Chemically, mecamylamine is a secondary aliphatic amine, with a pKaH of 11.2 Mecamylamine has been used as an orally-active ganglionic blocker in treating autonomic dysreflexia and hypertension, but, like most ganglionic blockers, it is more often used now as a research tool. (wikipedia.org)
Mecamylamine HCl is a potent, oral antihypertension agent and ganglion blocker, and is a secondary amine. (nih.gov)
Mecamylamine, a secondary amine, readily penetrates the brain and thus may produce central nervous system effects. (nih.gov)
Tablet1
Claritin-D 24 hour extended release tablets contain 10 mg loratadine in the tablet film coating for immediate release and 240 mg pseudoephedrine sulfate in the tablet core which is released slowly allowing for once-daily administration. (globalrph.com)
Large2
A large SAR study of mecamylamine and its analogs was reported by a group from Merck in 1962. (wikipedia.org)
These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency. (nih.gov)
Effects1
On the other hand, the effects of Mecamylamine HCl sometimes may last from hours to days after therapy is discontinued. (nih.gov)