• The anti-cancer medicine works by preventing tumor cells from multiplying and is approved in 76 countries in North America , Europe , South America and Asia for the treatment of advanced soft-tissue sarcomas as a single-agent, and in 69 countries for relapsed ovarian in combination with doxorubicin HCl liposome injection. (medicaex.com)
  • Few agents such as doxorubicin, ifosfamide and dacarbazine have proven to be effective in the therapy of soft tissue sarcomas ( 2 ). (spandidos-publications.com)
  • Doxorubicin, which has been the most frequently used chemotherapeutic agent in the treatment of soft tissue sarcomas, demonstrates response rates of 20-30% in disseminated disease ( 9 , 10 ). (spandidos-publications.com)
  • 1-7 Until recently, numerous agents have been combined with doxorubicin with limited benefit. (emjreviews.com)
  • 4 Aside from doxorubicin-based regimens, novel chemotherapy agents, eribulin and trabectedin, have demonstrated efficacy in the L-sarcomas, liposarcoma (LPS), and leiomyosarcoma (LMS), highlighting the role of histology-directed therapy for these malignancies. (emjreviews.com)
  • Background: Patients with metastatic medullary thyroid cancer (MTC) who progressed under tyrosine kinase inhibitors can benefit from an alkylating agent such as dacarbazine or temozolomide. (bvsalud.org)
  • Temozolomide is an alkylating agent and an antitumor drug, which can pass through the blood-cerebrospinal fluid barrier and is clinically used for the first-line treatment of brain tumors. (inclinicaltrials.com)
  • Eligible patients had to have experienced disease progression within the preceding 12 months and to have had no prior treatment with temozolomide, dacarbazine, capecitabine, or fluorouracil. (ascopost.com)
  • Dacarbazine and temozolomide: These traizene derivatives have mechanism of action: Methyl xanthines act in a salad or to a comparison of surgical site infections in children with lennox-gastaut syndrome. (riversideortho.com)
  • History of serious hypersensitivity to temozolomide or any other ingredients in TEMODAR and dacarbazine. (nih.gov)
  • Dacarbazine, also known as imidazole carboxamide and sold under the brand name DTIC-Dome, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. (wikipedia.org)
  • As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin's lymphoma, and in the MAID regimen for sarcoma. (wikipedia.org)
  • In this phase III trial, 502 patients with previously untreated metastatic melanoma were randomized to receive either ipilimumab plus dacarbazine, or dacarbazine plus placebo. (hcplive.com)
  • A combination of BRAF inhibitor, dabrafenib, and MEK inhibitor, trametinib, has shown promise in patients with advanced melanoma, including fewer serious side effects than the current standard single-agent BRAF-targeted therapy, vemurafenib. (hcplive.com)
  • The phase III COMBI-d trial will evaluate the combination of the two investigational agents versus dabrafenib alone in stopping or slowing the progression of metastatic melanoma, with a primary endpoint of PFS. (hcplive.com)
  • The phase III COMBI-v trial will compare the two investigational agents against the FDA-approved BRAF inhibitor, vemurafenib, in improving OS in patients with metastatic melanoma. (hcplive.com)
  • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. (hcplive.com)
  • These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma. (biomedcentral.com)
  • Dacarbazine was the mainstay in chemotherapy for metastatic melanoma for over two decades before the advent of immunotherapy and BRAF inhibitors around 10 years ago. (icvi.org.uk)
  • Advances in our understanding of melanoma molecular biology and host immunology have given ways to novel targets and therapeutic agents that have demonstrated unprecedented results in the management of metastatic disease and currently are being tested in the adjuvant stetting where recent data support a significant clinical impact of adjuvant ipilimumab. (amegroups.org)
  • Both drugs have been hailed as a major advance in melanoma care, as they are the first new agents in over a decade to show any improvement in survival for patients with the disease. (clinicalprofessionals.co.uk)
  • Zelboraf's approval was supported by a single international trial of 675 previously-untreated patients with late-stage melanoma. (clinicalprofessionals.co.uk)
  • In this open-label, phase 3 trial, we randomly assigned previously untreated HLA-A*02:01-positive patients with metastatic uveal melanoma in a 2:1 ratio to receive tebentafusp (tebentafusp group) or the investigator's choice of therapy with single-agent pembrolizumab, ipilimumab, or dacarbazine (control group), stratified according to the lactate dehydrogenase level. (fcshemoncreview.com)
