Single nucleotide po genetic association studies. Medical search. Frequent questions

Objective The aim of this study was to investigate the association of Exonuclease1 ( EXO1 ) genetic polymorphism and the development of cervical carcinoma. (bmj.com)
By contrast, we have not found a significant association between the EXO1 C908G polymorphism and cervical cancer risk ( P = 0.791). (bmj.com)
A larger population study will need to be carried out to further validate the potential association of EXO1 genetic polymorphism and cervical carcinoma. (bmj.com)
372 donors were genotyped using a custom precision medicine single nucleotide polymorphism (SNP) microarray. (nature.com)
The Association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C Gene Polymorphism with Susceptibility to Diabetic Nephropathy: A Meta-Analysis. (cdc.gov)
Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study. (cdc.gov)
Recognition of a similarly affected second cousin prompted a genome-wide homozygosity mapping study using high-density single nucleotide polymorphism (SNP) arrays. (clinicforspecialchildren.org)
The aim of this study was to detect carriers of CVM in Holstein population using Polymerase Chain Reaction- Primer-introduced restriction analysis and Restriction Fragment Length Polymorphism (PCR-PIRA and RFLP) methods. (researchgate.net)
G single nucleotide polymorphism (SNP) in the group-specific component (GC) gene for its association with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH) vitamin D levels and further to test a possible association with m. (bone-abstracts.org)
The significant association found between the CYP2C19 polymorphism and the MetS score but not with the individual associated traits, emphasizes the importance of lipid metabolism in a MetS common etiological pathway and consequently on the clustering of different cardiovascular risk factors. (biomedcentral.com)
To determine the association of inherited genetic variation and immune-associated adverse events in patients with metastatic melanoma treated with ipilimumab containing regimens by completing candidate-based gene and pathway analyses of genes involved in lymphocyte activation, cytokines, cytokine receptors and within the major histocompatibility complex (MHC) region and an agnostic genome-wide single nucleotide polymorphism (SNP)-based approach. (clinicaltrialsgps.com)
The high-temperature requirement factor A1 (HTRA1) gene located at 10q26 locus has been associated with age-related macular degenerative (AMD), with the significantly related polymorphism being (rs11200638, −625G/A), however, above association is not consistent. (biomedcentral.com)
Breeding new spinach cultivars with high nutritional value is one of the main goals in spinach breeding programs worldwide, and identification of single nucleotide polymorphism (SNP) markers for mineral element concentrations is necessary to support spinach molecular breeding. (biomedcentral.com)
Association between endothelial nitric oxide gene intron 4a4b VNTR polymorphism and plasma homocysteine concentrations in Tunisian male patients with myocardial infarction. (cdc.gov)
Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease. (cdc.gov)
Illumina single nucleotide polymorphism (SNP) chips, kompetitive allele-specific PCR (KASP) assays, genotyping-by-sequencing (GBS)) and sequencing (e.g. (biomedcentral.com)
To elucidate the genetic etiology of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) in the Japanese population, we conducted a polymerase chain reaction-single-strand conformation polymorphism analysis of the sulfonylurea receptor 1 (SUR1) and Kir6.2 genes in 17 Japanese PHHI patients, including a pair of siblings from a consanguineous family. (diabetesjournals.org)

