Size cell membrane permeability. Medical search. Frequent questions

Here, we have used two-color multiparameter flow cytometry to study simultaneously its effects on cell membrane permeability, intracellular pH, and cell size/structure of EMT6 mouse mammary tumor cells and HL-60 human promyelocytic leukemia cells in vitro . (aacrjournals.org)
The basic principle of the model is an osmotic imbalance in the cell membrane followed by an intracellular flow of sodium and simultaneous accumulation of water leading to the subsequent increase of BBB permeability. (nel.edu)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
Measure-ment of the ROS showed that the intracellular fluorescence of the 90‐s plasma‐treated cells led to significant fluorescence formation of 32 relative fluorescence units (RFU)/cell (9 × 10 4 fold, compared to the nontreated cells). (iucc.ac.il)
TTFields can induce a number of biological responses, including mitotic catastrophe, to kill cancer cells by targeting polarizable intracellular molecules. (conditionmed.org)
The process restores the excess of intracellular potassium and extracellular sodium and reinstates the negative resting membrane potential. (medscape.com)

Flexible Wall Permeability Cell, 1.4 to 4in dia. (globalgilson.com)
Flexible Wall Permeability Cell, for 1.4 to 4in dia. specimens, offer optimum performance with Gilson's HM-350M Master Control Panel or HM-350A Auxiliary Control Panel, as well as other manufacturer's systems. (globalgilson.com)

Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
It was present in structures such as kidney tubules and red blood cells, and related to proteins of diverse origins, such as in fruit fly brain, bacteria, the lens of the eye, and plant tissue. (wikipedia.org)
Also known as water channels, aquaporins are integral membrane pore proteins. (wikipedia.org)
Consequently, the purpose of these studies was to evaluate whether volume-sensitive tyrosine kinases mediate cell volume increases through effects on the activity or distribution of NSC channel proteins. (elsevierpure.com)
Given their small size and (relatively) low molecular weight, peptides have certain advantages over large proteins and antibodies. (boku.ac.at)
This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
Claudins are transmembrane proteins with four membrane-spanning regions that serve as the major cell-adhesion molecules of tight junctions. (rndsystems.com)
Tight junctions restrict the flow of ions and aqueous molecules between cells, and their permeability is determined by the profile of claudin expression and arrangement of claudins with other proteins at the paracellular barrier. (rndsystems.com)
Layers of cells + extracellular proteins such as skin. (pharmacology2000.com)
 Facilitated diffusion is a type of passive transport that allows substances to cross membranes with the assistance of special transport proteins. (slideshare.net)
Through the use of ion channel proteins and carrier proteins that are embedded in the cell membrane, these substances can be transported into the cell. (slideshare.net)
Mutations that result in alterations of the outer membrane porin proteins of Gram-negative organisms lead to decreased permeability of the drug through the outer membrane so less drug reaches the target enzyme. (cdc.gov)
Other possible factors include hereditary defects in proteins that are integral to the slit diaphragms of the glomeruli, activation of complement leading to damage of the glomerular epithelial cells and loss of the negatively charged groups attached to proteins of the GBM and glomerular epithelial cells. (msdmanuals.com)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

