NRTIProtease inhibitorNucleoside reverse transcriptase translocation inhibitorTenofovir disoproxIntegrase inhibitorsEmtricitabineNNRTIsNonnucleoside reverse transcriptLamivudineRegimensINSTIDrug resistance mutationsInvestigationalInfectionAbacavirRegimenCapsid inhibitorResistanceRilpivirineAntiviralEnzymeTherapeuticPolymerase activityAntiretroviralsPolymerasesElvitegravirEnzymesZidovudineDoseImmunodeficiencyCombinationCompoundsInfectionsDrugsConvertsBindPatientsNeuronsInhibitsVirusClass
NRTI8
- Since zidovudine was approved in 1987, six nucleosides and one nucleotide reverse-transcriptase inhibitor (NRTI) have been approved by FDA. (wikipedia.org)
- This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
- The active pharmaceutical ingredients (APIs) of [HA518 trade name] are the nucleoside reverse transcriptase inhibitors (NRTI) lamivudine and abacavir. (who.int)
- Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI), emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI), and tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor (NtRTI). (aidsmap.com)
- Emtricitabine belongs to a group of drugs called nucleoside reverse transcriptase inhibitors (NRTIs) and tenofovir is a nucleotide reverse transcriptase inhibitor (NRTI). (rxwiki.com)
- Through mathematical modeling, we assess the mechanisms by which HIV-1 can develop resistance against nucleoside analog reverse transcriptase inhibitors (NRTI). (plos.org)
- Nucleoside reverse transcriptase inhibitor (NRTI) transmitted drug resistance mutations (TDRMs) could increase the risk of virological failure (VF) of first-line integrase strand transfer inhibitor (InSTI)-based regimens. (nih.gov)
- maternal nucleoside reverse transcriptase inhibitor (NRTI) and NNRTI exposure increased with initiation of NNRTI-and NRTI- containing triple antiretroviral therapy (ART) earlier in gestation and at higher CD4 cell counts. (cdc.gov)
Protease inhibitor3
- In general, a protease inhibitor and two non-nucleoside reverse transcriptase inhibitors should be used initially. (cdc.gov)
- The guidelines from the U.S. Department of Health and Human Services (DHHS) recommend either TAF or TDF, the original version of tenofovir, and still include one protease inhibitor (PI)-based option: Prezista + Norvir. (positivelyaware.com)
- Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
Nucleoside reverse transcriptase translocation inhibitor2
- The Phase 2 study is designed to evaluate the safety and antiviral effect of an oral weekly regimen of Merck's investigational nucleoside reverse transcriptase translocation inhibitor, islatravir, in combination with Gilead's investigational capsid inhibitor, lenacapavir. (vih.org)
- The study, IMPOWER 22, will evaluate the efficacy and safety of islatravir -- Merck's novel investigational nucleoside reverse transcriptase translocation inhibitor (NRTTI) under evaluation for both treatment and prevention -- and is anticipated to begin by early 2021. (natap.org)
Tenofovir disoprox6
- 50 copies per millilitre (c/mL), a standard measure of HIV control, at week 48 when compared to a three-drug regimen of dolutegravir and two nucleoside reverse transcriptase inhibitors (NRTIs), tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), in treatment-naïve, HIV-1 infected adults. (gsk.com)
- The agreements cover the manufacture of TMC278 as a single agent medicine and a license to develop an FDC product using TMC278 with 300 mg tenofovir disoproxil fumarate and 300 mg lamivudine . (biospace.com)
- In July 2009 , Tibotec announced that it had entered into a license and collaboration agreement with Gilead Sciences, Inc. for the development and commercialization of a new, once-daily, fixed-dose antiretroviral product containing Tibotec's investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 ( rilpivirine hydrochloride ) and Gilead's Truvada® ( emtricitabine and tenofovir disoproxil fumarate ). (biospace.com)
- In treatment-naïve patients, the clinical study data on use of raltegravir are limited to use in combination with two nucleotide reverse transcriptase inhibitors (NRTIs) (emtricitabine and tenofovir disoproxil fumarate). (medthority.com)
- FOSTER CITY, Calif.--(BUSINESS WIRE)--March 8, 2006--Gilead Sciences, Inc. (Nasdaq:GILD) today announced that the U.S. Food and Drug Administration (FDA) has granted traditional approval status to its once-daily antiretroviral Viread(R) (tenofovir disoproxil fumarate) and its fixed-dose product Truvada(R) (emtricitabine and tenofovir disoproxil fumarate), which combines the company's two antiretrovirals Emtriva(R) (emtricitabine) and Viread in a single daily tablet. (gilead.com)
- Guidelines issued by the U.S. Department of Health and Human Services (DHHS) list emtricitabine and tenofovir disoproxil fumarate as preferred agents for use as part of a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen in appropriate patients who have never taken anti-HIV medicines before. (gilead.com)
