Significantly improved left ventricular function models of myocardial infarction models cardiovascular. Medical search. Frequent questions

The mean ejection fraction and cardiac output/index remained unchanged or increased. (nih.gov)
Older age, inpatient status, insulin use, reduced left ventricular ejection fraction at rest, and reduced MBFR were each independently associated with increased all-cause mortality among both symptomatic and asymptomatic people with diabetes. (medscape.com)
In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. (hindawi.com)
CS-exposed males exhibited enhanced increases in left ventricular end systolic and diastolic volumes, as well as reductions in ejection fraction and fractional area changes of left ventricular base. (biomedcentral.com)
After heart transplantation, the donor heart preservation with normoxic CM was associated with shorter re-beating time, histopathological scores, and left ventricular systolic diameter, higher ejection fraction, and fractional shortening of transplanted hearts. (researchsquare.com)
Assessment of left ventricular diastolic function is useful in risk stratification for patients with cardiovascular disease and can provide a diagnostic clue for heart failure with preserved ejection fraction. (medsci.org)
Cardiac catheterization showed normal coronary arteries ( Figures A and B ), a left ventricular (LV) ejection fraction of 20%, and grade 2 to grade 4 mitral regurgitation. (consultant360.com)
In 6 mildly sedated normal conscious mice assessed by echo, heart rate was 615 ± 25 min -1 (mean ± SE) and left ventricular ejection fraction (LVEF) was 0.94 ± 0.01. (biomedcentral.com)
In mice with normal cardiac function, CMR during deep sedation causes significantly less depression of heart rate and ejection fraction than imaging during general anesthesia with isoflurane. (biomedcentral.com)
Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)

In patients with cardiovascular disease, diltiazem hydrochloride injection administered intravenously in single bolus doses, followed in some cases by a continuous infusion, reduced blood pressure, systemic vascular resistance, the rate-pressure product, and coronary vascular resistance and increased coronary blood flow. (nih.gov)
Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)
Among patients with diabetes and without known coronary artery disease and referred for myocardial perfusion imaging, 12.7% had significant ischemia, and 60% had reduced myocardial blood flow reserve (MBFR) including those without symptoms of ischemia. (medscape.com)
This retrospective, observational study included 2730 consecutive patients with diabetes and without known coronary artery disease treated in a large health system in the bi-state Kansas City metro area during 2010-2016 who underwent pharmacologic rest/stress myocardial perfusion imaging (MPI) using rubidium-82 positron emission tomography . (medscape.com)
Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. (journaltocs.ac.uk)
We reviewed a decade of data from all patients with coronary heart disease enrolled in a single CR center (University of Michigan) to identify the prevalence of low-risk factors, which may inform on consideration for participation in alternative models of CR. (journaltocs.ac.uk)
In this observational study, we provide a first paradigm of identifying factors among coronary heart disease patients that may be considered low-risk and likely high-gain for participation in alternative models of CR. (journaltocs.ac.uk)
Cardiac catheterization and coronary angiography in the left panel shows severe left anterior descending coronary artery stenosis. (medscape.com)
This lesion was treated with stent placement in the left anterior descending coronary artery, as observed in the right panel. (medscape.com)
Coronary atherosclerosis appears in the majority of the diabetes population, with the mortality of up to 20% diabetic subjects caused by myocardial infarction ( 9 ). (spandidos-publications.com)
Results of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial confirmed that this practice independently associated with improved graft patency, as demonstrated by coronary angiography and saphenous vein graft intravascular ultrasonography. (medscape.com)
Methods and Results: Two weeks following coronary artery occlusion in rats, the expression levels of both TGFpi and TGFpRI were increased, but the expression of miR-101a was decreased at the site of the infarct and along its border. (cyberleninka.org)
In TC, however, levels of myocardial serum markers are elevated, coronary arteries are disease-free, and the heart is shaped like a takotsubo (the Japanese word for a pot used to catch octopus). (consultant360.com)
Compared to patients with HFpEF, those with HFmrEF were more likely to have comorbid acute myocardial infarction, infection and coronary artery disease, had higher level of N-terminal pro B-type natriuretic peptide (NT-proBNP), cardiac troponin, blood urea nitrogen (BUN), white blood cell (WBC). (researchsquare.com)
Acute Myocardial Infarction (AMI) is the most relevant form of coronary heart disease that is characterized by high mortality. (biomedcentral.com)
The main therapeutic measures in AMI are aimed at myocardial reperfusion as soon as possible with the restoration of blood flow by percutaneous coronary intervention (PCI) followed by guideline-directed medical therapy to prevent secondary events and progression to heart failure (HF). (biomedcentral.com)
There is evidence of the role of the microbiota in atherosclerotic disease, coronary artery disease, and myocardial infarction pathogenesis. (encyclopedia.pub)
Moreover, high levels of TMAO have been associated with vulnerable coronary plaque, plaque rupture, and long-term risks of incident cardiovascular events in patients with acute coronary syndrome [ 6 ] . (encyclopedia.pub)
In 1999 NICE examined the use of coronary stents as the first in a number of cardiovascular exercises, being followed by glycoprotein IIb/IIIa receptor blockers, and implantable defibrillators. (bmj.com)
Cardiovascular diseases (CVDs) encompass all pathologies of the heart or circulatory system, including coronary artery disease (CAD), myocardial infarction (MI), heart failure and peripheral vascular disease. (encyclopedia.pub)
To date, available therapies such as heart transplantation, pharmacological interventions, coronary artery bypass graft surgery, and ventricular assistant devices have significantly prolonged patients' longevity. (encyclopedia.pub)
Coronary atherosclerotic disease is a leading cause of mortality and morbidity due to major cardiovascular events in the United States and abroad. (bvsalud.org)
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)
Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)