However, the genetic contribution of NOS polymorphisms to FENO is not fully understood. (bmj.com)
The aim of this study was to investigate comprehensively the association between single nucleotide polymorphisms (SNPs) in all three NOS genes and FENO in an adult population, and to assess whether such associations are modified by asthma or atopy. (bmj.com)
The genetic effect of NOS polymorphisms on FENO, asthma, and atopy was estimated using multiple regression methods. (bmj.com)
Results This is the first study on the role of EXO1 K589E (rs1047840) and EXO1 C908G (rs10802996) polymorphisms in cervical cancer in a Chinese population. (bmj.com)
The approach involves using regression analysis to examine the relationship between linkage disequilibrium scores and the test statistics of the single-nucleotide polymorphisms (SNPs) from the GWAS. (wikipedia.org)
We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). (pedigree.org.au)
Large-scale genotyping studies have identified common variants (primarily single-nucleotide polymorphisms [SNPs]) with individually modest breast cancer risk that, in aggregate, account for considerable breast cancer susceptibility. (stanfordhealthcare.org)
Linking this functional annotation with known genetic polymorphisms revealed the presence of cardiovascular disease-associated polymorphisms in active CM enhancers. (nature.com)
Nucleotide polymorphisms leading to amino acid substitutions in the lanosterol demethylase gene ( cyp51A ) are associated with reduced susceptibility to azole drugs. (cdc.gov)
Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes: A Prospective Study. (cdc.gov)
Association of Vitamin D Receptor Genetic Polymorphisms With Nephrolithiasis and End-Stage Renal Disease: A Meta-Analysis. (cdc.gov)
Association of Polymorphisms in Antioxidant Enzyme-Encoding Genes with Diabetic Nephropathy in a Group of Saudi Arabian Patients with Type II Diabetes Mellitus. (cdc.gov)
NCBI has become a central repository for genomic sequence data in humans and other species and has developed many other public databases, such as dbSNP (for single nucleotide polymorphisms, or SNPs) and Entrez Gene (for genes) ( 5 , 6 ). (cdc.gov)
Genetic changes in germline cells like single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) are relate to the susceptibility of diseases. (cgu.edu.tw)
A total of 37 single nucleotide polymorphisms (SNPs) were genotyped and individually tested for association with the score, adjusting for confounding variables. (biomedcentral.com)
Fifty-four polymorphisms in eight candidate genes were genotyped in over 800 tuberculosis cases and healthy controls in a population-based case-control association study in a South African population. (biomedcentral.com)
Single polymorphisms as well as haplotypes of the variants were tested for association with TB using statistical analyses. (biomedcentral.com)
Lack of association between endothelial nitric oxide synthase gene polymorphisms and risk of premature coronary artery disease in the Greek population. (cdc.gov)
Genetic and pharmacogenetic associations between NOS3 polymorphisms, blood pressure, and cardiovascular events in hypertension. (cdc.gov)
Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: an updated meta-analysis and systematic review. (cdc.gov)
Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. (who.int)

Method In 1737 adults from a Swedish general population sample, FENO was measured and genetic variation in the NOS genes was assessed using 49 SNPs. (bmj.com)
Results In a multi-SNP model based on stepwise regression analysis, two SNPs in NOS2 and one in NOS3 showed independent associations with levels of FENO. (bmj.com)
Here, we describe the development and empirical validation of an SNP-based polygenic breast cancer risk score.A panel of 94 SNPs was examined for association with breast cancer in women of European ancestry undergoing hereditary cancer genetic testing and negative for pathogenic variants in breast cancer susceptibility genes. (stanfordhealthcare.org)
Key to the success of these studies is the accuracy of the allelic frequency calculations, the ability to identify false-positives arising from assay variability and the ability to better resolve association signals through analysis of neighbouring SNPs. (clinicforspecialchildren.org)
A total of 2402 SNPs identified from genotyping by sequencing (GBS) approach were used for genetic diversity and GWAS. (biomedcentral.com)

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. (nih.gov)
First, we performed gene-based analyses for MIR185 common variants and target genes using Psychiatric Genomics Consortium genome-wide association data. (escholarship.org)
Gene-based tests revealed association between common variants in 3 MIR185 target genes (ATAT1, SH3PXD2A, NTRK3) and schizophrenia. (escholarship.org)
However, the expression patterns of miR-185 and its target genes in mice, and the genetic association results for the 3 target genes, suggest that further research into the involvement of miR-185 and its downstream pathways in schizophrenia is warranted. (escholarship.org)
We identified multiple overlapping genetic variants between CRP and lipids and confirmed novel genes implicated in the biology of chronic inflammation. (biomedcentral.com)
Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
We can use genome-wide association studies (GWAS) to discover the relationship between those genetic variations and disease status then use it to discover cancer susceptible genes. (cgu.edu.tw)
In our lab, we tried to use integrate systems biology and genetic statistics to discover susceptible markers and signature genes in nasopharyngeal carcinoma and hepatocellular carcinoma. (cgu.edu.tw)
Wen-Hui Su* , Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai (2018) Mutations in NOTCH1 and nucleotide excision repair genes are correlated with prognosis of hepatitis B virus-associated hepatocellular carcinoma. (cgu.edu.tw)
To investigate the association between inherited genetics and survival in patients with metastatic melanoma treated with ipilimumab containing regimens by completing candidate-based gene and pathway analyses of genes involved in lymphocyte activation, cytokines profile, cytokine receptors and within the MHC region and an agnostic genome-wide SNP-based approach. (clinicaltrialsgps.com)

