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  • recombinant
  • The recombinant protein, rHuPH20, is a human hyaluronidase enzyme that increases the dispersion and systemic absorption of locally injected drugs by temporarily degrading hyaluronan under the skin. (bio-medicine.org)
  • doses
  • The news is based on the results of a small trial that investigated whether injections of low doses of pollen into the skin reduced the allergic reaction to grass pollen in people with hay fever. (www.nhs.uk)
  • Currently, the only effective preventative treatment for hay fever is known as immunotherapy, which involves injecting high doses of pollen into a deeper layer of skin. (www.nhs.uk)
  • However, due to the high doses involved there is always a risk that the treatment can trigger a serious and wide-ranging allergic reaction (anaphylaxis). (www.nhs.uk)
  • In this study much lower doses of pollen were injected into an upper section of the skin (the dermis) to see if the effect was similar to that found with traditional immunotherapy. (www.nhs.uk)
  • This was a randomised controlled trial that aimed to investigate whether injections of low doses of pollen into the skin could reduce the allergic reaction to grass pollen. (www.nhs.uk)
  • pharmacodynamic
  • Although a known effect of azacitidine, several of these were considered to be of increased severity with the combination, possibly reflecting a localized synergistic pharmacodynamic effect in the skin. (cnbc.com)
  • immune
  • At the end of the study, the researchers measured the early and late immune responses to the injections. (www.nhs.uk)
  • Chickenpox and shingles can affect you both by the virus attacking you and by an exuberant inflammatory and immune reaction. (ageofautism.com)
  • fever
  • This study was small, with only 30 participants and the effect of the injections on common hay fever symptoms such as sneezing and itchy, red watery eyes was not determined. (www.nhs.uk)
  • responses
  • Explain that anaphylactic reactions are severe, sometimes fatal allergic responses that require prompt treatment. (medpagetoday.com)
  • Early responses included the size of weal that formed after the injection. (www.nhs.uk)
  • At the end of the study there was no difference in the early responses to the injections. (www.nhs.uk)
  • However, the late responses to grass pollen were significantly reduced in group A, who had received regular injections of grass pollen, compared with those in the control groups B and C. (www.nhs.uk)
  • drug
  • One of these underwent rechallenge with the drug -- at the patient's request, Horn explained -- and experienced another anaphylactic reaction. (medpagetoday.com)
  • One problem for clinicians is that reactions to the drug can mimic an HAE attack, with its symptoms of pain and swelling. (medpagetoday.com)
  • elderly
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine injection in the elderly. (drugs.com)