• The lysosomal marker cathepsin-K was observed by immunohistochemistry on all tumours. (univr.it)
  • The S Protein is then processed/activated by the lysosomal Cathepsin L in the late endosomes (endo-lysosomes) following endocytosis of the virus. (promocell.com)
  • Lysosomal markers Cathepsin D and LAMP2a, as well as the lyososomal biogenesis transcription factor TFEB were frequently overexpressed in glioblastomas (10/23, 11/23, and 10/23 cases, respectively). (ox.ac.uk)
  • Lysosomal cathepsin proteases are secreted during cancer progression. (biomedcentral.com)
  • Proteome analyses revealed a high abundance of lysosomal enzymes and lysosome-associated proteins in cancer cells treated with TGFβ-1 and E64d. (biomedcentral.com)
  • Our results demonstrate an important role of lysosomal proteolysis in cellular remodeling during EMT and a pivotal contribution of lysosomal cysteine cathepsins to TGFβ-1 induced acquisition of breast cancer cell invasiveness. (biomedcentral.com)
  • Lysosomal cysteine cathepsins contribute to proteolytic events promoting tumor growth and metastasis. (imi-muenchen.de)
  • Lysosomal disturbance caused by glycosaminoglycans accumulation triggers secondary effects among which gangliosides GM2, GM3 and GD3 storage on central nervous system (CNS), involved on neurodegenerative process observed in MPS I. Recent studies have showed the expression of genes responsible for gangliosides metabolism are found to be significantly reduced on MPS I mice cerebellum and hippocampus, especially Neu1 gene which encodes neuraminidase 1 enzyme. (fapesp.br)
  • Together, neuraminidase 1, cathepsin A (Ctsa gene) and beta-galactosidase (Glb1 gene) enzymes belong to the lysosomal multienzyme complex (LMC), associated to some important functions like neuronal apoptosis. (fapesp.br)
  • The cysteine cathepsins have attracted significant research effort as drug targets. (wikipedia.org)
  • The established pro-metastatic role of specific cysteine cathepsins has until now been ascribed to their contribution to extracellular matrix remodeling. (biomedcentral.com)
  • We hypothesized that cysteine cathepsins affect transforming growth factor β-1 (TGFβ-1)-induced EMT of normal and malignant mammary epithelial cells. (biomedcentral.com)
  • The contribution of cysteine cathepsins was determined by addition of the general cysteine cathepsin inhibitor E64d. (biomedcentral.com)
  • Cathepsin D (an aspartyl protease) appears to cleave a variety of substrates such as fibronectin and laminin. (wikipedia.org)
  • Unlike some of the other cathepsins, cathepsin D has some protease activity at neutral pH. (wikipedia.org)
  • Cathepsin B, a thiol protease, has been reported to be involved in cancer progression and metastasis. (elsevierpure.com)
  • The suppressive effects of two kinds of protease inhibitors, leupeptin and dietary camostate (FOY-305), on tumorigenesis and progression in 1, 2-dimethylhydrazine (DMH)-induced rat colon neoplasm were examined in relation to tissue cathepsin B activity. (elsevierpure.com)
  • The cathepsin B activity levels in the tumor-bearing mucosa in the groups which received leupeptin or FOY-305 following DMH treatment were both significantly lower than that in the group which received neither protease inhibitor (P=0.046 and P= 0.0067, respectively). (elsevierpure.com)
  • Cathepsin Z is a protease synthesized by both bone remodeling cells - osteoclast and osteoblasts. (gertitashkomd.com)
  • Since these cell lineages produce the protease , cathepsin Z, the aim of this study was to investigate whether altered cathepsin Z mRNA levels are associated with osteoporosis in clinical samples. (gertitashkomd.com)
  • A further host protease required for activation of the S Protein is Cathepsin L which also facilitates SARS-CoV-2 entry into target cells through an alternative route. (promocell.com)
  • Inhibition of the Furin protease and Cathepsin L might therefore be an efficient way to attenuate the infection process and reduce the spread and severity of COVID-19. (promocell.com)
  • and finally, ( iii ) emphysematous and fibrotic lesions can be significantly attenuated by using a protease inhibitor active against neutrophil elastase. (biomedcentral.com)
  • SAR114137, a Cathepsin S inhibitor, did not progress past phase I for chronic pain. (wikipedia.org)
  • In 2022, STI-1558, a Cathepsin L inhibitor, received FDA clearance to begin phase I studies to treat COVID-19. (wikipedia.org)
