• In fluid dynamics, turbulence modeling is the construction and use of a mathematical model to predict the effects of turbulence. (wikipedia.org)
  • For most real-life turbulent flows, CFD simulations use turbulent models to predict the evolution of turbulence. (wikipedia.org)
  • These turbulence models are simplified constitutive equations that predict the statistical evolution of turbulent flows. (wikipedia.org)
  • In this model, the additional turbulence stresses are given by augmenting the molecular viscosity with an eddy viscosity. (wikipedia.org)
  • Still, turbulence models which employ the Boussinesq hypothesis have demonstrated significant practical value. (wikipedia.org)
  • Beyond this, most eddy viscosity turbulence models contain coefficients which are calibrated against measurements, and thus produce reasonably accurate overall outcomes for flow fields of similar type as used for calibration. (wikipedia.org)
  • More general turbulence models have evolved over time, with most modern turbulence models given by field equations similar to the Navier-Stokes equations. (wikipedia.org)
  • Professor Alfio Quarteroni of the École Polytechnique Fédérale de Lausanne (EPFL, Switzerland) is leading the Mathcard project in developing mathematical models of the blood flow in our cardiovascular system. (europa.eu)
  • In recent years, a novel research direction was initiated with a focus on the mathematical modelling, advanced computational simulations, and state-of-art experiments based on the combined particle imaging velocimetry (PIV) and magnetic resonance imaging (MRI) to mimic complex blood and air flows in the patient-specific cardiovascular and respiratory systems. (tudelft.nl)
  • He and his team use mathematical computation to research and develop beating heart simulations, modeling the interactions of the heart's fluid movement, physical structure, and electrical system. (unc.edu)
  • Further research concentrates on the development, the analysis, and the simulation of mathematical models for a better understanding of biological flows and biological tissues. (wias-berlin.de)
  • Current topics include the modeling of blood flows in the cardiovascular system, the development of multiscale methods for the simulation of vascularized tissues and biomaterials. (wias-berlin.de)
  • Turbulent flows are commonplace in most real-life scenarios, including the flow of blood through the cardiovascular system, the airflow over an aircraft wing, the re-entry of space vehicles, besides others. (wikipedia.org)
  • In fact, although in the introduction to the problem (paragraphs 1-8), Euler focuses on the discussion on blood flow through arteries, to such a degree to even proposing adhoc models for the behavior of their elastic cross-sections, surprisingly, and also somehow disappointing, is that the main body of the manuscript (paragraphs 9-34) is devoted to the modeling of flows through rigid tubes, driven by a piston pump. (scirp.org)
  • Image processing tools based on mathematical algorithms from statistics or variational methods enable a bulk of applications in the medical sciences. (wias-berlin.de)
  • Emphasis is given to the setup of physiologically accurate models associated with some vascular diseases built on virtual realistic geometries reconstructed from in vivo medical images, and to the use of highly integrated and efficient numerical algorithms for their simulation at acceptable computational costs. (utl.pt)
  • The theme this year is data for social justice, and our five teams will investigate mathematical algorithms and computational tools to analyze data in a wide range of applications. (emory.edu)
  • The team spent several years honing and refining the underlying mathematical modeling algorithms enabling HARVEY. (technologynetworks.com)
  • An associate professor in the Department of Mathematics at UNC, Griffith runs the Cardiovascular Modeling and Simulation Lab . (unc.edu)
  • Dosimetry models for the lower respiratory tract (LRT) of humans and rats are used to calculate deposition and retention using the principle of particle mass balance in the lower respiratory tract. (cdc.gov)
  • Realistic asymmetric lung geometries using detailed morphomet- ric measurements of the tracheobronchial (TB) airways in rats and humans are employed in model calculations. (cdc.gov)
