Diabetes was induced in fasted rats (12 h) by a single intraperitoneal injection of 120 mg kg -1 of alloxan monohydrate. (scialert.net)
Diabetes was induced in by a single intraperitoneal injection of 120 mg/kg alloxan monohydrate. (phytojournal.com)
The antidiabetic property of the methanolic leaf extract of Chromolaena odorata was evaluated in Wistar rats by inducing diabetes using a single intraperitoneal (I.P) injection of freshly prepared solution of alloxan monohydrate. (plantsjournal.com)
Diabetes was induced in Albino rats by administration of single dose of Alloxan monohydrate (150mg/kg). (ijpsr.com)
Diabetes was induced by a single dose of intraperitoneal injection of alloxan (100mg/kg) in Swiss Albino Mice. (pharmascholars.com)
Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
At the end of the study, the animals were fasted overnight, anaesthetized with an intraperitoneal injection of sodium pentobarbital (60 mg/kg), and sacrificed for obtaining tissues samples (liver, pancreases). (biomedcentral.com)
We previously reported mitigation of light-induced damage in the rat retina by intraperitoneal injection of hydrogen-rich saline (HRS). (arvojournals.org)
The diabetes was induced by the administration of 150 mg kg-1 streptozotocin via a single intraperitoneal injection. (iranjournals.ir)
Rats12
The antidiabetic effect of hydro alcoholic extract of the leaves of S. cuspidata were investigated in alloxan induced diabetic rats and the bioactive compounds were tested for their antidiabetic potential in vitro by inhibition of α-amylase enzyme. (phytojournal.com)
The extract was tested for acute and sub-chronic anti-hyperglycemic activity in alloxan induced diabetic rats and for acute toxicity test among normal rats. (biomedcentral.com)
In the present work, we studied the hypoglycemic and anti-lipemic effects of the aqueous extract prepared from fresh leaves of the plant (AECS), in the model of alloxan-induced diabetes in rats. (biomedcentral.com)
No significant changes were seen in control diabetic rats before (48 h after alloxan administration) and after distilled water treatment. (biomedcentral.com)
While no changes were seen in total cholesterol levels, a significant decrease was observed in plasma triglyceride levels, in the alloxan-induced diabetic rats after AECS treatment with both doses, as compared to the same groups before treatment. (biomedcentral.com)
Significant decreases in blood glucose (25%) and triglyceride levels (48%) were also observed in the alloxan-induced diabetic rats after 4 days treatment with AECS (200 mg/kg, p.o. (biomedcentral.com)
The ethanol extract of Solanum surratense at the dose of 200mg/kg and 400mg/kg, p.o. was administered as single dose per day to diabetes induced rats for a period of 21 days. (ijpsr.com)
From the above result, it is concluded that EESS root possesses significant anti-diabetic effects in Alloxan induced diabetic rats. (ijpsr.com)
The present study was conducted to investigate the anti-diabetic activity of Solanum surratense rootsin Alloxan induced diabetic rats. (ijpsr.com)
The effect of oral pretreatment of some antimicrobial agents was studied on the uterotropic response of immature female rats to a single oral dose of ethinyl oestradiol. (ijp-online.com)
Antidiabetic activity was evaluated by Aldose reductase, α -amylase and PTP1B inhibition assays in in vitro and Alloxan-induced diabetes in rats was used as an in vivo model. (hindawi.com)
Diabetic GK rats and control animals were randomly assigned to receive E4 or vehicle by intravitreal injection. (molvis.org)
Hyperglycemia2
Hyperglycemia was confirmed by the elevated glucose levels determined at 72 h after alloxan injection. (phytojournal.com)
Alloxan model of hyperglycemia - Cholic and Deoxycholic acid - Antioxidant enzymes - Lipases - Lecithin cholesterol acyltransferase - Plant antioxidants. (captaincube.com)
Mice2
The aim of the investigation was to evaluate the hypoglycemic and hypolipidemic activity of ethanolic extracts of different parts from the plant Ficus racemosa (FR) in alloxan-induced diabetic mice. (pharmascholars.com)
In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
Streptozotocin1