  • In addition to our assays for studying binding of SARS-CoV-2 to the ACE2 receptor and screening for respective inhibitors/drugs (see below), we offer the Furin Activity Assay Kit & Furin Inhibitor Screening Kit as well as Cathepsin L Activity Assay Kit & Cathepsin L Inhibitor Screening Kit as tools to develop new targeted therapeutics for Covid-19. (promocell.com)
  • To investigate the role of cathepsin inhibitor stefin B (Stfb) in mammary cancer, Stfb null mice were crossed with transgenic polyoma virus middle T oncogene (PyMT) breast cancer mice. (imi-muenchen.de)
  • • Amura Holdings Ltd. , of Cambridge, UK, said preclinical study results showed that oral administration of the firm's cathepsin K inhibitor compounds resulted in sustained and potent reduction of serum bone turnover biomarkers, which clinically correlates with a significant reduction in fracture rates. (bioworld.com)
  • Five cyclic peptides show inhibitory activity towards human cathepsins L, B, H, and K. Several inhibitors have reached clinical trials, targeting cathepsins K and S as promising therapeutics for osteoporosis, osteoarthritis, and chronic pain. (wikipedia.org)
  • Specific Furin and Cathepsin L inhibitors which block proteolytic activation of the S Protein , and thus SARS-CoV-2 virus entry and replication, are potential antiviral agents to counteract SARS-CoV-2 infection and pathogenesis. (promocell.com)
  • In addition, a broad range of other Cathepsin Assays , Cathepsin Inhibitors as well as recombinant Cathepsins , Cathepsin antibodies & ELISAs also useful to study SARS-CoV infections (e.g. (promocell.com)
  • These findings provide an additional rationale to use cathepsin inhibitors to stall tumor metastasis. (biomedcentral.com)
  • Camel's whey protein is not only composed of numerous soluble proteins, but also has indigenous proteases such as chymotrypsin A and cathepsin D. In addition to their high nutritional value, these whey proteins have unique characteristics, including physical, chemical, physiological, functional, and technological features that are useful in the food application. (uaeu.ac.ae)
  • Rabbit Polyclonal to MMP-8 Serine proteases, cathepsin G, and neutrophil elastase (hereafter referred as to elastase) were shown to induce homotypic cell-cell aggregationin vitropppt= 5). (angiogenesis-blog.com)
  • Assessment of the Effects of Serine Proteases within the Adherence Capacity of MCF-7 and MDA-MB-231 Cells Cathepsin G shows more potent aggregation-inducing activity against MCF-7 cells than does elastase [14] or chymotrypsin [28]. (angiogenesis-blog.com)
  • Therefore, among these proteases, cathepsin G was the most potent inducer of MCF-7 spheroidal aggregation. (angiogenesis-blog.com)
  • In particular, neutrophil elastase (NE), and other elastolytic proteases, such as cathepsin G, and macrophage elastase are thought to be the main causative factors of tissue damage in this condition. (biomedcentral.com)
  • High levels of this enzyme in tumor cells seems to be associated with greater invasiveness. (wikipedia.org)
  • Given that cancer cell lysosomes often exhibit high levels of the enzyme 'Cathepsin B,' responsible for protein degradation, the micelles specifically target these lysosomes. (hi-helsinki-city.com)
  • Cathepsin K, a member of a large family of cysteine peptidases, is an enzyme that breaks down the collagen bone matrix as part of a normal biological process. (bioworld.com)
  • The test is Cathepsin Z mRNA and is measured in human peripheral blood mononuclear cells. (gertitashkomd.com)
  • Authors found a strong correlation of elevated levels of Cathepsin Z mRNA in patients with osteopenia in addition to those with osteoporosis. (gertitashkomd.com)
  • Irrespective of the biological effects of cathepsin Z, it has now been shown for the FIRST TIME here that the increase in cathepsin Z mRNA in isolated PBMC fractions is very strongly diagnostic for osteoporosis, at least in the patient group studied. (gertitashkomd.com)
  • These results for cathepsin Z mRNA as a single biomarker are comparable to a peripheral blood biomarker panel consisting of 10 mRNAs including cathepsin Z mRNA for diagnosis of ischaemic stroke. (gertitashkomd.com)
