Single cellular differentiation during early. Medical search. Frequent questions

Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)

The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. (bvsalud.org)
function of proliferative responses provoked in the induction cell products favor immediate type hypersensitivity reactions, phase of contact allergy, the murine local lymph node assay serving as growth and differentiation factors for mast cells and (LLNA), has been accepted as a stand-alone method for skin eosinophils, the cellular effectors of the clinical manifestations of sensitization testing (NIH, 1999). (cdc.gov)

Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
Glycosylation is known to affect various cellular and physiological functions including regulation of enzymatic activities, cell differentiation and morphogenesis. (nih.gov)
The results demonstrate both independent and overlapping functions of two FGF8 homologues in mesoderm morphogenesis and differentiation. (biologists.com)
Differentiation involves morphogenesis but also cell-appropriate organelle biogenesis programs. (biomedcentral.com)

Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
We construct a molecular map of cellular differentiation from pluripotency towards all major embryonic lineages, and explore the complex events involved in the convergence of visceral and primitive streak-derived endoderm. (nih.gov)
Genetic analysis of early development in the Drosophila embryo has revealed that embryonic pattern formation depends on both maternal and zygotic genes. (silverchair.com)
Iwatsuki and colleagues have generated self-renewing pluripotent stem cells from the pre-gastrulation epiblast of the rat embryo and from other cellular sources: rat embryonic stem cells (rESCs) and epiblast-like cells derived from the rESCs. (bvsalud.org)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

Monocot leaves, where cell proliferation and differentiation are displayed along a linear developmental gradient, provide an ideally suited experimental system to study these processes. (biomedcentral.com)
It is not dissimilar to the gradient of proliferation and differentiation along developing roots [ 2 ] but, in contrast, it provides a unique opportunity to study chloroplast biogenesis and differentiation. (biomedcentral.com)

Cell signalling and transcriptional networks are known to regulate aspects of gastrulation, but the precise mechanisms have not been investigated at the single cell level. (sanger.ac.uk)
Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from 6.5 to 8.5 days post-fertilization. (nih.gov)
Furthermore, we use single-cell profiling to show that Tal1 -/- chimeric embryos display defects in early mesoderm diversification, and we thus demonstrate how combining temporal and transcriptional information can illuminate gene function. (nih.gov)
We engineered mice lacking a single cis element −1.8 kb upstream of the Gata2 transcriptional start site. (prolekarniky.cz)

FOXC2 is required during early development of the kidneys, including differentiation of podocytes and maturation of the glomerular basement membrane. (wikipedia.org)
These signaling pathways are important in many cellular processes such as cell growth and division (proliferation) or maturation (differentiation). (medlineplus.gov)

The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
Here, we have analyzed cis element regulation of the critical hematopoietic factor Gata2 , which is expressed in early precursors and repressed as GATA-1 levels rise during terminal differentiation. (prolekarniky.cz)

Project: Developing novel single-cell genomics methods to quantify cell-to-cell heterogeneity in cancers and stem cells. (confex.com)
However, the full promise of regenerative medicine has been difficult to achieve so far, partly due to our incomplete understanding of the genetic and epigenetic mechanisms regulating differentiation of stem cells to specific lineages and tissues. (confex.com)
We further investigated the epigenetic age of primed (representing early postimplantation) and naïve (representing preimplantation) pluripotent stem cells and observed that in all cases the epigenetic age of primed cells was significantly lower than that of naïve cells. (bvsalud.org)
These rat epiblast-derived stem cells (rEpiSCs) display germ-line competence that is characteristic of mouse formative stem cells and early signature of specification of germ layer lineages typical of primed state mouse epiblast stem cells. (bvsalud.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

