Skin from patients with systemic. Medical search. Frequent questions

Patients with both systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) are more likely to be female, Black, and diagnosed with limited cutaneous SSc. (medscape.com)
Cite this: Lupus May Overlap in Many Patients With Systemic Sclerosis - Medscape - Sep 15, 2023. (medscape.com)
Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by autoantibodies directed against self-antigens, immune complex formation, and immune dysregulation, resulting in damage to essentially any organ. (medscape.com)
Less common autoimmune diseases include systemic lupus erythematosus (SLE), also known as lupus, and vasculitis disorders (inflammation of blood vessels). (allergy.org.au)
Systemic lupus erythematosus (SLE) is a chronic autoimmune condition often associated with an increased susceptibility to infections. (medscimonit.com)
The US Food and Drug Administration (FDA) announced the approval of anifrolumab-fnia (Saphnelo™) for the treatment of moderate to severe systemic lupus erythematosus. (hcplive.com)
Recent studies, such as those funded by the Lupus Research Alliance (LRA), have played a pivotal role in analyzing the molecules' role in treating patients with SLE. (hcplive.com)
The FDA approval of anifrolumab-fnia potentially allows thousands of lupus patients to benefit. (hcplive.com)
Overview of Systemic Lupus. (merckmanuals.com)
Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
Rather, it might be more similar to complement-mediated TMA syndromes, which are well known to rheumatologists who care for patients with severe systemic lupus erythematosus or catastrophic antiphospholipid syndrome. (nature.com)
These relationships have been studied in various autoimmune diseases, including multiple sclerosis (MS), systemic sclerosis (SSc), type 1 diabetes (T1D), Grave's disease (GD), systemic lupus erythematosus (SLE), aplastic anemia (AA), and vitiligo. (frontiersin.org)
66% of those with lupus will develop some form of skin disease. (lupus.org)
In this episode of The Expert Series, Victoria Werth, MD will teach you about how lupus can affect the skin as she describes skin lupus subtypes and how to manage living with lupus. (lupus.org)
She's a dermatologist at Pennsylvania medicine in Philadelphia, Pennsylvania, with expertise treating lupus patients with skin disorders. (lupus.org)
Today, Dr. Werth will be speaking about skin lupus, beyond the butterfly rash. (lupus.org)
We're going to talk about skin lupus. (lupus.org)
And this is a variety of different conditions that happen in patients with lupus. (lupus.org)
And very often this again triggered by sun exposure and can be seen in people who also have systemic lupus. (lupus.org)
So we're going to talk about how to differentiate between cutaneous lupus and systemic lupus, and patients that can have skin lupus and not have systemic features. (lupus.org)
There may be systemic features, but not enough to be called systemic lupus. (lupus.org)
And then some patients with skin findings can also meet criteria for systemic lupus. (lupus.org)
Turns out that as we discussed before, the subtype of lupus that you can see, for instance, discoid lupus will determine how frequently people might have underlying systemic disease. (lupus.org)
So somebody has just localized disease that's above the neck with discoid lupus, if there's a less of a chance of going on to systemic lupus, you still need to have laboratories checked on a regular basis to make sure that other internal organs are not involved, but it's less likely when it's just a localized discoid lupus. (lupus.org)
And when that happens probably about 20% of the time, people can meet criteria for systemic lupus. (lupus.org)
With subacute, cutaneous lupus, there is probably about 50% chance of having systemic lupus but very often it's more mild. (lupus.org)
And the important thing is still to be screened for other underlying systemic disease but very often it's more mild when you have subacute, cutaneous lupus. (lupus.org)
And then with acute lupus, which is again the butterfly rash or could be more on extensor surfaces of the arms, photo-exposed, you know, areas that see the sun, it's more likely that people will meet criteria for systemic lupus. (lupus.org)
But really the bottom line is that when you have skin lupus still need to be really screened to make sure that things don't progress to more internal involvement. (lupus.org)
So people with cutaneous lupus and systemic lupus can have very similar features. (lupus.org)
There are some features in the skin that are not specific to lupus but can be associated with lupus and that can include sometimes hair loss, that can be different types of hair loss, then also vasculitis, sometimes people have hives. (lupus.org)
So there's a variety of other lesions that can be seen that again, are at increased frequency and can be associated with especially systemic lupus but also part of cutaneous lupus. (lupus.org)
Complications such as the development of lymphoproliferative disease in SchS and amyloidosis in CAPS, and the presence of comorbid diseases, such as systemic lupus erythematosus in UV, must be considered and monitored. (iasp-pain.org)
Widespread scleroderma can occur with other autoimmune diseases, including systemic lupus erythematosus and polymyositis . (medlineplus.gov)

