Largely based on SHARP, current guidelines recommend the use of statin monotherapy or ezetimibe plus statin for nearly all individuals ≥50 years old with reduced eGFR. (renalfellow.org)
Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial. (mdedge.com)
And that is found to be possible only with combination therapy than with statin monotherapy. (cmhealthfoundation.org)
Atorvastatin2
Using the search terms atorvastatin, simvastatin,pravastatin, rosuvastatin, fluvastatin, lovastatin, prospective trial, and randomized trial, the MEDLINE/EMBASE and the Cochrane Collaboration databases were reviewed for prospective randomized primary and secondary prevention trials of statin monotherapy. (unboundmedicine.com)
This study analysed the rates of cancer in adverse event reports filed with the US FDA in people taking ezetimibe, either alone or in combination with simvastatin and compared them with those taking simvastatin, atorvastatin or rosuvastatin. (centreformedicinesoptimisation.co.uk)
Ezetimibe plus simvastatin6
Among individuals with CKD, the strongest single-trial supporting cardiovascular risk-lowering benefit for statin therapies was demonstrated with ezetimibe plus simvastatin compared with placebo in the Study of Heart and Renal Protection (SHARP) , which demonstrated combination therapy with ezetimibe plus simvastatin was associated with primary cardiovascular risk reduction (major atherosclerotic events) for individuals with CKD, including those with severe reductions eGFR, including dialysis. (renalfellow.org)
The Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) demonstrated an additional benefit of ezetimibe plus simvastatin (compared with simvastatin alone) in preventing cardiovascular outcomes among individuals with known coronary artery disease. (renalfellow.org)
In IMPROVE-IT, individuals randomized to combination therapy with ezetimibe plus simvastatin experienced a greater mean reduction in both LDL cholesterol and triglycerides across all levels of eGFR. (renalfellow.org)
This seems to be the case here where the rates of cancer adverse event reports with ezetimibe and ezetimibe plus simvastatin, , appear significantly lower than for the statins studied. (centreformedicinesoptimisation.co.uk)
In spite of the limitations, post-marketing surveillance is a useful source of information about adverse effects and the findings from this large-scale analysis are consistent with the interim evidence from two large trials of ezetimibe plus simvastatin . (centreformedicinesoptimisation.co.uk)
In the Sprague-Dawley rat, very high, pharmacologically comparable dosages (150-1200 mg/kg/day) of structurally similar HMGRIs (lovastatin, simvastatin, pravastatin and L-647, 318) produced dose-related increases in the incidence and severity of skeletal muscle degeneration. (aspetjournals.org)
Lipid7
Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
These studies affirm the capacity of Berberine to reduce the "lipid profile" in patients who suffer of conditions like hypercholesterolemia or, more generally hyperlipidemia, whether administered as a monotherapy or in combination with common medications. (aliveda.com)
Combination of simvastatin with berberine improves the lipid-lowering efficacy. (aliveda.com)
Prescribers should continue to use evidence-based statins (e.g. simvastatin 40mg/day) first-line in most patients who require a lipid-lowering agent. (centreformedicinesoptimisation.co.uk)
Hypercholesterolemia2
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. (druglib.com)
We aimed to investigate the antidepressant effects of simvastatin as an adjuvant therapy in patients with moderate to severe depression. (druglib.com)
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (druglib.com)
A 2018 Cochrane meta-analysis included 10 RCTs (N = 21,919 patients) that evaluated the efficacy and safety of ezetimibe plus a statin (dual therapy) vs a statin alone or plus placebo (monotherapy) for the secondary prevention of CVD. (mdedge.com)
Fenofibrate with simvastatin is indicated as adjunctive therapy to diet and exercise in high cardiovascular risk patients with mixed dyslipidaemia to reduce triglycerides and increase HDL-C levels when LDL-C levels are adequately controlled with the corresponding dose of simvastatin monotherapy. (medscape.co.uk)
Dose of fenofibrate with simvastatin should not exceed 145 mg/20 mg daily in patients taking amiodarone, amlodipine, diltiazem or verapamil. (medscape.co.uk)
Patients were treated with Berberine, simvastatin, or the combination of both for two months. (aliveda.com)
Placebo1