FOX transcription factors are expressed during development and are associated with a number of cellular and developmental differentiation processes. (wikipedia.org)
From an engineering perspective, gene expression regulation can be viewed as the output of a network of complex chemical and physical processes, and understanding how these processes interact and integrate to govern cellular phenotypes has been a major focus of my graduate and postdoctoral research. (confex.com)
We are developing and applying methods to explore the genome, epigenome and transcriptome of single cells in order to better understand normal development and disease processes. (sanger.ac.uk)
We are developing wet-lab and computational methods to explore the transcriptomes of single cells, allowing for instance the discovery of novel cell types in complex tissues, the exploration of cell types/cell states and molecular processes involved in normal development and disease processes, and constructing roadmaps of cellular differentiation by pseudo-time ordering of single-cell transcriptomes. (sanger.ac.uk)
It reveals functionally distinct plastid and chloroplast development stages, identifies processes occurring in each of them, and highlights our very limited knowledge of the earliest drivers of plastid biogenesis, while providing a basis for their future identification. (biomedcentral.com)
Sci Immunol 2021) as well as others have uncovered distinct NK cell differentiation and memory processes. (varbi.com)
As a unique isoform of RyR in insect, the binding protein DmFKBP12 is essential as well in insect physiological and cellular processes. (biomedcentral.com)
Collier, the single Drosophila COE (Collier/EBF/Olf-1) transcription factor, is required in several developmental processes, including head patterning and specification of muscle and neuron identity during embryogenesis. (sdbonline.org)
Downloaded from plays a mechanistic role in cellular decision-making processes ( a ) 2 during differentiation is currently the object of intense study. (lu.se)

This feature on cell-cell communication is adapted from part of Chapter 4 of the 2023 Spatial and Single-cell Playbook. (frontlinegenomics.com)

To assess the developmental neurotoxicity of more realistic TRAP exposures, we exposed male and female rats during gestation and early postnatal development to TRAP drawn directly from a traffic tunnel in Northern California and delivered to animals in real-time. (nature.com)
Finally, we demonstrate how to use our developmental map for molecular cues that direct sequential cellular differentiation and define cells and locations associated to both normal development and spinal cord diseases. (scilifelab.se)
Taking advantage of the developmental gradient in the bread wheat leaf, we provide a simultaneous quantitative analysis for the development of mesophyll cells and of chloroplasts as a cellular compartment. (biomedcentral.com)
It was proposed by Conrad Hal Waddington to illustrate the various developmental pathways a cell might take toward differentiation. (asu.edu)

Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes-those that control cell proliferation or differentiation-allows cells to grow and divide uncontrollably to form a tumor. (medlineplus.gov)

During this fascinating process, a pluripotent stem cell population in the early embryo gives rise to the three germ layers from which all organ systems develop. (sanger.ac.uk)
Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. (todayinsci.com)
The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo. (breakingnewsweb.com)

Thus, my research interests are to develop novel single-cell genomics methods to better understand how changes in the epigenetic landscape during normal development regulates cellular differentiation, information that is critical towards realizing the full potential of regenerative medicine. (confex.com)
The epigenetic landscape integrates the connected concepts of competence, induction, and regulative abilities of the genes into a single model designed to explain cellular differentiation, a long standing problem in embryology. (asu.edu)

Nevertheless,we find that pyr and ths single mutants display defects in gastrulation and mesoderm differentiation. (biologists.com)
DmFKBP12 is first expressed at the syncytial blastoderm stage and undergoes increased expression during the cellular blastoderm and early gastrulation stages. (biomedcentral.com)

Can we find common cellular pathways associated with photoreceptor cell death caused by distinct genetic mutations? (nih.gov)

Together, this comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine. (nih.gov)
In summary, we demonstrate that the combination of single cell technologies with computational analysis tools enable the study of a variety of cellular mechanisms involved in complex biological systems such as early hematopoiesis and can be used to dissect perturbed differentiation trajectories associated with perturbations such as aging and malignant transformation. (cun.es)

The aim of the Sanger Institute-EBI Single-Cell Genomics Centre is to develop and apply methods for capturing the complete genetic content of single cells in a high-throughput manner, allowing us to explore the nature and role of cellular heterogeneity in normal development and disease. (sanger.ac.uk)

Unexpectedly, we find that during early cell fate specification, many human neural progenitor cells have lost their self-renewal capacity. (scilifelab.se)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. (cun.es)
In this study, we used single cell RNA sequencing (scRNAseq) to characterize an enriched population of human hematopoietic stem and progenitor cells (HSPCs) obtained from young and elderly healthy individuals. (cun.es)

Epigenomic mechanisms enable functional diversification of cells with identical genomes, and their study is fundamental to understanding cellular identity and function. (sanger.ac.uk)
This offers significant advantages for studying tumor pathogenesis and molecular mechanisms of oncogenesis caused by a single initiating oncogenic event introduced through the mouse germ line. (molvis.org)
Moreover, the multiple analyses conducted at the single-cell level allowed us to understand the mechanisms that underlie the cellular differentiation/specialization process. (unimore.it)
This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)

Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. (affbiotech.com)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)

To overcome this limitation, recent advances in molecular biology have enabled genome-wide single-cell measurements of the transcriptome, genome or certain epigenetic marks that capture this cell-to-cell heterogeneity. (confex.com)
These cells can self-renew, withstanding even extreme differentiation conditions to regenerate the tissue, maintaining its physiological heterogeneity. (unimore.it)

In TE strategies, the adult airway epithelial cells would be the most appropriate cellular source for restoring the airway epithelium. (unimore.it)
In the present study, we proved the ability of a culture system, largely used for the clinical expansion of different epithelial tissues, to safely and effectively maintain the long-term proliferative and differentiation potential of airway epithelial cells. (unimore.it)

After losing interest in molecular biology she decided to apply her knowledge of genetics to cellular biology, more specifically pattern formation and regeneration in the hydra, a genus of freshwater polyps. (wepapers.com)
The applicant must have a strong background in molecular biology, cell culture, cell modification, and cell differentiation as well as advanced flow cytometry. (varbi.com)

Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)

It is also involved in the early development of the heart. (wikipedia.org)
Similarly, in specific cases, such as cancers, viral infections and in certain cell-types during normal development, mutations and other structural variations within the genome also influences cellular functions. (confex.com)
To understand how the genome and epigenome regulates cellular function, development of high-throughput sequencing methods, known as next-generation sequencing, are beginning to unravel genome-wide correlations between the genome, epigenome and transcriptome within a large population of cells or tissues. (confex.com)
Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. (elifesciences.org)
Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. (todayinsci.com)
The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. (todayinsci.com)
Although the specific function of ALK receptor tyrosine kinase is unknown, it is thought to act early in development to help regulate the proliferation of nerve cells. (medlineplus.gov)
Collectively, these data indicate that exposure to real-world levels of TRAP during gestation and early postnatal development modulate neurodevelopment, corroborating epidemiological evidence of an association between TRAP exposure and increased risk of NDDs. (nature.com)
In development, lineage-restricted transcription factors simultaneously promote differentiation while repressing alternative fates. (prolekarniky.cz)
The project aim is to create a comprehensive molecular atlas of human prenatal development at the molecular resolution using state-of-the-art multi-omic technologies such as single-cell RNA-seq, Spatial Transcriptomics, in situ sequencing in order to provide deeper insight into how variations and deviations contribute to health and disease. (scilifelab.se)
This has catalyzed research in both early embryogenesis as a model system for mammalian development as well as regenerative medicine as a renewable source of unspecialized cells which can be converted into nearly any cell type required by a patient. (utexas.edu)
In mammals, the term refers chiefly to early stages of prenatal development, whereas the terms fetus and fetal development describe later stages. (breakingnewsweb.com)
The second phase is marked by the development of photosynthetic chloroplasts which occupy the available cellular space. (biomedcentral.com)
At Flinders University, I continue to research how these circular RNAs impact cellular development and cancer (NHMRC Investigator Leadership Grant and Project funding). (edu.au)
The usefulness of determination of electrophoresis of serum proteins has been specially analysed to detect early development of malignant growths in patients with colonic polyps regarding alfa-1/alfa-2 and alfa/beta. (nel.edu)
Recent research revealed a rejuvenation event during early development of mice. (bvsalud.org)
Somites are blocks of cells that contain distinct sections that diverge into specific types (axial or limb) of musculature and are an essential part of early vertebrate development. (asu.edu)

The HDCA Seminar Series 2022 invites you to join us on a journey of early human organogenesis of several organs at the single-cell and spatial resolution. (scilifelab.se)

We propose that the integration of Pyr and Ths function is required for robustness of Htl-dependent mesoderm spreading and differentiation, but that the functions of Pyr have become more specific, possibly representing an early stage of functional divergence after gene duplication of a common ancestor. (biologists.com)