The results highlight the need for clinicians to recognize the SSc-SLE overlap syndrome and to watch for scleroderma organ involvement in patients with features of SLE, Raynaud syndrome, anti-U1-RNP antibody positivity, or an isolated nucleolar pattern of antinuclear antibodies. (medscape.com)
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. (wikipedia.org)
The severity of these symptoms varies greatly among patients: Some having scleroderma of only a limited area of the skin (such as the fingers) and little involvement of the underlying tissue, while others have progressive skin involvement. (wikipedia.org)
Systemic scleroderma and Raynaud's can cause painful ulcers on the fingers or toes, which are known as digital ulcers. (wikipedia.org)
Calcinosis (deposition of calcium in lumps under the skin) is also common in systemic scleroderma, and is often seen near the elbows, knees, or other joints. (wikipedia.org)
Musculoskeletal The first joint symptoms that patients with scleroderma have are typically nonspecific joint pains, which can lead to arthritis, or cause discomfort in tendons or muscles. (wikipedia.org)
Lungs Some impairment in lung function is almost universally seen in patients with diffuse scleroderma on pulmonary function testing, but it does not necessarily cause symptoms, such as shortness of breath. (wikipedia.org)
Anti-topo I and ACA were found primarily in patients with scleroderma, CREST syndrome, and Raynaud's phenomenon. (nih.gov)
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibrous skin. (medindia.net)
Patients with systemic sclerosis, also known as systemic scleroderma, experience a sudden hardening, or fibrosis, of the skin. (medindia.net)
A rare connective tissue autoimmune disorder, systemic sclerosis, also known as scleroderma, is difficult to treat. (medindia.net)
Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
The above image shows the classic presentation of systemic sclerosis (SSc), also known as systemic scleroderma: thickened skin, a pinched nose, taut skin, and numerous telangiectasias. (medscape.com)
Systemic sclerosis is a generalized form of scleroderma which affects multiple organs at a time and if not treated timely can cause various complications. (selfgrowth.com)
Systemic sclerosis is known as scleroderma or progressive systemic sclerosis, or CREST syndrome. (selfgrowth.com)
Scleroderma also disrupts the skin, lymph, muscle and blood tissues. (selfgrowth.com)
Systemic scleroderma is a serious condition, while localized scleroderma carries a good prognosis and normal lifespan. (mountsinai.org)
In children, localized scleroderma is three times more common than the systemic form of the disease. (mountsinai.org)
Bosentan is currently under study in the US for systemic scleroderma. (mountsinai.org)
Several studies have demonstrated a reduction of new skin ulcers and accelerated healing of nondigital ulcers for certain scleroderma patients after taking Bosentan. (mountsinai.org)
The drug was approved in Europe in 2007 for the treatment of skin ulcers related to scleroderma. (mountsinai.org)
The name scleroderma comes from the Greek words skleros , which means hard, and derma , which means skin. (mountsinai.org)
People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)
Localized scleroderma usually affects only the skin on the hands and face. (mountsinai.org)
In morphea scleroderma, patches of hard skin form and can last for years. (mountsinai.org)
There is less than a 1% chance that this disorder will progress to systemic scleroderma. (mountsinai.org)
Linear scleroderma causes bands of hard skin across the face or on a single arm or leg. (mountsinai.org)
Systemic scleroderma is also called systemic sclerosis . (mountsinai.org)
Scleroderma is a disease that involves the buildup of fibrous tissue in the skin and elsewhere in the body. (medlineplus.gov)
Some types of scleroderma affect only the skin, while others affect the whole body. (medlineplus.gov)
Localized scleroderma (also called morphea) -- Often affects only the skin on the chest, abdomen, or limb but not usually on the hands and face. (medlineplus.gov)
Systemic scleroderma, or sclerosis -- May affect large areas of skin and organs such as the heart, lungs, or kidneys. (medlineplus.gov)

In patients with neuromuscular disorders, particularly progressive systemic sclerosis and visceral myopathy, the duodenum is frequently involved. (wikipedia.org)
Progressive systemic sclerosis predominantly affects women (3 to 8 women vs. 1 man). (scirp.org)
The objective of this presentation is to guide any practitioner towards diagnosis of renal crisis in the face of sudden multiple organ failure resulting from progressive systemic sclerosis. (scirp.org)
The etiology mentioned was progressive systemic sclerosis. (scirp.org)

Vascular lesions in the hand may be secondary to local pathology, a proximal source of emboli, or systemic diseases with vascular compromise. (springer.com)
Vascular lesions in the hand may be secondary to local pathology (e.g. tumour, malformation, trauma, iatrogenic cause, or drug injection), a proximal source of emboli (e.g. dissections or aneurysms), or systemic diseases with vascular compromise (e.g. rheumatic and vaso-occlusive diseases). (springer.com)
Systemic autoimmune diseases can affect many body organs and tissues at the same time. (allergy.org.au)
More than 1 million patients have been treated with the three currently available tumour necrosis factor (TNF) antagonists (adalimumab, etanercept, and infliximab) for a variety of diseases. (bmj.com)
It is more frequent in adults, and early diagnosis is crucial since it has been reported to be associated with serious underlying systemic disorders, such as myeloproliferative diseases and severe manifestations like anaphylaxis (2,3). (nih.gov)
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. (news-medical.net)
In systemic autoimmune diseases, the immune system cannot distinguish between self and non-self and subsequently responds to and harms several tissues and organs, including joints, kidneys, and blood vessels. (news-medical.net)
As in many other chronic diseases, the prevalence of fibromyalgia is increased, which may cause diagnostic confusion in patients with periarticular and generalized pain and fatigue. (merckmanuals.com)
Clinical and laboratory features can point to the presence of any of these diseases in patients initially presenting with chronic urticarial rash. (iasp-pain.org)
In contrast to CSU, where second-generation H1 antihistamines and omalizumab allow to control symptoms in most patients, systemic immunosuppression and anti-interleukin (IL)-1 therapies are needed in case of UV and autoinflammatory diseases, respectively. (iasp-pain.org)
The results, published January 11 in the journal Clinical Cancer Research , showed promising antiviral efficacy and safety in a phase II clinical trial of patients who had undergone stem cell transplantation to treat blood diseases including cancer. (scienceboard.net)
The trial enrolled 58 adult and pediatric patients who had undergone allo-SCT to treat blood diseases and had at least one of the six viral infections targeted by posoleucel. (scienceboard.net)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
and in patients with other chronic rheumatologic diseases. (msdmanuals.com)
Because of their contact with patients or infective material from patients, many health-care workers (HCWs)(e.g., physicians, nurses, emergency medical personnel, dental professionals and students, medical and nursing students, laboratory techni cians, hospital volunteers, and administrative staff) are at risk for exposure to and possible transmission of vaccine-preventable diseases. (cdc.gov)

