NephrinPodocyte slit diaphragmPodocytesProteinsMoleculesKIRREL1KidneyPodocinMutationsAdjustableIntracellularLampDevelopmentStructureSiteOpenSurfaceAreaPodocytesPodocyte slitFiltrationDiameterNephrotic syndromeIlluminationApertureSeptumLampIntercellularTRPC6LampsMembraneNeedleExtendsExperimentsDoubleMaintenancePerformanceFormationRangeForms
Nephrin6
- Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. (musc.edu)
- Nephrin is located at the cell surface in the area between two podocytes called the slit diaphragm. (encyclopedia.pub)
- Nephrin proteins are essential for forming the slit diaphragm, anchoring the slit diaphragm to podocytes, and filtering blood. (encyclopedia.pub)
- A shortage of functional nephrin at the podocyte cell surface impairs the formation of normal slit diaphragms. (encyclopedia.pub)
- thesis Investigating intracellular SNARE-mediated trafficking of the kidney slit diaphragm protein nephrin . (uoguelph.ca)
- This syndrome is an autosomal recessive disorder that affects 1/8200 Finnish neonates and is caused by a mutation in the NPHS1 gene, which codes for a podocytic slit-diaphragm protein (nephrin). (msdmanuals.com)
Podocyte slit diaphragm2
- Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. (ox.ac.uk)
- The podocyte slit diaphragm--from a thin greyline to a complex signalling hub. (encyclopedia.pub)
Podocytes7
- Here, we show that Lmx1b(-/-) podocytes have reduced numbers of foot processes, are dysplastic, and lack typical slit diaphragms, indicating an arrest in development. (nih.gov)
- Within the brain, dendrin is normally found in the forebrain and hippocampus and in the kidneys, dendrin is normally found in the slit diaphragm and podocytes. (wikipedia.org)
- In normal mature kidneys, dendrin is found only in the podocytes near the slit diaphragm. (wikipedia.org)
- Thrombospondin Type 1 Domain-Containing 7A (THSD7A) Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. (sfb1192.de)
- Moreover, its homolog Pard3b, and not Pard3a, is the dominant Par3 gene expressed in podocytes and found at the basis of the slit diaphragm, where it partially colocalizes with podocin. (uni-koeln.de)
- Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. (musc.edu)
- All can be found in podocytes of the kidney glomerulus, and play a role in barrier function in the slit diaphragm. (bio-techne.com)
Proteins5
- Our results indicate that reduced levels of proteins associated with foot processes and the glomerular slit diaphragm likely contribute, along with reduced levels of GBM collagens, to the nephropathy associated with NPS. (nih.gov)
- In conclusion, Par3A function is either dispensable for slit diaphragm integrity, or compensatory mechanisms and a high redundancy of the different polarity proteins, including Par3B, Lgl, or PALS1, maintain the function of the glomerular filtration barrier, even in the absence of Par3A. (uni-koeln.de)
- Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. (musc.edu)
- The slit diaphragm is known as a filtration barrier because it captures proteins in blood so that they remain in the body while allowing other molecules like sugars and salts to be excreted in urine. (encyclopedia.pub)
- This structure allows the passage of small molecules through the slit diaphragm while preventing larger molecules like proteins from passing through. (encyclopedia.pub)
Molecules4
- However, mRNA and protein levels for CD2AP and podocin were greatly reduced, suggesting a cooperative role for these molecules in foot process and slit diaphragm formation. (nih.gov)
- Reduction of Slit Diaphragm-associated Molecules by Sirolimus: Is it Enough to Induce Proteinuria? (ewha.ac.kr)
- Although sirolimus treatment reduced the expressions of slit diaphragm-associated molecules and increased serum creatinine levels, it failed to induce proteinuria. (ewha.ac.kr)
- Without a functional slit diaphragm, molecules pass through the kidneys abnormally and are excreted in urine. (encyclopedia.pub)
KIRREL11
- Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. (musc.edu)
Kidney1
- The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. (sdbonline.org)
Podocin3
