• 2023. https://www.nih.gov/news-events/news-releases/low-dose-atropine-eyedrops-no-better-placebo-slowing-myopia-progression#:~:text=Much%20stronger%20concentrations%20of%20atropine,while%20on%20the%20nightly%20eyedrops . (hcplive.com)
  • Two studies presented at AAO demonstrate that low dose atropine is associated with slowing myopia progression, but another study finds that this is not true. (hcplive.com)
  • The treatment will significantly slow the progression of myopia. (hcplive.com)
  • Pediatrics have previously used stronger doses of atropine (concentration: 0.5-1.0%) to slow myopia progression, but the dose leaves side effects such as light sensitivity and blurry near vision. (hcplive.com)
  • Darren J. Bell, MD, of the Medical Center Ophthalmology Associates in Texas presented the Phase III CHAMP (Childhood Atropine for Myopia Progression), a landmark, 3-year, placebo-controlled international clinical study, which showed lose-dose atropine is effective in slowing progression in children aged 3 - 17 years old who live in the U.S. and European Union. (hcplive.com)
  • A trial conducted by Pediatric Eye Disease Investigator Group (PEDIG) showed mixed results, finding low-dose atropine eyedrops (concentration 0.01%) did not do a better job than placebo at myopia progression. (hcplive.com)
  • Could we develop other approaches to treatment or prevention based on a better understanding of what causes myopia progression? (hcplive.com)
  • Growing Body of Research Suggests Low-Dose Atropine Can Help Slow Myopia Progression in Children. (hcplive.com)
  • Low-dose Atropine Eyedrops No Better Than Placebo for Showing Myopia Progression. (hcplive.com)
  • New research published in JAMA Ophthalmology has found 0.01% atropine eye drops did not slow myopia progression in a group of 187 US children. (aop.org.uk)
  • The researchers found that nightly low-dose atropine did not slow myopia progression when compared to placebo. (aop.org.uk)
  • The results of the study differ from five clinical trials in East Asian and South Asian populations with similar age and refractive error which found beneficial effects of atropine for limiting myopia progression. (aop.org.uk)
  • The first spectacles lenses that have demonstrated significant reduction of myopia progression over 36 months in a multi centre, multi-ethnicity study with children as young as 6 years old². (sightglassvision.com)
  • No clinically meaningful change in refractive error means that there was less than a 0.25D increase in myopia progression from baseline as measured by cycloplegic autorefraction. (sightglassvision.com)
  • Myopia (nearsightedness) cannot be stopped from getting worse, however, we can help slow it down. (drjulie.ca)
  • Here are 3 best ways to slow down your child's myopia. (drjulie.ca)
  • 1 Lam CSY, Tang WC, Tse DY, Lee RPK, Chun RKM, Hasegawa K, Qi H, Hatanaka T, To CH. Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomized clinical trial. (drjulie.ca)
  • AMSTERDAM - Patients with Parkinson's disease (PD) who are deep sleepers, defined as getting more slow-wave sleep, have slower progression of their disease compared to light sleepers, new research suggests. (medscape.com)
  • It indicates that higher slow-wave sleep predicts a slower progression of axial symptoms as well as gait and postural function in patients with Parkinson's disease. (medscape.com)
  • A UCSF-led study examining the impact of statins on the progression of multiple sclerosis found a lower incidence of new brain lesions in patients taking the cholesterol-lowering drug in the early stages of the disease as compared to a placebo . (medicalnewstoday.com)
  • It is important that we understand how statins impact the progression of multiple sclerosis in order to better inform physicians and patients of their effect since these drugs are so broadly used throughout the United States and the world, and to learn whether a relatively inexpensive oral therapy can slow the course of disease," said Waubant. (medicalnewstoday.com)
  • Older patients with newly diagnosed chronic lymphocytic leukemia (CLL) had an almost 80% reduction in the risk of disease progression or death with a fixed-duration, all-oral regimen, according to a randomized study. (medpagetoday.com)
  • Currently, ibrutinib is taken daily until disease progression and venetoclax is also dosed once daily as part of a 12-cycle combination therapy. (medpagetoday.com)
  • This is helping us to understand why patients with cancer who exercise exhibit slower disease progression and survive for longer. (acefitness.org)
  • Dr Anjay Rastogi, clinical chief of nephrology at University of California, Los Angeles reports on strategies to slow the progression of ADPKD, including lifestyle modifications, management of complications, and disease-specific therapy. (medscape.com)
  • Cite this: Slowing Progression of Autosomal Dominant Polycystic Kidney Disease - Medscape - Feb 25, 2022. (medscape.com)