patients may present with many years of symptoms or with acute, life-threatening disease. (medscape.com)
Early diagnosis and careful treatment tailored to individual patient symptoms have improved the prognosis in what was once perceived as an often-fatal disease. (medscape.com)
Of the 20 SoJIA patients, 5 achieved ACR 50% improvement in symptoms (ACR50) response criteria at 6 months. (bmj.com)
Other symptoms include: In the skin, systemic sclerosis causes hardening and scarring. (wikipedia.org)
Most patients (over 80%) have vascular symptoms and Raynaud's phenomenon, which leads to attacks of discoloration of the hands and feet in response to cold. (wikipedia.org)
Additionally, patients receiving anifrolumab-fnia had reductions in arthritis symptoms and severity of skin rash. (hcplive.com)
In RA patients unresponsive to treatment with traditional disease modifying antirheumatic drugs (DMARDs), therapy with a TNF antagonist has been shown to improve clinical signs and symptoms 4- , 6 and effectively inhibit radiographic progression. (bmj.com)
Systemic symptoms of leprosy are also possible. (medscape.com)
Treatment of MPCM depends on the presence of systemic involvement and/or the clinical symptoms of the disease itself. (nih.gov)
H1 receptor antagonists are considered the first-choice therapeutic option for control of symptoms among patients with skin mastocytosis (4,5). (nih.gov)
What Are The Symptoms Of Systemic Sclerosis? (selfgrowth.com)
Inform patients of warning signs and symptoms of hepatotoxicity. (nih.gov)
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening, delayed-onset drug reaction that is typically characterized by skin eruption and fever. (psychiatrist.com)
patients exhibit a wide array of signs and symptoms that do not always present concurrently. (psychiatrist.com)
Drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported with ziprasidone exposure. (psychiatrist.com)
Joint symptoms, ranging from intermittent arthralgias to acute polyarthritis, occur in about 90% of patients and may precede other manifestations by years. (merckmanuals.com)
Flushing, urticaria, angioedema, pruritus and respiratory symptoms occur in many patients but may be absent. (hse.ie)
Presentations are variable and include anaphylaxis urticaria and angioedema occurring immediately following exposure (immediate, IgE mediated) and severe cutaneous reactions such as Acute Generalised Erythematous Pustulosis ( AGEP), Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) and DRESS (drug rash, often desquamating with eosinophilia and systemic symptoms, including severe hepatic dysfunction) (variable time of onset, immune-mediated, non-IgE dependent). (hse.ie)
Results: The interviewed physicians reported that late presentation with dcSSc was common, with some patients presenting to primary care physicians after symptoms had persisted for up to 1 year. (uzh.ch)
Conclusion: Patients and primary healthcare providers can be unaware of the symptoms of dcSSc, therefore presentation and referral to specialist care are often late. (uzh.ch)
Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyrin-associated periodic syndromes (CAPS) and Schnitzler syndrome (SchS), can mimic CSU-like rash but represent rare disorders with systemic symptoms including fever, headache, conjunctivitis, and arthralgia. (iasp-pain.org)
24 hours), lesional burning, systemic symptoms, and/or increase in inflammatory markers (e.g. (iasp-pain.org)
Treatment involves a combination approach to treat the immune response, improve circulation, and stop the progression of skin symptoms. (mountsinai.org)
Learn how graft-versus-host disease (GVHD) can affect the skin, hair, and nail, and treatment options available to relieve symptoms. (bmtinfonet.org)
As Co-Director of the Multidisciplinary GVHD Clinic, she partners with oncologists, hematologists, nurses, and other experts to provide patients with comprehensive care to effectively address their symptoms. (bmtinfonet.org)
A buildup of a substance called collagen in the skin and other organs leads to the symptoms of the disease. (medlineplus.gov)

Systemic-onset juvenile idiopathic arthritis (SoJIA) and adult-onset Still disease (AoSD) are rare systemic inflammatory disorders of unknown aetiology. (bmj.com)
In a recent Nature Reviews Immunology journal study, researchers assess the role of neutrophil extracellular traps (NETs) in systemic autoimmune and autoinflammatory disorders. (news-medical.net)
Recent research has shown that neutrophils, particularly NETs released upon activation, have critical roles in the onset and progression of systemic autoimmune disorders and in the development of complex inflammatory responses that cause organ damage. (news-medical.net)
Uncontrolled diabetes mellitus (DM) is related to skin disorders, particularly dry skin. (hindawi.com)
Olive oil is currently used in topical applications for the treatment of several skin conditions, including dry skin, itch, and inflammation as well as disorders such as rosacea. (researchgate.net)
In this review article, we explore the available literature for publications related to the treatment of skin disorders using NAC therapy, seeking to better understand its methods of action and potential applications in the field of clinical dermatology. (jcadonline.com)

The researchers compared demographics, laboratory data, clinical features, and mortality between patients with SSc-SLE and patients with SSc only. (medscape.com)
The most important tool in the care of the patient with SLE is careful and frequent clinical and laboratory evaluation to tailor the medical regimen and to provide prompt recognition and treatment of disease flares. (medscape.com)
During the 2022 global monkeypox (mpox) outbreak, some patients have experienced severe clinical manifestations. (cdc.gov)
A CDC clinical team began providing consultations § to U.S. clinicians caring for patients with mpox, developing guidance and other online clinical resources for health care providers, and issuing health alerts ¶ when emerging clinical concerns (e.g., severe infections in patients with advanced HIV infection) were detected. (cdc.gov)
To assess the safety of adalimumab in global clinical trials and postmarketing surveillance among patients with rheumatoid arthritis (RA). (bmj.com)
As of 15 April 2005, the RA clinical trial safety database analysed covered 10 050 patients, representing 12 506 patient-years (PYs) of adalimumab exposure. (bmj.com)
Physical examination revealed a positive Darier sign (Figure 1, d) without other clinical signs suggestive of systemic involvement (e.g. lymphadenopathy, hepatosplenomegaly, malabsorption syndrome). (nih.gov)
Patients who fail to show substantial clinical benefit after adequate titration should be discontinued from POTIGA. (drugs.com)
discontinue if patients fail to show clinical benefit after adequate titration. (drugs.com)
Caution should be taken BEFORE applying the label of Penicillin Allergy to any patient, especially when the clinical indications are tenuous. (hse.ie)
Objective: To gain insight into clinical practice regarding referral, early diagnosis and other aspects of the management of patients with dcSSc in Europe and the USA. (uzh.ch)
Consistent with the prescribing information, physicians in clinical practice may treat patients with this system following any type of surgery including those that may not have been included in the phase 3 trials. (springer.com)
In this open clinical trial patients were assigned to an abbreviated build-up scheme. (researchgate.net)
Mutations of transglutaminase-1 in Chinese patients with autosomal recessive congenital ichthyosis: a case report with clinical and genetic analysis of Chinese cases reported in literature. (medscape.com)