  • A number of biologic agents have been approved or are being studied for the treatment of high-risk melanoma. (limamemorial.org)
  • Rafael Amado, Head of Oncology R&D for GlaxoSmithKline, said: "The results from the clinical studies of dabrafenib and trametinib presented at this meeting represent important progress towards understanding how these investigational agents could benefit patients with advanced and metastatic melanoma. (ilmelanoma.com)
  • The BREAK3 Study - a Phase III, randomized, open-label study which compared the tolerability, safety and efficacy of dabrafenib to dacarbazine in individuals with Sage III (advanced) or Stage IV (metastatic) melanoma. (ilmelanoma.com)
  • The approval of dabrafenib is based on results from one multicenter, international trial, specifically the pivotal, open-label Phase III BREAK-3 study that randomised 250 previously untreated adult patients with BRAF V600E mutation-positive unresectable or metastatic melanoma to receive dabrafenib or dacarbazine (chemotherapy) in a 3:1 ratio, respectively. (ilmelanoma.com)
  • Patient Findings: We describe two patients with metastatic MTC who developed a hypermutant phenotype after alkylating agent treatment. (bvsalud.org)
  • Although many chemotherapy regimens can be used in the second and third trimesters, other agents, such as rituximab and tyrosine kinase inhibitors (TKIs), should be avoided due to high risks of fetal harm. (cancertherapyadvisor.com)
  • The most common regimens within the cohort were adriamycin, cyclophosphamide and taxane, capecitabine and oxaliplatin (CAPOX), paclitaxel + carboplatin and a single agent cisplatin given concurrently with radiotherapy. (ecancer.org)
  • 1,334 patients with previously untreated advanced classical Hodgkin lymphoma were enrolled in the trial, and the safety profile of Adcetris+AVD was consistent with that known for the single-agent components of the regimen. (globalgenes.org)
  • Agents targeting vascular endothelial growth factors, platelet-derived growth factors, and cyclin-dependent kinases 4 and 6 have all shown some efficacy in various STS subtypes. (emjreviews.com)
  • 20,21 The increased efficacy of these agents is due to the complex STS genomic landscape, including alterations to KIT, PDGFR-β, vascular endothelial growth factor receptors (VEGFR), and colony stimulating factor-1. (emjreviews.com)
  • Dacarbazine was proven to be just as efficacious as procarbazine, another drug with similar chemistry, in the German trial for paediatric Hodgkin's lymphoma, without the teratogenic effects. (wikipedia.org)
  • than were interleukin-2-treated patients (16% vs 6%, P =.03) Patients receiving the combination also had increased average survival (by 7 months) over the single agent-from 11.1 months to 17.8 months. (hcplive.com)
  • We are planning regulatory submissions for dabrafenib and trametinib as single agent therapies and have recently started a Phase III programme to further investigate the effect of the combination in this disease. (ilmelanoma.com)
  • Fibromun has shown potent anti-tumor activity, both as single agent and in combination with other drugs, in several immunocompetent preclinical models inducing in most cases long-lasting complete responses. (philogen.com)
  • The predominant regimen was the weekly/bi-weekly intravenous administration of STZ combined with other oral anticancer agents. (cancerindex.org)
  • The investigation of ADCETRIS as a single agent or in novel combinations with other agents demonstrates its continued potential to help people impacted by early- and advanced stage Hodgkin lymphoma," said Marjorie Green, M.D., Senior Vice President and Head of Late-Stage Development at Seagen. (businesswire.com)
  • It is used as an antineoplastic agent and to induce diabetes in experimental animals. (cancerindex.org)
  • This review describes advances in chemotherapy, molecularly targeted, and immunotherapy agents for STS. (emjreviews.com)
  • At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
  • They cannot for antiemetic treatment, the number of agents, and the indica- be considered to be inclusive of all proper methods of care or tions for antiemetics have all increased as well. (marysfamilymedicine.org)
  • There are no studies that examine the effects of treatment with immune checkpoint inhibitors during pregnancy, with the exception of a single case report. (cancertherapyadvisor.com)
  • Several published clinical trials provide evidence that Doxil is an active agent in multiple myeloma and it is used in treatment combinations for multiple myeloma in general practice. (drugpatentwatch.com)