  • Back in the early 2000s, scientists tested an existing bacterial antibiotic drug called minocycline in human clinical trials to see if it could reduce inflammation and immune responses and therefore slow the progression of ALS in people living with the disease. (als.ca)
  • My hypothesis is that by changing the activity of SRSF3, I will be able to completely reprogram the function of the microglia and slow down disease progression in ALS," said Dr. Kriz. (als.ca)
  • If we can block that action, the microglia should remain normal longer, slowing the disease. (als.ca)
  • DESCRIPTION (provided by applicant): Recent work suggests that exercise that moderate-to-vigorous intensity physical exercise is associated with slowing of symptom progression (motor, cognitive, and psychiatric) in prodromal Huntington's Disease (HD). (neurodegenerationresearch.eu)
  • Results from a small clinical trial show that the Parkinson's disease drug ropinirole delayed the progression of amyotrophic lateral sclerosis (ALS) by an average of 27.9 weeks. (technologynetworks.com)
  • Now, researchers in the current study report the findings from a clinical trial of ropinirole in a small number of ALS patients, with its findings suggesting ropinirole slowed disease progression over a six-month period. (technologynetworks.com)
  • Ionis Pharmaceuticals) slowed disease progression and reduced the deterioration of quality of life in patients with hereditary transthyretin (hATTR) polyneuropathy. (neurologylive.com)
  • Fluoxetine was the only one that slowed the progression of the disease. (uvaphysicianresource.com)
  • Amplitude training - big movements - actually slows the progression of Parkinson's," said Moncheski, a physical therapist who specializes in working with those who have the disease. (bestlifehere.com)
  • The disease causes everything to get smaller and slower, including the voice. (bestlifehere.com)
  • Does uric acid-lowering treatment slow the progression of chronic kidney disease? (revistanefrologia.com)
  • Hyperuricemia has been proposed as an independent factor in the development and progression of chronic kidney disease (CKD). (revistanefrologia.com)
  • This is the first Phase 3 trial of any investigational medicine for Alzheimer's disease to deliver 35% slowing of clinical and functional decline," he said. (upi.com)
  • However, Eisai Co.'s Leqembi, co-marketed with Biogen, also showed it slowed disease progression, and it received FDA approval in January. (upi.com)
  • New research reveals a type of monoclonal antibody already tested in certain forms of cancer may be a promising treatment in stopping the progression of amyotrophic lateral sclerosis, or ALS, a fatal neurodegenerative disease. (news-medical.net)
  • The addition of denosumab to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) may inhibit the progression of bone erosion and improve bone microarchitecture in patients with rheumatoid arthritis (RA), according to study findings published in Arthritis Research & Therapy . (rheumatologyadvisor.com)
  • Slowing the Progression of Diabetic Kidney Disease. (bvsalud.org)
  • Since the 1990s, specific therapies have emerged and been approved to slow the progression of diabetic kidney disease , namely, renin-angiotensin-aldosterone system blockers (including angiotensin-converting enzyme inhibitors (ACEi) angiotensin receptor blockers (ARBs), the non-steroidal mineralocorticoid receptor antagonist (NS-MRA), finerenone, and sodium - glucose cotransporter-2 (SGLT2) inhibitors). (bvsalud.org)
  • Mechanistically, these different classes of agents bring different anti-inflammatory, anti-fibrotic, and complementary hemodynamic effects to patients with diabetic kidney disease such that they have additive benefits on slowing disease progression . (bvsalud.org)
  • Thus, all three classes (maximally dosed ACEi or ARB, low- dose SGLT-2 inhibitors , and the NS-MRA, finerenone) form the "pillars of therapy " such that, when used together, they maximally slow diabetic kidney disease progression. (bvsalud.org)
  • Increased vascular permeability is a major contributor to the progression of DR and the application of specific sEH inhibitors appeared to be capable of preventing disease progression in animal models. (euretina.org)
  • Consequently, interference in the disease at this stage of development may present an opportunity to halt an early stage of the disorder, potentially delaying disease progression and extending years of valuable vision. (euretina.org)
  • Can marijuana protect the immune system against HIV and slow disease progression? (eurekalert.org)
  • This study is important because it begins to explain how THC can influence disease progression in SIV-infected macaques. (eurekalert.org)
  • It also reveals a new way to slow disease progression. (eurekalert.org)
  • In the progression of the disease, continued dilation of the tubules through increased cell proliferation, fluid secretion, and separation from the parental tubule lead to the formation of cysts. (wikipedia.org)
