Small interfering rna interactions rna small nuclear. Medical search. Frequent questions

Although the in vitro acetylation assays revealed that HDAC5 decreased LSD1 protein acetylation, small interfering RNA (siRNA)-mediated HDAC5 knockdown did not alter the acetylation level of LSD1 in MDA-MB-231 cells. (johnshopkins.edu)
Overexpression of HDAC5 stabilized LSD1 protein and decreased the nuclear level of H3K4me1/me2 in MDA-MB-231 cells, whereas loss of HDAC5 by siRNA diminished LSD1 protein stability and demethylation activity. (johnshopkins.edu)
siRNA, small interfering RNA. (rupress.org)
in neural stem cells was further backed with the observation that intracranial viral transduction from the LSD1 little interfering RNA (siRNA) or intraperitoneal shot from the LSD1 inhibitors pargyline and tranylcypromine resulted in dramatically decreased neural progenitor proliferation in the hippocampal dentate gyri of wild-type adult mouse brains. (sciencepop.org)
Both chemical substance inhibition of LSD1 activity and little interfering RNA (siRNA) knockdown of LSD1 appearance led to proclaimed inhibition of neural stem cell proliferation. (sciencepop.org)
The conserved region around the C-terminus of the PIWI domain, which is required for small interfering RNA (siRNA) binding to AfPiwi, may function as the receptor site for the obligatory 5' phosphate of siRNAs, thereby specifying the cleavage position of the target mRNA. (rcsb.org)
We developed a generic automated eukaryotic short interfering RNA (siRNA) analysis tool, called RAPID. (uni-frankfurt.de)
Our tool captures diverse siRNA characteristics from small RNA sequencing data and provides easily navigable visualisations. (uni-frankfurt.de)
Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)

While previous studies have recognized small molecule inhibitors of MSI family proteins, none of these studies assessed anti\malignancy activities (Clingman et?al. (thetechnoant.info)
Further, a xenograft tumor model showed that Nek2 knockdown could improve the anti-tumor effect of sorafenib, whereas an analysis of tumor proteins showed that Nek2 regulates β-catenin protein levels and its nuclear translocation in vivo. (biomedcentral.com)
During Adv DNA replication, host cellular proteins such as nuclear factor I and POU2F1 are used by Adv [ 13 , 14 ]. (hindawi.com)
DNA methyltransferases are not limited to catalyzing DNA methylation, but also take part in the regulation of gene expression through interactions with other proteins that repress transcription and modify chromatin structure. (caister.com)
Its genome consists of three ssRNAs of negative polarity that encodes four proteins: the RNA-dependent RNA polymerase of 280 kDa, the movement protein of 54 kDa (54K), the coat protein and a small protein of 24 kDa (24K). (conicet.gov.ar)
Besides, studies of subcellular localization have showed the 24K in discrete nuclear bodies, which could be coincident with the localization of DICER1 and HYL1 proteins involved in microRNA biogenesis. (conicet.gov.ar)
We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
[ 9 ] which is made up of a complex of proteins and a small nuclear RNA named U1. (medscape.com)

Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
MicroRNAs (miRNAs) are a class of small (20-24 nucleotides (nt) long) non-coding RNAs. (biomedcentral.com)
Some regions of the genome encode non-protein-coding RNA like transfer RNAs, the RNA components of ribosomes, microRNAs and small interfering RNAs that regulate translation. (cilecenter.org)

gossypol as a potential small molecule inhibitor of MSI1\RNA conversation, and suggests that inhibition of MSI1's RNA binding activity may be an effective anti\malignancy strategy. (thetechnoant.info)
We show that small interfering RNA inhibition of SET8 expression leads to decreased cell proliferation and accumulation of cells in S phase. (rupress.org)
Inhibition of BTK in principal individual CLL cells by little interfering RNA promotes apoptosis. (healthandwellnesssource.org)
Several mechanisms of action have been proposed, including inhibition of thymidylate synthase and inhibition of RNA synthesis. (medscape.com)

Further, we developed a pipeline to characterise novel genome-wide endogenous short interfering RNAs (endo-siRNAs). (uni-frankfurt.de)