Group D: Diabetic group, in which DM was induced by single i.p. injections of streptozotocin (STZ). (biomedcentral.com)
Pancreatic1
VAD (10, 25, and 50 mg/kg, p.o.), and glibenclamide (10 mg/kg, p.o.) treated animals showed significant protection against alloxan-induced pancreatic tissue damage. (hindawi.com)
Glucose1
Furthermore, in alloxan-induced diabetes model MEPG (200 and 400 mg/kg, p.o.) and VAD (10, 25, and 50 mg/kg, p.o.) have showed significant and dose dependent antidiabetic activity by maintaining the blood glucose levels within the normal limits. (hindawi.com)
Administration1
It also showed a protective effect when it was given prior to alloxan administration. (ijp-online.com)
Levels1
The drug XE did not show a consistent effect on normal blood sugar levels but it effectively reversed the alloxan-induced changes in the blood sugar level and the beta-cell population in the pancreas. (ijp-online.com)
Alloxan was used to induce diabetes in rats and the blood glucose, lipid levels were estimated using commercial kits available in the market. (scialert.net)
The methanol extract of T. portulacastrum was administered for 7 days to normal and alloxan induced diabetes rats at a dose of 100, 200 and 300 mg kg -1 . (scialert.net)
The chronic effects of neonatal alloxan- (ALX) induced diabetes mellitus on ventricular myocyte contraction and intracellular Ca 2+ transport have been investigated. (uaeu.ac.ae)
Diabetes was induced in 5-day old male Wistar rats by a single intraperitoneal injection of ALX (200 mg/kg body weight). (uaeu.ac.ae)
Howarth, FC , Hassan, Z & Qureshi, MA 2011, ' The chronic effects of neonatal alloxan-induced diabetes mellitus on ventricular myocyte shortening and cytosolic Ca 2+ ', Molecular and cellular biochemistry , vol. 347, no. 1-2, pp. 71-77. (uaeu.ac.ae)
METHODS: Diabetes was induced by a single injection of alloxan (145 mg kg(-1) i.v.). After the development of diabetes (3 weeks), electrophysiological studies were performed using whole cell voltage clamp and ECG measurements. (unideb.hu)
METHODS AND RESULTS: Diabetes was induced by a single injection of alloxan, a subgroup of dogs received insulin substitution. (unideb.hu)
Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. (ijpsr.com)
Alloxan diabetes serves as a classic example of free radical pathology. (ijpsr.com)
Alloxan diabetes is an example of prior activation of the enzymatic systems. (ijpsr.com)
Diabetic rats4
It also produced beneficial effects on the lipid profile in normal as well as alloxan induced diabetic rats at the end of the treatment period (7th day). (scialert.net)
The objective of the present study was to evaluate the hypoglycemic and hypolipidimic activity of methanolic extract of Trianthema portulacastrum L. whole plant in normal and alloxan-induced diabetic rats. (scialert.net)
The anti-diabetic profile of the isolated compound was investigated in STZ- induced diabetic rats at single dose 50 mg/kg (b.wt). (jbclinpharm.org)
0.001) reduced blood sugar level in STZ-induced diabetic rats at single dose 50 mg/kg (b.w) respectively as matched to untreated diabetic control group. (jbclinpharm.org)
Chronic1
Under conditions of alloxan-induced diabetic rat model intensification of oxidative stress processes occur provoking changes, which are typical for chronic hepatitis. (ijpsr.com)
Liver1
Methods By injection of Bacillus Calmette-Guerin(BCG, 125 mg·kg-1) prepared rat model of immunological liver damage. (bvsalud.org)
Experimental1
In modern experimental diabetology streptozotocin, alloxan and dithizone induced diabetic rat models are the most preferable. (ijpsr.com)
Type2
No differences were observed either in the density or in the kinetics of the inward rectifier K(+) current (I(K1)), the rapid delayed rectifier K(+) current (I(Kr)), the transient outward current (I(to)) and the L-type calcium current (I(CaL)) between the control and alloxan-treated rabbits. (unideb.hu)
Numerous publications of recent years show a consistently high interest of these models concerning the issue of forming different complications on the background of DM type 1 and 2, such as macrovascular disease, neuropathy, retinopathy, nephropathy, except this alloxan model provokes oxidative stress. (ijpsr.com)