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  • roles
  • Present study directly defines the functional roles of SK2 channels in transgenic mice using a genetically engineered model, and provides a possible link between abnormalities in cardiac SK2 channels and cardiac arrhythmias. (nih.gov)
  • influx
  • Results suggest that SK2-channel activation may largely contribute to the sustained Ca2+ influx in the G0/G1 phase in comparison of that in the G2/M phase in Jurkat T-lymphocytes. (nih.gov)
  • afterhyperpolarization
  • Electrophysiological results showed that rats with visceral hypersensitivity presented a decrease in the SK channel-mediated afterhyperpolarization current ( I AHP ), and an increase in neuronal firing rates and c -Fos positive staining in the spinal DH. (frontiersin.org)
  • study
  • Yet, a recent study on human myometrium has shown that SK3 channels are exclusively found in telocytes, an interstitial Cajal-like cell type [ 18 ]. (hindawi.com)
  • In this study, we examined the influence of SK2 channels in the spinal DH on the pathogenesis of visceral hypersensitivity induced by colorectal distension (CRD) in rats. (frontiersin.org)
  • human
  • To this end, we tested a large number of AADs on the human K Ca 2.2 and K Ca 2.3 channels to assess their effect on this new target using automated whole-cell patch clamp. (sophion.com)
  • Small conductance Ca 2+ -activated K + channels (SK channels) in human myometrium have been shown to be downregulated in late pregnancy. (hindawi.com)
  • The aim was to investigate the presence of SK2 and SK3 in the human myometrium from nonpregnant women, pregnant women at term, and pregnancies delivered preterm and, in addition, to characterize the time of downregulation of these channels. (hindawi.com)
  • Several
  • New microfluidic and bioplotting devices offer increased resolution, little impact on cell viability and have been tested with several bioink materials including fibrin, collagen, hyaluronic acid, poly(caprolactone), and poly(ethylene glycol). (frontiersin.org)
  • decrease
  • Moreover, intrathecal administration of the SK2 channel activator 1-EBIO or CyPPA alleviated visceral hypersensitivity, reversed the decrease in I AHP and the increase in neuronal firing rates in spinal DH in rats that experienced CRD. (frontiersin.org)
  • Intrathecal administration of SK2 channel activator 1-EBIO or CyPPA prevented visceral hypersensitivity and decrease in I AHP . (frontiersin.org)