In the mid-1960s an alternative hypothesis (the "partition-diffusion model") sought to establish that the water molecules partitioned between the water phase and the lipid phase and then diffused through the membrane, crossing it until the next interphase where they left the lipid and returned to an aqueous phase. (wikipedia.org)
Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
Similar results were obtained from analyses of IgG1 molecules and an IgG1-Fc fragment produced by Expi293 cells. (bvsalud.org)
In general, these membranes are impermeable to organic solutes with large molecules, such as polysaccharides , while permeable to water and small, uncharged solutes. (wikidoc.org)
Water molecules travel through the plasma cell membrane, tonoplast (vacuole) or protoplast in two ways. (wikidoc.org)
Consider a permeable membrane, such as visking tubing , with apertures big enough to allow water (solvent) molecules, but not larger solute molecules, to pass through. (wikidoc.org)
When this membrane is immersed in liquid it is constantly hit by molecules of the liquid, in motion due to their thermal kinetic energy . (wikidoc.org)
If there is a solution on one side, and pure water on the other, the membrane is still hit by molecules from both sides at the same rate. (wikidoc.org)
However, some of the molecules hitting the membrane from the solution side will be solute molecules, and these will not pass through the membrane. (wikidoc.org)
So water molecules pass through the membrane from this side at a slower rate. (wikidoc.org)
Other molecules need assistance through the cell membrane through a process called facilitated diffusion. (studymode.com)
Osmosis is the spontaneous net movement of solvent molecules through a partially permeable membrane into a region of higher solute concentration‚ in the direction that tends to equalize the solute concentrations on the two sides. (studymode.com)
haracteristics ofC the plasma membrane include high electrical resistance and low permeability to highly polar drug molecules. (pharmacology2000.com)
ACTIVE TRANSPORT  The process needs energy (ATP) for transportation of drug molecules  Molecule moves into the cell against its concentration gradient in the lipid bi-layer membrane  Transport small particle ions through the membrane i.e. glucose, aminoacids, organic acids and inorganic ions (SO4-, PO4-, K+ etc). (slideshare.net)
PRIMARY ACTIVE TRANSPORT In primary active transport, hydrolysis of energy rich molecules such as ATP provide energy required for transport of molecules form lower concentration to higher concentration across membrane. (slideshare.net)
Some molecules and ions such as glucose, sodium ions, and chloride ions are unable to pass through the phospholipid bilayer of cell membranes. (slideshare.net)
 A vesicular transport protein, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane  Material move in or out of cell by mean of vesicles Also known as Bulk transport  Vesicular Transport Includes: Endocytosis  It is a type of active transport that moves particles, such as large molecules, parts of cells, and even whole cells, into a cell. (slideshare.net)

Due to the relatively high water permeability of some epithelial cells, it was long suspected that some additional mechanism for water transport across membranes must exist. (wikipedia.org)
Human retinal pigment epithelial cells (ARPE-19) were exposed to lipopolysaccharide (LPS) with or without caffeine. (frontiersin.org)

Concentrations as low as 1 µ m up to 100 µ m SRI 62-834 caused a rapid, dose-dependent increase in membrane permeability, initially towards outward efflux of the preloaded fluorescein probe bis(carboxyethyl)carboxyfluorescein (green fluorescence) and then towards influx of extracellular propidium (red fluorescence). (aacrjournals.org)
Mutations that enhance the organism's efflux capability increase the amount of drug pumped out of the cell. (cdc.gov)

mitochondrial membrane potential changes and cytochrome C localiation and released from mitochondria A549 and PC-3. (asiaipex.com)
Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)
We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)

However, PAF was more potent than SRI 62-834 in causing membrane permeabilization with both cell lines, whereas PAF was less active than SRI 62-834 in cytotoxicity assays. (aacrjournals.org)

Mechanisms of toxicity include inhibition of enzyme activity and protein synthesis, alterations in nucleic acid function, and changes in cell membrane permeability. (medscape.com)
DNA changes in cell membrane, integrity and cell permeability. (asiaipex.com)

It is a physical process in which a solvent moves, without input of energy, across a semi permeable membrane (permeable to the solvent, but not the solute) separating two solutions of different concentrations. (wikidoc.org)
Osmosis is the result of diffusion across a semi-permeable membrane. (wikidoc.org)
http://thegrabup.com/?p=811 Significance Of Osmosis (700-1200) Osmosis is a process of movement of solvent through a semi permeable membrane from an area of high water concentration to an area of low water concentration to equalize the concentration of solute to both side of the membrane. (studymode.com)
CELL MEMBRANE  Semi permeable membrane. (slideshare.net)

