• To further analyze the BMP-responsive Smads, we disrupted the murine Smad8 gene utilizing the Cre/ loxP system. (asm.org)
  • Researchers Dan Gazit and colleagues at Hadassah Medical Center in Israel engineered mouse mesenchymal stem cells, which reside in the bone marrow and fat tissue, to express a protein called Smad8 and another called BMP2, each involved in the formation of bone and cartilage. (eurekalert.org)
  • Recently, protein ubiquitination has been shown to mediate several important molecular functions in T cells that are linked to the avoidance or development of autoimmunity. (biomedcentral.com)
  • Xenopus injection assays indicated that this Smad8 deletion allele is still functional but has reduced ventralizing capability compared to the wild type. (asm.org)
  • Soluble Fc‐fusion proteins of the extracellular domains of ALK4, ALK5, ALK7 and Acvr2b were incubated with haemagglutinin (HA)‐tagged GDF11 and used in pull‐down assays. (embopress.org)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • Thus, dysregulation of such protein, which regulates embryogenesis or organogenesis may cause tumorigenesis and metastasis. (omicsonline.org)
  • Ubiquitin is a highly conserved 76 amino acid globular protein that is attached to substrate proteins to modify a variety of cellular processes. (biomedcentral.com)
  • Thompson R, Vardinogiannis I, Gilmore T. The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity. (labome.org)
  • however existing protocols usually do not predict compound functional effects, such as activation or inhibition, upon binding to their protein counterparts. (frontiersin.org)
  • Apweiler R, Attwood TK, Bairoch A et al (2001) The InterPro database, an integrated documentation resource for protein families, domains and functional sites. (springer.com)
  • Amir RE, Van den Veyver IB, Wan M et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. (springer.com)
  • Like D-17, the three cell lines expressed p53 proteins that were capable of activating promoters with p53 response elements on their own, and synergistically with Zhangfei. (biomedcentral.com)
  • The authors note that BMP and Smad proteins are involved in other tissues such as nerve and liver, suggesting that this type of delivery technology may be helpful for other degenerative diseases. (eurekalert.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • Akopian D, Shen K, Zhang X, Shan S-O (2013) Signal recognition particle: an essential protein-targeting machine. (springer.com)
  • Although first described as a mechanism for proteolysis of misfolded or damaged proteins, ubiquitination is now appreciated as an important modification for cellular trafficking and transcriptional activation, as well as for proteasomal- and lysosomal-mediated degradation of signaling intermediates in the regulation of normal cell function. (biomedcentral.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • Different patterns of covalent attachment of ubiquitin to target proteins provide a further level of specificity to regulation of cellular processes by ubiquitination. (biomedcentral.com)
  • Below, enzymes important to the regulation of protein ubiquitination in T cells will be described and their roles as negative regulators of autoimmunity will be considered in more detail. (biomedcentral.com)