• Loss of skeletal muscle mass, termed "atrophy", is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. (nih.gov)
  • Activation of Akt also inhibits FOXO and decreases expression of the E3 ubiquitin ligases Muscle Atrophy Fbox (MAFbx) and Muscle Ring Finger1 (MuRF1). (nih.gov)
  • It's long been suspected that atrophy at this junction is a weak link in sarcopenia, the loss of muscle mass we get with age," said Melov. (innovations-report.com)
  • Since exercise can improve muscle strength and endurance capacity, it can serve as a means of preventing muscle atrophy and reducing the risk of sarcopenia. (hindawi.com)
  • The myofibrils are composed of actin and myosin filaments, repeated in units called sarcomeres , which are the basic functional units of the muscle fiber. (wikipedia.org)
  • Experiments were designed to develop a reproducible technique for producing chronic strain injury to rat skeletal muscles as a model for cumulative trauma disorder (CTD), and to measure the functional outcome of repeated microtrauma in order to develop strategies and programs for its prevention. (cdc.gov)
  • A dynamometer was designed and built to control the velocity and range of movement of the rat foot during a strain overload and test the functional outcome in terms of muscle strength, endurance, and stiffness in-vivo. (cdc.gov)
  • Previous studies have shown that the number of satellite cells is increased by long-term or acute exercise training in humans and animals [ 4 , 5 ] and decreases during aging in conjunction with a reduction in the muscle quality and functional potential [ 6 ]. (hindawi.com)
  • These cells are normally quiescent but can be activated by exercise or pathology to provide additional myonuclei for muscle growth or repair. (wikipedia.org)
  • The appearance of muscle pathology was related to the strain rate. (cdc.gov)
  • Each motor neuron activates a group of muscle cells, and collectively the neurons and muscle cells are known as motor units . (wikidoc.org)
  • A brief survey is given of how motoneurons and motor units are used for the gradation Of muscle force during motor behavior. (hindawi.com)
  • The orientation, placement, and coordination of these muscles allow the human body to produce a wide range of voluntary movements. (cliffsnotes.com)
  • Over time, this leads to a lack of communication between the brain and the muscles, causing the patient to lose the ability to control muscle movements. (wisegeek.com)
  • These images are a random sampling from a Bing search on the term "Skeletal Muscle Relaxant. (fpnotebook.com)
  • Satellite cells can be mitotically quiescent or in an activated proliferative state during skeletal muscle turnover. (hindawi.com)
  • A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. (fpnotebook.com)
  • A synthetic propanediol dicarbamate derivative and an adjunct in the treatment of painful muscle spasms, Carisoprodol is a centrally acting skeletal muscle relaxant that relieves stiffness, pain, and discomfort caused by muscle injuries. (fpnotebook.com)
  • Children with a less severe form face the prospect of progressive muscle wasting, loss of mobility and motor function. (ucl.ac.uk)
  • The study, appearing on line in Aging Cell, provides a method to study sarcopenia, the degenerative loss of muscle mass that begins in middle age. (innovations-report.com)
  • Loss of skeletal muscle mass, known as sarcopenia, is a serious health issue that affects millions of aging adults. (hindawi.com)
  • Myasthenia gravis is an incurable disease that develops as a result of the breakdown of communication between the muscles and nerves of the body, leading to a loss of muscle control. (wisegeek.com)
  • Muscle fibres, or muscle cells , are formed from the fusion of developmental myoblasts in a process known as myogenesis . (wikipedia.org)
  • De Coppi's team has demonstrated that intravenous transplantation of amniotic fluid stem (AFS) cells enhances the muscle strength and improves the survival rate of the affected animals. (ucl.ac.uk)
  • Skeletal muscle cells are stimulated by acetylcholine , which is released at neuromuscular junctions by motor neurons . (wikidoc.org)
  • The ATP is produced by metabolizing creatine phosphate and glycogen within the muscle cells by mitochondria , as well by metabolizing glucose and fatty acids , obtained from blood and within the cell. (wikidoc.org)
  • This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. (springer.com)
  • Gap junctions are found in cardiac and smooth muscle, where they function to increase the speed of electrical communication, or depolarization, between cells. (reference.com)
  • In addition to gap junctions, other types of junctions include anchoring junctions and desmosomes, which keep muscle cells connected when they contract. (reference.com)
  • Researchers at MIT and the University of Pennsylvania have genetically engineered skeletal muscle cells to respond to light . (slashdot.org)
  • The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. (nih.gov)
  • Researchers have gained new insight into the mechanisms involved in how skeletal muscles lose their mass and strength as people age, called sarcopenia. (medicalxpress.com)
  • its long, thin, multinucleated fibres are crossed with a regular pattern of fine red and white lines, giving the muscle a distinctive appearance. (britannica.com)
  • While you can get cramps in any of your skeletal muscles, the most commonly affected ones are in your feet, calves and thighs. (wisegeek.com)
  • These two responses were noted in muscles commonly recruited for low level endurance activity. (cdc.gov)
  • H+, for example, lowers the pH of the muscle when present, making the environment more acidic, commonly known as lactic acid. (livestrong.com)
  • It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (fpnotebook.com)
  • The smallest thing can cause sore muscles in my neck and back, and when you touch many parts of my body, it feels like pushing on a bruise. (wisegeek.com)
  • Blood vessels, lymphatic vessels, and nerves enter and exit muscles through this layer . (bodybuilding.com)
  • Their thread-like axon processes run inside nerves and carry electrochemical impulses (= action potentials) to target muscles. (getbodysmart.com)