  • Dr. Shroff has been serving as the Principal Investigator on a NIH-NHLBI pre-doctoral training grant (Cardiovascular Bioengineering Training Program) since 2005 and the Coulter Translational Research Partnership II Program since 2013, and Co-Director on a NIH-NHLBI post-doctoral training grant (Training Program in Imaging Sciences in Translational Cardiovascular Research) since 2016. (pitt.edu)
  • The model was then used to simulate the hemodynamic response of hypovolemic subjects (blood volume reduced by 5-15%) subjected to similar gravitational stress and exercise profiles, providing insights into the physiological responses of experimental conditions not tested before. (tamu.edu)
  • It fundamentally requires mathematical modeling for physiological aspects that you can't directly image, but still need to account for. (unc.edu)
  • As an undergraduate student at Rice University, he became interested in heart models while working on a cardiac electrophysiology project with his undergraduate advisor, Steve Cox. (unc.edu)
  • At that time, the existing modelling software included fluid and structural dynamics - but not electrophysiology. (unc.edu)
  • We have invented a unique approach," he continues, "building 3D models for vessels where we need to simulate all details and using lower-order models for other parts. (europa.eu)
  • Dr. Randles is renowned in the scientific community for her innovative work developing HARVEY, a computational fluid dynamics model with the extraordinary capability to simulate the blood flow throughout the human body. (technologynetworks.com)
  • The software and repository are used to simulate cardiovascular and pulmonary solid and fluid mechanics and to provide spatially and temporally resolved benchmark solutions that are used by academic, government, and industry researchers to verify their computational methods. (stanfordchildrens.org)
  • By join DENIS@home you will donate the iddle times of your computer to develop and simulate mathematical models that investigate the heart. (usj.es)
  • These models are complex and it's neccessary to simulate them many times (varying the conditions or model parameters). (usj.es)
  • Cardiovascular diseases are responsible for 50 % of natural deaths in the EU. (europa.eu)
  • Mathematical models and computational techniques are nowadays utilized in medical sciences for noninvasive diagnostic, diseases characterization, therapy planning, and treatment monitoring. (wias-berlin.de)
  • Now a UNC mathematician, he creates computational models of the human heart to improve the prediction and treatment of cardiac diseases. (unc.edu)
  • More than 17 million people die each year of cardiovascular diseases (CVDs). (usj.es)
  • Primary symptoms are similar to those of other mixed-effects model was constructed, with adjustment viral diseases, and include fever, headache, myalgia, for possible confounding or random effects, to analyse the and gastrointestinal symptoms, with haemorrhagic time trend in CCHF seropositivity. (who.int)
  • Quantitative Biomedicine deals with the modeling, analysis, simulation, or optimization of complex systems in clinical and biological applications. (wias-berlin.de)
  • The research at WIAS focuses on efficient and robust models for biological tissues and fluids, on the usage of advanced mathematical models in data assimilation and medical imaging applications, as well as on techniques in optimization, machine learning, and optimal control for decision support in biomedicine. (wias-berlin.de)
  • First of all, the optimization of the new model we are developing has already finished (the first one we released). (usj.es)
  • The optimization has worked very well and many markers have been improved, but one of the model issues that we are trying to fix has reappeared after the optimization. (usj.es)
  • Before starting again, we are testing various optimization settings to try to optimize the model without getting to the point where the problem reappears. (usj.es)
  • The book also discusses blood flow through deformable blood vessels in human aorta, abdominal aortic aneurysm, carotid artery, coronary artery and plaque formation, along with content on stent deployment modeling and stent design and optimization techniques. (elsevier.com)
  • In addition to basic and translational research, Dr. Shroff and colleagues have developed and continue to develop novel, simulation-based material (i.e., mathematical models of biological systems and associated "virtual experiments") for education and engineering design. (pitt.edu)
  • Computational fluid dynamics and ex-vivo biomechanical simulations are utilized to inform experiments and facilitate rapid translation to the operating room for immediate patient benefit. (stanfordchildrens.org)
