We previously reported aberrant glycosylation of lumican, one of small leucine-rich proteoglycans (SLRPs), in aortic valves in patients with aortic valve stenosis (AS). (oatext.com)
Extending the study, we here characterized other SLRPs of proline/arginine-rich end leucine-rich repeat protein (PRELP), decorin, and biglycan in AS valves. (oatext.com)
Thus, secreted to the ECM PGs include large aggregating PGs, named hyalectans, small leucine-rich PGs (SLRPs), and basement membrane PGs. (hindawi.com)
The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. (molvis.org)
In severe invasive infections, S. pyogenes encounters and interacts with components of the extracellular matrix (ECM), including small leucine rich-proteoglycans (SLRPs). (lu.se)
Proline and arginine-rich finish leucine-rich repeat protein (PRELP) is a member of the small leucine-rich repeat proteoglycans (SLRPs) household. (molvisindex.org)
Our findings included a significant class of proteoglycans not previously associated with lymphomas as well as significant modulation of genes that code for extracellular matrix-associated proteins. (fortunepublish.com)
Human decorin is a small leucine-rich proteoglycan of 90-140 kDa that is associated with collagen fibrils in all connective tissue. (encyclopedia.pub)
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine kinases. (nebraska.edu)
Decorin can be an associate of the tiny leucine-rich proteoglycan (SLRP) family members and is among the most abundant proteoglycans from the interstitial matrix. (imacst.com)
These genes included collagens Type I and VI and the small leucine rich repeat family of proteoglycans (e.g., decorin, biglycan, osteomodulin, fibromodulin, and osteoadherin/osteoglycin) that reached peak expression at 24 h. (umassmed.edu)
Lumican1
Lumican is a member of the small leucine-rich proteoglycan (SLRP) proteoglycan Class II family. (gnu.ac.kr)
SLRP1
Moreover, we also identified a secreted molecule, Tsukushi (TSK), that belongs to the small leucine-rich proteoglycan family (SLRP) and inhibits signaling molecules, such as BMP and Wnt. (elsevierpure.com)
Collagen fibrils1
The stromal ECM connective tissue is a highly organized array of collagen fibrils and regulatory proteoglycans produced by a specialized fibroblast, the keratocytes. (shukti-chakravarti-lab.org)
Proteins5
Structural diversity of leucine-rich repeat proteins. (embl.de)
The superfamily of leucine-rich repeat proteins can be subdivided into at least six subfamilies, characterised by different lengths and consensus sequences of the repeats. (embl.de)
The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to 30 residue in length. (embl.de)
Myokines are small proteins (5-20 kDa) and proteoglycan peptides that are produced and secreted by skeletal muscle cells in response to muscle contractions. (encyclopedia.pub)
It includes a one covalently attached N-terminal glycosaminoglycan (GAG) string, made up of either chondroitin or dermatan sulfate, and 12 leucine-rich tandem Ipfencarbazone repeats representing the proteins core [4C6]. (imacst.com)
Fibromodulin1
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. (antibodies-online.com)
Corneal2
There is little or no progression of the corneal opacification and vision varies widely. (arizona.edu)
Anong the missing genes are those for the 4 small leucine-rich proteoglycans associated with this form of corneal dystrophy. (arizona.edu)
The main components of the aortic valve ECM are collagens, elastin, and proteoglycans (PGs) [8]. (oatext.com)
Chondroitin2
Chondroitin sulfate is the most predominant glycosaminoglycan found in articular cartilage, and it binds to the core protein to form proteoglycan aggregates. (finfactbuddy.com)
Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation. (cardiff.ac.uk)
Molecules1
The key components of articular cartilage are proteoglycans, which are large molecules composed of a core protein and attached glycosaminoglycan (GAGs) chains. (finfactbuddy.com)
Phenotype1
In this study, we characterize a 3D tumour model in which the PDAC acquires a more stroma-rich phenotype, which simulates more closely the in vivo situation, and provides evidence for the CAM-DR concept. (biomedcentral.com)
Articular cartilage1
However, when articular cartilage degeneration sets in, the structure and composition of proteoglycans break down, leading to a range of issues. (finfactbuddy.com)
Gene1
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. (creativebiomart.net)
Expression1
Funderburgh JL, Funderburgh ML, Mann MM, Corpuz L & Roth MR 2001 Proteoglycan expression during transforming growth factor beta -induced keratocyte-myofibroblast transdifferentiation. (jmolbiochem.com)
Tumor1
Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
Form1
HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
Cells1
Establishing a Pattern After typing any anti recoil numbers into two cells, you can grab the fill handle the tiny box in the lower-right corner of a selected cell with your cursor the crosshairs cursor, also known as the angry rabbit cursor and drag down or to the side, if free download cheats l4d2 numbers are listed horizontally. (mahavirelectricalsfurnitures.com)
Molecular1
BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)
The taxonomicdistribution of these families extracted from the Pfam protein familydatabase showed that members of the polyketide cyclase family and theactivator of Hsp90 ATPase homologue 1 family were distributed among allthree superkingdoms, while members of some bacterial families wereconfined to a small number of species. (embl.de)
Free1
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Size2
The glands may be decreased in number and smaller in size contributing to deficiencies of the tear film and unstable surface wetting. (arizona.edu)
These defects can range in size and depth, from small lesions to larger areas of cartilage damage. (finfactbuddy.com)