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Singlet OxygenOxygenRose BengalPhotosensitizing AgentsPhotochemistryPhotochemotherapyReactive Oxygen SpeciesSodium AzideLuminescent MeasurementsPeryleneLightOxygen ConsumptionPorphyrinsBromidesFree RadicalsOxidation-ReductionPeroxidesCarotenoidsHydrogen PeroxideHematoporphyrinsDermatitis, PhototoxicOrganosilicon CompoundsFree Radical ScavengersDihematoporphyrin EtherSpin TrappingFullerenesPhotosystem II Protein ComplexLactoperoxidasePeroxidasesHydroxyl RadicalPhotochemical ProcessesUltraviolet RaysMesoporphyrinsMethylene BlueLasersCarthamus tinctoriusElectron Spin Resonance SpectroscopyPhotosensitivity DisordersChlorophyllLipid PeroxidesDiuronOxygen CompoundsNaphtholsOxidative StressSuperoxidesLuminescenceTocopherolsPlastoquinonePhotobiologyPhotolysisTriacetoneamine-N-OxylAntioxidantsOxygen Inhalation TherapyCatalaseHydroxidesRhamnaceaeHematoporphyrin Derivative
ReactiveFree radicalsOxidationPhotosensitizerTripletMoleculesPorphyrinsFluorescence quantumSuperoxidePhotosensitizersEfficiencyTumor CellsIrradiationPhthalocyanineMolecular oxygenPhotooxidationMoleculeMechanismQuantumTherapeutic agentsProcessesCompoundsRadicalsLightCompoundAntimicrobial agentRapidlyPhotoactivationPropertiesTreatmentActivityPresenceShownPotentialCell
Reactive16
  • This energy reacts with oxygen to form ROS (Reactive Oxygen Specimen) that is highly reactive and kills the microbial cell walls and internal structures. (ricercaorale.it)
  • Singlet oxygen is viewed as among the important reactive oxygen species responsible for cellular harm associated with so-called photodynamic action [59,60]. (hsvinhibitor.com)
  • For this technology, light is used to trigger the generation of reactive oxygen species which subsequently inactivate or kill pathogenic microorganisms. (encyclopedia.pub)
  • energy transfer, in this case, produces highly reactive singlet oxygen species (ROS), for example, singlet oxygen ( 1 O 2 ), as a result of a 'Type II' photosensitization mechanism. (encyclopedia.pub)
  • PDT uses a modality-based photosensitizer, which selectively affects cancer cells, using excitation and light-absorption in the presence of oxygen to produce a high concentration of reactive oxygen species (ROS), such as singlet oxygen and other free radicals ( 7 - 9 ). (spandidos-publications.com)
  • 3. Reactive oxygen species (ROS) generation: The activated photosensitizing agents interact with oxygen molecules present in the skin, resulting in the generation of reactive oxygen species (ROS). (laser-removalmachine.com)
  • ROS, such as singlet oxygen, are highly reactive and can induce various biochemical and cellular changes. (laser-removalmachine.com)
  • Some photoactivated chemicals can generate reactive oxygen species (ROS) after photoactivation of chemicals by irradiation of light (290-700 nm). (aopwiki.org)
  • Moreover, riboflavin and flavins could produce reactive oxygen species (ROS) when exposed to light, inducing oxidative damage in cells and tissues, and thus are excellent natural photosensitizers. (bioseek.eu)
  • One of the most significant current discussions in Cu biochemistry relates to the mechanisms of the positive and negative actions of Cu ions based on the generation of reactive oxygen species, including radicals that can interact with DNA molecules. (mdpi.com)
  • Reactive oxygen species (ROS) are considered to be a main cause for cancer development, but they can also be used for cancer eradication. (duke.edu)
  • Porphyrins, which chelate redox inactive metals, for example Zn, demonstrate photo-sensitizing activity and thus can produce singlet oxygen and other reactive oxygen species in cancer cells on irradiation with visible light. (duke.edu)
  • After photoactivation, the photosensitizer occupies an excited triplet state from which it transfers its energy to neighboring oxygen molecules, thus generating singlet oxygen and reactive oxygen species ("oxidative stress") which lead to cell death mediated by apoptosis and/or necrosis. (uniud.it)
  • Photodynamic therapy, that is, excitation of a photosensitizer with light to generate reactive oxygen species such as singlet oxygen, has emerged as a noninvasive technique for cancer theranostics. (nycu.edu.tw)
  • Carotenoids are known to be powerful antioxidant substances playing an essential role in the reactions of neutralization of FR (mainly reactive oxygen species ROS). (mdpi.com)
  • The administered drug is generally a substance which can efficiently photosensitize the formation of singlet oxygen or other reactive species derived from oxygenand such species react with different biological targets, and cause cellular damage and finally, the cellular death. (primariabeuca.ro)
Free radicals2
Oxidation4
