• Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
  • Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • A low concentration of SsmTP also protects cells from oxidative damage by inhibiting programmed cell death (apoptosis) and the inflammatory response initiator caspase-1. (wikipedia.org)
  • Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
  • The role of hPOT1 in the cell proliferation, apoptosis and invasion of gastric cancer 7901 cells was determined by means of the RNA interference (RNAi) of hPOT1 mRNA. (bmj.com)
  • Transfection of hPOT1 siRNA into SGC-7901 cells led to a decrease in cell proliferation, colony formation and invasion, and also an increase of apoptosis. (bmj.com)
  • hPOT1 RNAi inhibits proliferation and invasion, and induces apoptosis of gastric cancer cells. (bmj.com)
  • The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
  • GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
  • Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)
  • Effects of RAD001 and letrozole (alone and in combination) on the proliferation and survival of MCF7/Aro and T47D/Aro cells were evaluated using proliferation assays, flow cytometry, immunoblotting, and apoptosis analyses. (aacrjournals.org)
  • The inhibition of cell proliferation was related to arrest of the cell cycle in the G0/G1 phase and increased apoptosis in response to PTGR1 knockdown as indicated by flow cytometry. (go.jp)
  • Cell cycle distribution and apoptosis were detected using flow cytometry. (hindawi.com)
  • 10 mg/mL) of Nidus Vespae decoction (NVD) inhibited SGC-7901 gastric cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. (hindawi.com)
  • Furthermore, the supernatant of THP-1 DCs significantly inhibited the proliferation of gastric cancer cells by inducing apoptosis and G1/S cell cycle arrest. (hindawi.com)
  • Here, we explored whether sesamin activates p53, which is widely inhibited in cervical cancer cells, thereby inducing p53-mediated apoptosis. (medsci.org)
  • Cell proliferation, cell cycle distribution, and apoptosis were evaluated by the CCK-8 assay and flow cytometry using PI/Annexin V staining, respectively. (medsci.org)
  • Pifithrin-α also reduced apoptosis and restored the proliferation of HeLa and SiHa cells exposed to sesamin. (medsci.org)
  • These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
  • Dovitinib also inhibited proliferation of the FGFR1OP2-FGFR1-positive KG1 and KG1A cell lines and induced apoptosis. (lclabs.com)
  • Cytotoxicity, antiproliferative and apoptosis-inducing capacity of ACNVs against hepatoma carcinoma cell were assessed. (dovepress.com)
  • ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
  • Research studies showed that parthenolide had a positive effect on the bone marrow microenvironment and a 'multi-faceted effect against MM cells, causing apoptosis. (canceractive.com)
  • Overexpression of Per2 promoted autophagy and apoptosis in OSCC cells and inhibited proliferation. (jcancer.org)
  • When the AKT activator SC79 was added to Per2-overexpressing OSCC cells, the increased autophagy, apoptosis and decreased proliferation were significantly rescued. (jcancer.org)
  • In conclusion, our research results demonstrate that Per2 suppresses OSCC progression by motivating autophagy, as well as inhibiting cell proliferation and promoting apoptosis, which were mediated by autophagy, in a PI3K/AKT/mTOR pathway-dependent manner. (jcancer.org)
  • Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • Bromodeoxyuridine (BrdU) immunocytochemistry and flow cytometry were applied to detect the proliferation of VSMCs. (hindawi.com)
  • To identify pyroptosis in the cells, electron microscopy was used to observe cell morphology, flow cytometry was used to detect the mitochondrial membrane potential, and the LDH release rate was analyzed by microplate reader. (researchsquare.com)
  • Cell cycle flow cytometry assay was used to analyze the effect of G6PC overexpression on the proliferation cycle of liver cancer cells . (bvsalud.org)
  • Cell cycle flow cytometry showed that G6PC overexpression had significantly inhibited the Huh7 cells G(1)/ S phase transition. (bvsalud.org)
  • Effects of antiestrogens on acetaminophen-induced proliferation were assessed by flow cytometry (0/0 S phase cells) and by cell counting. (cdc.gov)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
