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Acquired ImmunodeViralAIDSSpeciesVirusRetrovirusesReplicatesCell immunityAntigenic VariationPrimateInfectionImmune ResponsesRhesusTypeGenomeControl
Acquired Immunode1
Viral1
  • M-PMV was classified based on viral serotype as simian retrovirus type 3 (SRV-3). (wikipedia.org)
AIDS2
  • Shortly after its discovery, M-PMV was considered to induce simian AIDS (SAIDs). (wikipedia.org)
  • Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. (lookformedical.com)
Species1
  • Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. (wikipedia.org)
Virus6
  • To prevent the infection of this virus, two vaccines have been developed: a formalin-inactivated vaccine SRV-1 and a recombinant vaccine expressing M-PMV envelope glycoprotein gp70 and gp22. (wikipedia.org)
  • However, current studies have shown that M-PMV is unrelated to simian immunodeficiency virus (SIV), which is currently recognized as the simian counterpart of the human immunodeficiency virus. (wikipedia.org)
  • CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus. (ox.ac.uk)
  • 99% of CD8+ lymphocytes in live attenuated simian immunodeficiency virus macC8 (SIVmacC8) vaccinees from the onset of vaccination, maintained that depletion for 20 days, and then challenged with pathogenic, wild-type SIVmacJ5. (ox.ac.uk)
  • External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
  • Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
Retroviruses2
  • and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens. (bvsalud.org)
  • Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. (wikipedia.org)
Replicates1
  • Simian/human immunodeficiency virus SHIV(KU2) replicates with extremely high titers in macaques. (nih.gov)
Cell immunity1
  • Vaccines that stimulate T cell immunity to HIV-1: the next step. (ox.ac.uk)
Antigenic Variation1
  • These convergent responses despite antigenic variation may account for the continued efficacy of vaccines based on a single ancestral variant. (bvsalud.org)
Primate1
  • He describes the work of the U.S. regional primate centers and the outbreak of SAIDS in 1981. (nih.gov)
Infection1
  • Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future. (ox.ac.uk)
Immune Responses1
  • Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such antibodies, and efficacy trials have not demonstrated any benefit for vaccines designed to stimulate immune responses of CD8(+) T cells. (ox.ac.uk)
Rhesus3
  • Infected new-born Rhesus monkeys may develop immunodeficiency disease accompanied by opportunistic infections. (wikipedia.org)
  • Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques. (umassmed.edu)
  • The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08+ Rhesus Macaques. (umassmed.edu)
Type1
  • M-PMV was classified based on viral serotype as simian retrovirus type 3 (SRV-3). (wikipedia.org)
Genome1
  • In order to determine whether the DNA of the viral genome could be used as a vaccine if the DNA were rendered noninfectious, we deleted the reverse transcriptase gene from SHIVKU2 and inserted this DNA (DeltartSHIVKU2) into a plasmid that was then used to test gene expression and immunogenicity. (nih.gov)
Control1
  • The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. (ox.ac.uk)