Integrase inhibitors5
- Antiretroviral drugs for the treatment of HIV infections belong to six categories: Nucleoside and nucleotide reverse-transcriptase inhibitors, Non-nucleoside reverse-transcriptase inhibitors, protease inhibitors, entry inhibitors, co-receptor inhibitors and integrase inhibitors. (wikipedia.org)
- Long-acting injectable contraception is compatible with protease inhibitors and NNRTIs, but data are limited with integrase inhibitors. (medscape.com)
- In trial after trial, the integrase inhibitors are either as good as or better than older regimens, with clear safety and tolerability advantages. (positivelyaware.com)
- Dolutegravir has a higher barrier to resistance than the other two integrase inhibitors. (positivelyaware.com)
- Although these PIs have a few more side effects than integrase inhibitors, they're still well tolerated and don't have all the metabolic toxicity we saw with the older PIs. (positivelyaware.com)
Emtricitabine3
- NRTIs approved by the FDA are zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine and the only nucleotide reverse-transcriptase inhibitor (NtRTI) approved is tenofovir (see table 4). (wikipedia.org)
- Biktarvy , approved in Europe in 2018, is an all-in-one antiretroviral regimen that contains the integrase inhibitor bictegravir, tenofovir alafenamide (TAF) - a newer formulation that is easier on the kidneys and bones but may lead to higher lipid levels and weight gain - and emtricitabine. (aidsmap.com)
- It comes as a single tablet containing 2 drugs, emtricitabine and tenofovir . (rxwiki.com)
NNRTIs7
- Several classes of anti-HIV drugs interfere with this stage of HIV's life cycle: nucleoside reverse transcriptase inhibitors and nucleotide reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). (aidsmap.com)
- Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are an important part of HAART. (immune-system-research.com)
- Although the NNRTIs target HIV-1 RT, they are clearly different from the nucleoside RT inhibitors (NRTIs). (neb.com)
- The first-generation NNRTIs such as nevirapine and delavirdine easily loose their inhibitory potential against mutant virus strains that contain single amino acid mutations in their RT. (neb.com)
- NNRTIs have proven beneficial when included in drug combination (triple or quadruple) therapy, preferably in the presence of protease inhibitors and NRTIs. (neb.com)
- Although newer classes of drugs are available, the most commonly used drugs approved for the treatment of HIV infection fall into three classes: nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). (canada.ca)
- NNRTIs), a single mutation may be associated with a high level of resistance to drugs from that same class. (canada.ca)
Nonnucleoside reverse transcript1
- Good extraction efficiency and low limit of quantification make this a suitable method for use in clinical trials and for therapeutic drug monitoring of RGV, protease inhibitors, and nonnucleoside reverse transcriptase inhibitors, including ETV. (unito.it)
Lamivudine12
- Like Genvoya, it combines an integrase inhibitor (dolutegravir) with abacavir (ABC) and lamivudine (3TC), the two ingredients of Epzicom. (positivelyaware.com)
- ViiV Healthcare, the global specialist HIV company, majority owned by GlaxoSmithKline, with Pfizer Inc. and Shionogi Limited as shareholders, today announced that the European Commission has granted Marketing Authorisation for Dovato (dolutegravir/lamivudine) for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
- This treatment allows individuals to take a two-drug regimen in a single pill with dolutegravir at the core, building on the established potency and safety profiles of dolutegravir and lamivudine. (gsk.com)
- Dovato (dolutegravir 50 mg/ lamivudine 300 mg tablets) is authorised in the EU for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
- In the US the Food and Drug Administration (FDA) authorised Dovato, a complete, once-daily, single-tablet regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg for the treatment of HIV-1 infection in adults with no antiretroviral (ARV) treatment history and with no known resistance to either DTG or 3TC. (gsk.com)
- Lamivudine is a thymidine analogue that blocks viral replication by competitive inhibition of viral reverse transcriptase. (medscape.com)
- The 2-in-1 single-tablet regimen (STR) Dovato (dolutegravir/lamivudine) carried forward its good results out to two years. (positivelyaware.com)
- Lamivudine is a nucleoside analogue and reverse transcriptase inhibitor used in the therapy of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection. (nih.gov)