  • A series of cellular pathophysiological mechanisms involved in AS (e.g., differentiation, proliferation, and signalling pathways) are under the control of miRNAs. (hindawi.com)
  • In the model organism Dictyostelium discoideum , loss of the CLN5 homolog, cln5 , impacts various cellular and developmental processes including cell proliferation, cytokinesis, aggregation, cell adhesion, and terminal differentiation. (frontiersin.org)
  • The THP-1 DCs had significantly increased expression of cluster of differentiation 11c (CD11c), CD40, CD80, CD83, and CD86, as well as secretion of tumor necrosis factor-alpha. (hindawi.com)
  • T cell differentiation. (cdc.gov)
  • Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration of breast cancer cells. (medscimonit.com)
  • Functional analysis revealed that knockdown of PTGR1 significantly inhibited proliferation and colony formation by PC cells. (go.jp)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • In vivo , OP-B inhibited the growth of A549/DDP orthotopic tumor more significantly than that of A549 both in nude mice and zebrafish models. (researchsquare.com)
  • Dovitinib was examined on two human leukemic cell lines with differing FLT3 mutational status in vitro and in vivo, including MV4;11 cells expressing FLT3 internal tandem duplications (ITD) and RS4;11 cells with wild-type (WT) FLT3. (lclabs.com)
  • Dovitinib significantly inhibited KMS-11-luc tumor growth and improved animal survival at doses that inhibited FGFR3 signaling in KMS-11-luc tumors in vivo. (lclabs.com)
  • In vivo antitumor activity and toxicity were evaluated in Hep G2 cell xenograft model. (dovepress.com)
  • In vivo antitumor results showed that PEGylated ACNVs could significantly inhibit tumor growth without side effects. (dovepress.com)
  • In the present study, it was shown that FBXO17, which is a member of the F-box family, is abnormally downregulated in UCEC tissues compared with non-tumor endometrial tissues, and this was significantly associated with the clinical histological grade, as well as the abnormal proliferation of the UCEC cell line, Ishikawa, both in vitro and in vivo . (medsci.org)
  • Silencing PKM2 markedly inhibits proliferation and metastasis capacity in vivo and in vitro , and vice versa. (researchsquare.com)
  • In this study, OSCC cells with stable overexpression or silencing of Per2 were established to explore their biological functions and mechanism in vivo and in vitro . (jcancer.org)
  • Although vitamin E inhibits platelet aggregation in vitro, its effect in vivo has not been consistent. (medscape.com)
  • Experimental in vitro and in vivo research demonstrated decreased cell proliferation in desmoid cell cultures and small tumors when COX-2 was blockaded with pharmacologic agents. (medscape.com)
  • After treatment with different concentrations (0, 5, 10, and 20 μmol/L) of curcumin for 24 h, the inhibition of cell proliferation was detected, and the cell cycle variations of pulmonary smooth muscle were observed. (farmaciajournal.com)
  • During growth, genes associated with protein ubiquitination/deubiquitination, cell cycle progression, and proteasomal degradation were affected, while genes linked to protein and carbohydrate catabolism were affected during early development. (frontiersin.org)
  • The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)
  • 1 , 2 In recent years, mammalian cell-derived exosomes (a type of extracellular vesicle) have been widely used in the field of biomedicine, including diagnosis, regulation of disease progression and drug delivery. (dovepress.com)
  • However, whether PKM2 can promote head and neck squamous cell carcinoma (HNSCC) progression and immunosuppression remains unknown. (researchsquare.com)
  • The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)
  • However, the precise function of CLN5 in the cell and the pathway(s) regulating its function are not well understood. (frontiersin.org)
  • The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models. (aacrjournals.org)
  • The role of the mTOR pathway in estrogen response was evaluated in aromatase-expressing MCF7/Aro breast cancer cells by immunoblotting. (aacrjournals.org)
