The objective of this research was to address the fundamental issue of whether bone loss and muscle atrophy could be attenuated using weight-bearing aerobic exercise on a treadmill as a countermeasure in rats subjected to simulated weightlessness by hindlimb suspension. (cdc.gov)
Results: Femoral BMD of hindlimb-suspended (HS) rats subjected to treadmill exercise was significantly greater than femoral BMD of HS rats without exercise and also was equivalent to that of weight-bearing controls. (cdc.gov)
Muscle mass from HS rats exercised on a treadmill was significantly greater than muscle mass from HS rats that did not exercise. (cdc.gov)
Modulation of intracellular calcium ([Ca 2ϩ ]i) transient in response to -adrenoceptor stimulation in the hearts of hindlimb unweighted (HLU) rats during simulated weightlessness has not been reported. (archive.org)
Effects of isoproterenol on electrically induced single-cell contraction and [Ca 2ϩ ]i transient in myocytes of ventricles in HLU rats were significantly attenuated. (archive.org)
1984). Biotransformation Rats Thin layer chromatography (TLC) of the urine of rats treated with 14 C-metiram as single oral doses of 5 or 50 mg/kg bw, and a single oral dose of 100 mg/kg bw of a 15 N-metiram and 14 C-metiram suspension (1:1 ratio), revealed eight principal radioactive components. (inchem.org)
Weightlessness2
Conclusions: It was concluded that moderate aerobic exercise on a treadmill did attenuate bone loss and muscle atrophy due to simulated weightlessness by hindlimb suspension, however its effectiveness differed by tissue, anatomical site and parameter investigated. (cdc.gov)
In the present study, we adopted the rat tail suspension for 4 wk to simulate weightlessness. (archive.org)
Muscle atrophy1
Aerobic exercise as a countermeasure for microgravity-induced bone loss and muscle atrophy in a rat hindlimb suspension model. (cdc.gov)
Tail suspension test2
OBX significantly impaired cognitive behavior in a novel object recognition test and a modified Y-maze test and induced depression-like behavior in a tail suspension test. (hindawi.com)
Among these phenotypes, we found that CS mice exhibit an extremely low immobility time in both the tail suspension test (TST) and forced swimming test (FST). (fujita-hu.ac.jp)
Muscles2
2000 Neuroleptics increase c-fos expression in the forebrain: contrasting NADPH-diaphorase activity and c-fos expression in medullary neurons after fatiguing stimulation of hindlimb muscles in the rat - den 19 oktober 2003 kl 17:40. (web.app)
Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
The muscimol-induced current in the hippocampal CA1 pyramidal neurons and hippocampal expression of the 67-kDa isoform of glutamic acid decarboxylase significantly decreased in Usp46 mutant mice. (fujita-hu.ac.jp)
Behavior1
c-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). (web.app)
Results1
Results -Lame limbs had significantly lower peak vertical GRF, less flexion of the distal interphalangeal joint, and less extension of the metacarpophalangeal joint, compared with compensating limbs. (avma.org)
Inflammatory1
For example, one early study from 2010 showed that whey protein supplements might significantly reduce blood cholesterol, blood pressure, and inflammatory markers. (greatist.com)
Study2
In addition, in a 2005 study it was determined that nearly 100 genes key to the human immune system were either "not induced" or significantly inhibited when exposed to a weightless environment. (todayifoundout.com)
A prospective study of 120 men with TD receiving TRT observed that men who experienced improvement in symptoms had significantly higher baseline American Urological Association Symptom Index (AUASI) scores than those who experienced no change or interval worsening in symptoms [Pearl et al, taux testosterone homme. (uniiquelyraw.com)
Lower1
The manifestation of in HCC cells is definitely significantly lower than that in normal cells and upregulating manifestation inhibited cell proliferation, indicated that may be an antioncogene57. (colinsbraincancer.com)
No other bone parameters were found to vary significantly between groups. (cdc.gov)
Compared with the control group, no significant changes were found in heart weight, body weight, and mean arterial blood pressure, whereas LVP and ϮdP/dtmax were significantly reduced. (archive.org)