The 2015 IMPROVE-IT study, the largest included in the Cochrane review, was a double-blind RCT (N = 18,144) conducted at 1147 sites in 39 countries comparing simva-statin 40 mg/d plus ezetimibe 10 mg/d (dual therapy) vs simvastatin 40 mg/d plus placebo (monotherapy). (mdedge.com)
Statins3
Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
An analysis of post-marketing adverse event reports did not find any increased risk of cancer with ezetimibe▼ compared with statins, either alone or when taken in combination with simvastatin. (centreformedicinesoptimisation.co.uk)
NICE guidance on ezetimibe seems sensible - use ezetimibe monotherapy only if statins are contraindicated or not tolerated, and ezetimibe in combination with a statin in some limited circumstances where statins have not appropriately controlled cholesterol levels, despite appropriate dose titration and consideration of switching statins. (centreformedicinesoptimisation.co.uk)
Dosage1
500mg.org offers you the possibility to purchase inexpensive Simvastatin 5, 10, 20, 40 mg online and also find out more about Simvastatin side effects, dosage information and drug interactions. (llclinic.com)
Zocor2
Purchase Simvastatin without a prescription or Generic Zocor from 500mg.org and get exceptional drug on reduced international prices. (llclinic.com)
Buy generic Zocor online at the finest affordable cost from 500mg.org and get your Simvastatin pills sent at your doorstep in time. (llclinic.com)
Cardiovascular1
Riesgo coronario atribuible a los factores de riesgo cardiovascular en población española. (guiasalud.es)
Toxicity2
Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it may increase following concomitant drug therapy with the immunosuppressant, cyclosporine A (CsA), and possibly with certain other hypolipidemic agents. (aspetjournals.org)
Hepatic2
Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
Abbott received U.S. Food and Drug Administration (FDA) approval for SIMCOR(R), the first fixed-dose combination of two widely prescribed cholesterol therapies, Niaspan(R) (Abbott's proprietary niacin extended-release) and simvastatin. (worldpharmanews.com)
In another study, also conducted by Kong and colleagues in 2008, the ability of Berberine to reduce cholesterol and triglyceride concentrations was evaluated in comparison to simvastatin, a commonly used medication to treat these conditions. (aliveda.com)
Myopathy2
The SEARCH genome-wide association study, which has been independently replicated, found a significant association between the rs4149056 (c.521T>C) single-nucleotide polymorphism (SNP) in the SLCO1B1 gene, and myopathy in individuals taking 80 mg simvastatin per day, with an odds ratio of 4.5 per rs4149056 C allele. (plos.org)
Using data from the SEARCH study, calculated values for the clinical sensitivity, specificity, positive- and negative-predictive values of a test for the C allele to predict definite or incipient myopathy during 5 years of 80 mg/day simvastatin use were 70.4%, 73.7%, 4.1% and 99.4% respectively. (plos.org)
But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
The risk for clinically meaningful interactions by other medicinal products on linagliptin is low and in clinical studies linagliptin had no clinically relevant effect on the pharmacokinetics of metformin, glyburide, simvastatin, warfarin, digoxin or oral contraceptives. (ekbd.net)
Prescriptions2
Simvastatin was approved for use in the United States in 1991 and is still widely used with more than 40 million prescriptions being filled yearly. (nih.gov)
Having the ability to buy Simvastatin online or have other prescriptions filled online saves time, effort, and the price of a very long excursion. (llclinic.com)
Acute2
Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)
Simvastatin in the acute respiratory distress syndrome. (druglib.com)
Medications1
Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
Therapy1
Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
Oral1
After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. (druglib.com)
However, access to an authorized pharmacist is a phone call away when individuals buy Simvastatin online with trustworthy online sources. (llclinic.com)
Comparison1
By comparison, the best online sources for prescription drugs like Simvastatin frequently have wide-ranging drug info right on the website, so consumers can get replies to their questions quickly and readily when they purchase Simvastatin 5, 10, 20, 40 mg online, and they can easily print out the tips for future reference. (llclinic.com)
Effect1
Berberine demonstrates a comparable, if not superior, effect to Simvastatin. (aliveda.com)