Ventricular hypertrophy and/or dilatation are main structural changes that reflect a pathological response of the heart, accompanied by molecular and cellular changes that functionally translate into diastolic and/or systolic dysfunction [ 7 ]. (biomedcentral.com)
Other metrics such as proteinuria, serum creatinine, and prevalence of left ventricular hypertrophy rose with increasing West African ancestry, although estimated glomerular filtration rate decreased. (aacc.org)
A myocardial biopsy specimen showed mild hypertrophy of the myocytes and a small amount of interstitial fat ( Figure E ). These nonspecific findings can be seen with cardiomyopathy of undetermined cause. (consultant360.com)
Coarctation of the Aorta Coarctation of the aorta is a localized narrowing of the aortic lumen that results in upper-extremity hypertension, left ventricular hypertrophy, and, if severe, malperfusion of the abdominal. (msdmanuals.com)

Onco-cardiology, a new academic field, aims to improve the quality of life and prognosis of cancer patients and survivors with cardiovascular diseases (CVD). (go.jp)
Findings from the World Health Organization's Monitor Trends in Cardiovascular Diseases (MONICA) project involving 21 countries showed a 4% fall in CAD death rates. (medscape.com)
Although many therapeutic agents such as β-blockers and angiotensin-converting enzyme inhibitors are currently used to control cardiovascular diseases (CVD), there remains a substantially high incidence of CVD among diabetic patients, necessitating alternative strategies of targeted management [ 2 ]. (biomedcentral.com)
Cardiovascular diseases constitute a leading cause of death worldwide. (cyberleninka.org)
Extracellular matrix (ECM) metabolic imbalance is involved in various cardiovascular diseases such as heart failure, atrial fibrillation and myocardial infarction (MI], and may lead to pathological cardiac remodeling [1, 2]. (cyberleninka.org)
The progression of cardiovascular diseases is usually associated with numerous stimuli, including ischemia, inflammation, and pressure or volume overload, all of which may induce cardiac fibrosis. (cyberleninka.org)
Therefore, prolonged hypoxia may play a critical role in aberrant cardiac remodeling in cardiovascular diseases [4-6]. (cyberleninka.org)
Even though cardiovascular diseases (CVDs) are the main of cause of the global burden of diseases attributable to PM exposure, it remains difficult to show reliable associations between exposure to wildland fire smoke and cardiovascular disease risk in population-based studies. (frontiersin.org)
Among cardiovascular diseases (CVDs), myocardial infarction (MI) accounts for majority of death and disability and has high incidence rate in both developed and developing countries as seen over the past quarter century (Agrawal et al . (scialert.net)
These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. (mdpi.com)
It can lead to cardiovascular diseases [ 2 ] [ 3 ] . (encyclopedia.pub)
Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. (biomedcentral.com)
Comorbid diseases potentiate the morbidity of COPD, leading to increased hospitalisations, mortality and healthcare costs. (ersjournals.com)
Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year, representing one third of global mortality. (encyclopedia.pub)
These diseases are the primary mortality cause worldwide and significantly impact patients' quality of life. (encyclopedia.pub)

Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
Page 2 fibrillation or flutter, previous myocardial infarction, rheumatic valvular heart disease and Author Manuscript prosthetic heart valve) and psychosocial stress/depression [3]. (cdc.gov)

Myocardial injury of ST-segment elevation myocardial infarction (STEMI) initiates an intense inflammatory response that contributes to further damage and is a predictor of increased risk of death or heart failure (HF). (biomedcentral.com)
Presence of microvascular obstruction (MVO) derived from cardiac magnetic resonance (CMR) imaging is among the strongest outcome predictors after ST-segment elevation myocardial infarction (STEMI). (biomedcentral.com)

Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
The extent of ischemia did not significantly associate with all-cause mortality after accounting for MBFR in those with or without symptoms. (medscape.com)
Clinically, beneficial effects of GLP-1 have also been demonstrated in patients with myocardial ischemia and heart failure. (biomedcentral.com)
While the heart is capable of utilizing a variety of available substrates to generate adenosine triphosphate, this metabolic flexibility is compromised under circumstances in which the heart is stressed, particularly by myocardial ischemia. (biomedcentral.com)
Diabetes causes suppressed glucose oxidation leading to inefficient energy production, enhanced fatty acid metabolism, and increased susceptibility to myocardial ischemia and reperfusion injury. (biomedcentral.com)

