Freeman K-sets form a nested hierarchy of models of the dynamics of neuron populations at the mesoscopic (intermediate) level of the coordinated activity of cell assemblies of ~10 4 neurons with ~10 8 synapses that mediate between the microscopic activity of small neural networks, and the macroscopic activity of the entire brain . (scholarpedia.org)
In this article, we introduce a software framework that is capable of simulating large-scale, biologically realistic networks of spiking neurons embodied in a biomechanically accurate musculoskeletal system that interacts with a physically realistic virtual environment. (frontiersin.org)
The first benchmark is based on a large-scale balanced network, while the second one is a multi-region embodied brain simulation consisting of more than a million neurons and a billion synapses. (frontiersin.org)
Cortical brain regions were modeled as neural masses, each describing the average activity (spike density and spectral power) of a large number of interconnected excitatory and inhibitory neurons. (plos.org)
Activity dependent degeneration' (ADD) was simulated by lowering synaptic strength as a function of the spike density of the main excitatory neurons, and compared to random degeneration. (plos.org)
We then illustrate the ability of our framework to detect changes in α-synuclein dynamics at synapses in cultured cortical neurons, in response to membrane depolarisation, and show that detected differences are largely driven by increased protein mobility in the depolarised state, in agreement with previous findings. (bvsalud.org)
This script simulates a population of generalized integrate-and-fire (GIF) model neurons driven by noise from a group of Poisson generators. (readthedocs.io)
Towards a theory of cortical columns: From spiking neurons to interacting neural populations of finite size. (readthedocs.io)
Neural3
K-sets are used to model neural population dynamics with ODE to simulate mesoscopic K-fields. (scholarpedia.org)
The large-scale network consisted of 78 neural masses, connected according to a human DTI-based cortical topology. (plos.org)
In the first step a graph neural network is trained on simulated data to learn optimized low-dimensional summary statistics of the random walk. (bvsalud.org)
Dynamics2
Furthermore, we simulated progressive damage to brain regions based on their level of activity, and investigated its effect on the structure and dynamics of the remaining brain network. (plos.org)
Gromacs is a versatile package to perform molecular dynamics, i.e. simulate the Newtonian equations of motion for systems with hundreds to millions of particles. (nih.gov)
Data1
Cortical gene expression patterns were taken from the transcriptomic data of the AHBA ( http://human.brain-map.org/static/download ). (nature.com)
Activity1
Simulating the brain-body-environment trinity in closed loop is an attractive proposal to investigate how perception, motor activity and interactions with the environment shape brain activity, and vice versa. (frontiersin.org)