All LINEs encode a least one protein, ORF2, which contains an RT and an endonuclease (EN) domain, either an N-terminal APE or a C-terminal RLE or rarely both. (wikipedia.org)
Long non-coding RNA (lncRNA) is a type of RNA that contains over 200 nucleotides and that does not encode protein ( 5 , 6 ). (spandidos-publications.com)
Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
In our recent study, it was revealed that PXR interacts with DAZ-associated protein 1 (DAZAP1), which is an essential component of the paraspeckle, a membraneless nuclear body, and the interaction was disassociated by rifampicin, a ligand of PXR. (aspetjournals.org)
The fundamental engines of RNA silencing are RISC and RITS complexes, whose common components are 21-25 nt RNA and an Argonaute protein containing a PIWI domain of unknown function. (rcsb.org)
Our results demonstrated that NIMA-related kinase 2 (Nek2) binds β-catenin, blocking the interaction between this protein and the destruction complex, and ultimately contributing to sorafenib resistance for HCC. (biomedcentral.com)
In particular, quinolone-like compound 91 (C91) at a non-toxic nanomolar concentration reduced mSIN3b nuclear entry and occupancy at the RE1/NRSE within the Bdnf locus, and restored brain-derived neurotrophic factor (BDNF) protein levels in HD cells. (ox.ac.uk)
High glucose has been shown to induce inflammatory cytokines, chemokines, p38 mitogen-activated protein kinase, reactive oxygen species (ROS), protein kinase C (PKC), and nuclear factor-κB (NF-κB) activity in both clinical and experimental systems ( 7 - 12 ). (diabetesjournals.org)
These observations could be explained by interaction of a viral protein to precursors impeding the silencing machinery to access and process them. (conicet.gov.ar)
There are biochemical evidences of binding of 24K protein to long double strands RNAs in vitro. (conicet.gov.ar)
Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
This inhibits the formation of thymidylate and purines and arrests DNA, RNA, and protein synthesis. (medscape.com)

The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)
Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
For example, an individual miRNA may regulate multiple mRNAs, and in contrast, an individual gene may also be regulated by multiple miRNAs, thus representing a complex network of miRNA-mRNA interactions. (biomedcentral.com)
miRNAs are a class of small non-coding RNAs transcribed from miRNA genes ( MIRs ). (biomedcentral.com)

We also predicted phasing of siRNAs, which are regulated by the RNA interference (RNAi) pathway. (uni-frankfurt.de)
Further, using RAPID, we investigated the aberrations of endo-siRNAs, and their respective transcriptomic alterations caused by an RNAi pathway triggered by feeding small RNAs against a target gene. (uni-frankfurt.de)

A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
Another class of important small RNAs is the piRNAs. (biomedcentral.com)
Small RNAs including short-interfering (si)RNAs and piRNAs, and long RNAs such as long intergenic noncoding (linc)RNAs can direct histone modifications and cytosine methylation. (i-sis.org.uk)

For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)

87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)
The RNA-dependent RNA polymerase of the virus consists of PA, PB1, and PB2 subunits. (hku.hk)
With the wealth of knowledge from these studies, identification of small-molecule inhibitors that specifically disrupt the polymerase assembly or abrogate polymerase activities has emerged as an innovative and promising approach. (hku.hk)
In an attempt to facilitate the discovery of antiviral agents that target viral polymerase, isolated functional domains such as the PA endonuclease domain, the PB2 cap-binding domain, and the PA-PB1 interaction domains were expressed as screening targets. (hku.hk)
The docking analyses predicted the compounds targeting PA or PB2 interacted with enzyme active sites to abolish endonuclease or cap-binding activity of the polymerase, whereas the compound targeting the PA-PB1 interaction likely induced configurational changes that impeded polymerase assembly. (hku.hk)
Importantly, the established screening platforms for PA endonuclease inhibitors, PB2 cap-binding inhibitors, and PA-PB1 interaction disrupters should advance the development of a category of anti-influenza drugs that target viral polymerase. (hku.hk)

RNA silencing regulates gene expression through mRNA degradation, translation repression and chromatin remodelling. (rcsb.org)
PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells. (cirn-na.com)