This study provides strong confirmation of these susceptibility loci in multiple populations and shows that they make an important contribution to prostate cancer risk prediction. (pedigree.org.au)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
A catalog of genetic loci associated with kidney function from analyses of a million individuals. (ox.ac.uk)
Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). (ox.ac.uk)
Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. (biomedcentral.com)
Our large scale combined GWAS analysis identified numerous pleiotropic loci for CRP and lipids providing further insight in the genetic interrelation between lipids and inflammation. (biomedcentral.com)
Twentieth-century developments in biology and statistics established genetics as a science and led to the discovery of causal loci for many single-gene disorders. (cdc.gov)
Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear. (who.int)

This method allows mixed genetic effects in the univariate phenotype GWAS, a phenomenon commonly observed in genetic studies. (biomedcentral.com)
The purpose of this study was to conduct a genome-wide association study (GWAS) and to identify SNP markers associated with mineral elements in the USDA-GRIN spinach germplasm collection. (biomedcentral.com)
Initial efforts to dissect the genetic architecture of traits (e.g., quantitative trait locus (QTL) mapping and genome-wide association studies (GWAS)) and genomic prediction efforts have relied primarily on SNP markers. (biomedcentral.com)

A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. (pedigree.org.au)
Genetic predisposition to risk for or protection from type 1 diabetes (T1D) is highly polygenic, with the total possible set of disease-associated variants yet to be fully defined 1 . (nature.com)
Complementary methods for detecting genetic variants associated with T1D. (nature.com)
Association of matrix metalloproteinase-2 gene variants with diabetic nephropathy risk. (cdc.gov)
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. (escholarship.org)
In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. (escholarship.org)
The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. (escholarship.org)
We sought replication for novel CRP associations in an independent sample of 17,743 genotyped individuals, and performed in silico replication of novel lipid variants in 93,982 individuals. (biomedcentral.com)
By the 1990s, OMIM was adding more than 150 disease-related genetic variants per year, nearly all of them rare mutations discovered in families ( 1 ). (cdc.gov)
This study aimed to identify novel genetic variants in the CR2 extracellular domain of the epidermal growth factor receptor (EGFR) in healthy individuals and patients with six different types of adenocarcinoma, in Arabian peninsula populations. (biomedcentral.com)
We detected seven new EGFR genetic variants in 168 cancer patients and 114 controls. (biomedcentral.com)
Computational analysis of the genetic variants revealed a reduction in the stabilization of the EGFR tethered form for both V550M and the common R521K variant with low energetic state (− ∆∆G). Molecular interactions analysis suggested that these mutations might affect the receptor's function and promote tumorigenesis. (biomedcentral.com)

280 independent research projects studying β-cell physiology, β-cell differentiation, immunology, T1D biomarkers, technology development, T1D pathology, and diabetes etiology ( https://www.jdrfnpod.org/publications/current-npod-projects/ , accessed October 21, 2021). (nature.com)
Despite the sample size limitation of our study, this strategy can be useful to find genetic factors involved in the etiology of other disorders that are defined in a dichotomized way. (biomedcentral.com)
Genetic etiology of coronary artery disease considering NOS 3 gene variant rs1799983. (cdc.gov)
IMPACT: The novel gene-exposure interaction discovered in this study provides new insights into the etiology of esophageal adenocarcinoma. (who.int)