Johns Hopkins researchers have greatly increased understanding of the causes of systemic sclerosis, using mice, lab-grown cells and clues from a related disorder. (medindia.net)

In another patient, this therapy was associated with a worsening of lesions. (medscape.com)
Although surgical care has no direct role in the treatment of nephrogenic systemic fibrosis, patients who have undergone successful kidney transplantation may show resolution of the lesions. (medscape.com)
The skin lesions had been swabbed before September but diphtheriae var mitis were isolated from the specimens. (cdc.gov)
Most affected patients have been immunocompetent and experienced ≤10 rash lesions ( 1 ). (cdc.gov)
However, 90% of patients have a history of numbness first, sometimes years before the skin lesions appear. (medscape.com)
The latter system is based on the number of lesions and was intended to help field personnel to quickly triage patients for treatment. (medscape.com)
[ 49 ] Thus, a general classification of disease that combines elements of both of these systems is based on the number of skin lesions present and the number of bacilli found on tissue smears. (medscape.com)
Classification may be further refined by considering other criteria, such as the number of body areas affected and the size of the largest skin lesions. (medscape.com)
Skin lesions include malar butterfly erythema (flat or raised) that generally spares the nasolabial folds. (merckmanuals.com)
Patients with mucosal lesions were older (58 vs 30 years) and more frequently immunocompromised (37% vs 3.5%) compared to patients with. (lu.se)

Uncontrolled DM is highly correlated with various chronic complications, and amongst them is skin complication. (hindawi.com)
Dry skin treated properly in early stages can lower diabetes patients' morbidities and prevent complications, which includes infection, ulcer, and gangrene, which could result in amputation [ 4 ]. (hindawi.com)
DRESS consists of a combination of 3 or more of the following: cutaneous reaction (such as rash or exfoliative dermatitis), eosinophilia, fever, lymphadenopathy and one or more systemic complications such as hepatitis, nephritis, pneumonitis, myocarditis, and pericarditis. (psychiatrist.com)
Its progression is very slow, and it rarely, if ever, spreads throughout the body (becomes systemic) or causes serious complications. (mountsinai.org)

Osler was the first physician who recognized that systemic features of the disease could occur without skin involvement. (medscape.com)
There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse. (wikipedia.org)
Patients with greater cutaneous involvement are more likely to have involvement of the internal tissues and organs. (wikipedia.org)
ACA identified patients with less severe disease, whereas anti-topo I identified patients with skin and cardiac involvement and patients with malignancies. (nih.gov)
On the basis of the Phenotype Standardization Project Drug-Induced Skin Injury criteria, 4 we defined a case of DRESS as one that reported an onset of DRESS within 3 months of starting therapy, had evidence of involvement of the skin and/or internal organ system, and included at least 2 of the following: fever, eosinophilia and/or atypical lymphocytes, or lymphadenopathy. (psychiatrist.com)
Final diagnosis, generally following guideline-based recommendations, was by rheumatologists in most cases (or internal medicine physicians in France) and they remained responsible for global patient management, with lesser involvement in diagnosis and management by dermatologists. (uzh.ch)
People with diffuse skin disease (rather than limited skin involvement) may be more prone to progressive and internal organ disease. (medlineplus.gov)
Conclusion/Significance CL acquired in L. infantum-endemic European and Mediterranean areas displays unexpected high rates of mucosal involvement comparable to those of CL acquired in Latin America, especially in immunocompromised patients. (lu.se)
Involvement of peripheral nerves in patients with leprosy results in sensory, motor and autonomic dysfunctions along with deformities and disability. (bvsalud.org)

All performed tests were normal, thus excluding systemic disease. (nih.gov)

To help confirm a diagnosis of asthma, take spirometry measurements (Reduced FEV 1 and FEV 1 /FVC) before and after the patient inhales a short-acting bronchodilator (200-400 µg salbutamol or albuterol). (cdc.gov)
Until now we've had little insight and no effective treatment strategies for systemic sclerosis, and many patients die within a year of diagnosis," says Hal Dietz, a professor in the Institute of Genetic Medicine and director of the Smilow Center for Marfan Syndrome Research at Johns Hopkins. (medindia.net)
Formal diagnosis of NSF is usually made with a deep skin biopsy, which may show thickened collagen bundles with surrounding clefts, mucin deposition, and proliferation of fibroblasts and elastic fibers. (medscape.com)
What is the diagnosis of Systemic Sclerosis? (selfgrowth.com)
This heterogeneity can result in missing or delaying the diagnosis, with harmful consequences for the patient. (psychiatrist.com)
Physicians were asked to identify key steps in the patient pathway relating to patient presentation, diagnosis and referral, in addition to other treatment and follow-up processes. (uzh.ch)
Thus, improved awareness among patients and primary care physicians is necessary to facilitate earlier referral and diagnosis. (uzh.ch)
Once referred, more consistent use of the modified Rodnan skin score at diagnosis and follow-up may help to monitor disease progression. (uzh.ch)

