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  • tissues
  • The implication of our findings in clinical transplantation may be significant, as minor Ag reactivity has been implicated in the pathogenesis of multiple allograft tissues. (jimmunol.org)
  • Transplantation is now possible for many organs (heart, lung, liver, pancreas, kidneys) and tissues (skin, heart valves, cornea etc) enabled by the use of potent immunosuppressive drugs to maintain immunological tolerance ( 2 ). (frontiersin.org)
  • Evaluate human papillomavirus (HPV) as a possible etiologic cofactor in the development of cutaneous epidermal dysplasia/carcinoma from skin tissues of these patients. (clinicaltrials.gov)
  • Conversely rate of estrogen formation is high in skin and skin appendages and detectable in many other tissues biopsied from mature Hf/Hf or Hf/hf birds. (wikipedia.org)
  • The henny-feathering trait in males is the result of increased conversion of androgen to estrogen in skin Increased estrogen formation in the skin and other peripheral tissues of chickens with the henny-feathering trait is due to an enhanced activity of the aromatase complex of enzymes responsible for estrogen synthesis. (wikipedia.org)
  • A member of the tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. (wikipedia.org)
  • cancers
  • This induction and maintenance of impaired immunological surveillance is paralleled by a significant increase in the incidence of specific cancers, of which skin cancers are highest. (springer.com)
  • PURPOSE: Randomized clinical trial to study the effectiveness of acitretin in preventing skin cancers in patients with at least two previously treated skin cancers who have undergone organ transplantation. (clinicaltrials.gov)
  • Patients are stratified according to age (at least 18 to under 50 vs 50 to 59 vs 60 to 69 vs 70 and over), number of prior skin cancers in past 5 years (2 vs 3 vs at least 4), time since most recent skin cancer occurrence (less than 12 months vs at least 12 months), sunburn susceptibility (none vs moderate vs high), visible skin damage (mild vs moderate vs severe). (clinicaltrials.gov)
  • rejection
  • In this study, we examined graft rejection in three mouse models: 1) mismatch of male-specific minor Ags, 2) mismatch of minor Ags distinct from male-specific minor Ags, and 3) skin transplant. (jimmunol.org)
  • We found that T cell responses in BAFF-Tg mice are profoundly compromised, as indicated by their acceptance of islet allografts and delayed skin graft rejection. (jimmunol.org)
  • Kinetic analysis showed that MCs markedly accelerate skin rejection. (frontiersin.org)
  • The uncontrolled neutrophil influx accelerated rejection as antibody-mediated depletion of neutrophils delayed skin rejection. (frontiersin.org)
  • While treatment with immunosuppressive drugs has shown substantial progress in allotransplantation, there are currently no immunosuppressive drugs capable of preventing xenograft rejection in a pig-to-nonhuman primate transplantation model ( 1 , 6 , 7 ). (jimmunol.org)
  • treatment
  • In univariate analysis, older age, male sex, Child-Turcotte-Pugh A or B at transplantation, treatment with mycophenolate mofetil, skin type, and total pretransplant sun burden were associated to the development of NMSC. (cun.es)
  • Continued research is needed to better understand the pathogenesis and treatment of post-transplant effects on the skin. (springer.com)
  • The grafting serves two purposes: reduce the course of treatment needed (and time in the hospital), and improve the function and appearance of the area of the body which receives the skin graft. (wikipedia.org)
  • patients
  • Dr Chitoria led the team for transplanting the skin to the two patients. (business-standard.com)
  • The potential target group for skin transplantation as a result of hard-to-heal leg and foot ulcers in Sweden is estimated to be approximately 2 000 patients per year. (sbu.se)
  • We recommend full skin examinations annually and appropriate referral to dermatology when needed, especially in patients who may be at higher risk for skin cancer. (springer.com)
  • Hence
  • The mouse at the center of the controversy involved transplantation between two genetically similar strains, and hence had a conventional explanation. (wikipedia.org)
  • research
  • Published online: April 27, 2006 Truth and Trustworthiness in Research, by Caroline Whitbeck, Online Ethics Center at the National Academy of Engineering Skin Deep, review of The Patchwork Mouse, Time magazine, March 8, 1976 Joseph R. Hixson. (wikipedia.org)
  • work
  • The journal has published ground-breaking work in the areas of biomechanics, skin transplantation, and neurophysiology, and has published work by Nobel Prize winners Peter Medawar and August Krogh. (wikipedia.org)
  • partial
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • often
  • The lesions are usually as described above, but may occasionally be plaque-like (often on the soles of the feet) or even involved in skin breakdown with resulting fungating lesions. (wikipedia.org)
  • allogeneic
  • The EGE is of the opinion that "support for public cord blood banks for allogeneic transplantations should be increased and long term functioning should be assured. (stemcellcordblood.net)
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • rash
  • It is generally recognized as a papular or papulovesicular skin rash occurring mainly on the face and distal aspects of the four limbs. (wikipedia.org)
  • disorders
  • Mutations in the gene encoding this protein are associated with the genetic skin disorders pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. (wikipedia.org)
  • hair
  • The affected hair follicles become inflamed, so there may be noticeable tenderness, and there may even be noticeable redness and pustules in the scarred area, depending on the sensitivity of the skin. (griffincenter.com)
  • area
  • They can be used to numb any area of the skin as well as the front of the eyeball, the inside of the nose, ear or throat, the anus and the genital area. (wikipedia.org)
  • The area of skin innervated by a specific spinal nerve is called a dermatome, and the group of muscles innervated by a single spinal nerve is called a myotome. (wikipedia.org)