Diltiazem slows the ventricular rate in patients with a rapid ventricular response during atrial fibrillation or atrial flutter. (nih.gov)
In the AFFIRM study (Atrial Fibrillation Follow-up Investigation of Rhythm Management), an insignificant trend toward increased mortality was noted in the rate control group, and importantly, no evidence suggested that the rhythm-control strategy protected patients from stroke. (medscape.com)
0.001), higher prevalence of myocardial infarction ( p = 0.047), STEMI ( p = 0.045), atrial fibrillation ( p = 0.047), and anemia: lower erythrocytes count ( p = 0.037), hemoglobin concentration ( p = 0.034), and hematocrit ( p = 0.046), compared to "non-remodeled phenotype. (karger.com)

The prevalence of cardiovascular disease (CVD) is steadily rising and is expected to increase by a minimum of 10% over the next 20 years. (biomedcentral.com)
The prevalence in males was significantly higher than that in females, even in children (0.096% vs 0.010%, p=0.012). (go.jp)
The prevalence of type 2 diabetes mellitus is rapidly increasing, and it has emerged as a major public health problem worldwide. (aging-us.com)

As AF contributes to pathologic atrial and ventricular remodeling, restoration of sinus rhythm can slow or, in some cases, reverse atrial dilatation and left ventricular dysfunction. (medscape.com)
These findings strongly implicate rs6817105 minor allele in sinus node dysfunction and left atrial enlargement. (nature.com)
All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
The association between increased arterial stiffness and left ventricular diastolic dysfunction (LVDD) may be influenced by left ventricular performance. (medsci.org)
brachial-ankle pulse wave velocity, P wave dispersion, left ventricular diastolic dysfunction. (medsci.org)
The cardiac mortality and morbidity were increased in heart failure patients with left ventricular diastolic dysfunction (LVDD) [ 1 , 2 ]. (medsci.org)
Cardiac dysfunction was observed as a decrease in mean arterial pressure (MAP), heart rate (HR), left ventricular rate of peak positive and negative pressure change {(+) and (-) LV dP/dt} and elevated left ventricular end diastolic pressure (LVEDP) following ISP administration. (scialert.net)
Based on our work to date, we are also interested in understanding myocardial mitochondrial and vascular dysfunction as these have the potential to serve as novel therapeutic targets. (stanford.edu)
TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)

A biomarker model for prediction of MVO, which could easily be applied in a broad range of STEMI patients, might provide a practicable and cost effective alternative to CMR. (biomedcentral.com)

Clinicians should not screen asymptomatic, low-risk adults for cardiac disease using resting or stress electrocardiography, stress echocardiography, or stress myocardial perfusion imaging. (medscape.com)

Future work is needed to study whether treatment of reduced MBFR identified on screening asymptomatic high-risk patients with diabetes improves outcomes," conclude the investigators. (medscape.com)
Researchers did not have information on subjective outcomes such as nonfatal myocardial infarction . (medscape.com)
In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
There is no evidence that cardiac screening improves patient outcomes in asymptomatic, low-risk adults. (medscape.com)
conducted a meta-analysis of the effects of supplemental LC-OM3 on the outcomes of all-cause mortality, cardiac death, sudden death, myocardial infarction (MI), and stroke. (gertitashkomd.com)
Societal factors rather than genetics might drive disparities in cardiovascular disease (CVD) outcomes among individuals who self-identify as Black. (aacc.org)
Exposure of human populations to smoke emitted by these fires increases, thereby contributing to airborne pollution through the emission of gas and particulate matter (PM). The adverse health outcomes associated with wildland fire exposure represent an important burden on the economies and health systems of societies. (frontiersin.org)
Biomarkers of microvascular health could then represent possible markers for the early detection of poor cardiovascular outcomes. (frontiersin.org)
Looking forward, we think time-dependent analyses will be helpful to examine the temporal relationship between hypoglycemia and cardiovascular outcomes, which could shed light on hypoglycemia's contribution to CV risk. (closeconcerns.com)
After noncardiac etiology arrests and missing hospital outcomes were excluded from the analysis (n = 8,585), 31,689 OHCA events of presumed cardiac etiology (e.g., myocardial infarction or arrhythmia) that received resuscitation efforts in the prehospital setting were analyzed. (cdc.gov)

The clinical presentation of AF spans the entire spectrum from asymptomatic AF with rapid ventricular response to cardiogenic shock or devastating cerebrovascular accident (CVA). (medscape.com)

