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  • endothelial cells
  • The nests are separated by delicate sinusoidal vascular channels lined by a flattened, single layer of endothelial cells. (thefreelibrary.com)
  • Blood brain barrier (BBB) is a vasculature of the central nervous system (CNS) that is formed by capillary endothelial cells. (hindawi.com)
  • This is not a fixed structure but its function depends on the complex interplay between the different cell types such as the endothelial cells, astrocytes, pericytes, and the extracellular matrix of the brain and blood flow maintained in the microvessels or brain capillaries. (hindawi.com)
  • BBB is physically located in endothelium of blood vessels (capillaries) and acts as a "physical barrier" due to formation of complex tight junctions between adjacent endothelial cells. (hindawi.com)
  • Thus, association of astrocytes with the brain endothelial cells provides a modular organization that allows precise control over the substances that enter or leave the brain. (hindawi.com)
  • It includes endothelial cells, astrocytes, and blood capillaries in the brain, which form the major structural component of the blood brain barrier. (hindawi.com)
  • More specifically, the endothelial cells also possess transporters which show permeability characteristics and allow transport of oxygen and CO 2 across the BBB, bu these selectively prevent other substances from crossing [ 1 ]. (hindawi.com)
  • Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. (abcam.com)
  • In pre-active lesion, increased expression of CD55 in endothelial cells and robust CD97 expression on infiltrating leukocytes suggest a possible role of both molecules in immune cell migration through the blood-brain barrier. (wikipedia.org)
  • primary tumor
  • Prognosis for patients who have primary tumor sites within the bones often have higher survival rates and respond well to treatment options. (wikipedia.org)
  • While patients who have primary tumor sites within the nasopharynx region with metastases to the breast have very poor outcomes. (wikipedia.org)
  • substrate
  • PTPkappa is localized to cell-cell contact sites, where it colocalizes and co-immunoprecipitates with β-catenin and plakoglobin/γ-catenin β-catenin may be a PTPkappa substrate. (wikipedia.org)
  • migration
  • Upon lymphoid, myeloid cells and neutrophil activation, CD97 is upregulated to promote adhesion and migration to sites of inflammation. (wikipedia.org)
  • colorectal
  • Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. (medscape.com)
  • CD97 is expressed on many types of tumors including thyroid, gastric, pancreatic, esophageal, colorectal, and oral squamous carcinomas as well as glioblastoma and glioblastoma-initiating cells. (wikipedia.org)
  • Invasion
  • Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. (biomedcentral.com)
  • Cancer
  • The Skin Disease Program will formally kick-off with a day-long symposium designed to highlight skin stem cell research as it relates to regenerative medicine, cancer biology, cutaneous aging, and disease prevention. (constantcontact.com)
  • Furthermore, miR-206 is highly expressed in triple-negative breast tumors that grow independent of estradiol, and miR-206 is a predictor of worse overall survival in breast cancer patients. (wikipedia.org)
  • UCK2, however, is of particular scientific interest due to its overexpression in tumor cell lines, which makes it a target in anti-cancer treatments. (wikipedia.org)
  • One strategy for anti-cancer and anti-viral therapies involves using UCK2 to activate anti-tumor prodrugs through phosphorylation. (wikipedia.org)
  • PGRMC1 is over-expressed in breast tumors and in cancer cell lines from the colon, thyroid, ovary, lung, and cervix. (wikipedia.org)
  • PGRMC1 also promotes survival in human cancer cells after treatment with chemotherapy. (wikipedia.org)
  • In contrast, PGRMC1 promotes cell death in cancer cells after oxidative damage. (wikipedia.org)
  • For example, Rac1-dependent pathway inhibition resulted in the reversal of tumor cell phenotypes, suggesting Rac1 as a predictive marker and therapeutic target for trastuzumab-resistant breast cancer. (wikipedia.org)
  • For example, SCRIB is known to inhibit breast cancer formation and the depletion of SCRIB promotes neoplastic growth by disrupting morphogenesis and inhibiting cell death through an association with Myc. (wikipedia.org)
  • Interestingly, a significant role for sortilin has recently also been reported in the field of oncology, as it has been detected in several cancer cell lines. (wikipedia.org)
  • mARs have also been found to be expressed in breast cancer cells. (wikipedia.org)
  • In tumor cells, cells with decreased Grx2 are dramatically sensitized to cell death induced by the anti-cancer drug, DOX. (wikipedia.org)
  • Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). (wikipedia.org)
  • Recent studies have shown beyond doubt that the old classification paradigm of "small cell carcinoma vs. non-small cell carcinoma" is now obsolete, and that the correct "subclassification" of lung cancer cases is necessary to assure that patients receive optimum management. (wikipedia.org)
  • pathway
  • The activation of the JNK signal transduction pathway by MAP4K4 has been implicated in apoptotic regulation of many different cell types, tumorigenesis and/or inflammation. (wikipedia.org)
  • It was originally isolated in Drosophila melanogaster in a pathway (also known as the Scribble complex) with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae) as a tumor suppressor. (wikipedia.org)
  • Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. (wikipedia.org)
  • Alveolar
  • Alveolar soft part sarcoma is usually a poorly circumscribed mass with a soft and rubbery consistency that has a tan-pale to yellow cut surface, which may be accompanied by areas of hemorrhage or necrosis, especially in large tumors. (thefreelibrary.com)
  • Regeneration
  • In vitro models of muscle self-repair would facilitate the basic understanding of muscle regeneration and the screening of therapies for muscle disease. (nature.com)
  • Charge, S. B. & Rudnicki, M. A. Cellular and molecular regulation of muscle regeneration. (nature.com)
  • Lepper, C., Partridge, T. A. & Fan, C. M. An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. (nature.com)
  • Tidball, J. G. & Villalta, S. A. Regulatory interactions between muscle and the immune system during muscle regeneration. (nature.com)
  • Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration. (nature.com)
  • Turner, N. J. & Badylak, S. F. Regeneration of skeletal muscle. (nature.com)
  • Muscular dystrophies (MDs) are a heterogeneous group of inherited disorders, in which progressive muscle wasting and weakness is often associated with exhaustion of muscle regeneration potential. (frontiersin.org)
  • actively contribute to development of pathogenesis in several myophaties but only macrophages and sometimes eosinophils play a role in muscle regeneration ( Tidball and Villalta, 2010 ). (frontiersin.org)
  • humans
  • In humans, mutations in BIN1 have been associated with skeletal myopathies including centronuclear myopathy causing muscle weakness and myotonic dystrophy causing progressive muscle wasting, myotonia, cataracts, and heart conduction defects. (wikipedia.org)
  • mutations
  • Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations. (medscape.com)
  • prognosis
  • Nevertheless, the histologic features of ASPS have no prognostic significance, (2) and the better prognosis reported for tumors with this solid growth is due to their occurrence in the pediatric patient population and their propensity to involve the head and neck region. (thefreelibrary.com)
  • neuronal
  • The fine regulation of the brain-derived neurotrophic factor (BDNF) by sortilin is required for both neuronal and tumor cell survival. (wikipedia.org)
  • immunity
  • The event will provide a forum to present work related to tumor immunity in our research community, and identify opportunities for collaborative research initiatives. (constantcontact.com)
  • Biology
  • This month, the Matrix interviewed Laverne Martinez, Fellowship Coordinator and Sponsored Research Associate at the Harvard Department of Stem Cell and Regenerative Biology. (constantcontact.com)
  • stem
  • Stem Cells 31 , 384-396 (2013). (nature.com)
  • Blau, H. M., Cosgrove, B. D. & Ho, A. T. The central role of muscle stem cells in regenerative failure with aging. (nature.com)
  • Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. (nature.com)
  • An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. (nature.com)
  • Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. (nature.com)
  • Taking into account the advances in the isolation of new subpopulation of stem cells and in the creation of artificial stem cell niches, we discuss how these emerging technologies offer great promises for therapeutic approaches to muscle diseases and muscle wasting associated with aging. (frontiersin.org)
  • Due to these findings, other aspects were deeply investigated to increase the survival of injected stem cells into pathological muscle. (frontiersin.org)
  • Pathological conditions modify the microenvironment of stem cells (the so-called niche) preventing the activation of resident stem cells and reducing the success of exogenous cell therapies. (frontiersin.org)
  • By expressing a dominant negative form of PTPkappa or by using short-hairpin RNA for PTPkappa in bone-marrow derived stem cells, Erdenbayer and colleagues demonstrated that CD4(+) T cells development was inhibited. (wikipedia.org)