Cutaneous manifestations of systemic disease may be the initial complaint that causes patients to seek out a healthcare provider. (medscape.com)
Overall mortality rates have been reported to be 48% and 20% for patients with and without cutaneous manifestations, respectively. (medscape.com)
Here we identified three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation. (nature.com)
Immunological changes with induction of blocking IgG and decreases in cutaneous reactivity were detected in the patients. (researchgate.net)
We'll describe how cutaneous GVHD can affect activities of daily living, and we will summarize pharmacologic and non-pharmacological therapies that can help patients who have cutaneous GVHD. (bmtinfonet.org)
This form of the disease is classified as diffuse cutaneous systemic sclerosis (dcSSc). (medlineplus.gov)

Nephrogenic systemic fibrosis (NSF) is usually a chronic, progressive condition. (medscape.com)
Pathogenesis of dry skin in type 2 diabetes mellitus (T2DM) rises from the chronic hyperglycemia causing an increase in advanced glycation end-products (AGEs), proinflammatory cytokines, and oxidative stress. (hindawi.com)
Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune subepidermal blistering disease of the skin and mucus membranes. (medscape.com)
In addition, the US population is aging, and patients frequently have chronic concomitant illness. (springer.com)
There are two types of skin GVHD: acute and chronic. (bmtinfonet.org)
The FDA has approved three systemic therapies for chronic GVHD: ibrutinib (Imbruvica®) ruxolitinib (Jakafi®) and belumosudil (Rezurock®) which are helpful when treating skin GVHD. (bmtinfonet.org)
09:20): Chronic GVHD affects skin differently than acute GVHD and typically presents more than 100 days post-transplant. (bmtinfonet.org)
09:50): Chronic skin GVHD can be non-scarring or scarring. (bmtinfonet.org)
We will review the timeline of manifestations of chronic GVHD on the skin, hair, and nails. (bmtinfonet.org)

Topical calcipotriene (Dovonex) under occlusion has resulted in subjective improvement in 2 patients. (medscape.com)
Calcipotriene plus betamethasone dipropionate (Taclonex) seemingly might have a role in topical treatment for nephrogenic systemic fibrosis. (medscape.com)
In our case, despite the standard application of an increased dose of different H1-receptor antagonists combined with topical steroid preparations, the patient showed no response to treatment and suffered a significant adverse influence on her quality of life and daily activities. (nih.gov)
Combination of oral and topical Centella asiatica (CA) is expected to treat dry skin in T2DM patients more effectively through decreasing N(6)-carboxymethyl-lysine (CML) and interleukin-1 α (IL-1 α ) and increasing superoxide dismutase (SOD) activity. (hindawi.com)
A three-arm prospective, double-blind, randomized, controlled study was performed to evaluate the efficacy of the oral and topical CA extract in 159 T2DM patients with dry skin. (hindawi.com)
Systemic and topical adverse events were not significantly different between groups. (hindawi.com)
Other 25% included topical and/or systemic treatment. (aveneusa.com)
03:30): The first-line therapy for acute skin GVHD is usually a topical steroid or calcineurin inhibitor in the form or a cream, spray, gel or foam. (bmtinfonet.org)
Topical therapies for sclerotic skin GVHD are only minimally effective. (bmtinfonet.org)
Care must be taken when using topical salicylates over large areas, especially in children, because of reports of systemic salicylate intoxication. (medscape.com)
Salicylate toxicity has been reported with systemic absorption of topical salicylic acids in the treatment of children with ichthyosis. (medscape.com)
Topical tacrolimus, a macrolide immunosuppressant, should be used with caution because significantly elevated systemic tacrolimus levels have been reported in a patient with lamellar ichthyosis. (medscape.com)

SLE is a type I interferon response-heavy systemic autoimmune disease that displays high autoreactivity against nucleic acids and other nuclear and intracellular components. (news-medical.net)