Long interspersed nuclear elements (LINEs) (also known as long interspersed nucleotide elements or long interspersed elements) are a group of non-LTR (long terminal repeat) retrotransposons that are widespread in the genome of many eukaryotes. (wikipedia.org)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
Non-coding RNAs (ncRNAs), for a long time believed to be non-functional, are emerging as one of the most important and large family of gene regulators and key elements for genome maintenance. (biomedcentral.com)

Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)

Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
To identify genes, signaling pathways and networks that are controlled by SRC-3 and potentially important for hormone-dependent decidualization, we performed RNA-sequencing on HESCs in which SRC-3 levels were significantly reduced at the time of administering the deciduogenic stimulus. (frontiersin.org)
Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
While our genes are encoded by a varying sequence of nucleotides, the genotype is determined by the DNA sequence, both nuclear and mitochondrial. (cilecenter.org)
Others, on the other hand, depend on complex interactions between genes and life history and epigenetic signals from parents. (cilecenter.org)

Using this CasIP assay, we identified FECR1, a FLI1 exonic circular RNA that binds to the FLI1 promoter and epigenetically activates FLI1 in breast cancer cells. (biomedcentral.com)
A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)

Thus, a 3'OH group is freed for the reverse transcriptase to prime reverse transcription of the LINE RNA transcript. (wikipedia.org)
Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
The transcription actions of nuclear receptors is normally modulated by a thorough group of nuclear receptor cofactors (4 10 13 The id and characterization of the coregulator complexes are essential for understanding the mechanistic basis of nuclear receptor-regulated events. (sciencepop.org)
The lncRNAs have a broader spectrum of functions [ 2 , 3 ] such as regulation of transcription, RNA processing, nuclear-cytoplasmic transport, translation control and modulation of chromatin structure and are, therefore, a potential new class of cancer therapeutic targets [ 4 ]. (biomedcentral.com)
Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. (ox.ac.uk)

The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)
Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
Also, viral infection has proved to have a great impact on cellular small RNA expression and gene expression [ 9 - 11 ]. (hindawi.com)
RESULTS- Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase. (diabetesjournals.org)

MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
As these studies also revealed impaired cytochrome c release and a block in apoptosis upon small interfering RNA-mediated n-cofilin knockdown, n-cofilin was postulated to be essential for apoptosis induction. (nature.com)
Small RNAs are important regulators that modulate development, proliferation, differentiation, and apoptosis of organisms [ 15 , 16 ]. (hindawi.com)

These results suggest that paraspeckles play a role in trapping nuclear PXR in the absence of the ligand to negatively regulate transactivation of its downstream gene. (aspetjournals.org)

However, little is known about the molecular mechanisms underlying the aberrant activation of FLI1 in these solid tumors. (biomedcentral.com)
Molecular interactions involve several types of entities including Long non-coding RNAs (lncRNAs) and Small non-coding RNAs (sncRNAs), further divided into subclasses shortly called biotypes. (biomedcentral.com)

Using a CRISPR Cas9-guided immunoprecipitation assay, we identify a circular RNA in the FLI1 promoter chromatin complex, consisting of FLI1 exons 4-2-3, referred to as FECR1.Overexpression of FECR1 enhances invasiveness of MDA-MB231 breast cancer cells. (biomedcentral.com)
NcRNAs such as those involved in RNA interference can be independently inherited, and can also direct chromatin modification and DNA methylation see [7, 8] RNA Inheritance of Acquired Characters , and Nucleic Acid Invaders from Food Confirmed , SiS 63). (i-sis.org.uk)

RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
Arena-Idb provides a framework for network reconstruction of ncRNA heterogeneous interactions (i.e., with other type of molecules) and relationships with human diseases which guide the integration of data, extracted from different sources, via mapping of entities and minimization of ambiguity. (biomedcentral.com)
From a structure-based virtual screening of 7 million molecules, we selected 94 compounds predicted to interfere with REST complex formation by targeting the PAH1 domain of mSIN3b. (ox.ac.uk)

The viability of GBM cells was significantly decreased following RNA interference with DLEU1 and TRAF4 production. (spandidos-publications.com)

The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)

In addition, silencing of the IPO13 gene blocked nuclear translocation of c-Jun. (molvis.org)
RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)