Genotypic Analysis of COL4A1 Gene in Diabetic Nephropathy and Type 2 Diabetes Mellitus Patients: A Comparative Genetic Study. (cdc.gov)
Furthermore, chromatophore-localized biosynthetic pathways as well as multiprotein complexes include proteins of dual genetic origin, suggesting that mechanisms evolved that coordinate gene expression levels between chromatophore and nucleus. (frontiersin.org)
In families with shared genetic heritage, genome-wide SNP arrays with relatively high marker density allow disease gene mapping studies to be incorporated into routine diagnostic evaluations. (clinicforspecialchildren.org)
[ 19 ] studied steady-state levels of the mRNA encoding LEKTI (lymphoepithelial Kazal-type related inhibitor), the gene product of the SPINK5 gene, in cultured epidermal keratinocytes from a healthy control and 5 Netherton syndrome patients. (medscape.com)
It is caused by a point mutation (G→T) at nucleotide position 559 of the gene, bovine solute carrier family 35 member 3 (SLC35A3). (researchgate.net)
To the our best of knowledge, this is the first study to report the existence of homozygous and heterozygous mutations at positions 554, 555 and 559 in exon 4 of SLC35A3 gene in Indian Holstein cattle. (researchgate.net)
Since the identification of LRP5 as the causative gene for the osteoporosis pseudoglioma syndrome (OPPG) as well as the high bone mass (HBM) phenotype, LRP5 and the Wnt/β-catenin signalling have been extensively studied for their role in the differentiation and proliferation of osteoblasts, in the apoptosis of osteoblasts and osteocytes and in the response of bone to mechanical loading. (bone-abstracts.org)
As a genetic disease, cancer occupied various specific genetic changes in chromosome that can affect subsequent gene expression and finally leads to the process of tumourigenesis. (cgu.edu.tw)
Further studies using Larger sample size studies, including information about gene-environment interactions will be necessary to carry out. (biomedcentral.com)
Hypoxanthine phosphoribosyl transferase ( HPRT ) gene has been used for studies of the mutagenic effect of EO but not for PO. (who.int)

To determine whether isolates with this mutation are spreading into the United States, we conducted a passive surveillance-based study of 1,026 clinical isolates of A. fumigatus from 22 US states during 2011-2013. (cdc.gov)
Sequence of the cloned cDNAs revealed the single nucleotide mutation in two alternatively spliced isoforms of slow TnT mRNA. (clinicforspecialchildren.org)
Surprisingly, the sequence analysis of PCR product also revealed the presence of two previously unknown homozygous mutations (TG→CT) at nucleotide positions 554 and 555 in addition to the previously reported heterozygous mutation at position 559. (researchgate.net)
This randomized phase III trial studies how well initial treatment with ipilimumab and nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab in treating patients with stage III-IV melanoma that contains a mutation known as BRAFV600 and cannot be removed by surgery. (clinicaltrialsgps.com)
Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. (biomedcentral.com)
Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1. (diabetesjournals.org)

However, it is surprising that no phenotypic effects were observed in the carrier bull, necessitating further studies to fully elucidate the effects of these novel homozygous mutations. (researchgate.net)
Synonymous mutations should no longer be ignored in the genome-wide studies. (biomedcentral.com)
Given the functional impact of synonymous mutations, there is no reason to exclude these mutations from the studies related to human diseases including cancer. (biomedcentral.com)
There are already a bunch of studies reporting the disease-related synonymous mutations. (biomedcentral.com)
1) Bioinformatic analyses studying the global patterns of the collective effect of synonymous mutations. (biomedcentral.com)
Evolutionary study indicated that synonymous mutations in oncogenes were also suppressed due to undetermined selection pressure [ 25 ]. (biomedcentral.com)

Genetic changes in cancer cell can be found in two different cells-- germline cells and somatic cells. (cgu.edu.tw)

