• Human cell cultures and tissue studies, in-vitro tests, and artificial human "skin" and "eyes" mimic the body's natural properties and provide scientists with less-expensive alternatives to animal tests. (seacoastonline.com)
  • Other types of alternative methods that do not require the use of whole, living animas,l include in-vitro tests, computer modeling, tissue culture, human volunteer trials, and databases of tests that have been already done to avoid duplication. (wordpress.com)
  • The EpiDerm Skin Irritation Test was used to evaluate in vitro irritancy potential of OPA and glutaraldehyde. (cdc.gov)
  • Animal testing merely determines the level of toxicity. (wildlife-rescue.org)
  • Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. (google.com)
  • Because of ethical considerations, not to mention economic ones, of using animal models to predict toxicity against humans, a number of surrogate toxicity tests have been developed permitting more efficient and less controversial approaches to evaluating the capacity of compounds to impact the viability or well being of organisms. (google.com)
  • Regardless of the chemical tested and whether the test is for acute or chronic toxicity, all in vivo testing requires the reproducible administration of a known dose of the chemical under test, applied in a reproducible manner, that is generally related to the expected route of humans exposure. (studfiles.net)
  • As more people strive to live healthier lifestyles, mineral-based makeup has become more popular because it has a lightweight texture and makes your skin look radiant and luminous. (marykay.com)
  • Minerals occur naturally in the earth, have a lightweight texture and provide luminosity and radiance to the skin. (marykay.co.uk)
  • The unique formula in Classic Basic® Deep Cleanser 3 is designed for oily and/or blemish-prone skin to eliminate dirt and environmental elements which might clog pores. (marykay.de)
  • Matte type primer to prep skin for combination and oily skin. (aprilskin.com)
  • For example, routine handling, venipuncture, and gavage (the administration of test compounds through an oral tube) elicit striking elevations in pulse, blood pressure, and steroid hormone release that can persist for an hour or more after the event. (wildlife-rescue.org)
  • This work culminated in a report by Draize, his laboratory assistant, Geoffrey Woodard, and division chief, Herbert Calvery, describing how to assess acute, intermediate, and chronic exposure to cosmetics by applying compounds to the skin, penis, and eyes of rabbits. (wikipedia.org)
  • Skin irritancy tests clam noxious substances on the bare skin of rabbits, rats and mice, with observation made of irritation such as swelling, itching, soreness and inflammation. (seacoastonline.com)
  • In other tests, concentrated substances like shampoo are applied to the eyes of animals (usually rabbits) producing terrible long-lasting pain with swelling, discharge, blistering and destruction of the cornea. (wordpress.com)
  • In 1971, before the implementation in 1981 of the modern Draize protocol, toxicologists Carrol Weil and Robert Scala of Carnegie Mellon University distributed three test substances for comparative analysis to 24 different university and state laboratories. (wikipedia.org)
  • According to the British Research Defence Society, the Draize eye test is now a "very mild test," in which small amounts of substances are used and are washed out of the eye at the first sign of irritation. (wikipedia.org)
  • And TimeWise ® Matte-Wear ® Liquid Foundation is customized for your skin type. (marykay.com)
  • Using multiple clinical testing methods, including state-of-the-art 3D facial imaging, we tested TimeWise Repair ® Volu-Firm ® Advanced Lifting Serum from every angle to show how it helps reclaim your triangle of youth. (marykay.com)
  • In addition to working as an antioxidant* to help neutralize free radicals on skin as all TimeWise® Miracle Set 3D™ products do, it also provides broad-spectrum UVA/UVB protection. (marykay.pt)
  • Treat your skin to a new beginning with TIMEWISE. (partypop.com)
  • Using animals to conduct safety testing is fraudulent science because differences between species and even between individual animals of the same species lead to unreliable test results due to variances in absorption, distribution, metabolism and excretion of chemicals. (seacoastonline.com)
  • Long before they appear on the shelves of your local supermarket, these products have gone through a long and complex testing process that leaves millions of animals mutilated, burned, poisoned and gassed in outmoded and unnecessary tests. (wildlife-rescue.org)
  • However, the Food and Drug Administration (FDA) does urge companies to conduct whatever toxicological tests are appropriate to substantiate the safety of their products. (wildlife-rescue.org)
  • That's because no amount of animal testing can change the fact that many of these products are harmful if ingested or used in a way not intended by the manufacturer. (wildlife-rescue.org)
  • Despite the fact that they have been animal-tested, these products are no less deadly if a person eats or drinks them accidentally. (wildlife-rescue.org)
  • The manufacturers of cosmetics and household products claim that they perform tests on animals to ensure the safety of their products under customary use or possible abuse when in reality it is to limit the company's liability to its customers in case of a lawsuit. (wildlife-rescue.org)