We find that the small RNA transcriptome is altered, even if a gene unrelated to RNAi pathway is targeted. (uni-frankfurt.de)

Using HDAC5 deletion mutants and co-immunoprecipitation studies, we showed that HDAC5 physically interacted with the LSD1 complex through its domain containing nuclear localization sequence and phosphorylation sites. (johnshopkins.edu)
MSI1 contains a well\conserved RNA binding domain name (RBD) and exhibits sequence\specific RNA binding activity (Battelli et?al. (thetechnoant.info)
and mRNAs each contain at least one copy of the MSI1 consensus RNA binding sequence (MCS) (Battelli et?al. (thetechnoant.info)
RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
On this basis, we have studied the interaction of PrP with two reported DNA and RNA aptamers of sequence (GGAGGAGGAGGA), called D12 and R12. (unina.it)

This study investigated the role of long non‑coding RNAs (lncRNAs) in glioblastomagenesis progression. (spandidos-publications.com)

They interfere with DNA synthesis by blocking the methylation of deoxyuridylic acid. (medscape.com)
Vinca alkaloids act on the G and S phases of mitosis, inhibiting microtubule formation and inhibiting DNA/RNA synthesis. (medscape.com)
Anthracycline antineoplastics inhibit DNA and RNA synthesis by steric obstruction. (medscape.com)

Silencing of IL-15Ralpha by specific small interfering RNA in renal cell carcinoma had no effect on MbIL-15 production, indicating that the cytokine is not cross-presented by IL-15Ralpha in renal cell carcinoma cells but anchored to the membrane. (nih.gov)
Small interfering RNA demonstrated that silencing DLEU1 downregulated TRAF4. (spandidos-publications.com)

The FDA and EMA recommend in vitro testing of OATP1B1 interactions for drug candidates that are eliminated in part via the liver and/or will be co-administered with OATP1B1 substrates. (solvobiotech.com)

Furthermore, we find that SET8 interacts with proliferating cell nuclear antigen through a conserved motif, and SET8 is required for DNA replication fork progression. (rupress.org)

The outcome of viral infections depends on a complex during evolution that antagonize the host immune set of interactions between the viruses and their hosts. (cdc.gov)

Immunoprecipitation assays using PXR-overexpressing HepG2 (ShP51) cells revealed that PXR interacts with not only DAZAP1 but also NEAT1_2, a long noncoding RNA included in the paraspeckle, and that the interaction between PXR and NEAT1_2 was disassociated by rifampicin. (aspetjournals.org)
Immunoprecipitation and western blotting were then performed to identify regulatory interactions between β-catenin and Nek2. (biomedcentral.com)

These data suggest that FECR1 circular RNA acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes. (biomedcentral.com)
Thus, FLI1 drives tumor metastasis not only through the canonical oncoprotein pathway, but also by using epigenetic mechanisms mediated by its exonic circular RNA. (biomedcentral.com)
In this thesis work, a complete thermodynamic and kinetic investigation was performed using SPR, isothermal titration calorimetry and circular dichroism, in order to gain further information about the forces that drive this interaction. (unina.it)

We identified 36 new putative partners for PRMT6 and we validated the interaction in vivo for 7 of them. (embl.de)

In non-small cell lung cancer, the FLI1 expression score is associated with the stage of SCLC. (biomedcentral.com)
Human pregnane X receptor (PXR) is a major nuclear receptor that upregulates the expression of drug-metabolizing enzymes such as CYP3A4. (aspetjournals.org)
High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, and nuclear factor-κB (NF-κB) p65-dependent activation in THP-1 cells. (diabetesjournals.org)
Small inhibitory RNA to p47Phox in THP-1 cells abrogated high-glucose-induced TLR2 and TLR4 expression. (diabetesjournals.org)
In common with many drug metabolizing enzymes, OATP1B1 expression is known to be regulated by the nuclear hormone receptors FXR, HNF1α, HNF3β and HNF4α. (solvobiotech.com)

To this aim, several methodologies were used, such as fluorescence, surface plasmon resonance (SPR), nuclear magnetic resonance, differential scanning calorimetry, static light scattering and transmission electron microscopy. (unina.it)

