• Erratum to: Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. (edu.au)
  • This study shows that muscle TCTP and mTOR signaling are upregulated in a range of mouse models (mdx mouse, mechanical load-induced hypertrophy, and denervation- and immobilization-induced atrophy). (edu.au)
  • Studies performed in young adult mdx mice (a mild DMD mouse model) have yielded opposing results. (nih.gov)
  • Daily cromolyn injections were performed on young and exercised adult mdx mice and histological analysis confirmed that mast cell degranulation contributes to myofibre necrosis. (deepdyve.com)
  • This strategy is intended as a first step toward screening mice for phenotypic effects on bone and establishing the associated biomechanical mechanism by which function has been altered, and can be conducted without a background in engineering. (currentprotocols.com)
  • Furthermore, SFN treatment also reduced the central nucleation (∼40%), fiber size variability, and inflammation and improved the sarcolemmal integrity of mdx mice. (nih.gov)
  • We also studied Evans blue dispersion in transgenic mice bearing different dystrophin mutations, and we demonstrated that cytoskeletal and sarcolemmal attachment of dystrophin might be a necessary requirement to prevent serious fiber damage. (nih.gov)
  • We hypothesise that blockade of mast cell degranulation would reduce the extent of myofibre necrosis in the mdx mouse. (deepdyve.com)
  • Skeletal muscle has numerous biological functions including locomotion, thermoregulation, respiration, postural support, protection of bones and viscera, and also serves as a repository of amino acids in times of starvation or disease. (frontiersin.org)
  • Transgenic mdx mice show exclusive micro-dystrophin expression in skeletal muscle but not in the heart. (nih.gov)
  • Four-week-old mdx mice were treated with SFN by gavage (2 mg·kg body wt(-1)·day(-1) for 8 wk), and our results demonstrated that SFN treatment increased the expression and activity of muscle phase II enzymes NAD(P)H quinone oxidoreductase 1 and heme oxygenase-1 with a Nrf2-dependent manner. (nih.gov)
  • Here, we show that muscle-restricted expression of a localized insulin-like growth factor (Igf) -1 isoform maintained muscle integrity and enhanced satellite cell activity in SOD1 G93A transgenic mice, inducing calcineurin-mediated regenerative pathways. (rupress.org)
  • Muscle-specific expression of local Igf-1 (mIgf-1) isoform also stabilized neuromuscular junctions, reduced inflammation in the spinal cord, and enhanced motor neuronal survival in SOD1 G93A mice, delaying the onset and progression of the disease. (rupress.org)
  • In the present study, we establish skeletal muscle as a primary target in inherited forms of ALS by showing that localized expression of the coinherited MLC/mIgf-1 transgene exclusively in the skeletal muscle of SOD1 G93A mice counteracted the symptoms of ALS, induced satellite cell activity, stabilized neuromuscular junctions, and led to a reduction in astrocytosis in the SOD1 G93A spinal cord. (rupress.org)
  • We suggest that the inbred mice model presents an opportunity for researchers to investigate the genetic, and gene-environmental influence on the development of digit ratios. (jove.com)
  • The Na+, K+ pump in skeletal muscle: quantification, regulation and functional significance. (naver.com)
  • Properties of muscle fibers, i.e., their type, number and size, are important determinants of functional characteristics of skeletal muscle, and of the quality of meat in livestock. (frontiersin.org)
  • Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder involving the degeneration of motor neurons accompanied by skeletal muscle atrophy and paralysis. (rupress.org)
  • These findings provide novel data on the role and regulation of TCTP in skeletal muscle in vivo. (edu.au)
  • After the stretches, isometric stress during a tetanus was decreased significantly for both mdx and mdx:utrn(-/-) muscles compared with control muscles (P (jove.com)
  • While it is known that mTOR plays a major role in the regulation of skeletal muscle mass, very little is known about the role and regulation of TCTP in this post-mitotic tissue. (edu.au)
  • Lactate/proton co-transport in skeletal muscle: regulation and importance for pH homeostasis. (naver.com)
  • Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise. (naver.com)
  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective degeneration of motor neurons, atrophy, and paralysis of skeletal muscle. (rupress.org)
  • Modestly dystrophic mdx mice were injected with sActRIIB-Fc or PBS with or without voluntary wheel running exercise for 7 wk. (lu.se)
  • While many experimental therapies have shown great promise in treating skeletal muscle disease, an effective therapy for Duchenne cardiomyopathy remains a challenge in large animal models and human patients. (nih.gov)
  • Macroscopic and microscopic evaluation of EBD staining after intravenous dye injection into 3-mo-old normal control (a and b), mdx (c and d), and dy/dy (e and f) mice. (nih.gov)
  • Blue coloration of dy/dy and dy2J/dy2J mice observed by macroscopic evaluation was caused by dye uptake into the connective tissue, which is increased in these dystrophic animals. (nih.gov)