  • Animal research has been used as an alternative method when the study of humans is deemed impractical or unethical, or when animal biology is of primary interest, and animals are frequently used in biological and medical research, in the testing of drugs and commercial products, and in educational exercises in the sciences. (wildlife-rescue.org)
  • virtually and long before they appear on the shelves of our local supermarkets all of these products have gone through an extended and complex testing process that leaves millions of innocent animals poisoned, mutilated, burned and sacrificed in cruel tests. (wordpress.com)
  • According to Karen Lee Stevens, author of a web article on animal testing, there is no law that requires companies to test their personal care and household products on animals. (wordpress.com)
  • However, companies must conduct appropriate tests to corroborate the safety of their products before selling them to customers. (wordpress.com)
  • human clinical studies are also valuable and accepted means of testing products. (wordpress.com)
  • You're invited To try the new generation in skin care products that give your face a second chance with special Anti-aging benefits for a healthier, younger-looking complexion. (partypop.com)
  • They found that tests would: Misidentify a serious irritant as safe: 0-0.01% Misidentify a mild irritant as safe: 3.7%-5.5% Misidentify a serious irritant as a mild irritant: 10.3%-38.7% According to the American National Anti-Vivisection Society, solutions of products are applied directly into the animals' eyes, which can cause "intense burning, itching and pain. (wikipedia.org)
  • For example, the Draize Eye Test confines albino rabbits in stocks and drips chemicals into their forced-open eyes. (seacoastonline.com)
  • The test material is therefore not an eye irritant in rabbits. (europa.eu)
  • Clips are placed on the rabbits' eyelids to hold them open during the test period, which can last several days, during which time the rabbits are placed in restraining stocks. (wikipedia.org)
  • Retinyl Palmitate (Vitamin A Palmitate) functions as a conditioner that helps improve the appearance of skin (e.g., skin looks softer, smoother, etc.) or hair. (marykay.com)
  • Today, in response to pressure from the public and animal advocacy groups, many large consumer product companies have discontinued animal testing in favor of nonanimal alternatives. (wildlife-rescue.org)
  • Skin irritation: Key study: Experimental result: According to OECD 404. (europa.eu)
  • The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. (freepatentsonline.com)
  • In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. (freepatentsonline.com)
  • For example, toxicologists seeking more accurate or reliable methods have turned to cellular screening tests for many applications and have realized substantial savings in the process. (wildlife-rescue.org)
  • A 2004 study by the U.S. Scientific Advisory Committee on Alternative Toxicological Methods analyzed the modern Draize skin test. (wikipedia.org)
  • Animals should not be used in product testing because it is unnecessary, unreliable, and inhumane. (wordpress.com)
  • A skin-volume-supporting peptide helps maintain natural hyaluronic acid, †† a vital component of skin that plays a role in helping maintain youthful-looking volume and lift. (marykay.com)
  • Our peptide is made up of four amino acids linked together that help contribute to younger-looking skin. (marykay.pt)
  • Age-fighting foundations not only help create a flawless look, they can be used as an extension of your skin care regimen. (marykay.com)
  • It allows you to even out your skin tone to get a flawless look and beautiful base for colour cosmetics. (marykay.co.uk)
  • The animals' skin is shaved until raw, and the test product such as deodorant or after-shave astringent is applied. (wordpress.com)
  • On the other hand, if they wish to prove that the same chemical is a carcinogen, they produce other laboratory tests that show the product to be carcinogenic. (envirolink.org)
  • Animals may be re-used for testing purposes if the product tested causes no permanent damage. (wikipedia.org)
  • Animals are typically reused after a "wash out" period during which all traces of the tested product are allowed to disperse from the test site. (wikipedia.org)
  • This free radical fighting facial soap is gentle for all skin types, especially those with dry and mature complexions. (ebay.co.uk)
  • Vitamin B3 also works double duty as an antioxidant for additional free-radical defense on skin. (marykay.pt)
  • The cool blue gel contains botanical extracts rich in antioxidants to help sun-kissed skin feel cooled, refreshed and - most importantly - hydrated once again. (marykay.ie)
  • Work in harmony with natural antioxidants* to help support the skin barrier. (marykay.pt)
  • The next generation of advanced age-defying skin care is here. (marykay.com)
  • Washing (if done): After 4 hours the wrapping and patch were removed and the test site washed with water and gently dried. (europa.eu)
  • Treat your skin to a refreshing recovery from a day in the sun with After-Sun Replenishing Gel. (marykay.ie)
  • Animals are almost always utilized as the test models. (wildlife-rescue.org)
  • Many health charities fund tests on animals that include starving, crippling, burning, poisoning and cutting animals open to study diseases that affect humans, not animals. (seacoastonline.com)
  • The dose level applied to the skin of the animals was 250 mg instead of 500 mg for solids, as recommended in the guideline. (europa.eu)
  • The animals are euthanized after testing if the test renders irreversible damage to the eye or skin. (wikipedia.org)
  • Plant stem cells derived from gotu kola to help support the natural framework of the skin. (marykay.com)