Human genome epidemiology is the basic science for translating genomic research, relating genetic variation with variability in health status among well-defined groups of people. (cdc.gov)
BACKGROUND: Genetic variation in regulatory sequences that alter transcription factor (TF) binding is a major cause of phenotypic diversity. (bvsalud.org)
Genetic variation in brassinosteroid-responsive cis-elements likely contributes to trait variation. (bvsalud.org)
About a quarter of the ASB sites correlate with sequence variation in BZR1-binding motifs and another quarter correlate with haplotype-specific DNA methylation, suggesting that both genetic and epigenetic variations contribute to the high level of variation in ZmBZR1 occupancy. (bvsalud.org)
An additive genetic effect of GABRA2 rs279871 , NPY rs16147 and TPMT rs1142345 in the MetS score variation was also found. (biomedcentral.com)
Association of inherited variation with immune mediated adverse events and response to ipilimumab + nivolumab. (clinicaltrialsgps.com)
The study of structural variation within species and the characterization of the pan-genome has revealed extensive genome content variation among individuals within a species that is paradigm shifting to crop genomics and improvement. (biomedcentral.com)

LDSC can also be applied across traits to estimate genetic correlations. (wikipedia.org)
Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)
Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize that there are common genetic components involved in the clustering of MetS traits. (biomedcentral.com)
With the aim of identifying these common genetic components, we have performed a genetic association study by integrating MetS traits in a continuous MetS score. (biomedcentral.com)
Infection with the tuberculosis (TB) agent Mycobacterium tuberculosis ( M. tuberculosis ) and its subsequent outcomes (active TB, latent infection or clearance of the bacterium by the pulmonary immune system) are complex traits due to interactions between numerous host genetic susceptibility factors and the environment. (biomedcentral.com)
In general, validating the genetic markers of growth traits is the initial and crucial step to establish a MAS system (Allan et al 2007). (cipav.org.co)
High-throughput phenotyping for the genetic dissection of drought tolerance related traits in Zea mays and Triticum durum Desf. (lookformedical.com)
In this dissertation we expose the results of two research conducted using high-throughput phenotyping techniques with the aim of discovery the genetic bases underling drought adaptive traits in maize and durum wheat. (lookformedical.com)

In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the separate contributions of polygenic effects and various confounding factors, such as population stratification, based on summary statistics from genome-wide association studies (GWASs). (wikipedia.org)
Wonil Chung, Omer Weissbrod and Margaux Hujoel were awarded as semifinalists for the Charles J. Epstein Trainee Award for Excellence in Human Genetic Research for the 2018 American Society of Human Genetics Conference in San Diego, California this October. (harvard.edu)
In the first study, we used a maize Introgression Library (IL) derived from the cross between Gaspé Flint (an early flowering Canadian landrace) and B73 (an elite genetics reference line) which was previously shown to segregate for phenology and seminal root architecture (SRA). (lookformedical.com)

2018). Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. (harvard.edu)
2018). Mixed-model association for biobank-scale datasets. (harvard.edu)

Pooling genomic DNA samples within clinical classes of disease followed by genotyping on whole-genome SNP microarrays, allows for rapid and inexpensive genome-wide association studies. (clinicforspecialchildren.org)

Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk for cervical cancer. (bmj.com)
To indentify the presence of GH genotypes, the totals of 222 blood samples of Indonesian-grade cows (G 0 ) and their female progeny (G 1 ) as well as 2 blood samples of Ongole-breed sires (G 0 ) were used in this study by PCR-RFLP involving Msp1 enzyme-restriction. (cipav.org.co)
Significant genetic variations were found among the tested genotypes as evidenced by the 2 to 42 times difference in mineral concentrations. (biomedcentral.com)

NOTCH1 mediates tumorsphere colony activity in vitro {2nd level heading Our studies using doxycycline to suppress NOTCH1 activity in tumor bearing mice suggest that NOTCH1 inhibition prevents or, at a minimum, delays disease recurrence. (hdac-inhibitors.com)
Consistent with these and other studies, we show that constitutive expression of intra cellular NOTCH1 in the developing mouse mammary gland stimulates luminal fate, ultimately resulting in transformation of the mammary gland. (hdac-inhibitors.com)

This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
CONCLUSION: Our study provides a robust method for analyzing genome-wide variations of TF occupancy and identifies genetic and epigenetic variations of the brassinosteroid response transcription network in maize. (bvsalud.org)
ctDNA has the potential to accurately genotype the tumor and identify personalized genetic and epigenetic alterations of the entire tumor. (biomedcentral.com)