The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
Apart from wet-lab approaches, we also develop the computational means for the analysis of single cells. (sanger.ac.uk)
We are developing single-cell epigenomics technologies to overcome these limitations, enabling the discovery and classification of novel subpopulations of cells, the unknown epigenomic repertoire of rare cells and to obtain deeper insight in epigenomic maintenance and reprogramming. (sanger.ac.uk)
We are applying single cell sequencing techniques to profile the majority of the cells in mouse postimplantation embryos. (sanger.ac.uk)
Our signature-based screen established several categories of genes based on their comparative functions during the differentiation of ES cells. (utexas.edu)
Repressive role of Rbpj is also required for proper differentiation of ES cells by silencing core factors. (utexas.edu)
Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. (cun.es)
Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)
2 Lipids are major participants in the conversion of energy within cells, the transportation of substances, and cell growth, differentiation and apoptosis. (sanbio.nl)
My PhD and first postdoctoral position involved profiling single cell-specific transcriptomics and ionomics of live plant cells towards illuminating plant salinity tolerance and nutrient acquisition. (edu.au)
But these cells may be detected early via salivary biomarkers, prompting early treatment, according to the Oral Microbiology Research Group of the CEU Cardenal Herrera University in Valencia, Spain. (dentistrytoday.com)
We thus efficiently generate artery and vein cells, introduce stem-cell-based toolkits for biosafety-level-4 virology, and explore the arterial tropism and cellular effects of Nipah and Hendra viruses. (stanford.edu)
(B) Analysis of single cells however (e.g., by FISH) indicates that not all LADs mapped in cell populations are found at the nuclear periphery in all cells. (frontiersin.org)
These quality controls include/verify 1) the tissue-regenerative properties of the cells extracted from the biopsy, 2) the expression of some critical markers identifying the cellular identity, the tissue integrity and the early epithelial differentiation of the cultures. (unimore.it)
In mammals, pluripotent cells transit through a continuum of distinct molecular and functional states en route to initiating lineage specification. (bvsalud.org)
M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)

We are seeking a highly motivated and ambitious individual to join the research group of Professor Yenan Bryceson as a Postdoctoral Fellow to further elucidate the molecular regulation of human cytotoxic lymphocyte differentiation and harness insights for improved cellular immunotherapy of solid cancer. (varbi.com)
We seek further understanding of cytotoxic lymphocyte homing, differentiation and persistence, which can be harnessed for cellular immunotherapy of solid cancers. (varbi.com)
The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)

Further the the expression of gliogensis genes is much higher in human compared to the correspondent rodents at the early stage, suggesting earlier gliogenesis in human. (scilifelab.se)

Molecular, cellular, and physiological studies of glycobiology to define the functional sequences of genetic risk factors for AD. (nih.gov)
We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)

In insect, Drosophila melanogaster ryanodine receptor ( DmRyR ) cDNA was cloned from lava and the physical features of DmRyR single channel were characterized with in vitro overexpression system [ 16 ]. (biomedcentral.com)

I see nothing wrong ethically with the idea of correcting single gene defects [through genetic engineering]. (todayinsci.com)
In contrast with this model, this study shows that genetic ablation of the PSC does not cause an increase in blood cell differentiation or a loss of blood cell progenitors. (sdbonline.org)

A Single Element Maintains Repression of the. (prolekarniky.cz)

Researchers there have conducted a systematic review and meta-analysis of the salivary markers that show the highest efficacy for the early detection of oral cancer in different clinical trials. (dentistrytoday.com)
The aim was to identify cellular and cytogenetic markers of prognostic relevance to survival of high-risk MDS cases. (who.int)

The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. (sdbonline.org)

Although Gata2 is normally repressed in late-stage erythroblasts, the −1.8 kb mutation unexpectedly resulted in reactivated Gata2 transcription, blocked differentiation, and an aberrant lineage-specific gene expression pattern. (prolekarniky.cz)
Trajectory inference revealed that altered gene expression dynamics accompanied cell differentiation, which could explain age-associated changes in hematopoiesis. (cun.es)

Differentiation is a complex process involving actions of ES cell core factors, lineage specific regulators, epigenetic modifications, and chromatin remodelers. (utexas.edu)

Technological advances in MS techniques have revolutionised the field, enabling the profiling of thousands of lipids in a single assay. (sanbio.nl)

The Centre is strengthened by the Single Cell Genomics Core Facility that implements state-of-the-art single-cell technologies and provides high throughput single-cell isolation and sequence library preparation services. (sanger.ac.uk)
We will give specific focus to methodological and quantitative advances from the fields of genomics and single-cell biology, which have led to a revolution in the way we are understanding aging and tumor evolution. (irbbarcelona.org)

