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  • Antibody
  • This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS. (abcam.cn)
  • Nanog
  • The team, headed by professor Juan Carlos Ispizúa Belmonte , Ph.D., of the Gene Expression Laboratory and including professor Fred Gage , Ph.D., of the Laboratory of Genetics, demonstrates how a DNA-binding protein called Nanog coaxes mouse ES cells trying to differentiate into muscle cells back into an immature state. (salk.edu)
  • When BMP turns ES cells into muscle it activates a protein called Smad1, a DNA-binding protein that, in opposition to Nanog, switches on genes responsible for muscle cell fate. (salk.edu)
  • With Smad1 out of the game and Nanog in full control, cells revert to their forever-young state. (salk.edu)
  • Identifying the Nanog/Smad1 feedback loop indeed has significant implications for regenerative medicine. (salk.edu)
  • Nuclear
  • CK1delta enhances EPO secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (show EPAS1 Proteins ) and promoting its nuclear accumulation. (antibodies-online.com)
  • Our group, in parallel with others, identified two murine mab-21 genes ( Mab21l1 , Mab21l2 ) [ 5 - 8 ] and the human MAB21L2 gene, and showed that they encode nuclear proteins [ 6 ] that are 94% identical, 98% homologous to each other. (biomedcentral.com)
  • MAPK
  • We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes to a ventral vegetal gastrula region that could coordinate DV patterning with AP patterning ventrally without degrading P-Smad1/5. (zfin.org)
  • decrease
  • When the researchers looked for SMAD1 status in the biopsy specimens collected from patients enrolled in the phase I trial, they found that after treatment with azacitidine, there was a decrease in SMAD1 methylation and increase in SMAD1 protein, providing proof of principle. (healthcanal.com)
  • mice
  • The lack of effect of erythropoietin on hepcidin (show HAMP Proteins ) expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin administration in both C57BL/6 and mask mice. (antibodies-online.com)
  • pathways
  • In addition, the basic helix-loop-helix proteins of the Hey family are targets of both Notch and BMP pathways, providing the potential to further regulate ≤2000 additional mRNAs. (ahajournals.org)
  • molecule
  • Each TGF β subunit is synthesized as a large inactive precursor molecule bound to accessory proteins (LAP and LTBP). (hindawi.com)
  • complex
  • As shown in Figure 1 , latent TGF β is composed of a TGF β dimer in a noncovalent complex with the TGF β propeptide or latency-associated peptide (LAP) that remains bound to TGF β after secretion, retaining TGF β in an inactive form and the latent TGF β -binding protein (LTBP) which is linked to LAP by a disulfide bond [ 12 ]. (hindawi.com)
  • cells
  • Notably, we found that HSC-4 cells were the most responsive to BMP-2 stimulation, which resulted in the upregulation of Smad1/5/9 target genes such as the MET inducers ID1 and cytokeratin 9 (CK9). (spandidos-publications.com)
  • The motile properties of intermediate filament (IF) networks have been studied in living cells expressing vimentin tagged with green fluorescent protein (GFP-vimentin). (flora2world.com)
  • P-SMAD1/5 positive perivascular cells were alpha SMA positive and located around VWF positive endothelial cells. (kuleuven.be)
  • Some CD90 positive synovial fibroblasts were P-SMAD1/5 positive, as was part of the CD68 positive synovial cells but other cells of the haematopoietic lineage showed no SMAD1/5 phosphorylation. (kuleuven.be)
  • Show
  • these findings define a cis (show CISH Proteins )-regulatory enhancer network for Epo signaling during erythropoiesis, and provide the framework for future studies involving the interplay of epigenetics and Epo signaling. (antibodies-online.com)
  • development
  • Interestingly, SMAD1 is required for the development of particular substantia nigra neurons, which predominantly degenerate in Parkinson's disease, shedding light on the vulnerability of this subset of dopaminergic neurons. (bgu.ac.il)
  • Despite mounting evidence of their considerable importance in development, the biochemical properties and nature of MAB-21 proteins have remained strikingly elusive. (biomedcentral.com)