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  • proteins
  • Podocyte-specific deletion of autophagy-related 5 (Atg5) led to a glomerulopathy in aging mice that was accompanied by an accumulation of oxidized and ubiquitinated proteins, ER stress, and proteinuria. (jci.org)
  • HDAC6 formed a tight complex with parkin and used dynein or kinesin motor proteins in the accumulation or dispersion of parkin. (jneurosci.org)
  • The proteins of multidrug gene (the MDR-related protein, MRP1) and P-glycoprotein (P-gp) in MCF-7/MDR cells were downregulated after exposure to 2DG, accompanied with the suppression of the activity of ATP-dependent drug-efflux pump and transmembrane transporter, increasing the intracellular accumulation of DOX to reverse the chemoresistance in multidrug cancer cells. (hindawi.com)
  • liver
  • PEGylated dyes had significantly lower accumulation in the liver (p? (jove.com)
  • In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. (jove.com)
  • CHICAGO -- Extended criteria for liver donor allografts , including the use of living donors, increase access to liver transplantation and significantly reduce wait-list mortality while providing satisfactory outcomes, according to researchers at New York-Presbyterian Hospital. (thefreedictionary.com)