  • Treatment of MCF7/Aro cells with estradiol or androstenedione caused modulation of the mTOR pathway, a phenomenon reversed by letrozole or RAD001. (aacrjournals.org)
  • Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy. (nih.gov)
  • Though inducing more significantly pyroptosis by activating Caspase-1/GSDMD pathway, OP-B relieved DDP resistance of A549 cells. (researchsquare.com)
  • The mechanism of drug resistance in tumors are complex, which mainly includes drug concentration reduction in tumor cells, abnormal drug metabolic pathway, DNA damage repair dysfunction, regulation of autophagy, blocking of apoptotic pathways, and self-renewal or proliferation of tumor stem cells. (researchsquare.com)
  • combined BI2536 (an inhibitor of PLK1) with cisplatin (DDP) to treat ESCC cells and found the combination of two drugs had a synergistic effect on tumor inhibition and resulted in pyroptotic death of cancer cells by Caspase-3/GSDME pathway. (researchsquare.com)
  • Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
  • Zheng ZM, Wang YY, Chen M, Yang HL, Lai ZZ, Li MQ, Shao J. FBXO17 Inhibits the Wnt/β-Catenin Pathway and Proliferation of Ishikawa Cells. (medsci.org)
  • Studies have shown that various signaling pathways serve crucial roles in the tumorigenesis of UCEC, amongst which the Wnt/β-catenin pathway is of great interest due to its crucial role in cell proliferation and the huge potential as a therapeutic target. (medsci.org)
  • Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. (medsci.org)
  • principle bioactive ingredient of the herb feverfew, has been shown on multiple occasions to attack cancer stem cells largely through the nuclear factor kappa-B pathway. (canceractive.com)
  • In one ( 4 ), parthenolide and a non-steroidal anti-inflammatory, sulindac, synergistically brought about growth suppression and inhibited the nuclear factor-kappa B pathway in pancreatic carcinoma cells. (canceractive.com)
  • We present a rate equation model for the TGF-b pathway in endothelial cells together with novel measurements. (lu.se)
  • Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and cell proliferation assay were used to explore the functional role of the key lncRNAs in GBM. (spandidos-publications.com)
  • Cell proliferation was assessed using the Cell Counting kit‑8 cell viability assay. (spandidos-publications.com)
  • Cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay. (hindawi.com)
  • The sensitivity of NCI-H460, A549, A549/DDP, and A549/PTX cells to OP-B was determined by CCK-8 assay, and the results were further verified in orthotopic tumor nude mice model and zebrafish tumor model. (researchsquare.com)
  • The optimal dose of AH in the basal medium (FD) and medium containing serum (FDS) for keratocytes proliferation was identified using MTT assay. (blogspot.com)
  • Cell proliferation and clone formation assay were used to observe the proliferation of liver cancer cells . (bvsalud.org)
  • Transwell and scratch assay were used to observe the invasion and migration of liver cancer cells . (bvsalud.org)
  • Huh7 and SK-Hep1 cells proliferation assay showed that the number of proliferating cells in the AdG6PC group was significantly lower than the other two groups (P (bvsalud.org)
  • Clone formation assay showed that the number of clones was significantly lower in AdG6PC than the other two groups (P liver cancer cells . (bvsalud.org)
  • Transwell assay showed that the number of cell migration was significantly lower in AdG6PC than the other two groups (P (bvsalud.org)
  • The chemiluminescence assay is significantly more sensitive than RIA. (medscape.com)
  • The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
  • Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
  • Atherogenesis also may be promoted by the following activities of oxidized LDLs: (1) chemotactic action on monocytes, (2) cytotoxicity to endothelial cells, (3) stimulation of the release of growth factors and cytokines, (4) immunogenicity, and (5) possible arterial vasoconstrictor actions. (medscape.com)
  • endothelial cells. (lu.se)
  • In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)
  • Triptolide treatment inhibited the expression of tumor promoter Cav-1 and reduced CD147 and MMPs activities at both mRNA and protein levels. (nih.gov)
