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Sin3 Histone Deacetylase and Corepressor ComplexHistone Deacetylase InhibitorsHistone DeacetylasesHistone Deacetylase 1Histone Deacetylase 2HistonesNuclear Receptor Co-Repressor 2Nuclear Receptor Co-Repressor 1Hydroxamic AcidsRepressor ProteinsAcetylationCo-Repressor ProteinsMi-2 Nucleosome Remodeling and Deacetylase ComplexNuclear ProteinsDNA-Binding ProteinsTranscription, GeneticTranscription FactorsChromatinHistone AcetyltransferasesProtein BindingPromoter Regions, GeneticValproic AcidDepsipeptidesGene SilencingButyratesEnzyme InhibitorsCell LineCell Line, TumorProtein Structure, TertiaryMolecular Sequence DataGene Expression RegulationHeLa CellsSaccharomyces cerevisiae ProteinsReceptors, Thyroid HormoneImmunoglobulin J Recombination Signal Sequence-Binding ProteinAmino Acid SequenceTranscriptional ActivationSirtuin 1SirtuinsEpigenesis, GeneticAlcohol OxidoreductasesChromatin ImmunoprecipitationTwo-Hybrid System TechniquesReceptors, Retinoic AcidNucleosomesCell NucleusMutationMultiprotein ComplexesBinding SitesModels, BiologicalTransfectionGene Expression Regulation, FungalSin Nombre virusHistone DemethylasesMethylationHistone-Lysine N-Methyltransferasep300-CBP Transcription FactorsZinc FingersBlotting, WesternSignal TransductionRecombinant Fusion ProteinsSirtuin 2Receptors, NotchPrecipitin TestsChromatin Assembly and DisassemblyTrans-ActivatorsReceptors, Cytoplasmic and NuclearPhenylbutyratesAcetyltransferasesBasic Helix-Loop-Helix Transcription FactorsHistone CodeHomeodomain ProteinsCell DifferentiationApoptosisRetinoblastoma-Binding Protein 4DNA MethylationHistone ChaperonesCell CycleCell ProliferationProtein Processing, Post-TranslationalChromosomal Proteins, Non-HistoneAzacitidineBase SequenceRNA, Small InterferingRNA, MessengerProto-Oncogene ProteinsButyric AcidCyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, NeoplasticCell Cycle ProteinsSaccharomyces cerevisiaeDown-RegulationReverse Transcriptase Polymerase Chain ReactionAntineoplastic AgentsHeterochromatinGenes, ReporterIsobutyratesMacromolecular SubstancesImmunoprecipitationCells, Cultured
HDACTranscriptional corepressorChromatinInteractsSubunitProteinsProteinTRANSCRIPTIONRepressionFunctionalMSin3aCaenorhabditisDistinctEssentialCoreActivityDomainEffectsSourceDevelopmentDeacetylationTranscriptionalHDACsSIN3AMethylationIntrinsic histoneHDAC1VivoResiduesInteractionMSin3AProtein complexesMeCP2HelixEnzymeComplejoMechanismGene expressionDiseasesRepressorsGenesRoleAdditionEnzymesTermFormBiological
HDAC4
  • FUNCTION: Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. (genebe.net)
  • The key co-repressor complex components HDAC-2, Mi-2α/β and mSin3a are all critical to the regulation of gene transcription. (biomedcentral.com)
  • Wild type, PI3Kγ knock-out (PI3Kγ -/- ) and PI3K kinase dead knock-in (PI3Kδ D910/A910 ) transgenic mice were exposed to cigarette smoke for 3 days and the expression levels of the co-repressor complex components HDAC-2, mSin3a, Mi-2α and Mi-2β and HDAC-2 activity in the lungs were assessed. (biomedcentral.com)
  • SIN3-HDAC complex associated fac. (gsea-msigdb.org)
Transcriptional corepressor2
  • The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. (wikipedia.org)
  • SAP30 is a core subunit of the transcriptional corepressor SIN3 complex, but little is known about its role in gene regulation and human cancer. (bvsalud.org)
Chromatin2
  • The PAH2 domain of the scaffold protein SIN3A interacts with the specific Sin3 Interaction Domain (SID) of several transcription factors, such as MAD1, bringing chromatin-modifying proteins such as histone deacetylases, and it targets chromatin for specific modifications. (bvsalud.org)
  • The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. (natprobiotech.com)
Interacts2
  • Pf1 interacts with Sin3 through two independent Sin3 interaction domains (SIDs), Pf1SID1 and Pf1SID2. (psu.edu)
  • We show that Pf1 interacts with a mammalian homolog of the Drosophila Groucho corepressor, transducin-like enhancer (TLE). (psu.edu)
Subunit1
Proteins1
  • HDACs function by deacetylating of key components of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed conformation [ 1 , 16 ]. (biomedcentral.com)
Protein3
  • It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. (antikoerper-online.de)
  • The impact of oxidative stress on key components of the co-repressor complexes have only just started to be explored, with the very recent publication highlighting the impact of oxidative stress driven protein kinase-CK2 activation on co-repressor activity and HDAC2 function [ 20 ]. (biomedcentral.com)
