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  • hepatic
  • At an adequate dose, Silybum metabolites can be detected in the urine, peaking in 2 hours and continuing to be excreted for 48 hours, mostly in the form of monoglucuronides, followed by sulfate-glucuronides and diglucuronides, respectively, indicating a strong affinity for hepatic phase II enzymes. (restorativemedicine.org)
  • liver
  • Animal models of NASH have shown Silybum to decrease the severity of the disease as evidenced by reduced steatosis and histological improvement, significantly decrease liver weight and the liver-to-body weight ratio, 22 dramatically reduce TNF-α and transforming growth factor-β mRNA and malondialdehyde and increase liver glutathione. (restorativemedicine.org)