  • In conclusion, PTGR1 plays an essential role in PC cells and may be a potential therapeutic target for PC. (go.jp)
  • In conclusion, curcumin may protect the pulmonary arteries of MCT-induced PHA in rats and inhibit the proliferation of rat pulmonary artery smooth muscle. (farmaciajournal.com)
  • However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. (nih.gov)
  • In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. (nih.gov)
  • Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
  • Western blot result showed that G6PC overexpression had down-regulated the proliferation in cell -cycle related proteins expression. (bvsalud.org)
  • Meanwhile, triptolide treatment combined with Cav-1 knockdown in PCa cells enhanced the effects of anti-migration and anti-invasion, and those effects were restored following Cav-1-rescued. (nih.gov)
  • In cultured PECs, overexpression or knockdown of the IPO13 gene increased or decreased PEC proliferation, respectively. (molvis.org)
  • Lactate production and the expression of galectin-9, a critical immunosuppression molecule, were detected after PKM2 knockdown and overexpression in HNSCC cells. (researchsquare.com)
  • The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
  • This study aimed to explore the effects of Acacia honey (AH) on corneal keratocytes morphology, proliferative capacity, cell cycle, gene and protein analyses. (blogspot.com)
  • Flowcytometry was performed to evaluate the cell cycle analysis of corneal keratocytes. (blogspot.com)
  • Corneal keratocytes cultured in media supplemented with 0.025% AH showed an increase in proliferative capacity while retaining their morphology, gene and protein expressions with normal cell cycle. (blogspot.com)
  • This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
  • It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
  • Damage to the endothelium results in vascular smooth muscle cell proliferation. (aspetjournals.org)
  • In this work, we investigated the effect of l -citrulline on vascular smooth muscle cell proliferation. (aspetjournals.org)
  • These findings suggest that l -citrulline decreases vascular smooth muscle cell proliferation in the A10 cell line by acting on DNA synthesis by mechanisms that involve the ANP receptor. (aspetjournals.org)
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • An up-regulation of hPinX1 and down-regulation of hTERT were found in gastric cancer cells with hPOT1 siRNA. (bmj.com)
  • Perfect base pairing leads to the degradation of the mRNA (similar to siRNA), while imperfect complementarity inhibits translation. (genengnews.com)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • The endocytosis mechanism of ACNVs was evaluated on Hep G2 cells in the presence of different endocytosis inhibitors. (dovepress.com)
  • However, the biological functions and mechanism of Per2 in OSCC (OSCC: oral squamous cell carcinoma) remain unclear. (jcancer.org)
  • An increased hPOT1 expression significantly correlated with tumour serosal invasion, node metastasis and advanced stage. (bmj.com)
  • DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
  • For carcinoma, rapid proliferation, distant metastasis and immune escape rely heavily on energy metabolism. (researchsquare.com)
  • Aims To explore the role of hPOT1 in the proliferation and invasion of gastric cancer cells. (bmj.com)
  • Our findings suggest that NVD not only directly inhibits the growth of gastric cancer cells but also exerts indirect antitumor effects by enhancing immune function. (hindawi.com)
  • These data suggest AZD9567 that BRAFV600E in melanoma is an HSP90 client protein whose degradation induced by 17-AAG is usually potentially very important for its inhibitory effects upon melanoma cell growth. (biomasswars.com)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)
  • The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
  • Western blot was used to detect the effect of G6PC overexpression on the cell -cycle protein expression in liver cancer cells . (bvsalud.org)
  • The underlying molecular mechanisms by which androgen-independent PC cells acquire the capacity to proliferate remain largely unclear. (go.jp)