- Here we show, by immunoelectron microscopy, that podocin localizes to the podocyte foot process membrane, at the insertion site of the slit diaphragm. (jci.org)
- Podocin accumulates in an oligomeric form in lipid rafts of the slit diaphragm. (jci.org)
- We postulate that podocin serves in the structural organization of the slit diaphragm and the regulation of its filtration function. (jci.org)
Mutations1
- These defects are recapitulated in mouse models with ubiquitous deletions of the Slit ligands or Robo receptors and include additional heart defects not currently linked to SLIT or ROBO mutations in humans. (ox.ac.uk)
Adjustable1
- Adjustable Slit K. Continuously adjustable slit on diaphragm screen 100x100 mm2. (megadepot.com)
Intracellular1
- Lowering the microscope condenser under the stage or reducing the condenser diaphragm can improve contrast and improve intracellular details but it also lowers resolution. (canadiannaturephotographer.com)
Lamp5
- Set the magnifcation of the slit lamp at ×10. (cehjournal.org)
- Ensure that the patient is sitting comfortably at the slit lamp: at the correct height, with chin on the rest and forehead against the headband. (cehjournal.org)
- Set the magnification of the slit lamp at ×10. (cehjournal.org)
- Light from lamp falls on recording slit via mirror fitted on 'microphone' diaphragm. (sciencemuseumgroup.org.uk)
- The sound track was recorded on the edge of the film by a beam of light from a small battery operated lamp, reflected from a small mirror attached to a diaphragm vibrated by speech from the camera operator. (sciencemuseumgroup.org.uk)
Development2
Structure1
- Aug 7, 2014 Hemodynamic Control of Glomerular Filtration at the Single Nephron Level Disorders of Slit Diaphragm and Podocyte Structure and Function. (web.app)
Site1
- The coupling site includes a slit rubber diaphragm valve that is deflected and opened by introduction of a male luer fitting and closed by the removal of the male luer. (justia.com)
Open4
- This makes visualising the fluorescein semi-circles easier (with the slit diaphragm fully open). (cehjournal.org)
- As the elastomeric cap moves, a puncture or slit previously placed in the wall of the closed end of the elastomeric cap expands over the insert tube open end as the cap is collapsed axially. (justia.com)
- When the male adapter is removed, the compressed elastomeric cap expands and closes the puncture or slit over the open end of insert tube to close the valve. (justia.com)
- No. 5,251,873 may not open fully with male luer fittings at the "short" end of the allowable dimension, and since they also depend on the diaphragm for sealing around the male luer tip, they may also leak when a male fitting is mounted or may not fully close once opened. (justia.com)
Surface1
- It is used to sense the roughness of the given surface and it is mounted on the slit diaphragm. (engineeringtribe.com)
Area1
- Assuming that a slit diaphragm is 390 A wide, and that the pores of the slit diaphragm represent 26% of its area, the mean pore area is 3.96 cm2, of which 2.96 cm2 represents the area of peripheral pores. (silverchair.com)
Podocytes8
- Glomerular podocytes constitute the blood-urine barrier, and podocyte slit-diaphragm (SD), a modified tight junction, contributes to the glomerular permselectivity. (nih.gov)
- Within the brain, dendrin is normally found in the forebrain and hippocampus and in the kidneys, dendrin is normally found in the slit diaphragm and podocytes. (wikipedia.org)
- In normal mature kidneys, dendrin is found only in the podocytes near the slit diaphragm. (wikipedia.org)
- The proteins are found at the podocyte cell surface in the area between two podocytes called the slit diaphragm. (medlineplus.gov)
- The glomerular epithelial cells (podocytes) and the slit diaphragm connecting the podocyte foot processes play a primary role in the development of proteinuria . (medscape.com)
- Podocin is a stomatin protein family member with a predicted hairpin-like structure localizing to the insertion site of the slit diaphragm of podocytes, the visceral glomerular epithelial cells of the kidney. (nih.gov)
- Kidney podocytes are highly differentiated epithelial cells that type interdigitating foot procedures with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. (biospraysehatalami.com)