  • Steady state simulations were performed to investigate the effects of altered aortic pressure and blood vessel diameters on myocardial BF heterogeneity. (frontiersin.org)
  • The second difficulty is in modelling the topologies and geometries of the human body, both healthy and damaged. (europa.eu)
  • Simulations of cardiac electrical activation and mechanical pump function in hearts with shapes described by different combinations of shape components were performed. (plos.org)
  • This includes the development of mathematical methods for classical tasks of image processing like registration, denoising, equalization, and segmentation, but also (low-rank - sparse) data decomposition and functional correlations, e.g., in neurological processes, as well as data assimilation problems for integrating available images into physical models. (wias-berlin.de)
  • Further development of the model and methods will permit personalized assessment of patient BF status. (frontiersin.org)
  • We work on topics such as: physical and mathematical modelling, numerical methods, implementation issues, optimal design and parallel programming. (bsc.es)
  • Using clinical, epidemiological, statistical and economics methods, UKPDS investigators developed mathematical models that helped define predictors (risk factors) for cardiovascular disease including angina, myocardial infarction, stroke, peripheral vascular disease and death in Type 2 diabetes. (ox.ac.uk)
  • Methods: Using a mouse model of bleomycin (BLM)-induced lung fibrosis, in the current work we asked whether treatment with pro-resolution molecules, such as pro-resolving lipid mediators (SPMs) could ameliorate pulmonary fibrosis. (bvsalud.org)
  • The Marsden Lab at Stanford Engineering develops fundamental computational methods for the study of cardiovascular disease progression, surgical methods, treatment planning, and medical devices. (stanfordchildrens.org)
  • The standard methodology for fatigue to fracture testing, ASTM F3211, was developed in response to the increase in utilizing FtF testing to help model failure methods and limits for cardiovascular implants. (element.com)
  • Additionally, ASTM F2477 , Standard Test Methods for in vitro Pulsatile Durability Testing of Vascular Stents, is a common method in the cardiovascular industry that implements the test to success approach. (element.com)
  • Developing a parallel simulation code for complex physical systems capable of running efficiently in supercomputers requires wide-ranging background expertise, known as High Performance Computational Mechanics. (bsc.es)
  • While imaging techniques such as MRI have laid the groundwork for understanding cardiovascular mechanics, they can be expensive and time-consuming. (unc.edu)
  • He was hooked and went to graduate school at New York University, specifically, to work with Charlie Peskin -- a pioneer in heart modeling -- with the intent of modeling the coupling between the heart's electrical system and its mechanics. (unc.edu)
  • 8. Kenjeres S. (2009), "Recent Achievements in Multi-Scale Modelling and Simulations of Magnetofluiddynamic Phenomena: From Origin of Planetary Magnetic Field to Improved Magnetic Drug Targeting", Proceedings of the 7th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics, ExHFT-7, June 28 - July 03, 2009, Krakow, Poland, Eds. (tudelft.nl)
  • Our work seeks to better understand these phenomena through both mathematical analysis and computational simulation. (edu.au)
  • 11. Kenjeres S. (2013), "On Modelling and Simulations of (E)MHD Turbulent Transport Phenomena: Recent Progress and Challenges", 549 Wilhelm und Else Heraeus-Seminar on Liquid Metal MHD, Physikzentrum Bad Honnef, Germany, 15-18 October 2013. (tudelft.nl)
  • 9. Kenjeres S. (2012),"Recent Achievements in Modelling and Simulations of One- and Two-Way Coupled Turbulent MHD Phenomena", Focus session: Flow and Structure Formation in Plasmas and Magnetized Fluids, Physics @ FOM 2012, Veldhoven, The Netherlands, 18th January 2012. (tudelft.nl)
  • This mathematical modeling study explores some of the coronary vasculature based causes of myocardial blood flow (BF) heterogeneity. (frontiersin.org)
  • Topics include computer modeling of Purkinje fibers with different electrical potential applied, modeling of cardiomyopathies caused by sarcomeric gene mutations, altered sarcomere function, perturbations in intracellular ion homeostasis, impaired myocardial energetics at reduced costs, and more. (elsevier.com)