The key mechanisms underlying myocardial I/R injury include increased intracellular calcium concentration, sudden generation of reactive oxygen species (ROS) and inflammatory cytokines, adenosine triphosphate (ATP) depletion, and development of metabolic acidosis. (researchsquare.com)
This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach. (biomedcentral.com)
In metabolism-independent mechanisms, impaired heart function contributes to splanchnic circulation congestion, bowel wall edema, and altered intestinal barrier, resulting in bacterial translocation, passage of bacterial products in the bloodstream, and subsequent pro-inflammatory state. (encyclopedia.pub)
My laboratory's overall goal is to (i) understand the mechanisms of right heart failure in children and adults with congenital heart disease and (ii) to develop biomarkers as a plasma signature of myocardial events to better understand the mechanisms of heart failure, improve monitoring of disease progression, early detection of heart failure and risk-stratification. (stanford.edu)
Genetically engineered mouse models of human cardiovascular disease provide an opportunity to understand critical pathophysiological mechanisms. (biomedcentral.com)
It is very clear that the next decade will witness an explosion of information attempting to elucidate the associations between COPD and its systemic expressions, provide objective evidence of the mechanisms and, in the end, improve the management of patients with COPD. (ersjournals.com)
1 Thus, it is imperative to understand the mechanisms involved in inhibition of myocardial fibrosis. (dovepress.com)
The exact mechanisms by which cardiovascular risk factors predispose to AF are not understood fully but are under intense investigation. (medscape.com)

In a limited number of studies of patients with compromised myocardium (severe congestive heart failure, acute myocardial infarction, hypertrophic cardiomyopathy), administration of intravenous diltiazem produced no significant effect on contractility, left ventricular end diastolic pressure, or pulmonary capillary wedge pressure. (nih.gov)
In the ischemic myocardium, an increase in glucose uptake and subsequent ATP generated through glycolysis helps to sustain myocardial electric and mechanical performance, maintains cellular ultrastructure, promotes myocardial recovery. (biomedcentral.com)
The injured myocardium develops an evolving dependence on glucose as its preferred metabolic substrate while development of myocardial insulin resistance is associated with the progression of heart failure and increased incidence as well as severity of the damaged hearts. (biomedcentral.com)
Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. (consultant360.com)
In addition treatment with T. terrestris decreased the leakage of CK-MB and LDH enzymes from myocardium, there was a significant improvement in cardiac function as evidenced by correction of MAP, HR, LVEDP and contractility and relaxation. (scialert.net)
The current medical therapies are capable of rescuing the remaining viable tissues within the damaged heart, while the problem is an inability to replace lost myocardium with regenerated cardiovascular cells [ 2 ]. (biomedcentral.com)

The preliminary diagnosis was acute anterior wall myocardial infarction (MI) with cardiogenic shock and pulmonary edema. (consultant360.com)

Structural differences between ventricles could explain susceptibility to right ventricular arrythmias in Brugada syndrome. (norheart.no)
1) Larger intramural clefts between cardiomyocyte layers in the right ventricle compared to the left could be the cause of right ventricular arrhythmias in Brugada syndrome . (norheart.no)
Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome. (norheart.no)
We observed that cigarette smoking exacerbated both left and right ventricular remodeling only in males at an early stage of post-MI. (biomedcentral.com)
Worsened right ventricular remodeling in males was independent of pulmonary congestion. (biomedcentral.com)
Biomarkers, Socioeconomic Factors, and Right Ventricular Function After Surgical Repair for Tetralogy of Fallot. (stanford.edu)

the 2 procedures were equally effective in the treatment of low-risk patients with 3-vessel disease and in low- and intermediate-risk patients with left main CAD. (medscape.com)
In recent years, several randomized controlled trials (RCTs) have assessed the effects of supplemental long-chain omega-3 polyunsaturated fatty acids (LC-OM3), primarily eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ), on risk for various types of cardiovascular disease (CVD) events. (gertitashkomd.com)
In developed countries, cardiovascular disease is the main complication causing death resulted from diabetes ( 5 , 6 ). (spandidos-publications.com)
Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested in both preclinical and clinical studies. (biomedcentral.com)
The leading cause of death in end-stage kidney disease is related to cardiovascular disease. (biomedcentral.com)
Even mild chronic kidney disease (CKD) with isolated albuminuria has been associated with a 2- to 4-fold increased risk of cardiovascular events [ 1 ]. (biomedcentral.com)
The mechanistic relationship between renal functional decline and increasing rates of cardiovascular disease and mortality is complex and not fully explained by the frequent co-existence of conventional CVD risk factors such as diabetes, hypertension or dyslipidemia [ 8 ]. (biomedcentral.com)
Heart failure (HF) has been considered as one of the leading cardiovascular disease with high morbidity and high mortality in the world. (researchsquare.com)
Statistics suggests that nearly 50% of deaths from cardiovascular disease are associated with hypertension. (kjpp.net)
In this study, BAVENCIO plus best supportive care (BSC) as first-line maintenance therapy significantly extended the survival of patients with previously untreated locally advanced or metastatic UC whose disease did not progress on induction chemotherapy, compared with BSC only. (emdserono.com)
Ischemic heart disease (IHD), specifically acute myocardial infarction (AMI), is the most common type of heart disease. (biomedcentral.com)
Genetically engineered mice are useful for mechanistic studies of cardiovascular disease states, which depend, in part, on quantitative phenotypic characterization. (biomedcentral.com)
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow obstruction. (ersjournals.com)
However, in many patients the disease is associated with several systemic manifestations that can effectively result in impaired functional capacity, worsening dyspnoea, reduced health-related quality of life and increased mortality. (ersjournals.com)
And early studies have hinted that the type 2 diabetes drugs Actos and Avandia may help fight heart disease not only by improving blood sugar but also by battling inflammation. (natap.org)
But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)
Carotid artery wall thickness, a measure of arteries that supply the brain and an indicator of heart disease, also improved with Actos. (natap.org)
One of the most important complications of diabetes mellitus is cardiovascular disease [ 1 - 3 ]. (aging-us.com)
In a 15-year prospective cohort study of 132,250 Japanese subjects, Xu et al found that anemia and chronic kidney disease, alone and in combination, were associated with an increased risk of new-onset AF. (medscape.com)