  • Furthermore, the observation that subjects with osteopenia also showed a significant increase in cathepsin Z mRNA compared to non-osteoporotic controls, strongly suggests that if replicated in a larger study, the cathepsin Z mRNA in patients' PBMC preparations could form the basis of a test for osteoporosis , which could aid in the detection of osteoporosis before a critical and expensive fragility fracture occurs. (gertitashkomd.com)
  • Cathepsin Z mRNA has been shown for the first time to be significantly elevated in the PBMCs of patients with either osteopenia or osteoporosis compared to non-osteoporotic controls. (gertitashkomd.com)
  • However, the increase in cathepsin Z mRNA level in osteopenia/osteoporosis was also observed when male and female participants over the age of 50, or female participants over the age of 50 were analysed. (gertitashkomd.com)
  • ITT, GTT, and MTT showed that CS rats were neither insulin resistant nor glucose intolerant, but mRNA expression of cholecystokinin (CCK) in the duodenum was higher and that of CPT1, PPARα, and PGC1α in liver were lower than in CR rats. (frontiersin.org)
  • Activities for serine peptidases (chymotrypsin-, trypsin-, and elastase-like), cysteine peptidases (cathepsin B-, cathepsin L-, and calpaine-like), and aminopeptidase (B-like peptidases) were tested fluorometrically with peptides coupled to 7-amino-4-methylcoumarin. (edu.pe)
  • Cathepsin B has also been implicated in the progression of various human tumors including ovarian cancer. (wikipedia.org)
  • However, the percentage of small tumors was significantly higher in the group in which leupeptin was supplied during DMH administration. (elsevierpure.com)
  • The ratio of cathepsin B activity in the tumors to that in the tumor-bearing tissue (T/Tb) was significantly increased with increasing tumor size (P=0.009). (elsevierpure.com)
  • Cathepsin B may function as a beta-secretase 1, cleaving amyloid precursor protein to produce amyloid beta. (wikipedia.org)
  • Plasma adipokine profiling showed significantly higher concentrations of the novel adipokines cathepsin S (5.1 x 10(4) vs 4.3 x 10(4) ng/L, P = 0.003) and chemerin (4.1 x 10(5) vs 2.7 x 10(5) ng/L, P = 0.0008) in morbidly obese patients than normal weight controls, besides the established differences in adiponectin and leptin concentrations. (ox.ac.uk)
  • PMSF attenuated cell aggregation on cathepsin G-treated substrates, but the effect was fragile in cells pretreated with high concentrations of cathepsin G. In contrast, PMSF did not suppress cell aggregation on elastase-treated FN. (angiogenesis-blog.com)
  • In contrast, higher concentrations (greater than 40?nM) of chymotrypsin and trypsin were required to induce aggregation. (angiogenesis-blog.com)
  • Our data showed that NOD.H2ᴴ⁴ thyrocytes cultured with low NaI concentrations had significantly higher apoptotic rates compared to CBA/J thyrocytes. (mun.ca)
  • A chymotrypsin-like peptidase showed the highest activity in both parasites, and it had 10 times higher activity in T. solium than in T. saginata. (edu.pe)
  • Since cathepsin G offers chymotrypsin-like and trypsin-like substrate specificities, we 1st compared the activity of cathepsin G with elastase, chymotrypsin, and trypsin. (angiogenesis-blog.com)
  • Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
  • Cathepsin K, among other cathepsins, plays a role in cancer metastasis through the degradation of the extracellular matrix. (wikipedia.org)
  • There are, however, exceptions such as cathepsin K, which works extracellularly after secretion by osteoclasts in bone resorption. (wikipedia.org)
  • Increased reactive oxygen species lead to secretion of cathepsin D by an mechanism that is currently not well understood. (medscape.com)
  • Ulteriorly, endogenous collagenase was shown to degrade IMCT crucial components, while endogenous cathepsins had little effect. (bvsalud.org)
  • Cathepsin K is the most potent mammalian collagenase. (wikipedia.org)
  • As a result, prozac causes pain specific regions of the peptide within the micelle structure are cleaved by Cathepsin B enzymes. (hi-helsinki-city.com)
  • Moreover, cathepsin G, but not elastase, induced aggregation on poly-L-lysine substrates which are not decomposed by these enzymes, and the action of cathepsin G was nearly completely attenuated by PMSF. (angiogenesis-blog.com)
  • Stroke Traumatic brain injury Alzheimer's disease Arthritis Ebola, Cathepsin B and to a lesser extent cathepsin L have been found to be necessary for the virus to enter host cells. (wikipedia.org)