Another extension of LDSC, known as stratified LD score regression (abbreviated SLDSR), aims to partition heritability by functional annotation by taking into account genetic linkage between markers. (wikipedia.org)

LDSC can be used to produce SNP-based heritability estimates, to partition this heritability into separate categories, and to calculate genetic correlations between separate phenotypes. (wikipedia.org)

A familial case of osteogenesis imperfecta: study of genotype-phenotype correlation. (bone-abstracts.org)

The sequence of bases from one nucleotide to the next in line is the code for the assembly of spe- cific amino acids to make specific types of proteins. (1library.co)

[ 7 ] Further, larger studies are necessary to elucidate the safety and efficacy of pimecrolimus in Netherton syndrome patients. (medscape.com)

The general principles of cardiac development have been studied in great detail on a morphological and molecular basis. (nature.com)
Three additional affected Mennonite individuals, ages 8 months to 50 years, were subsequently identified by directed molecular genetic testing. (clinicforspecialchildren.org)
Nowadays, molecular biology researchs are featured a wide range of antimicrobial peptides (AMP)-related topics such as AMP genome library construction, development of antimicrobial peptides and their mimetics as therapeutic agents, structure/function analysis, cloning and expression, regulation, mechanisms of action, microbial escaping strategies and human disease associations. (ukessays.com)
The Indonesian local-grade cattle is composed of unknown proportion of the Madura, the Sumba, and the Ongole breed combinations, all were combined into a single group because it was impossible to delineate the exact breed composition and is so far only supported by preliminary molecular analysis (Mohamad et al 2009). (cipav.org.co)

Human genetic analyses generated no evidence of the involvement of MIR185 in schizophrenia. (escholarship.org)

There are three biomarkers of effect currently being applied to measure PO exposure in humans: DNA adducts, hemoglobin adducts, and sister chromatid exchanges (SCE). (who.int)

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
Jihye Kim received an American Association for Cancer Research Scholar-in-Training Award for the work she will be presenting at the AACR Annual Meeting in Chicago, Absolute risk prediction models for pancreatic cancer. (harvard.edu)
The strongest known genetic risk factor is the 22q11.2 microdeletion. (escholarship.org)
The Telomeres Mendelian Randomization Collaboration (2017) Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study. (cgu.edu.tw)

In conclusion, this study does not support a role for CHRM2 in cognitive ability. (nih.gov)

Future studies will investigate the source of endogenous nucleic acids recognized following membrane fusion events. (mdpi.com)

No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. (nih.gov)
We found a significant association between CYP2C19 rs4244285 and the MetS score not detected using the MetS dichotomic approach. (biomedcentral.com)
High exposures to EO in workers showed a significant increase in HPRT mutant frequency compared to controls, while at low exposures no such association was found. (who.int)

On the other hand, genetic changes in somatic cells like chromosome aberration and alteration of genetic expression can be found in tumor tissues which can be studied by integration of various biological information using bioinformatic and comparative genomic strategies. (cgu.edu.tw)

Six statistical methods were used for association analysis. (biomedcentral.com)

Methods This study was conducted with 126 patients diagnosed with cervical cancer and 278 people with no cancer history. (bmj.com)
In a current NIH R01 longitudinal kidney imaging study, we obtained kidney MRF results in ARPKD patients with excellent repeatability and no need for intravenous contrast or sedation. (pkdcure.org)
The proposed studies would provide a key element needed to conduct clinical trials of CHF treatments and ultimately improve outcomes for ARPKD patients. (pkdcure.org)
The aim of this study was to assess clinical features that contribute to the specific phenotypic presentations and disease course of FMD.Methods: The study consisted of 100 patients with FMD treated at Clinic for Neurology, Clinical Center of Serbia, who were longitudinally observed. (lookformedical.com)
1 However, a study evaluating tract infections), particularly in immunocompromised carbapenem restriction practices at a hospital in Manila patients. (who.int)