The multivariate models adjusted for demographic characteristics, clinical risk factors, and other variables. (medscape.com)
The addition of baPWV and PWDC to a clinical mode could significantly improve the R square in prediction of E/Ea and C statistic and integrated discrimination index in prediction of LVDD (p ≤ 0.010). (medsci.org)
The addition of baPWV and PWDC to a clinical model improved the prediction of high E/Ea and LVDD. (medsci.org)
Heart failure (HF) is a complex clinical syndrome caused by any structural or functional impairment of ventricular filling orejection of blood[1].It has been considered as one of the major public health concerns with high mortality and economic burden of the patients all over the world. (researchsquare.com)
The key functions of NICE are technology appraisal of both new and existing interventions, in order to assess clinical benefit and cost effectiveness. (bmj.com)
HTA groups such as NICE and ANAES (Agence Nationale d'Accreditation et d'Evaluation en Sante) in France are seen as being much more influential since they impact on clinical practice and reimbursement. (bmj.com)
Investigations have moved into phase I and II clinical trials examining the safety and efficacy of ADSCs in the setting of myocardial infarction. (biomedcentral.com)
In this review, we discuss the differentiation and paracrine functions of ADSCs, the strategies promoting their therapeutic efficacy, and their clinical usage. (biomedcentral.com)
Increasing numbers of animal and clinical studies have focused on ADSCs and their therapeutic application in treating IHDs. (biomedcentral.com)
The goal is to create a targeted biomarker panel for clinical utility to be used in conjunction with imaging data to improve overall prediction of risk. (stanford.edu)
Because most acute cardiovascular events are associated with thrombosis, intensive antiplatelet therapy offers a major clinical benefit to diabetic patients. (aging-us.com)
Determine which clinical assessments and tests are needed for a patient with cardiovascular symptoms. (cdc.gov)

The experiments were conducted on ventricular tissue from male rats five weeks after a myocardial infarction due to artery occlusion. (norheart.no)
The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. (spandidos-publications.com)
reported that miR-21 knockdown significantly suppressed left atrial fibrotic remodeling, tissue fibrosis, and AF persistence in rats with heart failure after experimental myocardial infarction 8 . (nature.com)
Isoproterenol was administered in rats to induce myocardial infarction. (scialert.net)
This study aimed to assess the effects of exogenous hydrogen sulfide (H 2 S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. (kjpp.net)
After a model of rats with AAC was built surgically, AAC + H 2 S group and H 2 S group were injected intraperitoneally with H 2 S (100 μmol/kg) daily. (kjpp.net)
Therefore, increasing the expression of P-eif2α reverses the activation of the PI3K/AKT1 signaling pathway by H 2 S. In conclusion, these findings suggest that exogenous H 2 S can ameliorate MF in rats with AAC by inhibiting pyroptosis, and the mechanism may be associated with inhibiting the phosphorylation of eif2α and activating the PI3K/AKT1 signaling pathway to inhibit excessive cell autophagy. (kjpp.net)
A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)

Breast cancer treatment can be improved with biomarkers for early detection and individualized therapy. (cdc.gov)
Combination of these biomarkers did not increase predictive utility compared to hs-cTnT alone ( p = 0.349). (biomedcentral.com)
Combining these biomarkers could not further improve predictive utility compared to hs-cTnT alone. (biomedcentral.com)

Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
Transforming growth factor beta (TGF-P) signaling pathway plays a pivotal role in mediating cardiac fibroblast (CF) function and cardiac fibrosis. (cyberleninka.org)
Echocardiographic parameters, myocardial fibrosis, NOX2 expression and EndMT were assessed. (dovepress.com)
Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)