  • infection with ebola virus causes a severe disease accompanied by high mortality rates, and there are no licensed vaccines or therapies available for human use. (liverpool.ac.uk)
  • Background:Serum cathepsin B activity has been considered a potential marker of tumor progression. (medscimonit.com)
  • The aim of this study was to assess serum cathepsin activity during tumor progression and regression.Material/Methods: Of 60 female rats inoculated with Morris hepatoma cells, 45 were treated with BRT, and the remaining 15 were left without treatment. (medscimonit.com)
  • SNP rs13720, which is located in the 3′UTR of cathepsin Z (CTSZ), showed the strongest association (odds ratio [OR] = 2.15, P = 7.62 × 10 -7 ) with progression to jaundice stage in GWAS. (elsevierpure.com)
  • High-density association mapping at the CTSZ and negative elongation factor complex member C/D (NELFCD) loci, which are located within a strong linkage disequilibrium (LD) block, revealed that an intronic SNP of CTSZ, rs163800, was significantly associated with jaundice-stage progression (OR = 2.16, P = 8.57 × 10 -8 ). (elsevierpure.com)
  • Frequency of borderline positive C-ANCA and all positive PR3-ANCA (positive + borderline positive) was significantly higher in the CHB group ( P = 0.009 and P = 0.005, resp. (hindawi.com)
  • Cathepsin L-deficient mice were shown to have less adipose tissue, lower serum glucose and insulin levels, more insulin receptor subunits, more glucose transporter (GLUT4) and more fibronectin than wild type controls. (wikipedia.org)
  • Serum cathepsin B activity was determined, tumor volumes were measured, and histological examinations of the tumor tissues were performed.Results: Of the 45 BRT-treated rats, tumor regression was observed in 31 rats, and serum cathepsin activity was analyzed in these rats. (medscimonit.com)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • C-reactive protein (CRP) levels were significantly higher in patients than in controls and there was a significant correlation between serum and salivary CRP levels. (who.int)
  • Para la elaboración de este artículo de revisión narrativa se consultaron las publicaciones disponibles a neutrófilos en el través de una búsqueda automatizada en las bases de datos de PubMed, Scopus y Embase. (bvsalud.org)
  • Osteoclasts are the bone resorbing cells of the body, and they secrete cathepsin K in order to break down collagen, the major component of the non-mineral protein matrix of the bone. (wikipedia.org)
  • Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. (biomedcentral.com)
  • The cathepsin A activity in lysates of metastatic lesions of malignant melanoma is significantly higher than in primary focus lysates. (wikipedia.org)
  • The genetic knockout for cathepsin S and K in mice with atherosclerosis was shown to reduce the size of atherosclerotic lesions. (wikipedia.org)
  • In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
  • Specifically, cathepsin-B activity, IL-1beta, IL-18, and IL-33 levels were significantly higher in BMWCNT than FMWCNT treated mice. (cdc.gov)
  • The results obtained indicate that leupeptin may have suppressed tumor growth by lowering the tissue cathepsin B activity. (elsevierpure.com)
  • Although no particular peptidase had high activity in T. solium, and was absent in T. saginata, or vice versa, different patterns of activity were found. (edu.pe)
  • Minimal levels of cathepsin B were present in both species, and higher levels of elastase-like and cathepsin L-like activity were observed in T. saginata. (edu.pe)
  • Remarkably, reduced invasion was also evident if E64d was removed 24 h before the invasion assay in order to allow for recovery of cathepsin activity. (biomedcentral.com)
  • One of them, VHH-B9, showed high selectivity for BACE1 and efficacy in lowering BACE1 activity in vitro. (biorxiv.org)
  • We previously reported that rats prone to obesity exhibit an exaggerated increase in glucose oxidation and an exaggerated decline in lipid oxidation under a low-fat high-carbohydrate (LF/HC) diet. (frontiersin.org)
  • Such a mechanism may explain why CS rats share many characteristics observed in rats fed a high-glycemic index diet. (frontiersin.org)
  • Cathepsin K is involved in osteoporosis, a disease in which a decrease in bone density causes an increased risk for fracture. (wikipedia.org)
  • Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. (biomedcentral.com)
  • Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. (biomedcentral.com)
