated Kinases Adenosine Triphosphate CDC2-CDC28 Kinases Thiophenes Phosphoproteins Hydrazines Antibodies, Monoclonal Heterocyclic Compounds with 4 or More Rings HSP90 Heat-Shock Proteins Sulfones Proteins Nitriles Protein Kinase C-delta Protein Kinase C-alpha Actins DNA Primers Pyridones Multiprotein Complexes Benzoquinones Angiogenesis Inhibitors Proto-Oncogene Proteins c-met AMP-Activated Protein Kinases Tyrosine

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

High-Throughput Screening Assays Drug Evaluation, Preclinical Inhibitory Concentration 50 Models, Molecular Drug Design Drug Screening Assays, Antitumor Drug Discovery Xenograft Model Antitumor Assays Blotting, Western Models, Biological Combinatorial Chemistry Techniques Molecular Targeted Therapy Crystallography, X-Ray Transfection Microscopy, Fluorescence Molecular Docking Simulation Drug Delivery Systems Reverse Transcriptase Polymerase Chain Reaction Flow Cytometry Gene Expression Profiling Sequence Alignment Immunoblotting Disease Models, Animal Mutagenesis, Site-Directed Immunohistochemistry Gene Knockdown Techniques Enzyme Assays Tumor Burden Transplantation, Heterologous Surface Plasmon Resonance Models, Chemical Biological Assay

Phenomena and Processes63

Phosphorylation Mitosis MAP Kinase Signaling System Signal Transduction Protein Binding Molecular Structure Apoptosis Cell Proliferation Inhibitory Concentration 50 Structure-Activity Relationship Binding Sites Mutation Amino Acid Sequence Cell Cycle Chromosome Segregation Dose-Response Relationship, Drug Cell Survival Protein Structure, Tertiary Kinetochores RNA Interference Kinetics Combinatorial Chemistry Techniques Cell Cycle Checkpoints Drug Synergism Enzyme Activation Substrate Specificity M Phase Cell Cycle Checkpoints Catalytic Domain Gene Expression Regulation, Neoplastic Drug Resistance, Neoplasm Cytokinesis Transfection Polyploidy Cell Division Down-Regulation Time Factors Base Sequence Gene Expression Regulation, Enzymologic Protein Conformation Anaphase Protein Transport Cell Movement Up-Regulation Sequence Homology, Amino Acid Gene Expression Transcription, Genetic Gene Expression Regulation Cell Physiological Processes Phenotype Cell Differentiation Centromere Cell Adhesion Ploidies Molecular Weight Meiosis Chromosomes Protein Processing, Post-Translational Aneuploidy Molecular Conformation G2 Phase Protein Interaction Domains and Motifs Catalysis Protein Multimerization

Disciplines and Occupations3

Drug Design Drug Discovery Immunohistochemistry

Technology, Industry, Agriculture1

Combinatorial Chemistry Techniques

Information Science4

Molecular Sequence Data Amino Acid Sequence Base Sequence Molecular Docking Simulation

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Technology, Industry, Agriculture Information Science

Aurora Kinases Aurora Kinase A Aurora Kinase B Aurora Kinase C Small Molecule Libraries Protein-Serine-Threonine Kinases Protein Kinase Inhibitors Cell Line, Tumor Enzyme Inhibitors High-Throughput Screening Assays Drug Evaluation, Preclinical Phosphatidylinositol 3-Kinases Antineoplastic Agents Phosphorylation Mitosis Protein Kinases Piperazines Pyrimidines MAP Kinase Signaling System Signal Transduction Protein Binding Molecular Structure Apoptosis Cell Proliferation Inhibitory Concentration 50 Benzamides Spindle Apparatus Models, Molecular Drug Design Azepines Pyrazoles Molecular Sequence Data Drug Screening Assays, Antitumor Structure-Activity Relationship Indoles HeLa Cells Binding Sites Mutation src-Family Kinases Amino Acid Sequence Cell Line Drug Discovery Cell Cycle Proteins Cell Cycle Xenograft Model Antitumor Assays Neoplasms Chromosome Segregation RNA, Small Interfering Thiazoles Dose-Response Relationship, Drug Quinazolines Cell Survival Blotting, Western Protein Structure, Tertiary Calcium-Calmodulin-Dependent Protein Kinases p38 Mitogen-Activated Protein Kinases Kinetochores Protein-Tyrosine Kinases Organophosphates Mice, Nude RNA Interference Kinetics Models, Biological Combinatorial Chemistry Techniques Pyridines Cell Cycle Checkpoints Molecular Targeted Therapy Drug Synergism Histones Enzyme Activation Crystallography, X-Ray Substrate Specificity Mitogen-Activated Protein Kinase Kinases Cells, Cultured Sulfonamides JNK Mitogen-Activated Protein Kinases Protein Kinase C M Phase Cell Cycle Checkpoints Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Catalytic Domain Gene Expression Regulation, Neoplastic Microtubules Extracellular Signal-Regulated MAP Kinases Drug Resistance, Neoplasm Cyclic AMP-Dependent Protein Kinases Cytokinesis Transfection Recombinant Proteins Centrosome Cyclin-Dependent Kinases Tumor Cells, Cultured Polyploidy Microtubule-Associated Proteins Imidazoles Mitogen-Activated Protein Kinase 1 Ligands Receptor Protein-Tyrosine Kinases Nuclear Proteins Aneugens

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