  • A tortuous pathway to develop, validate, and translate patient-specific computational models of left atrial haemodynamics to support occluder implantations. (oeaw.ac.at)
  • In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. (plos.org)
  • It would take one week on a supercomputer to solve one heartbeat in the aorta," he says, which rules out using a 3D model for the whole system. (europa.eu)
  • Development of appropriate mathematical and numerical models for large-scale computational simulations of the human cardiovascular system. (utl.pt)
  • The interest in the use of mathematical modeling and numerical simulation in the study of the cardiovascular system (and its inherent pathologies) has greatly increased in the past few years. (uni-linz.ac.at)
  • We provide a novel mathematical model of the cardiovascular system that incorporates gravitational stress generated by centrifugation and lower body cycling exercise, and we validate it with experimental measurements from human subjects. (tamu.edu)
  • It is well known that the modern understanding of the cardiovascular system undoubtedly starts with the work of William Harvey (1578-1657) who published his discovery of the circulation of blood in 1628. (scirp.org)
  • Her work focuses on utilising large health care cohort data, surveillance data and health system data to construct micro-simulation models of health, especially in high HIV-prevalence countries with two research aims. (imperial.ac.uk)
  • System dynamics modeling is an underused tool for informing and refining public health interventions. (cdc.gov)
  • The lab bridges engineering and medicine through the department of Pediatrics, the department of Bioengineering, and the Institute for Computational and Mathematical Engineering. (stanfordchildrens.org)
  • It provides practical guidance on how a bioengineering or medical problem can be modeled, along with which computational models can be used. (elsevier.com)
  • 2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran. (who.int)
  • Math-CVML is a research group within the Centre for Mathematical Sciences. (lu.se)
  • 2Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran. (who.int)
  • Although known principally as a clinical trial, the UK Prospective Diabetes Study (UKPDS) provided longitudinal data which helped define the natural history of cardiovascular complications in Type 2 diabetes. (ox.ac.uk)
  • We developed and validated a computational model to study the acute cardiovascular response to centrifugation combined with lower body ergometer exercise. (tamu.edu)
  • The model captures the cardiovascular response for a range of centrifugation and exercise profiles, and it shows promise in simulating additional conditions where data collection is difficult, expensive, or infeasible.NEW & NOTEWORTHY Artificial gravity combined with exercise is a potential countermeasure for spaceflight deconditioning, but the long-term and acute cardiovascular response to such gravitational stress is still largely unknown. (tamu.edu)
  • Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome. (mit.edu)
  • One major research topic at WIAS is the physics-based modeling of medical images. (wias-berlin.de)
  • For each of the fields to which we contribute, we identify these particular aspects and carry out research on them in order to develop efficient and accurate sector-targeted simulations. (bsc.es)
  • She specialise as an epidemiologist and mathematical modeller, working on the interface between research and policy. (imperial.ac.uk)
  • Because his passion for computer modeling seems innate, it's no surprise that Griffith pursued research. (unc.edu)
  • For now, we will use the O'Hara and Rudy model, one of the most used in research. (usj.es)
  • One of the hypotheses being investigated is that aberrant vascular stiffness changes are involved in the genesis of certain cardiovascular pathologies (e.g., preeclampsia, isolated systolic hypertension in elderly). (pitt.edu)
  • Biophysical computational models of the heart provide a quantitative framework for mapping changes in anatomy to whole heart function. (plos.org)
  • These models can also help predict the effects of drugs in the heart. (usj.es)
  • My personal goal is to see the transfer of knowledge, models, computer codes, and experimental approaches from my engineering Lab to practical clinical applications. (tudelft.nl)
  • To dissect vascular mechanisms, a 3D human vasculature model based on known experimental coronary morphometry and a space filling algorithm was implemented. (frontiersin.org)