Nanocarriers, with the properties of smaller particle size, and long circulation time, would be advantageous in diagnostic and therapeutic applications. (hindawi.com)
The sonication time/media combination that produced the smallest hydrodynamic particle size (NiO suspended in DM and sonicated for 20 minutes) produced a greatest increase in cathepsin-B release, as well as IL-1beta, and IL-18 release, compared to other sonication/media combinations. (cdc.gov)

It also has an impact on bacterial cell membrane permeability and RNA synthesis. (factmr.com)
Its antibacterial activities could be interpreted by the absorption of silver ions onto the negatively charged bacterial cell wall, causing deactivation of cellular enzymes, disruption of membrane permeability, leading to eventual cell lysis and death. (virusarmor.com)

This membrane, like those in human cells, is selectively permeable, allowing certain substances to pass through while blocking others. (exploratorium.edu)
Oral administration of drugs remains the most common method of drug delivery because the cells lining the intestine tend to be quite permeable and because oral ingestion is generally accepted by patients. (justia.com)
As above, suppose a permeable membrane separates equal amounts of pure solvent and a solution. (wikidoc.org)
It is the diffusion of water through a partially permeable membrane from a more dilute solution to a more concentrated solution - down the water potential gradient) Note: diffusion and osmosis are both passive‚ i.e. energy from ATP is not used. (studymode.com)
movement of water from a region of high water potential to a region of low water potential through a partially permeable membrane. (studymode.com)
DIFFUSION Diffusion is the movement of small particles across a selectively permeable membrane like the cell membrane until equilibrium is reached. (slideshare.net)
In addition, because the nerve membrane is permeable to potassium ions and impermeable to sodium ions, 95% of the ionic leak in excitable cells is caused by K + ions in the form of an outward flux, accounting for the negative resting potential. (medscape.com)

In liver cells, the influx of Na + mediated by nonselective cation (NSC) channels in the plasma membrane contributes importantly to regulation of cell volume. (elsevierpure.com)
Several chemical compounds, synthetic or from natural sources, such as the phenothiazines, and natural products, have direct activity against many species of bacteria, enhancing the activity of a specific antibiotic, reversing the natural resistance of specific bacteria to given antibiotics, promoting the elimination of plasmids from bacteria and inhibiting transport functions of the plasma membrane in regard to given antibiotics. (springer.com)
Plasma membrane composed of an amphipathic lipid bilayer. (pharmacology2000.com)

Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)

Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)

This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)
Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)
We studied the effects of an Acanthamoeba encephalitis isolate belonging to the T1 genotype on human brain microvascular endothelial cells, which constitute the blood-brain barrier. (asm.org)
Using an apoptosis-specific enzyme-linked immunosorbent assay, we showed that Acanthamoeba induces programmed cell death in brain microvascular endothelial cells. (asm.org)
Acanthamoeba -mediated brain endothelial cell death was abolished using LY294002, a phosphatidylinositol 3-kinase inhibitor. (asm.org)
These results were further confirmed using brain microvascular endothelial cells expressing dominant negative forms of phosphatidylinositol 3-kinase. (asm.org)
This is the first demonstration that Acanthamoeba -mediated brain microvascular endothelial cell death is dependent on phosphatidylinositol 3-kinase. (asm.org)
We have demonstrated that pathogenic Acanthamoeba exhibits more than 60% binding to human brain microvascular endothelial cells (HBMEC), which constitute the blood-brain barrier ( 2 ). (asm.org)
As it enters the endothelial cells that line the smooth muscle walls of blood vessels, an enzymatic reaction occurs that converts arginine to nitric oxide. (healthguardian.com)
The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
Proteinuria occurs because of changes to capillary endothelial cells, the glomerular basement membrane (GBM), or podocytes, which normally filter serum protein selectively by size and charge. (msdmanuals.com)

Kits correspond to specific testing specimen size and contain the individual components required: one anodized aluminum specimen cap and pedestal, two Porous Stones, two Latex Membranes, and four O-Rings. (globalgilson.com)