SIGNIFICANCE STATEMENT This study revealed that PXR interacts with paraspeckle components NEAT1_2 and DAZAP1 to suppress CYP3A4 induction by PXR, and the interaction is dissociated by PXR ligands. (aspetjournals.org)

Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)
The IgSF11-expressing cells in OA subchondral bone were found to be involved in osteoclast maturation and bone resorption and colocalized with receptor-activator of nuclear-factor κ-B (RANK), the key osteoclast differentiation factor. (iasp-pain.org)

It may act as a competing endogenous RNA and influence tumorigenesis of GBM. (spandidos-publications.com)
2006). Our focus is usually on the function of MSI1 in tumorigenesis and on the development of small molecule inhibitors of MSI1 as a possible novel therapeutic approach. (thetechnoant.info)

However, the details of Adv and host interaction still remains poorly defined. (hindawi.com)

The doping SO42- anion in a polymer skeleton could confine lithium polysulfides (LiPSs) by polar-polar interaction to inhibit the shuttle effect and enhance the conductivity of PPy to accelerate polysulfide conversion. (bvsalud.org)

RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
A number of small-molecule compounds, i.e. (hku.hk)

Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)

Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)

The recognition of compounds that specifically interfere with proteinCprotein interactions is usually acknowledged as a challenging task, there is usually an even more severe lack of compounds that directly affect proteinCRNA interactions. (thetechnoant.info)

To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)

Although hemolysis and lipemia do not interfere with this assay, they are best avoided. (medscape.com)

This review summarizes the identification and functional characterization of the miRNAs, which respond to M. oryzae or its elicitors and describes the current understanding of the complicated but well-organized network in the context of rice- M. oryzae interaction. (biomedcentral.com)

5FMC is a nuclear complex that can only be recruited by Chtop when the latter is arginine-methylated by Prmt1. (embl.de)
Complex drug interactions involving OATP1B1, other uptake and efflux transporters, and drug-metabolizing enzymes (DMEs) have been described, as have clinically important genetic polymorphisms, resulting in label recommendations, dose adjustments, and product withdrawals. (solvobiotech.com)

Next, we identified full-length nuclear HER3 association and regulation of a 122 bp region of the cyclin D1 promoter. (plos.org)

LSD1 features in neural stem cells through interaction with Furthermore. (sciencepop.org)
Although miRNAs have been examined in Adv type 3-infected human laryngeal epithelial cells and Adv type 2-infected human lung fibroblast cells [ 19 , 20 ], there is no research about small RNA profiling in whole blood of Adv-infected pneumonia children. (hindawi.com)

[ 5 ] it has a sensitivity of 95%-100%, especially if it is found in high titers (ie, 1:1,000,000) and in isolation (ie without other extractable nuclear antigens such as anti-double stranded DNA). (medscape.com)

The functional domains present within ORF1 vary greatly among LINEs, but often exhibit RNA/DNA binding activity. (wikipedia.org)
Chronic visceral pain is a classic example of gene × environment interaction which results from maladaptive changes in neuronal circuitry leading to neuroplasticity and aberrant neuronal activity-induced signaling. (frontiersin.org)

Anatomy16

Organisms27

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes75

Information Science4

Health Care1

SiRNA9

Proteins8

MicroRNAs3

Inhibition4

Endogenous short1

Protein12

MiRNA5

SiRNAs2

PiRNAs3

Cell proliferation1

Polymerase7

Regulates2

Genome8

Genomes1

Genes7

Binds2

Transcription5

Gene expression5

Apoptosis3

Regulate1

Molecular2

Chromatin2

Molecules4

Interference1

Antisense1

Translocation2

Transcriptome1

Sequence5

LncRNAs1

Synthesis3

Silencing2

Vitro1

Progression1

Viral1

Immunoprecipitation2

Circular3

Putative1

Expression5

Surface plasmon r1

Paraspeckle1

Receptor3

Tumorigenesis2

Poorly1

Inhibit1

Molecule2

Biological functions1

PIWI1

Compounds1

Assays1

Assay1

Characterization1

Complex2

Regulation1

Cells2

Isolation1

Activity2