Chronically, microvascular and macrovascular complications are the major reasons for increasing morbidity and mortality in patients with diabetes. (spandidos-publications.com)
An increased requirement for pharmacologic or mechanical support in the weaning process was associated with higher morbidity and mortality and longer times on CPB. (medscape.com)
Preoperative risk stratification can facilitate the identification of patients at increased risk for perioperative morbidity and mortality, but it does not take into account significant intraoperative factors. (medscape.com)
Nevertheless, it is essential to maintain vigilance in the OR, especially in addressing an aging population at increased risk for surgical morbidity and mortality. (medscape.com)

The main risk factor raising the mortality and morbidity of type 1 DM is cardiovascular complications. (spandidos-publications.com)

However, in rare instances, worsening of congestive heart failure has been reported in patients with preexisting impaired ventricular function. (nih.gov)
Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two related and growing health care problems [ 1 , 2 ], with an increasing trend in elderly people [ 3 ]. (hindawi.com)
By maintaining the atrial contribution to cardiac output, symptoms of heart failure and overall quality of life can improve. (medscape.com)
Data suggest that intact FGF23 level in plasma is independent predictor of cardiovascular death in patients with heart failure and provides added value to standard of care, natriuretic peptide (NT-proBNP) plasma level, for risk estimation. (cusabio.com)
Despite the increasing population of heart failure patients, the number of heart transplantation has not increased proportionally over the past 2 decades due to the shortage of donor hearts(2). (researchsquare.com)
Heart failure and myocardial infarction are insulin-resistant states that are associated with a significant risk for either concurrently having or subsequently developing newly-onset diabetes [ 3 ]. (biomedcentral.com)
Multivariable adjusted Cox models evaluated any link between West African ancestry and risk of CVD events such as heart failure, death, and nonfatal myocardial infarction (MI). (aacc.org)
TC generally improves rapidly within a few weeks with supportive management, with almost full recovery of LV function, although traditional heart failure medication has been used. (consultant360.com)
As the survival continues to improve, so also has the incidence of heart failure. (stanford.edu)
In mice with heart failure, the sedation/anesthesia regimen had no clear impact on cardiac function. (biomedcentral.com)
In mice with heart failure, there was a non-significant trend toward preservation of physiologic heart rate during deep sedation, but no discernable differential effect on LV systolic function. (biomedcentral.com)
The discussion on SAVOR and EXAMINE centered about the increased risk of hospitalization for heart failure found in SAVOR and the trend toward the same result observed in EXAMINE. (closeconcerns.com)
Other important safety findings (pancreatitis, hypoglycemia, kidney function) were also discussed, but were overshadowed by the heart failure discussion. (closeconcerns.com)

Levels of N-terminal pro-brain-type natriuretic peptide increases in response to exercise in patients with pulmonary arterial hypertension. (cusabio.com)

Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. (spandidos-publications.com)
This provides an excellent opportunity to intervene in order to reduce the number and severity of cardiovascular events. (medscape.com)

Researchers developed univariate and multivariable Cox proportional hazards models to assess the association of abnormal MPI variables with all-cause mortality in the overall population and in symptomatic and asymptomatic patients with diabetes. (medscape.com)
Limitations for this study included potential referral bias - especially among asymptomatic people who generally are not referred for imaging when high-risk features are missing - and no information on duration of diabetes, quality of glycemic or lipid control, renal function, or diabetic end-organ damage, which are all factors that could help stratify risk in asymptomatic people with diabetes. (medscape.com)
Clinicians should therefore emphasize strategies to reduce cardiovascular risk even further among low-risk adults by treating modifiable risk factors (smoking, diabetes, blood pressure, hyperlipidemia, overweight, and exercise). (medscape.com)
Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. (spandidos-publications.com)
To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. (spandidos-publications.com)
However, there is an increasing interest in using natural foods as herbal treatments, including as diabetes therapeutics ( 11 - 14 ). (spandidos-publications.com)
Herbal and traditional Chinese medicine have also exhibited a strong impact on treatment of cardiovascular complications in diabetes ( 17 ). (spandidos-publications.com)
They improve blood sugar by reducing insulin resistance, a hallmark of type 2 diabetes. (natap.org)
Unfortunately, these figures are expected to increase over the next years due to an increase in CVD risk factors, such as obesity and diabetes, as well as an expansion of the elderly population [ 3 ] . (encyclopedia.pub)
Dr. Julio Rosenstock spoke on the ongoing CAROLINA cardiovascular outcome trial for BI/Lilly's Tradjenta (linagliptin), which he discussed recently during a Sanofi symposium on cardiovascular considerations in diabetes - read our coverage of his full talk on CVOTs on page 4 of our EASD 2013 Day #1 Report at http://www.closeconcerns.com/knowledgebase/r/19d6b5c0 . (closeconcerns.com)
We produced an animal model of type 2 diabetes mellitus using ApoE −/− mice. (aging-us.com)