  • With increasing globalization and advancements in modern medicine, novel therapeutic approaches such as targeted molecular therapy [ 4 ], immunotherapy [ 5 ], and latent/residual tumor cell ablation have been used to improve clinical outcomes for cancer patients, but the prognosis for patients with gastric cancer remains poor. (hindawi.com)
  • Near-Infrared Light Activates Molecular Nanomachines to Drill into and Kill Cells," Liu, D. (biola.edu)
  • Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
  • Studies in this laboratory have shown that acetaminophen, a widely used analgesic/antipyretic, induces DNA synthesis and proliferation in estrogen responsive (ER +) but not estrogen-nonresponsive (ER-) cultured. (cdc.gov)
  • MiR-506 mimics, inhibitor, and negative control (NC) were transfected into MDA-MB-231 breast cancer cells. (medscimonit.com)
  • VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. (hindawi.com)
  • The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
  • Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
  • Zaprinast, a phosphodiesterase type V inhibitor, enhanced 5-bromo-2′-deoxyuridine incorporation in serum-stimulated cells. (aspetjournals.org)
  • TACH101 is a first-in-class small molecule inhibitor of KDM4 histone demethylase, an epigenetic modifier important for cancer stem cell proliferation. (ca.gov)
  • Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. (cdc.gov)
  • Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • An elaborate network of signaling pathways orchestrates the communication between cancer cells and the surrounding stroma. (degruyter.com)
  • The second goal of this research was to establish if estrogen receptor pathways are involved in mediating the acetaminophen induced proliferation of ER+ cells. (cdc.gov)
  • A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)
  • To our knowledge this is the first demonstration of a treatment that inhibited a specific miRNA that resulted in a significant increase in survival. (genengnews.com)
  • The findings revealed that nuclear factor kappa B, a marker of inflammation, was significantly reduced in those men assigned to green tea compared with those in the control group. (lesliebeck.com)
  • Pyroptosis is a type of programmed cell death that associated with inflammation, which characterized by cell swelling, destruction of membrane structural integrity and cytoplasmic contents release, like interleukin-1β (IL-1β), interleukin-18 (IL-18) and lactate dehydrogenase (LDH) (5). (researchsquare.com)
  • It promotes cell growth in low concentrations in vitro (i.e. outside a living organism), but is cytotoxic in high concentrations. (wikipedia.org)
  • The n-hexanesoluble,acetone-soluble and water-soluble fractions obtained from the acetone extract of A. indica shoots inhibited thegermination and the growth of roots and shoots of six test plant species. (researchgate.net)
  • We followed up this analysis by showing that loss of cln5 alters the intracellular and extracellular amounts of proliferation repressors during growth and increases the extracellular amount of conditioned medium factor, which regulates cAMP signalling during the early stages of development. (frontiersin.org)
  • Finally, consistent with the differential expression of genes associated with proteasomal degradation in cln5 - cells, we also observed elevated amounts of a proteasome subunit and reduced proteasome 20S activity during cln5 - growth and starvation. (frontiersin.org)
  • In addition, RPE cells proliferate and secrete various proangiogenic factors, including vascular endothelial growth factor (VEGF), which serves an important role in AMD-associated CNV ( 4 ). (spandidos-publications.com)
  • TACH101 also significantly slowed tumor growth in CRC models and showed high sensitivity in CRC with Microsatellite Instability High (MSI-H) status. (ca.gov)
  • Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)
  • Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. (lclabs.com)
  • Estrogens significantly contribute toward the growth and development of endometrial cancers. (scirp.org)
  • The saRNAs were screened by transfection in human (HepG2 and A549) or murine (CT26, BNL.1ME and RAW264.7) cells, and mRNA levels of the target genes were measured by qPCR. (aacrjournals.org)
