Supranuclear Palsy, ProgressiveAphasia, Primary ProgressiveDisease ProgressionMultiple Sclerosis, Chronic ProgressiveMyoclonic Epilepsies, ProgressiveOphthalmoplegia, Chronic Progressive ExternalDisease Models, AnimalJC VirusTime FactorsAtrophyMagnetic Resonance ImagingBrainBulbar Palsy, ProgressiveTreatment OutcomeFatal OutcomePrimary Progressive Nonfluent AphasiaPneumonia, Progressive Interstitial, of SheepMutationNerve DegenerationMultiple SclerosisPedigreeMice, TransgenicFollow-Up StudiesPhenotypeAgingKidneyMice, Inbred C57BLImmunohistochemistrySyndromeNeurodegenerative DiseasesTomography, X-Ray ComputedProteinuriaFibrosisMultiple Sclerosis, Relapsing-RemittingCerebellar AtaxiaRetinal DegenerationRetrospective StudiesBiopsyMice, KnockoutGlomerulonephritisCells, CulturedHearing Loss, SensorineuralMolecular Sequence DataDogsSperm MotilityKidney DiseasesMotor Neuron DiseaseCholestasis, IntrahepaticParkinson DiseaseKidney GlomerulusProgressive Patient CareAtaxiaAge of OnsetAmyotrophic Lateral SclerosisSpinal Cord DiseasesSpinal CordSeverity of Illness IndexChronic DiseaseRats, Sprague-DawleyMuscle, SkeletalRNA, MessengerFacial HemiatrophyDose-Response Relationship, DrugNeuronsAnalysis of VarianceAlzheimer DiseaseMultiple System AtrophyLungDementiaPneumoconiosisMicroscopy, ElectronPrognosisDog DiseasesBrain DiseasesBase SequenceMutation, MissenseGlomerulosclerosis, Focal SegmentalOphthalmoplegiaScleroderma, SystemicProspective StudiesNeuropsychological TestsDNA Mutational AnalysisBiological MarkersPulmonary FibrosisMyoclonusAphasia, BrocaTauopathiesRecurrenceGenes, RecessiveAge FactorsDrug Administration ScheduleAntineoplastic Combined Chemotherapy Protocolstau ProteinsFrontotemporal DementiaHuntington DiseaseRetinitis PigmentosaMuscle WeaknessLafora DiseaseParkinsonian DisordersNeurologic Examination