  • Conclusions: Cathepsin B may play an important role, not only in tumor expansion, but also during the processes of cancer cell death and resorption. (medscimonit.com)
  • CONCLUSIONS: Our findings underscore the relevance of the novel adipokines cathepsin S and chemerin, but foremost the potential of this novel method for both comprehensive adipokine profiling in large patient cohorts and for biological discovery. (ox.ac.uk)
  • The discrimination ratio of the COS group in the Y-maze experiment was 59.3% higher than that of the ETOH group. (bvsalud.org)
  • Region and season significantly change the ratio of compounds in camel's milk. (uaeu.ac.ae)
  • The plasma concentration of Rapa delivered by FAF was 8-fold higher with a significantly increased plasma-to-whole blood ratio relative to free Rapa, 24 h after injection. (usc.edu)
  • These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. (nature.com)
  • We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients. (nature.com)
  • The development of a method to reliably identify high-risk atherosclerotic plaques is seen as one of the major quests of contemporary cardiovascular medicine. (nature.com)
  • We here propose the use of near-infrared autofluorescence (NIRAF) for the identification of high-risk atherosclerotic plaques. (nature.com)
  • Mouse cathepsin L is homologous to human cathepsin V. Mouse cathepsin L has been shown to play a role in adipogenesis and glucose intolerance in mice. (wikipedia.org)
  • Our data showed that high salt intake failed to significantly affect the incidence and severity of SAT in NOD.H2ᴴ⁴ mice or EAT in Tgprimed C57BL/6J and T4p2553-primed CBA/J mice relative to mice on a normal diet. (mun.ca)
  • In 6/14 (52%) the expression was high, with a quantitative increase of ≥3 fold induction in 4 angiomyolipoma compared to normal tissue. (univr.it)
  • The changes in the value of tissue cathepsins B and L, MDA and histopathological changes were examined. (ogu.edu.tr)
  • High-fat (HF) diets, when compared to high-carbohydrate (HC) diets, are more at risk to induce body weight gain because of the large storage capacities of adipose tissue and the low satiating effects of high fat diets, as compared to the low capacities of the glycogen stores and of the de novo lipogenesis cost ( 6 ). (frontiersin.org)
  • High efficiency delivery of such agents to the lung, therefore, will not only have a positive impact on lung inflammation, but will also have disease-modifying effects on the progressive loss of lung function caused by chronic degradation of lung tissue. (ddw-online.com)
  • For immunohistochemical staining, sections were stained with the antibodies LC3B-II and cathepsin-K. LC3B-II was also analyzed by immunofluorescence. (univr.it)
  • We also supply a choice of Biochemicals with known inhibitory effects on SARS-CoVs as well as a range of high-quality Antibodies specifically directed against particular components of SARS-CoV and the ACE2 receptor. (promocell.com)
  • For all participants, the mean ages of the non-osteoporotic control, osteopenia and osteoporosis groups were significantly different at 56, 65 and 69 years with the ages of the osteopenia and osteoporosis groups being significantly different from the non-osteoporotic control group ( P = 0.025 and 0.0045 respectively, ANOVA post hoc Dunnett multiple comparison with a control). (gertitashkomd.com)
  • Specifically, the soleus muscle weight and muscle-weight-to-body-weight ratios in the astaxanthin group were significantly higher than in the control group, but tibialis anterior muscle mass was similar between the two dietary groups. (newhope.com)
  • 0.05), did reduce significantly MDA value compared to treatment group (p (ogu.edu.tr)
  • Cathepsin zymography separates different cathepsins based on their migration through a polyacrylamide gel co-polymerized with a gelatin substrate. (wikipedia.org)
  • incidence rates were highest for leukemia (46.6), central nervous system (CNS) neoplasms (30.8), and lymphoma (27.3). (cdc.gov)
  • Cathepsin A increased in muscles moderately affected by muscular dystrophy and denervating diseases. (wikipedia.org)
  • Lastly, we have examined whether a high salt diet can exacerbate autoimmune thyroiditis because previous studies by other groups had suggested this diet as a predisposing factor for autoimmune diseases in general. (mun.ca)