Anakinra treatment has been reported to be effective in some patients with systemic-onset juvenile idiopathic arthritis (SoJIA) or adult-onset Still disease (AoSD). (bmj.com)
Corticosteroid treatment has for many years been the sole effective treatment in most patients with SoJIA or AoSD with a severe, polycyclic or persistent course. (bmj.com)
Of all treatments, extracorporeal photopheresis (ECP) seems to provide the best, albeit mild and extremely expensive, treatment modality for nephrogenic systemic fibrosis. (medscape.com)
[ 64 ] reported on successful treatment of nephrogenic systemic fibrosis with photodynamic therapy in a kidney transplant recipient. (medscape.com)
[ 68 ] suggest that UV light therapy has a role in the treatment of nephrogenic systemic fibrosis, based on 2 cases with which they were involved. (medscape.com)
A trial of localized psoralen plus UV-A treatment in one patient produced no improvement. (medscape.com)
[ 69 ] noted 8 patients with nephrogenic systemic fibrosis, 5 of whom were treated with ECP for a mean number of 34 treatment sessions over a mean of 8.5 months. (medscape.com)
Alternatively, patients may begin treatment with varenicline and then quit smoking between days 8 and 35 of treatment. (drugs.com)
In patients who have successfully stopped smoking by the end of 12 weeks of initial treatment, consider an additional 12 weeks of therapy to increase the likelihood of long-term abstinence. (drugs.com)
Encourage patients who are motivated, but unable to quit smoking during 12 weeks of initial treatment (for reasons other than intolerability due to adverse events) or those who have relapsed after varenicline therapy to make another attempt to quit smoking once factors responsible for such failure have been identified and addressed. (drugs.com)
A number of the compounds that proved effective in SSS mice and systemic sclerosis cells are currently being explored by drug companies for the treatment of other conditions, prominently including cancer. (medindia.net)
Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin types. (ox.ac.uk)
BACKGROUND: Few data exist on differences in treatment effectiveness and safety in atopic dermatitis patients of different skin types. (ox.ac.uk)
OBJECTIVE: To investigate treatment outcomes of dupilumab, methotrexate, and ciclosporin, and morphological phenotypes in atopic dermatitis patients, stratified by Fitzpatrick skin type. (ox.ac.uk)
Skin type may influence treatment effectiveness of dupilumab. (ox.ac.uk)
Analyses of these data demonstrate that long term adalimumab treatment is generally safe and well tolerated in patients with RA. (bmj.com)
Even if the WHO allows for initial classification without testing, it is recommended that a bacillary index is determined to ensure that patients are receiving the proper treatment. (medscape.com)
What is the treatment for Systemic Sclerosis? (selfgrowth.com)
Ayurvedic Treatment of Systemic Sclerosis involves the balancing of vitiated doshas, which are responsible for all body ailments. (selfgrowth.com)
Although skin problems are often found in T2DM patients, the awareness and choice of treatment are commonly lacking. (hindawi.com)
POTIGA is a potassium channel opener indicated as adjunctive treatment of partial-onset seizures in patients aged 18 years and older who have responded inadequately to several alternative treatments and for whom the benefits outweigh the risk of retinal abnormalities and potential decline in visual acuity. (drugs.com)
Monitoring and treatment can reduce the risk of visual morbidity in most patients. (nih.gov)
Nivolumab ( Opdivo , Bristol-Myers Squibb) has been approved by the US Food and Drug Administration (FDA) for use in the treatment of hepatocellular carcinoma (HCC) in patients who have previously been treated with sorafenib ( Nexavar , Bayer). (medscape.com)
We are proud to bring the potential for clinically meaningful responses with Immuno-Oncology therapy to these advanced-stage HCC patients, who have had limited treatment options for years," said Chris Boerner, president of the US commercial division at Bristol-Myers Squibb. (medscape.com)
Within six weeks of treatment, 83% of the 12 adenovirus patients responded, as did 100% of the 27 BK virus patients, 96% of the 24 CMV patients, 100% of the two Epstein-Barr virus patients, and 75% of the four human herpes virus 6 patients. (scienceboard.net)
for example, patients who require 72 h of treatment would require use of three systems consecutively. (springer.com)
Two patients with truncating mutations had liver fibrosis that in one patient resolved on treatment with the Src kinase inhibitor dasatinib. (nature.com)
After completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 2 years. (bcan.org)
7-10 However, in their randomized, double-blind trial conducted at the University of Minnesota, Grant et al 11 found that, compared with placebo, NAC treatment yielded significant improvement in skin picking severity. (jcadonline.com)
Fifty-three patients were studied, and 15 of 32 patients (47%) who received NAC treatment were "much" or "very much" improved, compared with four of the 21 patients (19%) who received placebo treatment. (jcadonline.com)
Depending on the severity and extent of GVHD, the treatment may be localized, such as a cream, or systemic, such as steroids that affect the entire body. (bmtinfonet.org)
Maintenance treatment was continued for a mean of 9.1 +/- 4.3 months in these patients. (bvsalud.org)
Six patients have remained free of disease activity during a follow-up period of 11.1 +/- 4.2 months after treatment was stopped. (bvsalud.org)

In Asians the incidence of an enlarged armspan to height ratio in Marfan patients was noted to be lower (25) and prior studies of Asian (and also Afro-Caribean) populations demonstrated different distributions of armspan and height, so one should consider these ethnic differences when using cut-off values (26). (marfan.org)

NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs. (nih.gov)
NSF is a fibrotic disease of the skin and internal organs that develops in patients with renal insufficiency after exposure to gadolinium-based contrast agents (GBCAs). (medscape.com)
SSc is a systemic connective tissue disease characterized by vasomotor instability, fibrosis, and immunologic disturbances, as well as by atrophy of the skin, subcutaneous tissue, muscles, and internal organs. (medscape.com)
It usually affects the skin but in some cases it causes harm beyond the skin such as, digestive tract, blood vessels and other internal organs. (selfgrowth.com)
It affects the skin by causing hardened tissue or ulcers and may harm the internal organs. (mountsinai.org)

This raises the possibility that systemic sclerosis patients could eventually be treated with similar compounds in humans, Dietz says. (medindia.net)
In Systemic sclerosis patients suffer with the changes in texture and appearance of the skin due to excessive collagen production, which is a component of connective tissue. (selfgrowth.com)

For some patients, this hardening occurs only in limited areas, but for others, it quickly spreads across the body and to organs such as the heart, intestines and kidneys. (medindia.net)
The skin, synovial joints, kidneys, lungs, blood vessels, and heart are some of the many organs affected by this broad inflammation, making it the classic systemic autoimmune disorder. (news-medical.net)

Patients with end-stage renal disease undergoing hemodialysis: Maximum of 0.5 mg once daily. (drugs.com)
Screen patients for acute kidney injury and other conditions that may reduce renal function. (nih.gov)
Most patients with NSF are undergoing hemodialysis or peritoneal dialysis or have had a renal transplantation. (medscape.com)
In recent years, new guideline recommendations (including limiting GBCAs and delaying the use of these agents in patients with acute renal failure) have helped to vastly reduce the number of cases of NSF. (medscape.com)
Dosing adjustments are recommended in geriatric patients and in patients with moderate or severe renal or hepatic impairment. (drugs.com)
Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. (nih.gov)
High salt diets ( 1 , 2 ), renal impairment ( 3 - 6 ), inflammation, and infection ( 7 - 11 ) can induce Na + accumulation in skin tissues that can be simulated by addition of approximately 40 mM NaCl to standard cell culture media (= high salt condition, HS) ( 2 , 8 , 12 , 13 ). (frontiersin.org)
For patients on renal dialysis, an additional dose of [HA570 trade name] is recommended after each dialysis. (who.int)