  • Sin3 has four paired amphipathic alpha helices (PAH1 to -4) that are protein-protein interaction motifs and is the scaffold upon which the complex assembles. (psu.edu)
TRANSCRIPTION4
  • A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES. (bvsalud.org)
  • Gene transcription is tightly regulated by a highly complex and dynamic set of processes central to which is the recruitment of co-repressors to promoter bound sequence specific transcription factors [ 1 - 3 ]. (biomedcentral.com)
  • Pf1 associates with mSin3A in vivo and recruits the mSin3A complex to repress transcription when fused to the DNA binding domain of Gal4. (psu.edu)
  • Pf1 binds TLE in an mSin3A-independent manner and recruits functional TLE complexes to repress transcription. (psu.edu)
Repression3
  • Furthermore, we found that the Sin3 histone deacetylase complex was required to sustain H3K27me3 occupancy and stably maintain gene repression by directly interacting with P55. (bvsalud.org)
  • Our results revealed a novel mechanism by which P55 and Sin3 participate in the normal distribution of facultative heterochromatic modifications and the stable maintenance of gene repression in eukaryotes. (bvsalud.org)
  • Mutations in a minimal fragment of Pf1 that encompasses Pf1SID1 inhibited mSin3A binding yet only slightly impaired repression when targeted to DNA, implying that Pf1 might interact with other corepressors. (psu.edu)
Functional1
  • Although the latter is predominantly associated with the NuRD complex they are structurally similar and no functional or cell type specific differentiation between Mi-2α and Mi-2β has yet been made [ 6 ]. (biomedcentral.com)
MSin3a2
  • Both the mSin3a and Mi-2/NuRD co-repressor complexes are large multi-component complexes in which not all of the components and their functions have been identified [ 2 , 6 ]. (biomedcentral.com)
  • The mSin3A-histone deacetylase corepressor is a multiprotein complex that is recruited by DNA binding transcriptional repressors. (psu.edu)
Caenorhabditis1
  • The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans. (ritsumei.ac.jp)
Distinct1
  • Buehl CJ, Goff NJ, Hardwick SW, Gellert M, Blundell TL, Yang W, Chaplin AK , Meek K. Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. (le.ac.uk)
Essential1
  • Kuzdere T, Flury V, Schalch T , Iesmantavicius V, Hess D, Bühler M. Differential phosphorylation of Clr4SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis. (le.ac.uk)
Core1
  • Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. (genebe.net)
Activity1
  • Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K . The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. (le.ac.uk)
Domain2
  • SET domain bifurcated histone ly. (gsea-msigdb.org)
  • This study developed a high-throughput, next-generation sequencing-based screening method, repressive-domain (RD)-seq, to systematically identify RDs in complex DNA-fragment libraries. (sdbonline.org)
Effects2
  • The MLH and MutL ketoacyl-CoA species extend with complexes of MutS analyses to exchange signal subsequent effects. (erik-mill.de)
  • The steps of infantile sites linked and represented extensively form UniProt ECM-associated gene whereby effects circulate to the associated building before any further complex. (erik-mill.de)
Source2
Development1
  • Development in higher organisms requires proper gene silencing, partially achieved through trimethylation of lysine 27 on histone H3 (H3K27me3). (bvsalud.org)
Deacetylation4
  • 1. Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. (nih.gov)
  • 5. Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. (nih.gov)
  • Presumably all SID-containing proteins are targeted to a DNA region either by direct DNA binding or interaction with a DNA-binding partner, and recruit the Sin3-complex, which ultimately leads to deacetylation and repression of transcription. (eu.org)
  • Histone acetylation and deacetylation affect the patterns of gene expression in cellular differentiation, playing pivotal roles in tissue development and maintenance. (bvsalud.org)
Transcriptional7
  • The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. (wikipedia.org)
  • 13. Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. (nih.gov)
  • Sin3 specifically interacts with a diverse set of transcriptional repressors, the first of which were identified as the MAD-family members. (eu.org)
  • The modulation of chromatin accessibility is one of the key mediators of transcriptional regulation, and variation in chromatin accessibility across individuals has been linked to complex traits and disease susceptibility. (biomedcentral.com)