- Lamivudine is phosphorylated intracellularly to the triphosphate which competes with the naturally occurring cytidine triphosphate for incorporation into the growing HIV or HBV DNA chain by the viral polymerase, thereby inhibiting polymerase (or reverse transcriptase) activity and causing chain termination. (nih.gov)
- Lamivudine is indicated for the treatment of HBV infection as a single agent and for HIV infection in combination with other HIV medications. (nih.gov)
- Abacavir, lamivudine, and zidovudine belong to a class of medications known as nucleoside reverse transcriptase inhibitors . (rxhealthmed.ca)
- Abacavir, lamivudine, and zidovudine prevent reverse transcriptase from working properly. (rxhealthmed.ca)
Regimens7
- All four are integrase inhibitor-based regimens, and all but one (Triumeq) contain TAF, the new version of tenofovir. (positivelyaware.com)
- In discussing initial options, let's start with the single-tablet regimens (STRs). (positivelyaware.com)
- Resistance is uncommon with any integrase inhibitor, and extremely unlikely to happen if you're taking your meds, but so far we haven't seen any resistance when dolutegravir-based regimens are used for initial therapy. (positivelyaware.com)
- While daily, single tablet oral regimens are available for people living with HIV, oral or injectable regimen options that allow for less frequent dosing have the potential to address preference considerations, as well as issues associated with stigma, adherence, and privacy. (vih.org)
- Access to second-line ART regimens in developing countries is problematic, mainly because of the expense of HIV protease inhibitors (PIs). (lww.com)
- One example is single-tablet regimens, such as Atripla ® , Complera ® , and Stribild ® , although these still require daily pill administration. (nature.com)
- The mean time on ART was 75.5 months (95% confidence interval [CI]: 69.0-81.9 months), and 93.7% of the patients were receiving non-nucleoside reverse transcriptase inhibitor-based regimens. (who.int)
INSTI2
- 50 c/mL) on a stable antiretroviral regimen for at least six months with no history of virological failure and no known or suspected resistance to any non-nucleoside reverse transcriptase inhibitor (NNRTI) or integrase strand transfer inhibitor (INSTI). (jnj.com)
- 50 HIV-1 RNA copies/mL or a single viral load ≥ 200 copies/mL after 3 months from antiretroviral therapy start) was evaluated in the overall population and according to the InSTI employed. (nih.gov)
Drug resistance mutations4
- Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C. (bvsalud.org)
- This study investigates how nonnucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations of subtype C affect replication capacity. (bvsalud.org)
- The 103N, 106A, 106M, 181C, 188C, 188L, and 190A drug resistance mutations were placed in a reverse transcriptase (RT) that matches the consensus subtype C sequence as well as the HXB2 RT, as a subtype B reference. (bvsalud.org)
- To investigate the extent to which drug resistance mutations are missed by standard genotyping methods, we analyzed the same plasma samples from 26 patients with suspected multidrug-resistant human immunodeficiency virus type 1 by using a newly developed single-genome sequencing technique and compared it to standard genotype analysis. (scienceopen.com)
Investigational2
- At the 77th Scientific Sessions of the American Diabetes Association, Merck in partnership with Pfizer presented data from two Phase 3 studies of ertugliflozin, an investigational oral SGLT-2 inhibitor in development to help improve glycemic control in adults with type 2 diabetes, which met their primary endpoints. (finchannel.com)
- Lenacapavir is Gilead's potential first-in-class, investigational long-acting HIV-1 capsid inhibitor in development for the treatment and prevention of HIV-1 infection. (vih.org)
Infection2
- The BRIGHTE study is a two-cohort (randomised and non-randomised), phase III clinical trial evaluating the safety and efficacy of the HIV-1 attachment inhibitor fostemsavir in heavily treatment-experienced adults with HIV-1 infection. (gsk.com)
- This guideline presents updated data about drug interactions between protease inhibitors and non-nucleoside reverse transcriptase inhibitors for treatment of HIV infection together with rifamycins for treatment of TB. (cdc.gov)
Abacavir1
- Triumeq has dolutegravir (Tivicay), everyone's favorite integrase inhibitor, but it requires taking abacavir (ABC), which has some disadvantages over tenofovir, especially now that TAF is available. (positivelyaware.com)
Regimen6
- People aged 65 or older who switched to the Biktarvy single-tablet regimen had a high probability of maintaining an undetectable viral load, researchers reported this week at the 23rd International AIDS Conference (AIDS 2020: Virtual) . (aidsmap.com)
- The data from our dolutegravir-based two-drug regimen development programme challenges this, and with the authorisation of Dovato, people living with HIV can for the first time start treatment on a once-daily, single-pill, two-drug regimen with the knowledge that efficacy is non-inferior to a three-drug regimen whilst containing fewer antiretrovirals. (gsk.com)