Water can pass through the cell membrane through simple diffusion because it is a small molecule, and through osmosis, in cases where the concentration of water outside of the cell is greater than that of the inside. (wikipedia.org)

Like other ether lipids it is of interest as a membrane-active antitumor agent. (aacrjournals.org)
For example, transport of agents across skin has proved difficult in part because the outer layer of skin termed the stratum corneum consists of tightly packed cells with intercellular lipids which severely impede passage of substances through this barrier. (justia.com)
The majority of inositol lipids reside in membranes and serve as substrates for kinases, phosphatases, and phospholipases. (asm.org)

Furthermore, outer membrane permeability of the host organism(s) will be adjusted in-process using moleculobiological tools. (boku.ac.at)
The goal is to quantify and link outer membrane permeability to different mechanical properties of the cell. (boku.ac.at)

Permeability in many tissues is low because cell membranes are generally composed of lipid bilayers that are relatively impermeable to ionized and uncharged polar species. (justia.com)
Once membrane depolarization is complete, the membrane becomes impermeable to sodium ions again, and the conductance of potassium ions into the cell increases. (medscape.com)

1987. The effect of electrically generated silver ions on human cells. (cdc.gov)
This resting potential is determined by the concentration gradients of 2 major ions, Na + and K + , and the relative membrane permeability to these ions (also known as leak currents). (medscape.com)
The concentration gradients are maintained by the sodium/potassium ATP pump (in an energy-dependent process) that transports sodium ions out of the cell and potassium ions into the cell. (medscape.com)
Initially, sodium ions gradually enter the cell through the nerve cell membrane. (medscape.com)
Although the exact mechanism by which local anesthetics retard the influx of sodium ions into the cell is unknown, 2 theories have been proposed. (medscape.com)

2in (50.8mm) O-Ring tightly secures the Latex Membrane around the soil specimen in Triaxial Cells or Flexible-Wall Permeability Test Cells . (globalgilson.com)
Optional accessories include the HMA-506 Specimen Height Indicator for Triaxial/Permeability Testing and the HMA-521 Digital Pore Pressure Gauge w/Transducer. (globalgilson.com)

The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)

In most cells, water moves in and out by osmosis through the lipid component of cell membranes. (wikipedia.org)
Osmosis is the spontaneous net movement of water across a semipermeable membrane from a region of low solute concentration to a solution with a high solute concentration, down a solute concentration gradient. (wikidoc.org)
Osmosis is important in biological systems as many biological membranes are semipermeable. (wikidoc.org)
Osmosis provides the primary means by which water is transported into and out of cells . (wikidoc.org)
The turgor pressure of a cell is largely maintained by osmosis, across the cell membrane, between the cell interior and its relatively hypotonic environment. (wikidoc.org)
This could either be due to the water potential on both sides of the membrane being the same, or due to osmosis being inhibited by factors such as pressure potential or Osmotic pressure. (wikidoc.org)
Osmosis is a process of a fluid that will pass through a semipermeable membrane into a solution which most of the time has a higher concentration. (studymode.com)

However the first report of protein-mediated water transport through membranes was by Gheorghe Benga and others in 1986, prior to Agre's first publication on the topic. (wikipedia.org)
Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
An increase in transport of energy with cells for metabolism and protein synthesis, causing an increase in osmotic cellular function. (yourhairstrands.com)
Increase in protein synthesis, causing a change in cell membrane permeability. (yourhairstrands.com)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

These findings indicate that volume-sensitive increases in p60 c-src and/or related tyrosine kinases play a key role in the regulation of membrane Na + permeability, suggesting that increases in the NSC conductance may be mediated in part through rapid recruitment of a distinct pool of channel-containing vesicles. (elsevierpure.com)
We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)

Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)