  • One class of repressors function as transcriptional 'poisons', forming protein complexes with activators to retain them in the cytoplasm, or rendering them unable to bind DNA. (biologists.com)
  • SAP30 is a core subunit of the transcriptional corepressor SIN3 complex, but little is known about its role in gene regulation and human cancer. (bvsalud.org)
  • For example, the intrinsic histone acetyltransferase activity of transcriptional coactivator p300 is especially required for the expression of myogenic regulatory factors including Myf5 and MyoD, and consequently for skeletal myogenesis. (bvsalud.org)
HDACs2
SIN3A1
  • MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al. (nih.gov)
Methylation4
Intrinsic histone1
  • 15. In vitro targeting reveals intrinsic histone tail specificity of the Sin3/histone deacetylase and N-CoR/SMRT corepressor complexes. (nih.gov)
HDAC11
  • Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. (nih.gov)
Vivo1
  • 14. Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. (nih.gov)
Residues1
  • A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE residues of NUCLEOSOMES . (bvsalud.org)
Interaction1
  • To study more complex relationships involving multiple biological interaction types, we assembled an integrated Saccharomyces cerevisiae network in which nodes represent genes (or their protein products) and differently colored links represent the aforementioned five biological interaction types. (biomedcentral.com)
MSin3A2
  • In humans, the Sin3 protein has two splice isoforms: mSin3A and mSinB. (eu.org)
  • May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. (nih.gov)
Protein complexes1
  • Examples of network themes include a pair of protein complexes with many inter-complex genetic interactions - the 'compensatory complexes' theme. (biomedcentral.com)
MeCP22
  • Moreover, ChIP experiments demonstrated that EZH2 and MeCP2 repressor complexes were associated to the heavily methylated enhancer region in the absence of RA while both complexes were displaced during RA stimulation. (nih.gov)
  • MeCP2 is also shown to interact with Sin3/Histone deacetylase co-repressor complex. (ukessays.com)
Helix1
  • Sin3 contains paired amphipatic helix repeat domains (PAH) that mediate protein-protein interactions. (eu.org)
Enzyme1
  • Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides. (nih.gov)
Complejo2
  • Complejo de enzimas y BOMBAS DE PROTONES que se encuentran en la membrana interna de la MITOCONDRIA y en las membranas bacterianas. (bvsalud.org)
  • El complejo proteico proporciona energía en forma de gradiente electroquímico, que puede ser utilizado por ATPASAS MITOCONDRIALES TRANSLOCADORAS DE PROTONES o por ATPASAS BACTERIANAS TRANSLOCADORAS DE PROTONES. (bvsalud.org)
Mechanism1
  • Gene-specific targeting of the Sin3 co-repressor complex by DNA-bound repressors is an important mechanism of gene silencing in eukaryotes. (eu.org)
Gene expression1
  • In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini. (biologists.com)
Diseases1
  • TEs can affect nearby gene activity and have been linked to complex traits and diseases, including cancer and diabetes [ 13 , 14 ]. (biomedcentral.com)
Repressors1
  • Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors. (biologists.com)
Genes1
  • The development of complex, multicellular organisms requires that transcription of many genes be spatially restricted. (biologists.com)
Role1
  • BACKGROUND: This study aimed to investigate the role of histone deacetylase 5 (HDAC5) in ventricular remodeling and explore the therapeutic potential of the HDAC5 inhibitor LMK235. (bvsalud.org)
Addition1
  • In addition, Sin3 has a histone deacetylase binding site. (eu.org)
Enzymes1
  • A complex of enzymes and PROTON PUMPS located on the inner membrane of the MITOCHONDRIA and in bacterial membranes. (bvsalud.org)
Term1
  • 3. Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation. (nih.gov)
Form1
  • The protein complex provides energy in the form of an electrochemical gradient, which may be used by either MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES or BACTERIAL PROTON-TRANSLOCATING ATPASES. (bvsalud.org)
Biological2
  • Representing networks in terms of network themes provides a useful simplification of complex biological relationships. (biomedcentral.com)
  • The brain arguably is one of the most complex biological tissues and enables the organism to sense, remember, and respond to its environment. (nih.gov)