- [2] If approved, it will be the first single pill, two-drug regimen that could benefit people living with HIV in Europe. (jnj.com)
- Approval of a single pill, two-drug regimen will reduce the number of antiretrovirals virologically suppressed HIV patients have to take and are exposed to in the long-term, representing a true advancement in HIV care," said Dr. Josep M Llibre, Infectious Diseases Dept, University Hospital Germans Trias i Pujol, Badalona, Barcelona. (jnj.com)
- If approved by the FDA, the new product would be the first and only complete Highly Active Antiretroviral Therapy (HAART) regimen for HIV available in a single once-daily fixed-dose tablet. (gilead.com)
- Alert EU Panel Backs Dolutegravir/Rilpivirine Combo Pill for HIV The once-daily pill can maintain viral suppression in patients on a stable antiretroviral regimen with no known or suspected resistance to a non-nucleoside reverse transcriptase inhibitor or integrase inhibitor. (medscape.com)
Capsid inhibitor1
- it is an HIV capsid inhibitor. (positivelyaware.com)
Resistance4
- Whereas UC-84, the prototype compound, only weakly inhibits many RTs bearing single point resistance mutations, inhibition by UC-781 is little affected. (rcsb.org)
- The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors. (gc.ca)
- Our model correctly predicts for HIV-1 that resistance against nucleoside analog reverse transcriptase inhibitors (NRTIs) can be conferred by decreasing their incorporation rate, increasing their excision rate, or decreasing their affinity for the polymerase enzyme. (plos.org)
- It can readily be embedded in extended models of the complete HIV-1 reverse transcription process, or analogous processes in other viruses and help to guide drug development and improve our understanding of the mechanisms of resistance development during treatment. (plos.org)
Rilpivirine5
- In June 2014, ViiV Healthcare UK Ltd and Janssen Sciences Ireland UC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, announced a collaboration to investigate the potential of combining dolutegravir and rilpivirine in a single-pill in order to expand the treatment options available to people living with HIV. (jnj.com)
- EDURANT (rilpivirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1). (druglib.com)
- Rilpivirine: a second-generation nonnucleoside reverse transcriptase inhibitor. (druglib.com)
- The objective of the study was to determine the impact of food and different meal types on the pharmacokinetics of rilpivirine, a nonnucleoside reverse transcriptase inhibitor. (druglib.com)
- In this open-label, randomized, crossover study, healthy volunteers received a single, oral 75 mg dose of rilpivirine either with a normal-fat breakfast (reference), under fasting conditions, with a high-fat breakfast, or with a protein-rich nutritional drink. (druglib.com)
Antiviral3
- Gilead Sciences reported strong antiviral results over 10 days with a single subcutaneous injection of GS-6207. (positivelyaware.com)
- Alert EU Panel Backs Antiviral Peramivir for Uncomplicated Flu The neuraminidase inhibitor helps speed alleviation of fever and flu symptoms in adults and children aged 2 years and older who have uncomplicated influenza. (medscape.com)
- Alert Drug That Claims to Kill Flu as Soon as 1 Day Okayed in Japan Baloxavir marboxil is a novel cap-dependent endonuclease inhibitor with potent fast-acting antiviral efficacy for the treatment of influenza types A and B. (medscape.com)
Enzyme6
- NRTIs inhibit the reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of the human immunodeficiency virus (HIV). (wikipedia.org)
- Most standard HIV drug therapies revolve around inhibiting the reverse transcriptase enzyme (RT), an enzyme that is necessary to the HIV-1 virus and other retroviruses to complete their life cycle. (wikipedia.org)
- The reverse transcriptase featured in the Luna One-Step RT-qPCR products is an engineered WarmStart ® enzyme developed for robust performance and increased thermostability. (neb.com)
- RNase Inhibitor is an acidic, 52 kDa protein that is a potent non-competitive inhibitor of pancreatic-type ribonucleases such as RNase A, RNase B and RNase C. The enzyme is provided as a fusion of the porcine RNase Inhibitor gene with a proprietary 22.5 kDa protein tag. (qiagen.com)
- Dilutions of the enzyme were made in 1X RNase Inhibitor Reaction Buffer and added to 1000 μL reactions containing 1mM cytidine 2',3'-cyclic monophosphate, 1μg RNase A in a 1X reaction buffer containing 100mM Tris-Acetate, 1mM EDTA, pH 6.5. (qiagen.com)
- Single-stranded exonuclease was determined in a 50 μL reaction containing 10,000 cpm of a radiolabeled single-stranded DNA substrate and 10 μL of enzyme solution incubated for 4 hours at 37°C. (qiagen.com)