  • Recently we have shown in vitro that singlet oxygen mediated oxidation of lens crystallins produces effects very similar to those documented for crystallins from old or cataractous lenses and suggested that near UV photodynamic effects may play a major role in vivo in aging in the human lens. (johnshopkins.edu)
  • In the present work we demonstrate that certain oxidation products of tryptophan which have been identified in human lens can act as near UV photosensitizers, producing singlet oxygen. (johnshopkins.edu)
  • Samuel Zigler, J & Goosey, JD 1981, ' PHOTOSENSITIZED OXIDATION IN THE OCULAR LENS: EVIDENCE FOR PHOTOSENSITIZERS ENDOGENOUS TO THE HUMAN LENS ', Photochemistry and Photobiology , vol. 33, no. 6, pp. 869-874. (johnshopkins.edu)
  • Activation of oxygen might occur due to intermediate formation of peroxides, which always appear during slow oxidation processes, no matter what is the nature of the oxidizing compound. (msu.ru)
Photosensitizer5
  • The quantification of singlet oxygen in various photosensitizers, including berberine, is essential for determining their photosensitizer efficiencies. (emerginginvestigators.org)
  • Here, we report the usage of time course 1H nuclear magnetic resonance (NMR) spectroscopy to trap singlet oxygen via a 4+2 cycloaddition with terpinene, as well as theoretical calculations by time-dependent density functional theory (TD-DFT) towards quantification of berberine's singlet oxygen production against two known photosensitizers, methylene blue and rose bengal, to determine berberine's efficacy as a singlet oxygen photosensitizer. (emerginginvestigators.org)
  • BACKGROUND: Photodynamic therapy (PDT) activates a photosensitizer by visible light to generate cytotoxic oxygen species that lead to cell death. (bvsalud.org)
  • It involves the use of a photosensitizing molecule and a source of light with a wavelength that corresponds to the absorption band of the photosensitizer. (uniud.it)
  • We now report on the molecular mechanism that results in LJ001's specific inhibition of virus-cell fusion.The antiviral activity of LJ001 was light-dependent, required the presence of molecular oxygen, and was reversed by singlet oxygen ( 1 O 2 ) quenchers, qualifying LJ001 as a type II photosensitizer. (utmb.edu)
Triplet2
  • Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet oxygen to specifically oxidize guanine residues, thereby halting cell replication and leading to cell death. (emerginginvestigators.org)
  • However, this interaction did not restrict the formation of excited singlet and triplet states and hence the formation of singlet oxygen required for photocatalysis. (seals.ac.za)
Molecules3
  • These agents are typically photosensitive dyes or compounds that can absorb light energy and transfer it to nearby cells or molecules. (laser-removalmachine.com)
  • Photodynamic Therapy (PDT) is a form of light therapy involving specific light, and a photosensitizing chemical substance that preferentially absorbs that light, that then interacts with molecular oxygen (O2) to generate high-energy oxygenated and toxic molecules, the cause the death of unwanted cells, such as microbial pathogens or malignant cells. (amaregenmed.com)
  • A term peroxide I apply to those oxygen-containing compounds whose function is similar to that of hydrogen peroxide and whose molecules contain at least one -O-O- group. (msu.ru)
Porphyrins1
  • When used with photodynamic therapy, the accumulation of photoactive porphyrins produces a photodynamic reaction that results in a cytotoxic process dependent upon the simultaneous presence of oxygen. (medscape.com)
Fluorescence quantum1
  • Gold nanoparticles were found to enhance the singlet oxygen quantum yield while lowering the fluorescence quantum yields. (seals.ac.za)
Superoxide1
  • Cercosporin produces singlet oxygen and superoxide when irradiated by light, and damages plants by causing a peroxidation of the membrane lipids. (fermentek.com)
Photosensitizers5
  • This has potential application in photodynamic therapy, alongside other such compounds which also act as photosensitizers and produce singlet oxygen in situ. (emerginginvestigators.org)
  • We postulated that the singlet oxygen produced by photoirradiation of berberine would be superior in terms of singlet oxygen production to the aforementioned photosensitizers when irradiated with UV light, but inferior under visible light conditions, due to its strong absorbance of UV wavelengths. (emerginginvestigators.org)
  • We envision that similar processes can be utilized for the evaluation of berberine analogs or other photosensitizing agents and the identification of other potential medicinally significant singlet oxygen photosensitizers. (emerginginvestigators.org)
  • LJ001 did not mediate any apparent damage on biogenic cellular membranes, likely due to multiple endogenous cytoprotection mechanisms against phospholipid hydroperoxides.Based on our understanding of LJ001's mechanism of action, we designed a new class of membrane-intercalating photosensitizers to overcome LJ001's limitations for use as an in vivo antiviral agent. (utmb.edu)