Lesional skin biopsy usually demonstrates leukocytoclastic vasculitis (UV) or neutrophil-rich infiltrate (CAPS and SchS). (iasp-pain.org)

This is especially the case in young children where infectious illnesses are commonly associated with skin rashes (exanthema, and urticaria) and antibiotics used in the context of acute infection can be incorrectly labelled as the allergic trigger. (hse.ie)
No patient experienced cytokine release syndrome, an acute systemic inflammatory condition. (scienceboard.net)
The safety and effectiveness of fentanyl ITS for acute postoperative pain management has been demonstrated in a range of surgery and patient types studied in seven phase 3 trials (three placebo-controlled trials and four active-comparator trials). (springer.com)
Fentanyl iontophoretic transdermal system (ITS) [IONSYS ® , The Medicines Company, Parsippany, NJ, USA] was approved by both the US Food and Drug Administration (April 2015) and the European Medicines Committee (November 2015) for the short-term management of acute postoperative pain in adult patients requiring opioid analgesia in the hospital [ 7 ]. (springer.com)

1- , 3 These agents provide considerable benefit to patients with rheumatoid arthritis (RA). (bmj.com)
As the most common systemic autoimmune illness, rheumatoid arthritis causes a heavy strain on both the patient and society. (news-medical.net)
Particularly in the initial phases of the disease, rheumatoid arthritis patients have an abundance of neutrophils in their inflamed joints that might produce NETs locally. (news-medical.net)
Patients with rheumatoid arthritis have elevated amounts of NETs in their blood, which are correlated with levels of anti-citrullinated protein antibodies (ACPAs) and other systemic inflammatory markers. (news-medical.net)

In 2011, Elmholdt noted that low-dose oral imatinib mesylate slightly improved skin texture but not joint mobility in patients with nephrogenic systemic fibrosis. (medscape.com)
[ 65 ] found that UV-A1 phototherapy improves nephrogenic systemic fibrosis. (medscape.com)
[ 67 ] found that nephrogenic systemic fibrosis responded to high-dose intravenous immunoglobulin. (medscape.com)
[ 70 ] reported on a patient who had nephrogenic systemic fibrosis and had multiple previous exposures to gadolinium (Gd3 + )-based MRI studies and experienced a substantial decrease in pain and skin changes after a trial of intravenous sodium thiosulfate. (medscape.com)
In 2008, Kreuter et al found limited effects of UV-A1 phototherapy in 3 patients with nephrogenic systemic fibrosis. (medscape.com)
Nephrogenic systemic fibrosis does not require inpatient care. (medscape.com)
Nephrogenic Systemic Fibrosis has occurred in patients with impaired elimination of GBCAs. (nih.gov)
The above image shows nephrogenic systemic fibrosis (NSF), or nephrogenic fibrosing dermopathy, on the leg of an affected patient. (medscape.com)

In certain types of tissues, including skin, fibrillin-1 helps make up the scaffolding for cells. (medindia.net)
Systemic sclerosis is the result of excessive secretion as well as accumulation of collagen in the connective tissues of the body. (selfgrowth.com)
It is a fibrous protein called collagen that makes up connective tissues including skin. (selfgrowth.com)

The substantial adverse effects of corticosteroids led to a strategy of using various immunosuppressive drugs to minimize the need for corticosteroids, improving the prognosis for patients. (medscape.com)
Specifically in the CheckMate-040 study, immune-mediated hepatitis requiring systemic corticosteroids occurred in 5% of patients (8 of 154). (medscape.com)

Known history of serious hypersensitivity reactions or skin reactions to varenicline. (drugs.com)
There have been reports from around the world of reactions from caterpillar stings, including dermatologic, pulmonary, and other systemic reactions. (aafp.org)
Serious adverse reactions occurred in 49% of patients. (medscape.com)
The most frequent serious adverse reactions reported in at least 2% of patients were pyrexia, ascites, back pain, general physical health deterioration, abdominal pain, and pneumonia. (medscape.com)
The drug was discontinued because of adverse reactions in 11% of patients, and 32% of patients had a dose delay for an adverse reaction. (medscape.com)
Only 8 systemic reactions were registered, which represented 7/47 (14.9%) of patients and 8/429 (1.9%) of administered doses. (researchgate.net)

Two patients stopped anakinra due to severe skin reaction, and two patients due to infection: one visceral leishmaniasis and one varicella. (bmj.com)

18:26): Stretch marks, also known as striae, may develop with prolonged systemic steroid use, and are very challenging to treat. (bmtinfonet.org)

Absorption may occur after skin or eye contact with liquid or vapor Lewisite. (cdc.gov)
Systemic absorption may occur following skin or eye exposure to liquid or vapor Mustard-Lewisite Mixture. (cdc.gov)

Nevirapine should not be used in patients with severe hepatic impairment (Child-Pugh C, see section 4.3). (who.int)

Alternatively, ex vivo gene therapy has been reported for lamellar ichthyosis, with which normal gene expression of TGM1 has been restored and the phenotype correction was observed in engrafted lesional skin in vivo on the back of immunodeficient mice. (medscape.com)

Anifrolumab-fnia blocks type I interferons, a main factor that leads to tissue damage and symptom severity in patients with SLE. (hcplive.com)