found that the manifestation of NLRP3 in HCC cells was significantly downregulated and even completely absent, and its manifestation was negatively correlated with the pathological grade and medical stage of HCC, indicating that the NLRP3 inflammasome was involved in the progression of HCC51. (colinsbraincancer.com)
Control1
Method: Bone and muscle from control and hindlimb-suspended groups with and without exercise were evaluated by bone mineral density (BMD), mechanical tests, bone histomorphometry and muscle mass. (cdc.gov)
Injection1
Four weeks after 6-OHDA injection, the intensity and maximal area of contact were significantly decreased in the affected paws and the swing speed significantly decreased in all four paws. (biomedcentral.com)
Animal1
Suspensions were made individually for each animal freshly before use and injected i.p. in a dose of 5, 15, or 30?mg/kg according to the experiment. (chiflatironsofficial.com)
Components1
Incubation with -glucuronidase/sulphatase did not significantly alter the proportion of radioactive components. (inchem.org)
Mass1
Transfer of body weight from lame to compensating limbs was smooth, without elevation of the body mass into a suspension phase. (avma.org)
Response1
LVP and ϮdP/dtmax were significantly attenuated in the HLU group in response to isoproterenol administration. (archive.org)
Methods2
More particularly, the present invention relates to injectable suspensions having improved injectability, and to methods for the preparation of such injectable suspensions. (justia.com)
METHODS ：BRE nanocrystal suspensions were prepared by media milling method. (bvsalud.org)
Vivo2
The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the fluid phase of the suspension significantly reduces in vivo injectability failures. (justia.com)
Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased in vivo . (frontiersin.org)
Disperse1
Resuspendability describes the ability of the suspension to uniformly disperse with minimal shaking after it has stood for some time. (justia.com)
Concentration3
Chapter, increase in the viscosity, density, particle size, and concentration of solids in suspension hinders the syringeability of suspensions. (justia.com)
Both forms of selenium increased significantly the amplitude of single twitches in EDL and SOL muscle in a concentration dependent manner. (biomedcentral.com)
In 0.5 ppm concentration both selenium compounds increased significantly the selenoprotein N expression only in EDL muscle. (biomedcentral.com)
Reduces1
Peripheral nervous system (PNS) injury due to disease or trauma leads to sensory and/or motor dysfunction, which significantly reduces the patient's quality of life. (frontiersin.org)
Syringe1
Clogging refers to the blockage of syringe needles while administering a suspension. (justia.com)
Treatment3
50 kDa treatment showed significant hindlimb improvement over MCM (scirp.org)
Treatment with EDR improved the reference memory and accuracy in the probe trial as evaluated in Morris water maze, as well as novel object recognition and significantly alleviated motor deficits in these mice. (nih.gov)
This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31 P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. (aacrjournals.org)
Non-invasive detection of cancer in its early stages is of great interest since early cancer diagnosis, in combination with precise cancer therapies, could significantly increase the survival rate of patients. (biomedcentral.com)
Larger1
Pachylemur was similar to but significantly larger and more robust than living ruffed lemurs (genus Varecia). (wikipedia.org)
Recovery1
Recovery of the infected quarter is rare, and can significantly impact the animal's future productivity, especially if infection is prior to the first calving 2 . (msd-animal-health-hub.co.uk)
Levels2
1. Hindlimb-suspension and spaceflight both alter cGMP levels in rat choroid plexus. (nih.gov)
Moreover, protein levels of c Myc and Aurka were also significantly increased in V617F/EpoR cells in-the absence and presence of Epo stimulation. (mirnasynthesis.com)
Hindlimb suspension (HS) has been used widely as a preclinical model of atrophy to study a variety of skeletal muscle adaptations including reduced gravity, disuse, and reloading (R) following disuse [ 30 - 35 ]. (hindawi.com)
Cells1
We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)
Vehicle1
The suspension was transferred to a glass beaker and the remaining vehicle was added. (europa.eu)
Daily1
While the grip force did not change, 5 ppm selenium diets significantly increased the speed of voluntary running and the daily distance covered. (biomedcentral.com)