Initial studies may be false positives or may propose a stronger genetic effect than subsequently found to be the case. (biomedcentral.com)

The polybasic nuclear localization sequence (NLS) on the lipins as well as the oligomerization of lipins mediates membrane association. (aocs.org)

Subsequent studies showed the anticancer routines of honokiol in lots of can cer cell lines and tumor versions. (hdac-inhibitors.com)

The exact mechanism through which stomoxyn-ZY kill targeted pathogens not well understood and need further studies. (ukessays.com)

In this study, we use lipoplexes containing purified reovirus p14 fusion protein as a model of exogenous fusion and a cell line expressing p14 protein as a model of endogenous fusion, which is illustrated here. (mdpi.com)
used biochemical techniques to study how an Hsp70 protein in the endoplasmic reticulum called BiP forms oligomers. (elifesciences.org)

We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism. (biomedcentral.com)

In this study we evaluated a familial case including a mother and a daughter, classified as OI type I. The daughter had more severe clinical featu. (bone-abstracts.org)
Even so, convincing evidence for its importance in the control of mycobacterial infections has been found in both experimental and clinical studies. (biomedcentral.com)

In fact, the term 'oncobiome' has been recently adopted to refer to the emerging field of research devoted to the study of the interplay between the human microbiome and cancer development [23]. (deepdyve.com)
As a complex condition, MetS results from a complex interplay between many genetic and environmental factors. (biomedcentral.com)

In addition, our study provides a functional map of the non-coding genome of human CMs throughout life. (nature.com)
Wen-Hui Su *, Allan Hildesheim, and Yu-Sun Chang (2013) Human Leukocyte Antigens and Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma: Old Associations Offer New Clues into the Role of Immunity in Infection-Associated Cancers. (cgu.edu.tw)
In relation to "CFS", the most-studied viruses have been the Epstein-Barr Virus (EBV) and the Human Herpes Virus-6 (HHV-6). (investinme.org)

Causality of Diabetic Nephropathy and Age-related Macular Degeneration: A Mendelian Randomization Study. (cdc.gov)
Causality between sarcopenia and diabetic nephropathy: a bidirectional Mendelian randomization study. (cdc.gov)

2006). Also, the hemoglobin adduct is strongly correlated with measured concentrations of PO (8h TWA) (Boogaard et al. (who.int)

Funding This study was funded by the Swedish Research Council for Worklife and Social research (FAS), grants 2001-0263, 2003-0139, Swedish Heart and Lung Foundation grant 20050561 and a collaborative research grant from AstraZeneca. (bmj.com)
Funding received for this research study was from Project of Medical Research Fund of Guangdong Province Government, China (No. 2010068). (bmj.com)
Genetic resistance - What about mental health impacts - this is a new area of research has well. (ukdiss.com)

Multiple dosing regimens were assessed in a randomized, double-blind, placebo-controlled study (S3B30040) to determine efficacy, tolerability, and evaluate constipation rate. (researchgate.net)

1997. A comparison of doses from 137Cs and 210Po in marine food: A major international study. (cdc.gov)

Finally, we combined MINI-AC predictions from bulk and single-cell AC datasets to identify general and cell-type specific maize leaf regulators. (bvsalud.org)

Anatomy16

Organisms2

Diseases23

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology9

Phenomena and Processes99

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture1

Information Science18

Named Groups9

Health Care38

Geographicals9

Polymorphism17

Polymorphisms21

SNPs5

Genes10

Loci8

GWAS3

Variants12

Etiology4

Gene10

Mutation6

Mutations6

Germline1

Variation7

Traits8

Genetics3

20182

Genome-wide association1

Genotypes3

NOTCH12

Epigenetic3

Markers1

Phenotypes1

Genotype:phenotype1

Bases1

Elucidate1

Molecular4

Analyses1

Humans1

Risk4

Conclusion1

Investigate1

Significant3

Genomic1

Statistical1

Patients5

Initial1

Sequence1

Tumor1

Pathogens1

Protein2

Inflammation1

Clinical2

Interplay2

Human3

Mendelian2

Concentrations1

Research3

Efficacy1

19971

Datasets1