  • These data demonstrate that a high salt diet is not a risk factor for all autoimmune diseases. (mun.ca)
  • In this context, slowing down the rate of glucose absorption by adding insoluble fibers to a high sucrose diet was shown to reduce fat deposition and alleviate the evolution of the symptoms of metabolic syndrome ( 14 ). (frontiersin.org)
  • The level of ubiquitinated proteins was significantly lower in the soleus muscles of the astaxanthin group, but not in the tibialis anterior muscles when compared with the control group. (newhope.com)
  • Glioblastomas showed cytoplasmic overexpression of autophagic proteins in a varying extent, so that cases could be grouped into low and high expression groups. (ox.ac.uk)
  • Many of these proteins were more significantly enriched in amyloid plaques than Aβ. (researchsquare.com)
  • Trypsin-like and cathepsin B-like activities were significantly higher in T. solium. (edu.pe)
  • XP is a severe genetic disease carrying a very high predisposition to skin cancers caused by severe burns when patients are exposed to UV light. (bioworld.com)
  • However, upon treatment with the lysosomotropic agent Leu-Leu-OMe, cancer cells lacking Stfb exhibited a significantly higher sensitivity to apoptosis. (imi-muenchen.de)
  • In the present study, the frequency of ANCA was high in both groups. (hindawi.com)
  • The expression of cathepsin K in cultured endothelial cells is regulated by shear stress. (wikipedia.org)
  • The protein expression level of ß-arrestin-2 in the COS group was 2.85 times higher than that in the ETOH group. (bvsalud.org)
  • PTEN was also significantly related with LC3B but not LC3A expression, in both immunohistochemistry and gene expression analysis. (ox.ac.uk)
  • ART exhibited significant anti-angiogenic role on granulomas illustrated by remarkable milder intensity and significantly lower expression values of VEGF and CD34 immunostaining compared to PZQ and non-treated groups. (degruyter.com)
  • Significantly, these micelles incorporate 'RGD peptides,' known for their selective targeting ability towards receptors overexpressed on cancer cell membranes. (hi-helsinki-city.com)
  • The CHB group had a relatively higher frequency of ANCA positivity compared to controls. (hindawi.com)
  • Interpretation: Higher vaccination coverage in Nam Dinh than TT Hue likely contributed to substantial declines in rotavirus positivity observed in Nam Dinh following rotavirus vaccine introduction. (cdc.gov)
  • However, the idea of replacing fat with carbohydrate is now challenged by the respective quality of fats and carbohydrates ( 11 ), insisting on the adverse effects of high glycemic index carbohydrate on the control of food intake and on the evolution of insulin resistance ( 12 , 13 ). (frontiersin.org)
  • Within this work, we took benefit of electroencephalography (EEG) to give a direct access to brain function with higher time resolution and also a wonderful sensitivity. (ezh2inhibitor.com)
  • It has been seen that cathepsin L values did not reduce significantly for both groups. (ogu.edu.tr)
  • In the higher age groups, the debilitating effects of chronic obstructive pulmonary disease (COPD) and chronic bronchitis represent significantly higher causes of morbidity and mortality. (ddw-online.com)
  • Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
  • These studies showed that phosphorylated Aβ, pyroglutamate Aβ species and SMOC1 were significantly higher in DS plaques, while oligomers were significantly higher in EOAD. (researchsquare.com)
  • Cathepsins have a vital role in mammalian cellular turnover. (wikipedia.org)
  • Cathepsin K has also been shown to play a role in arthritis. (wikipedia.org)
  • Building space heating load and swimming pool heat loss evaluated by the TRNSYS simulation.Figure ten presents the simulation final results of your power demand and provide of your FC-CHP technique with the ELT (a) and FTO (b) FC operating method, such as the constructing electrical energy load, thermal load, fuel cell Chlorpyrifos-oxon In Vivo electric power generation, heat generation (higher grade and low grade), and efficient heat. (cathepsin-s.com)
  • 15%. The multiplex immunoassay results correlated significantly with ELISA measurements. (ox.ac.uk)
  • These results suggest that cathepsin G induces MCF-7 aggregation through a cell-oriented mechanism. (angiogenesis-blog.com)
  • These results suggest that ANCA may have a high prevalence in Turkey. (hindawi.com)