However, there are many different aspects of biology and cellular biochemistry that cannot be explained by these types of systems approaches. (nih.gov)
Your efforts aim to identify and experimentally validate new approaches for cellular therapy of advanced solid cancers. (varbi.com)

20 mg of each tissue sample was used for the isolation of total cellular RNA. (nel.edu)

Single-cell genome analyses overcome these issues. (sanger.ac.uk)

When faced with these environmental hazards, progenitors may deviate from their correct pathway or change their potential, leading to a reduction in the pool of progenitors available for later stages of differentiation. (elifesciences.org)
The PSC contributes to lymph gland homeostasis by regulating blood cell differentiation, rather than by maintaining core progenitors. (sdbonline.org)

Further, premature blood cell differentiation when PSC specification or signaling was impaired, led to assigning the PSC a role equivalent to the vertebrate hematopoietic niche. (sdbonline.org)

Immune modulation of HIV-1 reservoir size in early-treated neonates. (harvard.edu)
Initial analysis of Collier/Early B Cell Factor function in the lymph gland revealed the role of the Posterior Signaling Center (PSC) in mounting a dedicated cellular immune response to wasp parasitism. (sdbonline.org)

Mutations in the ALK gene change single protein building blocks (amino acids) in ALK receptor tyrosine kinase. (medlineplus.gov)
Although DmFKBP12 is distributed evenly between the anterior to posterior poles of the blastoderm egg, the protein is expressed more strongly in the cortex of the early Drosophila gastrula with the highest concentration found in the basement membrane of the cellular blastoderm. (biomedcentral.com)

Fertilized egg, through the profile as under-membrane cortex distribution concentering onto basement at cellular blastoderm, to the profile as three-gem layer localization in primitive neuronal and digestion architecture of early Drosophila gastrula. (biomedcentral.com)

Therefore, here we propose a model showing how the airway epithelial renewal and differentiation process could occur. (unimore.it)

Likewise, specific serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins can be modified by N-acetylglucosamine (O-GlcNAc) transferase (OGT), which adds a single sugar N-acetylglucosamine. (nih.gov)
Lipid research encompasses the large-scale profiling of cellular lipids, the quantification of specific lipids in biological samples and the documentation of the interactions between lipids and other lipids, proteins and metabolites within the body. (sanbio.nl)

Lipid analysis can be challenging due to the sheer number of different cellular lipids, which can range from tens to hundreds of thousands, and their varied concentration in samples. (sanbio.nl)

Here, by performing single-cell RNA sequencing, spatial transcriptomics and in situ sequencing, we integrate the datasets and provide a comprehensive single-cell and spatial transcriptomic atlas of the developing human spinal cord of the first trimester, from postconceptional week 5 to 12. (scilifelab.se)

The state-of-the-art apparatus offers a high throughput system for screening at sub-cellular level. (lu.se)

Uncovering how an entire class of non-coding RNAs, called circular RNAs, are formed and regulated across cell differentiation lead to a seminal publication in the field. (edu.au)

We are developing single-cell genome sequencing technologies to enable the discovery of the entire spectrum of DNA mutation -including the acquisition of ploidy changes, aneuploidies, copy number variants, structural variants, retrotranspositions, indels, and single nucleotide variants. (sanger.ac.uk)

Anatomy54

Organisms10

Diseases7

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes70

Disciplines and Occupations2

Information Science4

Mesenchymal Stem2

Growth and differentiation factors2

Morphogenesis4

Embryonic5

Proliferation and differentiation2

Transcriptional4

Maturation2

Terminal differentiation4

Stem cells6

Processes9

20231

Developmental4

Cell proliferation1

Embryo3

Epigenetic landscape2

Gastrulation2

Pathways1

Trajectories2

Role of cellular heterogeneity1

Progenitor cells3

Mechanisms4

Regulator2

Heterogeneity2

Epithelial cells2

Molecular biology2

Proliferative1

Development17

Organs1

Mesoderm1

Cells16

Lymphocyte4

Genes1

Functional2

Vitro1

Genetic2

Repression1

Markers2

Cues1

Gene expression2

Lineage1

Assay1

Genomics2

Approaches2

Tissue1

Analyses1

Progenitors2

Specification1

Immune2

Protein2

Drosophila1

Process1

Proteins2

Lipid1

Transcriptomic1

High throughput1

RNAs1

Nucleotide1