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  • tissues
  • These micro RNAs have pivotal roles in development and physiology of muscle tissues including the heart. (mirbase.org)
  • however, emerging research suggests that vitamin D may also benefit a plethora of extra-skeletal target tissues and systems. (springer.com)
  • enhances
  • miR-133 enhances myoblast proliferation by repressing serum response factor (SRF) mIR-133 suppresses SP1 expression In rats, miR-133b is expressed in retinal dopaminergicamacrine cell, and this expression is significantly increased during early stage during retinal degeneration. (wikipedia.org)
  • renal
  • Elevation of renal miR-196a/b expression by hydrodynamic-based delivery of a miR-196a/b-expressing plasmid before or shortly after UUO significantly downregulated profibrotic proteins, including collagen 1 and α -smooth muscle actin, and mitigated UUO-induced renal fibrosis. (asnjournals.org)
  • In the UUO model, miR-196a/b silenced TGF- β -Smad signaling, decreased the expression of collagen 1 and α -smooth muscle actin, and attenuated renal fibrosis. (asnjournals.org)
  • pathways
  • Here, we used RNA-Seq to identify pathways that are disrupted in diseased muscle using AR113Q knock-in mice. (jci.org)
  • expression
  • RhoA expression is negatively regulated by miR-133a in bronchial smooth muscles (BSM)and miR-133a downregulation causes an upregulation of RhoA, resulting in an augmentation of contraction and BSM hyperresponsiveness. (wikipedia.org)
  • mice
  • Ubiquitinated ADRM1 was detected in AR113Q muscle, indicating the occurrence of stalled proteasomes in mutant mice. (jci.org)