- The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY . (bvsalud.org)
Podocyte slit2
- The podocyte slit diaphragm--from a thin grey line to a complex signalling hub. (medlineplus.gov)
- Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (cdc.gov)
Filtration3
- We postulate that podocin serves in the structural organization of the slit diaphragm and the regulation of its filtration function. (jci.org)
- The slit diaphragm is known as a filtration barrier because it captures proteins from blood so that they remain in the body while allowing other molecules like sugars and salts to be excreted in urine. (medlineplus.gov)
- Podocyte damage or dysfunction results in loss of the characteristic foot processes that normally interdigitate and form the selective permeability barriers composed of filtration slits bridged by slit diaphragms. (nih.gov)
Diameter1
- The aperture diameter of the slit length has been extended, from 10mm to 14mm (continuously variable from 0-14mm), allowing a wider area of anterior segment illumination and also a wider field of view. (marco.com)
Nephrotic syndrome1
- [ 6 ] The slit diaphragm is often missing in MC nephrotic syndrome (MCD) kidneys. (medscape.com)
Illumination3
- Single-element LED illumination provides unbeatable clarity, and the fully-integrated background illumination makes the Ultra M2 an affordable option for slit lamp imaging. (marco.com)
- The diffuser mounted to column hardware can be easily inserted into slit illumination path for improved general overview of the eye. (freyophthalmics.com)
- The digital slit lamp LED illumination source eliminated heat and infra red emission associated with traditional light sources. (freyophthalmics.com)
Aperture2
- Cobalt Filter, Red Free, Yellow Filter Natural Density and Open Aperture Diaphragm For Infinitely Variable Slit Lengths. (goelscientificinstruments.com)
- A concave end of the septum is exposed through an aperture in the cap, and a peripheral flange portion of the septum is squeezed between the housing inlet and the cap, causing the septum's concave end to bulge and flatten, thus improving the sealing of the septum's slit. (justia.com)
Septum8
- An injection set with a slit septum held in place in the inlet of a housing by a cap affixed to the inlet. (justia.com)
- Extending through the septum slit is a drug transfer spike having a ball-shaped tip sharp enough to penetrate the diaphragm of a drug vial but not so sharp as to puncture the skin of a user. (justia.com)
- One type of injection site includes a slit extending through the septum which permits the injection site to be penetrated by a blunt piercing member. (justia.com)
- One object of the present invention is to minimize leakage through the slit of a pre-slit septum in an injection site during or after being penetrated by a cannula. (justia.com)
- When medication is to be administered from a syringe through a drug transfer spike inserted into a connector through its septum, the syringe is first filled from a drug vial through the same drug transfer spike by inserting the spike through the diaphragm that closes the inlet of the drug vial. (justia.com)
- It is therefore a related object of the invention to provide a drug transfer spike having a piercing member which is sharp enough to penetrate a drug vial diaphragm but blunt enough to prevent coring or abrasion of the septum and also to avoid puncturing a user's skin. (justia.com)
- The septum's cylindrical body includes first and second ends, a peripheral portion, a concave surface in one or both end(s), and a slit which extends axially from the concave surface in the first end at least substantially into the septum. (justia.com)
- There are also provided, particularly for use with the injection site, a syringe and a drug transfer spike having a piercing member extending through the septum's slit and terminating in a ball-shaped tip, resulting in a device which is sharp enough to penetrate a drug vial membrane but blunt enough to prevent injury to the user and coring or abrasion of the injection site septum. (justia.com)
Lamp8
