The proton - coupled folate transporter ( PCFT ) mediates intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus. (nih.gov)
Therefore, in the last few decades, numerous pharmacogenomics studies have been conducted to decode associations of SNPs in genes encoding MTX membrane transport proteins that could change MTX influx and/or efflux function and, consequently, could be responsible for MTX interpatient therapeutic outcomes variability, both regarding clinical response and/or adverse drug reactions (ADRs) occurrence. (medscape.com)
[ 17 ] This transporter can mediate either influx or efflux depending of the prevailing substrate and pH gradients with net rates of monocarboxylate transport being determined by the difference between influx and efflux. (medscape.com)
Role1
A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome , aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. (wikipedia.org)
Function2
This SNP is characterized by a substitution of a T to a G in an intronic region of SLC16A7 and, despite its impact on transporter function being unknown, there is one study that associates G allele with better response to MTX in JIA. (medscape.com)
In order to function properly the serotonin transporter requires the membrane potential created by the sodium-potassium adenosine triphosphatase . (wikipedia.org)
Table1
Table 2 summarizes the effect of SNPs in genes encoding for low-dose MTX influx transporters that are of interest to MTX therapeutic outcome. (medscape.com)
Cells1
It has previously been accepted that MTX could enter cells by SLC19A1 and the presence of other influx transporters has not been thoroughly explored. (medscape.com)