Additionally, caffeine treatment restored the integrity of the ARPE-19 monolayer assessed by transepithelial electrical resistance (TEER) and the sodium fluorescein permeability test. (frontiersin.org)

However, because water is a polar molecule this process of simple diffusion is relatively slow, and in tissues with high water permeability the majority of water passes through aquaporin. (wikipedia.org)
He had been studying the Rh blood group antigens and had isolated the Rh molecule, but a second molecule, 28 kilodaltons in size (and therefore called 28K) kept appearing. (wikipedia.org)
At a molecular scale, every time a molecule hits the membrane it has a defined likelihood of passing through. (wikidoc.org)
Water is one molecule that can diffuse freely in a cell. (studymode.com)
With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)

The transport of various agents such as metabolites, drugs and nutrients across tissues is a function primarily of three factors: tissue permeability, the presence or absence of a driving force and the size of the area through which transport occurs. (justia.com)

NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. (scientificarchives.com)
Therefore, it is important to determine how the agglomeration state of the nanoparticles affects their interaction with cells and animals. (cdc.gov)
Current evidence suggests that macrophage engulfed nanoparticles can cause lysosomal membrane permeability and release of cathepsin-B, thus activating the NLRP3 inflammasome. (cdc.gov)

The eradication mechanism involves ROS generation, membrane permeability, and changes in cell size. (iucc.ac.il)
Example:  Quateranary Ammonium compound  Sulphonic acids Ion pair transport is a passive transport mechanism in which the drug forms a reversible neutral complex with endogenous ion of the GIT, passively diffused through the membrane and reaches systemic circulations. (slideshare.net)
The mechanism of damage to these structures is unknown in primary and secondary glomerular diseases, but evidence suggests that T cells may upregulate a circulating permeability factor or downregulate an inhibitor of permeability factor in response to unidentified immunogens and cytokines. (msdmanuals.com)

lontophoresis induces the formation and/or enlargement of pores within tissues, which in turn increase tissue permeability to ionic and polar agents and drive these agents through such pores. (justia.com)
International bi-monthly journal of cell signaling, tissue protection, and translational research. (conditionmed.org)
Water is sometimes called 'the perfect solvent‚' and living tissue (for example‚ a human being's cell walls) is the best example of a semipermeable membrane. (studymode.com)
Definite Action: Shockwave physiotherapy instrument uses electromagnetic shockwave energy to aim at the affected areas of human body to activate osteoblasts and tissue cells, which has minimal effect on the surrounding tissues. (paineasetherapy.com)

It may also be used to describe a physical process in which any solvent moves‚ without input of energy‚ across a semipermeable membrane separating two solutions of different concentrations. (studymode.com)

but both physiologic (e.g. insulin) and pathologic (e.g. oxidative stress) stimuli that are known to stimulate tyrosine kinases are associated with large increases in membrane Na + permeability to ∼80 pA/pF or more. (elsevierpure.com)

HL-60 cells were more sensitive to SRI 62-834 than were EMT6 cells in terms of both cytotoxicity and membrane permeability. (aacrjournals.org)
Assessment of the cytotoxicity and antitumor activity of the active component of Dionysia ancheri as new record plant in iraq was applying MTT and HCS assay of two different human cancer cell line including :- A549 and PC3 cell line. (asiaipex.com)

Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)

Local anesthetics inhibit depolarization of the nerve membrane by interfering with both Na+ and K+ currents. (medscape.com)

American Journal of Respiratory Cell and Molecular Biology. (lu.se)

Substances that can pass easily through the membrane of the egg will follow the principles of diffusion. (exploratorium.edu)

After the eggshell is removed, a thin membrane (actually, two membranes held tightly together) remains. (exploratorium.edu)

The osmotic entry of water raises the turgor pressure exerted against the cell wall , until it equals the osmotic pressure, creating a steady state . (wikidoc.org)

To improve cell-membrane permeability, conjugating cell-penetrating peptides (CPPs) to PPI-inhibiting peptides is a useful method for developing intracellularly targeted PPI inhibitors. (bvsalud.org)