  • Centrifugation and exercise profiles were simulated and compared with experimental data gathered on 12 subjects exposed to a range of gravitational levels (1 and 1.4G measured at the feet) and workload intensities (25-100 W). The model was capable of reproducing cardiovascular changes (within1 SD from the group-averaged behavior) due to both centrifugation and exercise, including dynamic responses during transitions between the different phases of the protocol. (tamu.edu)
  • Simulations of experimental conditions not used for model development corroborate the model's predictive capabilities. (tamu.edu)
  • While these computational models evaluate the stresses and strains on the tested systems, the models need to be validated with experimental data to ensure the predicted results align with benchtop results. (element.com)
  • With a deeper understanding of human cardiovascular physiology, Dr. Randles seeks to empower medical professionals who can tap the models for insights that enable more effective treatments for patients. (technologynetworks.com)
  • Electrophysiological models are a powerful tool to study the electrical activity of cardiac cells under normal or pathological conditions. (usj.es)
  • In the mixed effects model, random intercepts of the country and parallel of latitude were applied as 3 levels of the model (prevalence rate of each study, nested within countries and latitude parallel). (who.int)
  • Despite reporting increasing trends for seroprevalence of CCHF in previous reviews and the fixed effects model of the present study, the secondary mixed effects modeling showed a decreasing trend. (who.int)
  • By using mathematical modelling, simulation, smart material and robotics, Kwok focuses on design for additive manufacturing, functional design and fabrication, and cybermanufacturing. (concordia.ca)
  • It focuses on patient-specific modeling in pediatric and congenital heart disease, as well as adult cardiovascular disease. (stanfordchildrens.org)
  • Furthermore, a closed-loop circulatory model delivered the pressure values acting on the endocardium. (kit.edu)
  • Under a common theme that changes every summer, the site hosts several teams who develop innovative mathematical solutions that help process, analyze, and generate data sets. (emory.edu)
  • This year, we will have six projects centered on the theme models meet data. (emory.edu)
  • Applications include storm surge modeling and neuroscience and mathematical techniques cover a variety of topics ranging from data assimilation to deep neural networks and reinforcement learning. (emory.edu)
  • Our theme this year is 'Models meet Data' and a list of projects will be posted in February. (emory.edu)
  • Each application field requires specific solutions on every aspect: pre-process and input data management, simulation strategies, output analysis and validation. (bsc.es)
  • Building whole-of-plant virtual models from scanned data requires scattered data interpolation combined with clustering, smoothing, regularisation, partitioning and processing to generate realistic virtual models. (edu.au)
  • This 3rd edition will focus on data integration, model verification and validation. (upf.edu)
  • She has worked closely with the Dutch HIV cohort data, carried out modelling work, projecting the future non-communicable disease burden of patients ageing with HIV (in particular cardiovascular disease) and evaluating impact of interventions for policy guidance in The Netherlands. (imperial.ac.uk)
  • The data produced will be used as an input for a machine learning model that predicts susceptibility of bacteria to a panel of antibiotics. (liverpool.ac.uk)
  • and other respected institutions, provides a way to capture medical images and patient data to create specific blood flow simulation and analysis models. (stanfordchildrens.org)
  • Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes. (ox.ac.uk)
  • As a validated model that estimates impact using available implementation data, PRISM is a useful tool for rapid evaluation of SDOH initiatives. (cdc.gov)
  • We conducted multilevel modeling using Stata 14 for data analysis. (who.int)
  • Pediatric re-stenosed pulmonary artery model is depicted with marked points of unstable wall shear stress (WSS) which brings about the thinner layers by platelets. (cardiovascularmechanics.org)
  • The model consisted of 21 compartments, including the upper body, renal, splanchnic, and leg circulation, as well as a four-chamber heart and pulmonary circulation. (tamu.edu)