Background/Aims: Hypoxia is a basic pathological challenge that is associated with numerous cardiovascular disorders including aberrant cardiac remodeling. (cyberleninka.org)
At the same time, the presence of cardiovascular disorders can be responsible for gut dysbiosis. (encyclopedia.pub)

These cells have the potential to differentiate into cardiovascular lineages, such as cardiomyocytes (CMs), endothelial cells (ECs), and vascular smooth muscle cells (VSMCs) [ 7 ]. (biomedcentral.com)
Qin R , Zhu H , Wang F , Song M , Lin P , Xing Y , Zhang W , Zhong M , Wang Z , . Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation. (aging-us.com)

Clinicians should conduct cardiovascular risk assessment with a global risk score combining individual risk factor measurements into a single quantitative estimate of risk. (medscape.com)

Risk stratification and early preventive measures can reduce major cardiovascular events given the long latent asymptomatic period. (bvsalud.org)

The group most likely to survive an OHCA are persons who are witnessed to collapse by a bystander and found in a shockable rhythm (e.g., ventricular fibrillation or pulseless ventricular tachycardia). (cdc.gov)

We identified spleen as an important source of these cardiovascular complications in Hmox1 −/− mice. (springer.com)
Describe cardiovascular symptoms and complications associated with post-COVID conditions. (cdc.gov)
Today I'll present an overview of post-COVID conditions as an introduction of the main presentation on evaluating and supporting patients with cardiovascular symptoms and complications following COVID-19. (cdc.gov)

Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
On the one hand, it improves early post-MI survival by decreasing the occurrence of cardiac rupture. (springer.com)
However, several randomized controlled trials have demonstrated that a strategy aimed at restoring and maintaining sinus rhythm neither improves survival nor reduces the risk of stroke in patients with AF. (medscape.com)
Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
The survival of patients with AMI has been substantially improved by advanced medical treatments and device-based therapies. (biomedcentral.com)
The majority of persons who experience an OHCA event, irrespective of etiology, do not receive bystander-assisted cardiopulmonary resuscitation (CPR) or other timely interventions that are known to improve the likelihood of survival to hospital discharge (e.g., defibrillation). (cdc.gov)
Because nearly half of cardiac arrest events are witnessed, efforts to increase survival rates should focus on timely and effective delivery of interventions by bystanders and emergency medical services (EMS) personnel. (cdc.gov)

are at increased risk for atherosclerosis, and more recently, psoriasis has been tied to an increased risk of aortic stenosis. (msdmanuals.com)

Researchers calculated MBFR as the ratio of myocardial blood flow at stress to flow at rest for the entire left ventricle. (medscape.com)
In the Brugada syndrome, the function of the cardiac sodium channel Na V 1.5 is commonly lost in both the left and right ventricle, although arrhythmias preferentially arrise from the right ventricle. (norheart.no)
Cleft differences were similar in both mice groups, but conduction velocities were only impaired during increased pacing of the right ventricle in the genetically modified mouse model . (norheart.no)
Aortic stenosis (AS) is narrowing of the aortic valve, obstructing blood flow from the left ventricle to the ascending aorta during systole. (msdmanuals.com)

There is no doubt that comorbidities increase the risk of hospitalisation and mortality in COPD patients, especially as the airway obstruction becomes more severe 1 . (ersjournals.com)

His-Purkinje tissue, atrial and ventricular muscle, and extranodal accessory pathways. (nih.gov)
Simona Salerno 's PhD work uses two-photon microscopy to assess the electrophysiology of ventricular tissue from small animals. (norheart.no)
Following acute sodium current inhibition, conduction slowing was also present in right , but not left, ventricular tissue from wild-type mice . (norheart.no)
In the border zone between normal and scarred ventricular tissue, action potentials and calcium transients are normal deep down in the tissue, but not in the superficial connective tissue structures. (norheart.no)
The relationship between monocyte subset and macrophage phenotype is still to be resolved, however tissue macrophages clearly have diverse functions and are key inflammatory mediators [ 23 ]. (biomedcentral.com)
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and tissue antioxidant, reduced glutathione (GSH) along with a concomitant increase in the lipid peroxidation product malonaldehyde (MDA). (scialert.net)
Pretreatment with T. terrestris resulted in the increased activities of SOD, CAT, GSHPx and prevention of depletion of tissue glutathione along with inhibition of lipid peroxidation. (scialert.net)
We observed that H 2 S can improve left ventricular function and the deposition of myocardial collagen fibers, inhibit pyroptosis, down-regulate the expression of P-eif2α in myocardial tissue, and inhibit cell autophagy by activating the phosphatidylinositol 3-kinase (PI3K)/AKT1 signaling pathway (p (kjpp.net)
Adipose tissue also has a significantly higher stem cell density than bone marrow (5% versus 0.01%) [ 7 ]. (biomedcentral.com)
The decrease of bone tissue mass and boost of marrow adiposity with improving age can be connected with a intensifying upsurge in oxidative tension (Operating-system) [31]. (tech-strategy.org)