  • We believe this new option, given as a single injection administered in less than five minutes, could transform the treatment experience for both patients and physicians. (businesswire.com)
  • Although encompassing a diverse array of agents that act on the anti-tumoral immune system (e.g. monoclonal antibodies, small molecules, tumor vaccines, and viral or cellular therapies), the most frequently utilized immunotherapies are immune checkpoint inhibitors (ICIs). (bmj.com)
  • Asparaginase as a single agent induces in the majority of the cases a complete remission, but because this time is usually short, the administration of other chemotherapy agents is needed. (vin.com)
  • Marine-derived chemotherapy agents, eribulin and trabectedin, are active in selecting STS subtypes. (emjreviews.com)
  • The median PFS was 5.1 months with dabrafenib (95% CI: 4.9, 6.9) compared to 2.7 months with dacarbazine (95% CI: 1.5, 3.2). (ilmelanoma.com)
  • Dacarbazine is considered to be highly emetogenic, and most patients will be pre-medicated with dexamethasone and antiemetic drugs like 5-HT3 antagonist (e.g., ondansetron) and/or NK1 receptor antagonist (e.g., aprepitant). (wikipedia.org)
  • not intended to supplant physician judgment with respect to As antiemetic usage has grown, the classes of agents available particular patients or special clinical situations. (marysfamilymedicine.org)
  • Updated results will also be presented from a phase 1 study of the investigational agent SEA-BCMA in patients with relapsed/refractory multiple myeloma. (businesswire.com)
  • Bristol Myers Squibb is inspired by a single vision - transforming patients' lives through science. (businesswire.com)
  • PD-1 inhibitors are commonly used today rather than ipilumimab and interferon formulations due to lesser toxicity with these agents. (medscape.com)
  • Therefore, we recommend that STZ, which is the only cytotoxic agent available against NET, should be used in daily practice in Japan. (cancerindex.org)
  • Similar to the selective activity of cytotoxic agents and small molecule inhibitors, immunotherapy, which has revolutionised management of numerous cancers, has also demonstrated activity in select STS subtypes. (emjreviews.com)
  • The company's broad therapeutic portfolio currently includes novel agents in oncology, haematology, neurology, ophthalmology and supportive care. (scitechanddigital.news)
  • In 2010, Vical reported encouraging results in Phase 2 trial, a single-arm, open-labeled study in which 127 chemo-refractory or chemo-intolerant patient subjects were treated with high-dose Allovectin-7. (drugdiscoverynews.com)
  • YONDELIS ® (trabectedin) is a novel, multimodal, synthetically produced antitumor agent, originally derived from the sea squirt , Ecteinascidia turbinata . (scitechanddigital.news)
  • Both agents are effective in liposarcoma, while trabectedin also has activity in leiomyosarcoma. (emjreviews.com)
  • Dacarbazine as single-agent therapy for relapsed lymphoma in dogs. (nih.gov)
  • Over the next five years, Dr. Chawla's medical research will continue its focus on development of cancer gene therapy, vaccines, immunotherapies (treatments that use the body's own defenses to combat cancer) and anti-angiogenic agents (drugs to block development of blood vessels and starve the tumor) to treat soft-tissue sarcomas. (sarcomaoncology.com)
  • Drug therapy only suppresses the respiratory mucosa , tetracyclines and chloramphenicol chapter 30: Antifungal agents chapter 21: Emetics. (riversideortho.com)
  • Beginning 4 weeks after the end of radiotherapy, administer TEMODAR orally in a single dose on days 1-5 of a 28-day cycle for 12 cycles. (nih.gov)
  • Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. (wikipedia.org)
  • The median overall PFS was 7.4 months (95% CI, 5.5-9.2), which was comparable to results with single-agent vemurafenib. (hcplive.com)
  • This study is a single-center, prospective, one-arm clinical study, which is planned to be carried out in Cancer Hospital of Chinese Academy of Medical Sciences. (inclinicaltrials.com)
  • For injection: 100 mg as a lyophilized powder in single-dose vial for reconstitution. (nih.gov)
  • Consequently, this review (which is being presented in two parts) consists of a perspective on current opportunities and the "work in progress" and is not a compendium of clinical trials with novel targeted agents still seeking an indication. (cancernetwork.com)
  • This phenotype was characterized by a high tumor mutational burden (TMB) and a mutational signature indicative of alkylating agent mutagenesis (single-base substitution 11). (bvsalud.org)