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  • expression
  • Impaired function of shoulder muscles, resulting from rotator cuff tears, is associated with abnormal deposition of fat in muscle tissue, but corresponding cellular and molecular mechanisms, likely reflected by altered gene expression profiles, are largely unknown. (uzh.ch)
  • Here, an analysis of muscle gene expression was carried out by semiquantitative RT-PCR in total RNA extracts of supraspinatus biopsies collected from 60 patients prior to shoulder surgery. (uzh.ch)
  • A total of 11 MyHCs is coded by 6 myosin heavy chain ( MYH ) genes which are widely expressed in body muscles and 5 other genes with limited expression in specialized skeletal muscles. (biomedcentral.com)
  • Here, we review the pattern of expression of myosin genes during muscle development, focusing especially on embryonic and neonatal MyHCs. (biomedcentral.com)
  • Insulin-like 6 (Insl6) is a poorly characterized member of the insulin-like/relaxin family of secreted proteins, whose expression is upregulated upon acute muscle injury. (biomedcentral.com)
  • Conversely, muscle-specific overexpression of Insl6 protected against the development of myositis as indicated by reduced lymphocyte infiltration in muscle, diminished inflammatory cytokine expression and improved motor function. (biomedcentral.com)
  • Insl6 transcript expression in muscle was reduced in a cohort of dermatomyositis and polymyositis patients. (biomedcentral.com)
  • Expression of both actin and myosin heavy chain mRNA was greatly decreased when the ISMs became committed to die. (naver.com)
  • At the protein level, actin expression was reduced by 84% at the time the muscles were committed to die. (naver.com)
  • MLC3 expression was not significantly affected, whereas levels of MLC2 transcripts were significantly elevated in the white muscle only of juvenile sea bream after administration of T4. (ualg.pt)
  • In: Strohman R.C., Wolf S. (eds) Gene Expression in Muscle. (springer.com)
  • ATPase
  • Comparing the DSC data with temperature dependences of intrinsic fluorescence parameters and S1 ATPase inactivation, we have identified these two calorimetric domains as motor domain and regulatory domain of the myosin head, the motor domain being more thermostable. (mdpi.com)
  • Myosin is a hexameric ATPase cellular motor protein. (genecards.org)
  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. (genecards.org)
  • synthesis
  • The reduction in actin and myosin heavy chain synthesis presumably plays a role in the rapid dissolution of the muscles. (naver.com)
  • Our results confirm that muscle cells are sensitive to alterations in extracellular concentrations of AA for induction of protein synthesis and anabolism. (biomedcentral.com)
  • Therefore, the present study was conducted to evaluate how provision of extracellular amino acids influenced on cellular expressions and content of transcripts of amino acid transporters and myofibrillar MHC2A as well as α-actin as possible markers for the synthesis of contractile proteins in skeletal muscles at feeding relevant for clinical nutrition studies. (biomedcentral.com)
  • Molecular
  • While the molecular basis of ISM atrophy is largely unknown, the commitment of the muscles to die has been shown to require the repression of specific genes and the activation of others. (naver.com)
  • It is not meant to be a review on such a wide topic, but it will tell the story of how the understanding of the mechanisms underlying the heterogeneity and plasticity of skeletal muscle power output has been developing in our laboratory and of how our experimental approach has been updated to further our knowledge of the mechanisms from the cellular level to the molecular level. (springer.com)
  • Fluck M, Hoppeler H (2003) Molecular basis of skeletal muscle plasticity-from gene to form and function. (springer.com)
  • distal
  • Mutations in MYH3 or MYH8 are responsible for distal arthrogryposis syndromes, characterized by congenital joint contractures and orofacial dysmorphisms, supporting the importance of muscle contractile activity and body movements in joint development and in shaping the form of the face during fetal development. (biomedcentral.com)
  • cDNA
  • The total length of the rat skeletal muscle MLCK cDNA was 2823 base pairs with an open reading frame of 1830 base pairs. (cshl.edu)
  • mutations
  • We used Flexor Digitorum Brevis (FDB) isolated from young (~2-months old) and old (~14-months old) wild type and mdx mice, and human Abductor Hallucis (AH) and gastrocnemious muscles carrying the DA-1 mutations. (sigmaaldrich.com)
  • heterogeneity
  • The capacity to accomplish such variable motor tasks relies on the very fine motor control performed by the nervous system and on the very large functional heterogeneity and plasticity of skeletal muscles. (springer.com)
  • MYH3
  • In addition, we discuss the human pathologies due to mutation of MYH3 and MYH8 and the unsettled question of the functional significance of these myosins. (biomedcentral.com)