The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
Given these advantages, ADSCs may be better candidates for myocardial regeneration than bone marrow-derived stem cells. (biomedcentral.com)

Cardiac function, histology, and infarct size were assessed, and inflammatory markers quantified by RT-PCR. (biomedcentral.com)
At day 7, infarct size was increased by cigarette smoking in males only, which was accompanied by enhanced collagen deposition in both the infarcted and peri-infarcted areas. (biomedcentral.com)
Recent data suggested that microRNA-101a (miR-101a) exerted anti-fibrotic effects in post-infarct cardiac remodeling and improved cardiac function. (cyberleninka.org)
CMR imaging was performed within the first week after infarction to assess infarct characteristics, including MVO. (biomedcentral.com)

Cardioprotective effects of Hmox1 were demonstrated in experimental models of myocardial infarction (MI). (springer.com)
The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. (biomedcentral.com)
We assessed cardiac response in two experimental models of CKD and tested macrophage and chemokine implication in monocytopenic CCR2 −/− and anti-CXCL10 treated mice. (biomedcentral.com)
Experimental evidence suggests that these factors may be causally related to CVD, but the direction of causality is difficult to determine, as a major confounder is their reduced renal clearance or metabolism with reduced kidney function. (biomedcentral.com)

The pharmacological properties of herbal remedies, including the amelioration of insulin sensitivity, the promotion of insulin secretion, the increase of glucose uptake by adipose and muscle tissues, the inhibition of sugar absorption in intestines and the generation of sugar by hepatocytes, have been demonstrated in several studies ( 15 , 16 ). (spandidos-publications.com)
Accordingly, mechanism of enhancing myocardial energetic efficiency by stimulating glucose availability and utilization has led to the vigorous pursuit of therapeutic approaches designed to augment glucose uptake and oxidation. (biomedcentral.com)
One such area of interest is the ability to modulate myocardial glucose uptake and its impact on cardioprotection. (biomedcentral.com)

In multiple logistic regression analyses for independent predictors of myocardial damage, the adjusted odds ratios for myocardial damage (peak CK >3,000 U/L) in quartiles 3 and 4 of the D-T3-time were 4.0 (95% CI: 1.0-16.1) and 7.0 (95% confidence interval (CI): 1.4-36.0), respectively. (go.jp)

Cardiovascular magnetic resonance (CMR) provides precise reproducible assessment of cardiac structure and function, but, in contrast to echocardiography, requires that the animal be immobilized during image acquisition. (biomedcentral.com)
Cardiovascular magnetic resonance (CMR) provides quantitatively precise characterization of cardiac structure and function noninvasively in vivo , but can be somewhat hindered by the need to immobilize the animal during image acquisition. (biomedcentral.com)

Patients diagnosed with portopulmonary hypertension (POPH) had significantly higher BNP levels in comparison with those patients without. (cusabio.com)
Myocardial injury caused by pressure overload that is accompanied by hypertension shows a close association with cardiovascular death. (kjpp.net)

Delivery of miR-101a mimics significantly suppressed the expression of TGFpRI and p-Smad 3, CF differentiation and collagen content of CFs. (cyberleninka.org)

Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)

[ 36 ] Clinically silent recurrences of AF in the rhythm-control group are theorized to be responsible for the increased rates of thromboembolic events and mortality noted in this cohort. (medscape.com)

Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
Peripheral lung inflammation may cause a "spill-over" of cytokines, such as interlukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α, into the systemic circulation, which may increase acute-phase proteins such as C-reactive protein (CRP). (ersjournals.com)

A study in JAMA Cardiology found no significant associations between West African ancestry and blood pressure (BP), kidney function, and left ventricular mass changes in response to antihypertensive therapy. (aacc.org)

Conduction slowing predisposes to functional block and initiation of ventricular arrhythmias. (norheart.no)

Anatomy12

Organisms4

Diseases56

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Phenomena and Processes28

Information Science5

Health Care35

Ejection fraction10

Coronary24

Hypertrophy4

Diseases15

Valvular heart d2

Elevation myocardial2

Ischemia5

Atrial fibrillation3

Prevalence3

Dysfunction9

STEMI1

Stress myocardial perfusion1

Outcomes10

Rapid ventricular response1

Mechanisms8

Myocardium6

Cardiogenic shock1

Right ventricular6

Disease19

Clinical12

Rats8

Biomarkers3

Fibrosis4

Morbidity and morta4

Mortality and morbidity1

Heart failure13

Pulmonary1

Severity of cardiovascular events2

Diabetes12

Disorders2

Vascular2

Clinicians1

Asymptomatic1

Fibrillation1

Complications3

Survival7

Atherosclerosis1

Ventricle4

Severe1

Tissue10

Bone marrow-derived2

Infarct4

Experimental4

Glucose uptake3

Predictors1

Magnetic resonance2

Hypertension2

Differentiation1

Attenuate1

Events1

Necrosis2

Cardiology1

Conduction1