Therapeutic1
- Each of these APIs, marketed as the therapeutic component of single products, is well-established and documented for the treatment of HIV/AIDS in combination with other products. (who.int)
Polymerase activity1
- This agent competes with the natural substrate deoxyguanosine triphosphate (dGTP) to inhibit HBV polymerase activity (ie, reverse transcriptase). (medscape.com)
Antiretrovirals2
- Booster drugs are used to 'boost' the effects of protease inhibitors and some other antiretrovirals. (aidsmap.com)
- The high potency of each drug allows for a low dose of both antiretrovirals and therefore, once approved, JULUCA™ will be the smallest once-daily single-pill available. (jnj.com)
Polymerases1
- It does not interfere with the activities of other RNases and modifying enzymes like polymerases and reverse transcriptases. (qiagen.com)
Elvitegravir1
- Genvoya , which includes the integrase inhibitor elvitegravir, is similar to Stribild except that it contains TAF rather than TDF. (positivelyaware.com)
Enzymes2
- Cobicistat is a mechanism-based inhibitor of cytochrome P450 (CYP) enzymes of the CYP3A family. (rxlist.com)
- The most commonly used drugs used in ART target the reverse transcriptase (RT) and protease enzymes. (canada.ca)
Zidovudine1
- The first nucleoside reverse-transcriptase inhibitor with in vitro anti-HIV activity was zidovudine. (wikipedia.org)
Dose2
- Under the agreement, the generic manufacturers will be entitled to manufacture once-daily 25 mg TMC278 as a single agent medicine and a fixed-dose combination (FDC) product. (biospace.com)
- Alert Self-injectable Belimumab for SLE Approved in Europe With training, patients with SLE can administer the new subcutaneous formulation as a once-weekly injection from a single-dose prefilled syringe or from a single-dose autoinjector. (medscape.com)
Immunodeficiency3
- Darunavir is an inhibitor of the human immunodeficiency virus ( HIV -1) protease . (rxlist.com)
- Reference: Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. (neb.com)
- Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. (scienceopen.com)
Combination1
- The combination of these medications into a single product creates a simpler alternative to taking these medications individually. (rxhealthmed.ca)
Compounds1
- Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI) lead compounds have been discovered. (neb.com)
Infections1
- The first major class of drugs found useful in slowing HIV infections are collectively called "reverse transcriptase inhibitors" (shown in red). (cellsalive.com)
Drugs2
- The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. (wikipedia.org)
- A simple solid phase extraction procedure was applied to 500 muL aliquots of plasma, and chromatographic separation of the drugs and internal standard (quinoxaline) was achieved with a gradient (acetonitrile and phosphate buffer) on an C-18 reverse-phase analytical column with a 28-minute analytical run time. (unito.it)
Converts1
- It converts the viral single-stranded RNA into an integration competent double stranded DNA. (wikipedia.org)
Bind1
- X-ray crystal structures of four HIV-1 RT-carboxanilide complexes (UC-10, UC-38, UC-84, and UC-781) reported here reveal that all four inhibitors bind in the usual NNI site, forming binary 1:1 complexes with RT in the absence of substrates with the amide/thioamide bond in cis conformations. (rcsb.org)
Patients1
- a first-in-class drug for patients of all ages with hemophilia A with factor VIII inhibitors. (medscape.com)
Neurons2
- Because of these profound effects on ligand specificity, reverse transcription-PCR was used to understand the expression of the FL and ED receptor isoforms at the level of single neurons. (jneurosci.org)
- The predominant expression pattern of either FL or ED isoforms in single embryonic DRG neurons establishes the existence of two subpopulations exhibiting differential responsiveness to trkB ligands, indicating that regulated splicing of the extracellular domain of trkB may serve as a mechanism to restrict neuronal responsiveness to the neurotrophins. (jneurosci.org)
Inhibits1
- ZLM-66 inhibits wild type (WT) HIV-1 reverse transcriptase (RT) with an IC 50 of 41 nM, as well as suppresses multiple HIV-1 mutant strains with EC 50 s of 13 nM, 13 nM, 24 nM, 25 nM and 58 nM against HIV-1 WT, K103N, L1001, E138K, and Y181C, respectively. (immune-system-research.com)
Virus2
- Tenofovir is a nucleotide analogue (adenosine monophosphate) reverse transcriptase and hepatitis B virus (HBV) polymerase inhibitor. (medscape.com)
- Reverse transcriptase is a part of HIV required to infect cells and make more virus. (rxhealthmed.ca)
Class1
- MK-8591 is an HIV medication from a new drug class, called nucleoside reverse transcriptase translocation inhibitors (NRTTIs). (positivelyaware.com)