However, peptide-based PPI inhibitors generally have low cell-membrane permeability because of their large molecular size. (bvsalud.org)

Aquaporins have six membrane-spanning alpha helical domains with both carboxylic and amino terminals on the cytoplasmic side. (wikipedia.org)
Because aquaporins are usually always open and are prevalent in just about every cell type, this leads to a misconception that water readily passes through the cell membrane down its concentration gradient. (wikipedia.org)

The results showed that a penetratin-conjugated LRH-1-derived peptide (Penetratin-st7) predominantly inhibited DLD-1 cell growth at 20 µM treatment via inhibition of the Wnt signaling pathway. (bvsalud.org)

Single gas permeation through SAPO-34 membranes decreased with molecular size for H 2 , CO 2 , N 2 , CH 4 , and n-C 4 H 10 . (mrs.org)

Use a giant cell-a de-shelled chicken egg-to explore the comings and goings of cellular substances. (exploratorium.edu)

The current study evaluated the role of NLRP3 inflammasome activation in the pulmonary bioactivity of nano-sized nickel -oxide (NiO) subjected to differing dispersion methods. (cdc.gov)
In this project, we use principles from multidimensional solid-state NMR spectroscopy to design new MRI pulse sequences and data processing methods for investigating cell density, shape, alignment, heterogeneity, and membrane permeability. (lu.se)

According to the World Health Organization (WHO), it corresponds to the 5th most common neoplasia worldwide, being the Squamous Cell Carcinoma (SCC) the most common malignancy. (bvsalud.org)

Test Cells are constructed with heavy-wall clear acrylic chambers and solid machined aluminum bases. (globalgilson.com)

In vitro antitumor activity was seen over the same concentration range, as measured by tetrazolium dye reduction and cell growth curves. (aacrjournals.org)
The bactericidal activity of vancomycin is mostly due to its reduction of cell-wall formation. (factmr.com)

In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)

Zeolite membranes are composed of inorganic microporous crystals that are attractive for gas separation because their pore sizes are uniform and typically less than 1 nm. (mrs.org)
The silicoaluminophosphate analog of chabazite, SAPO-34, is an attractive membrane material for the separation of light gases, because the pore size of SAPO-34 crystals (0.4 to 0.45 nm) is close to the kinetic diameters of light gases. (mrs.org)

It's a glycopeptide antibiotic that works by inhibiting cell walls from forming. (factmr.com)
It prevents N-acetylmuramic acid and N-acetylglucosamine peptide subunits from being incorporated into the peptidoglycan matrix, the most critical structural component of Gram-positive cell walls. (factmr.com)

Anatomy3

Chemicals and Drugs2

Phenomena and Processes4

Technology, Industry, Agriculture1

Intracellular6

Flexible Wall Permeability Cell2

Proteins20

Molecules17

Epithelial cells2

Efflux2

Mitochondrial3

Causing membrane permeabilization1

Changes in cell membrane2

Semi-permeabl4

Particle Size2

Bacterial cell2

Permeable7

Plasma membrane3

Permeabilization2

Cellular membranes1

Endothelial16

Latex Membranes1

Small molecule1

Lipids3

Outer membrane2

Impermeable2

Ions5

Triaxial2

Phospholipid bilayer1

Osmosis7

Protein5

Vesicles2

Biological3

Sodium1

Molecule5

Occurs1

Nanoparticles3

Mechanism3

Tissue4

Separating two solutions of different concentrations1

Increases1

Cytotoxicity2

Capillary2

Depolarization1

Molecular Biology1

Diffusion1

Tightly1

Osmotic1

CPPs1

Large molecular size1

Aquaporins2

Inhibition1

Permeation1

Substances1

Methods2

Squamous Cell Carc1

Test Cells1

Reduction2

Integrity1

Pore2

Walls2