  • Our main objective is to put tailored HPC-based simulations to solve complex multi-physics problems into the hands of applied science. (bsc.es)
  • As a result, in cardiac models, representing patient anatomy using a limited number of modes of anatomical variation can cause a loss in accuracy of simulated electromechanical function. (plos.org)
  • This highlights the need to have high fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a large impact on cardiac function. (plos.org)
  • Voksel's Anatomical Modeling, Surgical Planning, 3D Printing with Engineer - Surgeon Collaboration Training ' was held on 23rd February in Istanbul. (cardiovascularmechanics.org)
  • To estimate the impact of the timing and intensity of such measures, we built a mathematical model of COVID-19 transmission that incorporates age-stratified risks and contact patterns and projects numbers of hospitalizations, patients in intensive care units, ventilator needs, and deaths within US cities. (cdc.gov)
  • This report demonstrates how the Prevention Impacts Simulation Model (PRISM) can be incorporated in evaluations to estimate cumulative longer-term impacts of SDOH initiatives. (cdc.gov)
  • A biophysical model of human coronary vasculature was used to explain the imaging observations, and highlight causes of coronary BF heterogeneity. (frontiersin.org)
  • The validated software Digital Avatar Platform (DAP) of Computational Life is modeling human and animal body mathematically. (cardiovascularmechanics.org)
  • My interest is to take these simulations 'from maths to ward' and make them available on a platform for clinical use," says the professor. (europa.eu)
  • In this talk I will introduce the main mathematical models which are nowadays used for the description of these mechanisms, and I will show different applications to cases of clinical interest. (uni-linz.ac.at)
  • The Stanford BASE program brings together experts from multiple specialties across the Stanford University campus and its hospitals-including computational modeling, tissue engineering, genetics, and molecular biology-to create bold new solutions for children with heart disease. (stanfordchildrens.org)
  • Chaste- Developing software for realistic heart simulations. (ox.ac.uk)
  • European Science Foundation Award for the organization of the European Heart Modelling workshop. (ox.ac.uk)
  • In this article, we review the test to success and fatigue to fracture methodologies, their differences, and how they are critical in evaluating the durability of stents, heart valves, occluders, and other cardiovascular devices for safety and regulatory approval. (element.com)
  • The deformation of the four-chamber heart models was simulated using a finite-element mechanical solver with a sliding boundary condition to mimic the tissue surrounding the heart. (kit.edu)
  • Computational model of cardiovascular response to centrifugation and lower body cycling exercise. (tamu.edu)
  • 2) The role of pulsatile arterial load (vascular stiffness in particular) in cardiovascular function. (pitt.edu)
  • 3) Cardiovascular actions of relaxin and its therapeutic potential in the context of three pathologies: (i) relaxin-induced maternal vascular remodeling and associated functional benefits in preeclampsia, (ii) relaxin-induced left atrial remodeling and suppression of atrial fibrillation, and (iii) relaxin-induced left ventricular remodeling and associated functional benefits in the setting of diastolic dysfunction. (pitt.edu)
  • From the beginning, we wanted HARVEY to serve as a tool to assist medical practitioners in the cardiovascular arena. (technologynetworks.com)
  • Because time is an explicit parameter incorporated in species-specific constants such as mu- cociliary clearance rates used in the models, the impact of the application of optimal model structures to refine adjustments and assumptions used in default risk assessment approaches to address exposure duration are discussed. (cdc.gov)
  • Furthermore, we wish to be able to invert this process and provide a model capable of producing candidate crystal structures that correspond to a set of desired properties, while avoiding over-prediction. (liverpool.ac.uk)
  • Nonetheless, all the mathematical developments, assumptions and justifications were included. (scirp.org)
  • We used the Prevention Impacts Simulation Model (PRISM) in a rapid evaluation to better understand the implementation and potential impact of MCPs' SDOH initiatives. (cdc.gov)