  • These results point out the importance of intermolecular interactions between photosensitizers, which is essential to guide the design of self-assembled phototheranostic agents with improved performance. (materials-chain.com)
Efficiency1
  • This study investigated the photosensitizing efficiency of the Ru(phen)2(pPDIp)(PF6)2 complex, RupPDIp, against S. brasiliensis and C. albicans. (bvsalud.org)
Tumor Cells1
Irradiation1
Phthalocyanine1
  • The study was extended by conjugating amino functionalized magnetic nanoparticles (Fe₃O₄) to indium octacarboxy phthalocyanine to study the photophysical behaviour of the conjugate as a potential bi-functional anti-cancer agent (hyperthermia and photodynamic therapy applications). (ru.ac.za)
Molecular oxygen3
  • REVIEW: Primary Mechanisms of Photoactivation of Molecular Oxygen. (msu.ru)
  • Then, the discovery of photodynamic action is described, which was shown to result from pigment photosensitized activation of molecular oxygen. (msu.ru)
  • A conception stating that molecular oxygen is chemically rather passive and special activation mechanisms are needed to involve it into chemical and biological processes appeared in the scientific literature in the middle of XIX century. (msu.ru)
Photooxidation1
  • Quite a few chemical compounds generally present in the particulate matter, especially PAHs, are known to act as photosensitizing agents efficiently photogenerating singlet α adrenergic receptor Antagonist web oxygen [6,7,9] by sort II photooxidation. (hsvinhibitor.com)
Molecule1
  • The transformation from passive to active oxygen can only occur owing to decomposition of the oxygen molecule (O=O). It is obvious that destruction of one of these bonds and transformation of O=O into -O-O- requires less energy than the destruction of two bonds [ 2 ]. (msu.ru)
Mechanism1
  • must have a mechanism that causes activation of oxygen, which comes from the atmosphere. (msu.ru)
Quantum3
  • The conjugates showed significantly higher singlet oxygen quantum yields and therefore enhanced photocatalytic activity compared to the phthalocyanines. (seals.ac.za)
  • The singlet oxygen quantum yields obtained were higher at 0.56 for 2-hexagonl PtNPs in DMF while that of 2 was 0.52 in the same solvent. (ufh.ac.za)
  • The potential toxicity of seven different types of quantum dots without shell (L-cysteine-CdTe, TGA-CdTe, MPA-CdTe, TGA-CdSe) and with the shell (GSH-CdSe@ZnS, GSH-CdTe@ZnS,) with different capping agents were evaluated. (ru.ac.za)
Therapeutic agents1
  • Because of this dual nature of ROS action, both antioxidant and prooxidant therapeutic agents have been developed and some have shown clinical promise. (duke.edu)
Processes1
  • The last review, by Coppellotti and co-workers, reports on porphyrin/phthalocyanines/chlorines photosensitized processes in the prevention and treatment of water- and vector-borne diseases. (uniud.it)
Compounds1
  • However, these organic compounds are almost indifferent to free or passive oxygen. (msu.ru)
Radicals1
Light9
Compound1
Antimicrobial agent2
  • Riboflavin as a promising antimicrobial agent? (bioseek.eu)
  • Besides maintaining human health, different sources reported that riboflavin can inhibit or inactivate the growth of different pathogens including bacteria, viruses, fungi and parasites, highlighting the possible role of riboflavin as an antimicrobial agent. (bioseek.eu)
Rapidly1
Photoactivation1
  • New definitions of these reactions are proposed on the basis of the mechanisms of oxygen photoactivation. (msu.ru)
Properties1
  • The complex is able to preserve the fluorescence and singlet oxygen photosensitizing properties of the dye. (url.edu)
Treatment3
  • This agent is indicated for treatment of adults with metastatic basal cell carcinoma or with locally advanced basal cell carcinoma that has recurred following surgery, or those who are not candidates for surgery or radiation. (medscape.com)
  • Porfimer is a photosensitizing agent that is FDA approved for the treatment of obstructive esophageal cancer , completely or partially obstructing endobronchial non-small-cell lung cancer (NSCLC), Barrett's esophagus . (wikidoc.org)
  • Treatment of the expensive agents of Lyme growth. (jimeflynn.com)
Activity1
Presence1
Shown1
  • This process is based in the photodynamic response of a photosensitizing agent, as shown in the first step illustrated in Figure 1 . (encyclopedia.pub)
Potential1
  • These agents decrease cohesiveness of abnormal hyperproliferative keratinocytes and may reduce potential for malignant degeneration. (medscape.com)
Cell1
  • The most common chemotherapeutic agent used in superficial basal cell carcinoma is topical 5-fluorouracil. (medscape.com)