  • Given its slow progression, painless nature, ignorance about the disease and its causes, and scarcity of medical and health facilities in the areas where it occurs, many patients present late with advanced disease, when amputation may be the only available treatment. (who.int)
  • Interpretation RAPID-OLE supports the continued efficacy of A1PI in slowing disease progression during 4 years of treatment. (lu.se)
  • New Alzheimer's research from UVA Health suggests that enhanced light sensitivity may contribute to "sundowning" - the worsening of symptoms late in the day - and spur sleep disruptions thought to contribute to the disease's progression. (news-medical.net)
  • Reuters Health - 08/01/2021 - A lifestyle intervention centered on the DASH diet, which is high in fruits, vegetables, whole grains and low-fat dairy products, may be able to slow the progression of atherosclerosis and reduce the volume of noncalcified plaque in patients with nonobstructive coronary atherosclerosis, a new pilot study from Poland hints. (medicom-publishers.com)
  • may be effective in slowing the progression of atherosclerosis and decreasing plaque vulnerability" in patients with nonobstructive coronary atherosclerosis, the researchers say. (medicom-publishers.com)
  • They also looked at an index of seven UPDRS 3 symptoms (the UPDRS progression factor), which, according to Dr Schreiner, best indicates PD progression. (medscape.com)
  • In people with overweight and obesity, losing weight can improve knee osteoarthritis symptoms, and some evidence supports that it may also slow joint structural changes," King, of the department of medicine at the University of Toronto, said in an email. (medscape.com)
  • Keeping B cells outside of the brain by blocking their migration but retaining them in the blood could reduce MS symptoms and progression - without the infectious side effects because they are not depleted from the rest of the body. (medicalnewstoday.com)
  • we all look to supplements to relieve our symptoms and hope that they can somehow slow down progression. (alsnewstoday.com)
  • However, there are several things patients can do to slow the progression of COPD and control symptoms. (cdc.gov)
  • Quitting can slow the progression of COPD and may mean fewer symptoms or flare ups. (cdc.gov)
  • In clinical terms, the progression was much faster in the group of light sleepers compared to the group of deep sleepers," he said. (medscape.com)
  • They found that patients taking fluoxetine for clinical depression had a significantly slower rate of developing dry AMD. (uvaphysicianresource.com)
  • May 3 (UPI) -- Pharmaceutical giant Eli Lilly said Wednesday results from a Phase 3 study on its Alzheimer's treatment slowed clinical cognitive and functional decline by 35% compared with a placebo. (upi.com)
  • It is the first anti-amyloid treatment the FDA has fully approved and the first to clearly slow cognitive decline in patients with early Alzheimer's. (legalinsurrection.com)
  • Here are some lifestyle changes that may help slow the progression of diabetic macular edema, as well as diabetic retinopathy more broadly. (tiptechblog.com)
  • Treatment of diabetic animal models with an inhibitor of the sEH enzyme appeared to prevent both pericyte loss and vascular permeability suggesting a potential therapeutic role for sEH inhibitors to delay the development and progression of DR. (euretina.org)
  • Early detection of rapid kidney function decline combined with appropriate interventions hold promise for stopping or slowing progression of renal insufficiency among these workers. (cdc.gov)
  • Research shows that systematic sensory stimulation may help slow the development of dementia, says Håpnes. (who.int)
  • Although the study was small with only 81 participants and its primary endpoint, designed to evaluate MS progression in patients following their first attack, was not met, the researchers found over the 12-month course that 55.3 percent of participants did not develop new brain lesions when administered statins compared with 27.6 percent of the placebo group. (medicalnewstoday.com)
  • High levels of vitamin D may help slow the progression of breast cancer, researchers suggested Tuesday. (advocate.com)
  • The researchers used a variety of measures to assess how effective ropinirole was at slowing ALS progression, including participants' physical activity, their ability to eat and drink on their own and changes in mobility, muscle strength and lung function. (technologynetworks.com)
  • Bradley D. Gelfand, PhD, and a team of researchers at UVA Health have found evidence that the popular antidepressant drug fluoxetine, commonly known as Prozac, could prevent or slow the progression of dry AMD. (uvaphysicianresource.com)
  • The researchers also found that eating a wide variety of fruits and vegetables may help prevent or slow retinopathy due to the vitamins, minerals, fiber, and other nutrients they contain. (tiptechblog.com)
  • Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. (ox.ac.uk)
  • Background Purified α1 proteinase inhibitor (A1PI) slowed emphysema progression in patients with severe α1 antitrypsin deficiency in a randomised controlled trial (RAPID-RCT), which was followed by an open-label extension trial (RAPID-OLE). (lu.se)
  • More than 150 patients were originally intended, but enrollment was stopped due to slow recruitment after 81 patients were randomized. (medicalnewstoday.com)
  • Patients assigned to the combination of ibrutinib (Imbruvica) and venetoclax (Venclexta) had yet to reach median progression-free survival (PFS) after a median follow-up of 27 months, whereas the control regimen of obinutuzumab (Gazyva) and chlorambucil led to a median PFS of 21.0 months. (medpagetoday.com)
  • 30 Jul 2019 --- Vitamin D supplementation may slow the progression of Type 2 diabetes in newly diagnosed patients and those with prediabetes, according to a study published in the European Journal of Endocrinology. (nutritioninsight.com)
  • Lilly said the 35% slowing of progression was the outcome of a trial involving 1,182 patients with early-stage Alzheimer's. (upi.com)
  • Addition of denosumab to csDMARDs may be effective in slowing the progression of bone erosion and improving bone microarchitecture in patients with RA. (rheumatologyadvisor.com)
  • Un échantillon choisi à dessein de 50 patients souffrant de glaucome, âgés de 12 à 18 ans, consultant un centre de soins externes en ophtalmologie au Caire (Égypte) a bénéficié d'un programme éducatif sur cette maladie, visant à corriger leurs idées fausses et leurs attentes, et comportant des démonstrations et des formations de perfectionnement sur les soins oculaires. (who.int)
  • This process is known as mechanotransduction and plays a fundamental role in the progression of solid tumours, such as breast cancer. (ecancer.org)
  • A study published today in the journal Nature Materials demonstrates a cellular mechanism that could be pivotal in slowing the progression of breast tumours. (ecancer.org)
  • Furthermore, we show that stromal cells in pancreatic tumours, which actively participate in PDAC progression, are enriched for ABCC3, and that its inhibition may contribute to stroma reprogramming. (unich.it)
  • The study showed that blocking ALCAM in mice lessens the flow of B cells to the brain and slows the progression of MS. (medicalnewstoday.com)
  • She will conduct lab experiments using cultured microglia from adult SOD1 mice as they are excellent models of human ALS progression and the immune system. (als.ca)
  • RESULTS: Using both mouse models and human cell lines of PDAC, we show that the pharmacological inhibition of ABCC3 significantly decreased PDAC cell proliferation and clonal expansion in vitro and in vivo, remarkably slowing tumour growth in mice xenografts and patient-derived xenografts and increasing the survival rate in a transgenic mouse model. (unich.it)
  • To quantify deep sleep, investigators used a measure called slow-wave energy (SWE). (medscape.com)
  • The investigators found that a higher dose was effective, and by the 4- or 5-year follow-up, children could have as-needed treatment if they had a stable progression. (hcplive.com)
  • Currently Georgetown University is looking for participants for a randomized, double blind, placebo-controlled study to evaluate the impact of low doses of a cancer fighting drug on slowing the progression of neurodegenerative diseases. (nursepartners.org)
  • They had higher physical activity and experienced a slower decline in mobility, muscle strength and lung function compared to those in the placebo group. (technologynetworks.com)
  • Throughout the open-label extension, the placebo-inotersen group exhibited greater neurologic worsening from NEURO-TTR baseline than the inotersen-inotersen group, and earlier initiation of inotersen resulted in better outcomes in measures of neuropathy progression, neuropathy-related QOL, and health-related QOL," Brannagan and colleagues concluded. (neurologylive.com)
  • The study findings suggest that high-dose supplementation of vitamin D can improve glucose metabolism to help prevent the development and progression of diabetes. (nutritioninsight.com)
  • Pericyte loss is thought to be among the first of the vascular changes brought about by diabetes leading to downstream secondary changes and progression of more the full blown pathology. (euretina.org)
  • Poor control of diabetes accelerates their progression. (who.int)
  • But treatment can prevent and slow vision loss and other complications related to DME. (healthline.com)
  • The estimated difference between the two treatment arms translated into a 78.4% reduction in the risk of progression or death in favor of ibrutinib-venetoclax. (medpagetoday.com)