Oral prednisone (60 mg PO qd) has been effective in several cases, but it has been discontinued in some patients because of its adverse effects. (medscape.com)
In 1 of 2 patients, intralesional alpha interferon (3 MU 3 times weekly) improved the skin, although in both patients, it had to be discontinued because of its adverse effects. (medscape.com)
Dosage may be reduced temporarily or permanently in patients who experience intolerable adverse effects. (drugs.com)
Applying a label of Penicillin Allergy to a patient is a significant issue and will impose restrictions for prescribing with multiple potentially adverse outcomes (e.g.sub-optimal antibiotic effectiveness, more expensive and potentially more harmful antibiotic regimens). (hse.ie)
Because of the significant long-term adverse effects, reserve systemic retinoids for severe disease that is refractory to conventional therapy. (medscape.com)

all presented with systemic inflammation and recurrent neutrophilic small vessel vasculitis. (nature.com)

Some patients can develop pulmonary hypertension, or elevation in the pressures of the pulmonary arteries. (wikipedia.org)

The infections in patients with SLE, primarily involving the skin, respiratory tract, and urinary tract, can significantly complicate disease management. (medscimonit.com)
CAo and CAt combination can be used to significantly improve dry skin condition through increasing SOD activity in T2DM patients with controlled blood glucose. (hindawi.com)
Concentration of AGEs in diabetes patients is significantly higher due to the hyperglycemic state and oxidative stress. (hindawi.com)
The COVID-19 pandemic significantly influences dermatology patients' continued care, especially those on systemic therapy. (medgadget.com)
CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)
We observed that patients with multibacillary leprosy had significantly more severe changes in nerve conduction parameters as compared to that of paucibacillary leprosy. (bvsalud.org)

Respiratory and Systemic Infection Laboratory, from the lesion. (cdc.gov)
As with intravenous patient-controlled opioid analgesia, fentanyl ITS is to be used only in patients who are alert enough, have appropriate respiratory function (e.g., high oxygen saturation levels, no hypoventilation), and have adequate cognitive ability to understand the directions for use. (springer.com)
Numerous case reports have been published indicating workers and patients experiencing respiratory problems, anaphylaxis, skin reactivity, and systemic antibody production. (cdc.gov)

The diffuse form also affects the skin above the elbows and knees and can also spread to the torso. (wikipedia.org)
Patients with limited systemic sclerosis have a better prognosis than those with the diffuse form. (wikipedia.org)

Diabetes mellitus affects the skin with several mechanisms where hyperglycemia and advanced glycation end-products (AGEs) are the two main factors. (hindawi.com)

No dose adjustment is necessary in patients with mild to moderate hepatic impairment (see sections 4.4 and 5.2). (who.int)

This study aimed to evaluate the occurrence, management, and patient outcomes associated with infections in a group of 74 SLE patients at a single center in Saudi Arabia, spanning a 5-year period. (medscimonit.com)
New approaches, such as multimodal analgesia and enhanced recovery after surgery (ERAS) protocols, have been introduced to improve pain management and patient outcomes in the postoperative setting. (springer.com)
Secondary outcomes included: changes in immunoglobulin titers and changes in dose-response skin prick tests. (researchgate.net)

Patients report severe and recurrent itching of large skin areas. (wikipedia.org)

METHODS: Sixteen patients with clinically diagnosed mycetoma, who did not show any evidence of a fungal etiology, were treated presumptively for actinomycetoma. (bvsalud.org)

Steroids had been stopped in two cases and the dose was decreased by 45% to 95% in 12 patients. (bmj.com)
Management also includes supportive care and systemic steroids in more severe cases. (psychiatrist.com)
06:36): For patients with widespread skin GVHD, systemic steroids or light therapy may be the preferred option. (bmtinfonet.org)

This phase I trial studies the side effects and best dose of belinostat when given together with tremelimumab and durvalumab in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and has spread to nearby tissue or lymph nodes (locally advanced). (bcan.org)
Excoriation disorder is characterized by the repetitive and compulsive picking of the skin, leading to tissue damage. (jcadonline.com)

But Dietz's group was struck by the similarities between systemic sclerosis and a less severe, much rarer condition called stiff skin syndrome (SSS), which does run in families, and they suspected that learning more about SSS would also shed light on systemic sclerosis. (medindia.net)
Pleural punctures carried out resulted in inflammatory pleural fluid rich in eosinophils, associated with a biological inflammatory syndrome, in a patient with history of auto-immunity recently discovered. (scirp.org)

Absorption across the skin begins within minutes. (cdc.gov)
Ingestion of either Lewisite or Mustard-Lewisite Mixture is an uncommon route for exposure but can lead to local effects and systemic absorption. (cdc.gov)

Numerous studies have linked neutrophils to the pathogenesis of systemic autoimmunity. (news-medical.net)
Many of the autoantigens generated by neutrophils in NETs, including double-stranded deoxyribonucleic acid (DNA), citrullinated peptides, histones, myeloperoxidase (MPO), and proteinase 3 (PRTN3), are known to be attacked by the adaptive immune system observed in systemic autoimmunity. (news-medical.net)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)

Anatomy36

Organisms16

Diseases87

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Psychiatry and Psychology2

Phenomena and Processes33

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture9

Information Science3

Health Care12

Lupus35

Scleroderma32

Progressive systemic sclerosis4

Diseases15

Symptoms26

Disorders6

Clinical14

Causes of systemic sclerosis1

Lesions10

Complications4

Involvement9

Excluding systemic disease1

Diagnosis8

Cutaneous6

Chronic10

Topical12

Autoimmune disease1

Treatment33

Incidence1

Internal organs5

Sclerosis patients2

Kidneys2

Renal8

Biopsy1

Acute4

Rheumatoid arthritis4

Nephrogenic8

Tissues3

Corticosteroids2

Reactions6

Visceral1

Steroid1

Occur2

Severe hepatic1

Lamellar ichthyosis1

Severity1

Adverse5

Inflammation1

Hypertension1

Significantly6

Respiratory3

Diffuse2

Affects the skin1

Hepatic1

Outcomes3

Recurrent1

Etiology1

Steroids3

Tissue2

Syndrome2

Absorption2

Neutrophils3