Loading...
  • helices
  • The modularity in NPC architecture is reflected in its hierarchical and symmetrical organization that partitions the predicted nup folds into three groups: the transmembrane group containing transmembrane helices and a cadherin fold, the central scaffold group containing β-propeller and α-solenoid folds, and the peripheral FG group containing predominantly the FG repeats and the coiled-coil fold. (pnas.org)
  • Hille
  • C 9 + blocks because, unlike K + , which is thought to dehydrate partially as it moves into the narrow part of the pore ( Hille, 1973 ), C 9 + cannot shed its covalently linked ethyl groups. (rupress.org)
  • The filter is the narrowest region of the pore and is approximately 4 × 6 Å ( Hille, 2001 ). (aspetjournals.org)
  • homologous
  • This transmembrane domain arrangement is homologous to that of other ion channels in a large superfamily that includes voltage-gated calcium channels and Shaker potassium channels ( Venkatachalam and Montell, 2007 ). (rupress.org)
  • Consensus structural alignment based on homologous templates revealed an intersubunit anesthetic binding cavity within the transmembrane domain of the GABAaR, which showed a correlation of ligand docking scores with experimentally measured GABAaR potentiation. (stanford.edu)
  • channel
  • The S4 segment contains many positive charges such that a high positive charge outside the cell repels the helix, keeping the channel in its closed state. (wikipedia.org)
  • In general, the voltage sensing portion of the ion channel is responsible for the detection of changes in transmembrane potential that trigger the opening or closing of the channel. (wikipedia.org)
  • Further, they are "open channel blockers," meaning they have access to their binding site in the pore only when the channel gate is open. (rupress.org)
  • Since TEA + is similar in size to a hydrated K + ion, does this mean that the channel normally closes with a K + ion in the inner vestibule? (rupress.org)
  • Voltage-gated sodium (Na + ) channels are targets for local anesthetic (LA) drugs that bind in the inner pore of the channel with affinities related to the channel gating states. (aspetjournals.org)
  • LA drugs block the Na + channel pore, accessing their binding site in nerve and skeletal muscle mainly or entirely from the cytoplasm through the inner pore ( Narahashi and Frazier, 1971 ). (aspetjournals.org)
  • novel
  • To study development of CKD and novel therapeutic interventions in CKD, we use the 5/6th nephrectomy ablation model, a well known experimental model of progressive renal disease, resembling several aspects of human CKD. (jove.com)
  • sequence
  • generously note, old experiments using TEA + and analogues to block K channels ( Armstrong, 1971 ) suggested that the activation gate is inside and that the search should be in the intracellular segments of the sequence. (rupress.org)
  • similar
  • The head is similar in size to a K + ion with one hydration shell, roughly 8 Å, and this is thought to make C 9 + acceptable to the inner end of the pore. (rupress.org)
  • family
  • Phylogenetic analysis showed that the MHX family is limited to plants, and constitutes a sixth family within the CaCA superfamily. (beds.ac.uk)
  • Genus Orthoreovirus is one of 15 recognized genera in Family Reoviridae , a large, diverse group of non-enveloped viruses with segmented, double-stranded RNA genomes . (prolekare.cz)
  • structure
  • The NPC is also one of the largest assemblies of defined structure in the cell, with a size of ≈50 MDa in yeast and up to 100 MDa in vertebrates. (pnas.org)
  • inner
  • At physiological pH (7.4), they are mostly protonated and soluble in lipid membranes ( Catterall and Mackie, 1996 ), so they can access the inner pore from the outside solution. (aspetjournals.org)
  • feature
  • This work implies that a global metabolic compartmentalization and coupling of neurons and glial cells is a conserved, fundamental feature of bilaterian nervous systems independent of their size. (sdbonline.org)