  • Although the addition of denosumab to conventional treatment did not lead to a statistically significant improvement in bone erosion, numerical improvements in these parameters suggest that the addition of denosumab to csDMARDs may inhibit the progression of bone erosion," the study authors said. (rheumatologyadvisor.com)
  • The goal of treatment is to stop the progression of the RA. (medlineplus.gov)
  • The aim was to investigate the prolonged treatment effect of A1PI on the progression of emphysema as assessed by the loss of lung density in relation to RAPID-RCT. (lu.se)
  • Overall, progress has been slow in 2019, but in many countries the political will remains to keep this item on the agenda. (oliverwyman.com)
  • Over a mean observation time of about 5 years, the levodopa equivalent dose was significantly increased, as were the UPDRS 3 score and the "progression factor. (medscape.com)
  • Ibrutinib and venetoclax showed a significant improvement in progression-free survival compared to standard-of-care chemoimmunotherapy in first-line CLL. (medpagetoday.com)
  • Women who took tucatinib experienced longer progression-free survival (time before their cancer worsened), longer overall survival time and response of cancer (shrinking or disappearing). (facingourrisk.org)
  • Could GLP-1 RA Drugs Ease Knee OA Pain, Slow Progression? (medscape.com)
  • However, there are certain drugs, commonly known as anti-B cell drugs, which help moderate attacks and delay the progression of disability. (medicalnewstoday.com)
  • As a result, research to find drugs capable of effectively slowing down the progression of ALS is sorely needed. (technologynetworks.com)
  • It lends support to the idea that vitamin D has a role in the progression of breast cancer,' he told Reuters. (advocate.com)
  • Although the scientists do not know whether the low levels of vitamin D are a cause or a consequence of the cancer, their findings and the results of other studies suggest that low levels of vitamin D may be involved in the progression of early breast cancer to more advanced stages. (advocate.com)
  • It is well-established that a common mechanical alteration in cancer progression involves tissue hardening. (ecancer.org)
  • MONDAY, March 23, 2015 (HealthDay News) - Vitamin D supplements may slow or prevent low-grade prostate cancer from progressing, a small new study suggests. (ehealth-news.com)
  • Epithelial mesothelioma is the most common, and these cancer cells cling more strongly to each other, so metastasis is slower with this type of mesothelioma. (mesothelioma.net)
  • Early progression of this cancer may see it spread throughout the abdomen, but distant metastasis only occurs later and outside the abdomen. (mesothelioma.net)
  • Research by an optometrist at the University of Houston (UH) supports the continued investigation of optical treatments that attempt to slow the progression of nearsightedness in children. (news-medical.net)
  • Nystagmus, slow saccades, and abnormal fundoscopic examination findings are present in varying degrees. (medscape.com)
  • This will slow joint destruction and prevent deformities. (medlineplus.gov)
  • Efforts to prevent and/or slow progression of CKD are essential. (cdc.gov)
  • The potential of targeting ABCC3 with MCI-715 to counteract PDAC progression was additionally tested in several animal models of PDAC, including xenograft mouse models and transgenic mouse model of PDAC. (unich.it)
  • Can the key to slowing ALS progression be found in the immune cells of the brain? (als.ca)
  • In the proposed study, MR will be used to assess the impact of fitness and an exercise intervention on well established markers for HD progression in the brain including: volume of the caudate and putamen and white matter integrity using diffusion weighted imaging. (neurodegenerationresearch.eu)
  • and 2) Does a moderate-to-vigorous exercise intervention influence the progression of motor impairment and brain degeneration in prodromal HD? (neurodegenerationresearch.eu)
  • We hypothesize that initiating a moderate intensity physical exercise program will substantially slow progressive striatal volume loss and improve connectivity in prodromal HD. (neurodegenerationresearch.eu)
  • Experts believe that deep sleep (slow-wave sleep) is the most restorative type of sleep. (medscape.com)
  • Subgroup analyses showed that the difference in follow-up time and CKD population type in the studies may explain the controversy about the role of uric acid-lowering therapies in CKD progression. (revistanefrologia.com)
  • Overall, said Dr. Mathers, who was not involved in the worsk, "this new study provides some further information on the mechanisms through which a DASH-type diet may lower CVD risk by preventing progression of atherosclerotic plaques. (medicom-publishers.com)
  • The association we found between slow-wave sleep and PD progression was very robust," said Dr Schreiner. (medscape.com)
  • Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. (hindawi.com)
  • This measure represents the depth and duration of slow-wave sleep," said Dr Schreiner. (medscape.com)