  • Sequence-dependent specificity was confirmed by modifying 2 to 3 nucleotide residues in the seed binding region of the lead sequences, which in each case significantly reduced induction of target mRNA compared to the parental saRNA sequences. (aacrjournals.org)
  • Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
  • Glucose-6 phosphatase catalytic subunit inhibits the proliferation of liver cancer cells by inducing cell cycle arrest]. (bvsalud.org)
  • Pulmonary embolism is a blockage of an artery in the lungs by a blood clot, fat, air or clumped tumor cells. (sciencedaily.com)
  • A urinary marker of oxidative DNA damage was significantly decreased in urine from men consuming green tea compared with controls. (lesliebeck.com)
  • Estradiol and androstenediol concentrations were also significantly higher in the co-cultured cells. (scirp.org)
  • Similarities between acetaminophen- and estradiol-induced proliferation of cultured, estrogen-responsive breast cancer cells. (cdc.gov)
  • this moiety appears to influence estradiol- and xenoestrogen-induced ER+ cell proliferation. (cdc.gov)
  • These data suggest the p-phenol moiety is important in both estradiol- and acetaminophen-induced ER+ cell proliferation. (cdc.gov)
  • In MCF7 and 1470 cells (but not in MDA MB-231 cells), both antiestrogens inhibited proliferation induced by acetaminophen and by estradiol. (cdc.gov)
  • These data also suggest that there are similarities between estradiol- and acetaminophen-induced proliferation. (cdc.gov)
  • Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium to examine the expression of IPO13 and K17. (molvis.org)
  • The THP-1 human monocytic cell line was used as a source of monocytic effector cells for analyzing proliferation and dendritic cell (DC) induction. (hindawi.com)
  • However, a low concentration (≤10 mg/mL) of NVD significantly increased the proliferative ability of THP-1 in serum-containing medium and caused an increase in dendritic protrusions with the typical morphology of DCs compared to the negative control in serum-free medium. (hindawi.com)
  • Many breast cancers are dependent for proliferation on estrogens synthesized from androgens (i.e., androstenedione) by aromatase. (aacrjournals.org)
  • We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
  • In 4/4 human melanoma cell lines with BRAFWT (SK-Mel-2, SK-Mel-31, SK-Mel-147, and SK-Mel-103), no degradation occurred with 17-AAG concentrations up to 2.5 M, Vegfa whereas 17-AAG induced degradation in 5/5 cell lines with BRAFV600E (or BRAFV600D) mutations (SK-Mel-1, SK-Mel-5, SK-Mel-19, SK-Mel-28, and WM 266.4). (biomasswars.com)
  • SK-Mel-2 melanoma cells have been reported to contain either an [9, 17] or a [11] mutation, but sequencing of the amplified exons 3 of and in the cells used in our experiments confirmed that this mutation is usually (S1 Fig). Incubation of these cultured cells with concentrations of 17-AAG up to 1 1 M revealed effects on both AZD9567 BRAF and CRAF. (biomasswars.com)
  • Relative MEK and ERK phosphorylations were diminished at increasing concentrations of 17-AAG in and mutated human melanoma cell lines. (biomasswars.com)
  • The data showed that serum prostate-specific antigen (PSA) concentrations were significantly lower at the end of the study compared with baseline levels in men consuming green tea. (lesliebeck.com)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • Therapeutic concentrations of p-acetamidophenol (- 0.1 mM) significantly increased proliferation, and the relative order of potency was p- greater than m. greater than o-acetamidophenol. (cdc.gov)
  • The viability of GBM cells was significantly decreased following RNA interference with DLEU1 and TRAF4 production. (spandidos-publications.com)
  • Better still, parthenolide and costunolide can decrease detyrosinated microtubules without significantly disrupting the overall microtubule network or cell viability. (canceractive.com)
  • Sesamin (75 and 150 μM) clearly inhibited SiHa and HeLa cell proliferation in a dose-dependent fashion, but did not affect the proliferation of Hs68 cells. (medsci.org)
  • The results demonstrate that DLEU1 and TRAF4 is highly expressed in GBM tissues and promotes proliferation of GBM cells. (spandidos-publications.com)