- The Marco Ultra M2 slit lamp was designed with functionality, comfort, and durability in mind. (marco.com)
- Stepper Magnification Slit Lamp is made from best grade components with aid of advanced technology. (goelscientificinstruments.com)
- LED slit lamp by FREY S.J. is designed for very high performance and reliability. (freyophthalmics.com)
- Digital slit lamp SL-100 comes with all elements important for demanding user. (freyophthalmics.com)
- Digital slit lamp integrates all components and cabling required for connecting and controlling digital camera system. (freyophthalmics.com)
- Digital slit lamp electronic circuit controlling LED light intensity is very precise for best slit light performance and control. (freyophthalmics.com)
- You may also like SL-100 FREY Slit Lamp. (freyophthalmics.com)
- slit-lamp divisions. (subrion.org)
Intercellular2
- These changes include formation of interdigitating foot processes, replacement of tight junctions with slit diaphragms, and the concomitant opening of intercellular urinary spaces. (embl-heidelberg.de)
- On the user interface of adjacent FPs a customized intercellular junction referred to as the slit diaphragm (SD) is normally formed. (biospraysehatalami.com)
TRPC61
- Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion channel expressed at the slit diaphragm. (ru.nl)
Lamps3
- The Ultra M Slit Lamps are neat and compact with no exposed wiring, giving them a noticeably sleek and stylish appearance. (marco.com)
- I invested in Marco's Ultra Series of slit lamps many years ago, and I still haven't seen anything that. (marco.com)
- Meet FREY Digital LED Slit Lamps, Digital Imaging System and Eyemager™ - proprietary software application designed exclusively for FREY slit lamps. (freyophthalmics.com)
Membrane2
- A very fine membrane forms between adjacent foot processesthe slit diaphragm. (cckn-ia.org)
- Thus, for plasma ultrafiltrate to reach the glomerular urinary space, it must traverse the capillary endothelium, basement membrane and the slit diaphragm. (cckn-ia.org)
Needle1
- The present invention relates generally to medical systems for administering fluids to a patient, and more particularly to pre-slit injection sites and a needle replacement called a "drug transfer spike," for use in such systems. (justia.com)
Extends1
- It lies under the diaphragm in the right upper abdomen and midabdomen and extends to the left upper abdomen. (medscape.com)
Experiments1
- The Multiple Slits on Glass Plate comprises a glass plate with four different numbers of multiple slits for quantitative diffraction experiments. (labworld.co.uk)
Double2
- With the double slit experiment , Young demonstrated that light can be extinguished by interference , which is unthinkable for particle beams. (zxc.wiki)
- light source adjustment part: electric diaphragm can be installed (minimum) φ 3mm), or the electric double opening slit of our product can be installed, and the slit range is 0- φ 50mm (min. (zgskis.com)
Maintenance2
- This revealed strong podocyte upregulation of PRKCI, aka atypical PKC, which is required for maintenance of slit diaphragms, and decreased podocyte - mesangial NPNT-ITGA8 signaling in FSGS. (asn-online.org)
- 1. Oil-less diaphragm type pump,maintenance free, fast vacuum accumulation. (everichmed.com)
Performance2
- Combining the strength of tungsten carbide with the precision of diamond particles, our Tungsten Carbide Industrial Slitting Blades offer exceptional cutting performance in hard materials like tiles, porcelain, and granite. (tungstencarbide-parts.com)
- Enhanced Safety: Tungsten carbide industrial slitting blades offer enhanced safety as they maintain their integrity and cutting performance even under heavy loads, reducing the risk of accidents. (tungstencarbide-parts.com)
Formation1
- Mutations in the NPHS1 or NPHS2 gene result in a decrease or absence of functional protein, which impairs the formation of normal slit diaphragms. (medlineplus.gov)
Range1
- Compatibility: Tungsten carbide industrial slitting blades are compatible with a wide range of cutting tools and machinery, allowing for easy integration into existing cutting systems. (tungstencarbide-parts.com)
Forms1
- the cranial part forms the diaphragm). (medscape.com)