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  • tumor
  • Classifications based on gene expression profiles have expanded the detailed classification of breast cancer by revealing cellular identity profiles, with particular emphasis on presence of stem cells and the nature of the immune response to the tumor. (biomedcentral.com)
  • Genetic
  • Changes in gene expression that reset a cell program from a normal to a diseased state involve multiple genetic circuitries, creating a characteristic signature of gene expression that defines the cell's unique identity. (biomedcentral.com)
  • Pathways
  • Integrated pathways analysis indicates that these genes are involved in response to hormone stimulus, activation of protein kinase activity, and apoptotic process, among others. (frontiersin.org)
  • The blog relates an up-to-date interweaving of results from several newer fields of research: exosome molecular communications, cancer genetics and epigenetics, cancer gene silencing and activation pathways, and cell senescence theory. (anti-agingfirewalls.com)
  • promoters
  • In mammalian genomes, CpG islands are typically 300-3,000 base pairs in length, and have been found in or near approximately 40% of promoters of mammalian genes. (wikipedia.org)
  • Unlike CpG sites in the coding region of a gene, in most instances the CpG sites in the CpG islands of promoters are unmethylated if the genes are expressed. (wikipedia.org)
  • tissue
  • Although GBM grows within the skull, we investigated the concordance of methylation in glioma tissue, and paired serum DNA and the potential correlation with response and time to progression. (aacrjournals.org)
  • The comprehensive adipose-panel allows parallel assessment of tissue methylation and genotypes. (xtalks.com)
  • human
  • In one of the early successes of this initiative, the first complete map of a human epigenome (detailing DNA methylation for two human cell lines) was published in Nature last November. (bcr.org)
  • somatic
  • In ∼10% of JAK2V617F-negative PMF, another somatic mutation at codon 515 of the transmembrane-juxtamembrane junction of the thrombopoietin receptor gene, MPL, has also been identified ( 19 ). (aacrjournals.org)