  • A total of 330 significantly differential genes were identified through large-scale transcriptome sequencing, among which 103 genes were upregulated and 227 genes were downregulated. (mdpi.com)
  • Activity of TKI258 against primary cells and cell lines with FGFR1-fusion genes associated with the 8p11 myeloproliferative syndrome. (lclabs.com)
  • We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. (osti.gov)
  • When lncHERG is highly expressed, cell multiplication, invasion and migration are inhibited in GBM ( 16 ). (spandidos-publications.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. (medscimonit.com)
  • Human HeLa and SiHa cervical cancer cells and normal Hs68 dermal cells were used as cell models. (medsci.org)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
  • However, it is still unknown whether it can improve the drug resistance of lung cancer cells. (researchsquare.com)
  • Both were shown to selectively decrease detyrosinated tubulin in cancer cells independent of their inhibition of NF-κB.The two compounds showed reduction in the frequency of microtentacles and inhibition of reattachment in breast cancer. (canceractive.com)
  • To investigate the effects of glucose-6-phosphatase catalytic subunit (G6PC) recombinant adenovirus on proliferation and cell cycle regulation of liver cancer cells . (bvsalud.org)
  • Scratch repair rate was significantly lower in AdG6PC than the other two groups (P liver cancer cells . (bvsalud.org)
  • G6PC inhibits the proliferation, cell -cycle related expression, and migration of liver cancer cells by inhibiting the G(1)/ S phase transition. (bvsalud.org)
  • human breast cancer cells. (cdc.gov)
  • The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
  • In addition to the balance between tumors and the immune system, there is also a balance between tumors and the nonimmune cells that surround them [ 10 ]. (hindawi.com)
  • The opposite results were obtained in Per2-silenced OSCC cells. (jcancer.org)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
  • Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
  • In addition, l -citrulline also inhibited serum-induced DNA synthesis, measured as 5-bromo-2′-deoxyuridine incorporation. (aspetjournals.org)
  • However, serum levels were significantly higher with mild or severe pre-eclampsia compared with normal pregnancies and significantly higher with severe rather than with mild pre-eclampsia. (who.int)
  • Vitamin E appears to enhance lymphocyte proliferation, decrease the production of immunosuppressive prostaglandin E2, and decrease levels of immunosuppressive serum lipid peroxides. (medscape.com)
  • Thus, both the ability of antitumor drugs to kill tumor cells and their effects on immune function and normal tissue cells should be studied. (hindawi.com)
  • TACH101 is intended to target colorectal cancer (CRC) stem cells as well as the bulk tumor by inhibiting proliferation. (ca.gov)
  • In CRC animal models, TACH101 treatment reduced the number of cells with cancer stem cell features and reduced the number of tumor-initiating cells. (ca.gov)
  • it attacks cancer stem cells. (canceractive.com)
  • Pancreatic cancer - Pancreatic cancer contains a large number of different types of cancer stem cells at its heart. (canceractive.com)
  • Multiple Myeloma - As long ago as 2003, Johns Hopkins Medical School found a particular type of cancer stem cell in the bone marrow microenvironment which was both the origin of MM and the driver of recurrence. (canceractive.com)
  • Leukaemia - Also in 2005, a team of researchers including Monica Guzman, PhD, of the University of Rochester Medical School, showed that Parthenolide was a potent anti-leukaemia aid and could kill cancer stem cells, without damaging healthy cells. (canceractive.com)
  • Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
  • Additionally, cln5 - cells displayed increased intracellular and extracellular amounts of discoidin, which is involved in cell-substrate adhesion and migration. (frontiersin.org)
  • Vitamin E has been demonstrated to inhibit platelet adhesion, as measured by a laminar flow chamber when blood from patients who have taken vitamin E supplements is tested. (medscape.com)
  • Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)