• Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
  • To identify key genes differentially expressed in the human retinal pigment epithelium (hRPE) following low-level West Nile virus (WNV) infection. (molvis.org)
  • The number of differentially expressed genes (DEGs) from comparison groups in cultivated ginseng was higher than that in wild ginseng. (biomedcentral.com)
  • Significant changes in gene expression, the production of vital proteins controlled by genes, were also revealed. (uni-bayreuth.de)
  • In the past few decades, studies have focused on investigating the genes and proteins responsible for the development and progression of HCC ( 3 ). (spandidos-publications.com)
  • Traditional western blot The full total proteins of every group was extracted using RIPA lysis buffer (Beijing solarbio technology & technology co. (physiciansontherise.org)
  • ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
  • The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
  • 14] provided evidence of the association between the polymorphisms of the OLR1 gene and growth traits, as well as dairy quality parameters in buffalo. (researchsquare.com)
  • Considering the aforementioned studies, there has been little research conducted on the impact of genetic polymorphisms in the OLR1 gene on fecundity traits in livestock, and no research on their association with fecundity traits in Awassi sheep. (researchsquare.com)
  • The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. (who.int)
  • Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
  • Thymidine kinase gene amplicon sequences (339 bp) from 21 lynx were all identical to those of poxviruses to new regions through relocation of their from cowpox virus isolated from a person in Norway and natural host species is possible ( 10 ). (cdc.gov)
  • We found shifts of AMF and total fungi community structures caused by recurrent drought and plant species richness, but no buffering of drought effects by plant diversity. (ufz.de)
  • Alpha-diversity (VT or ASV richness) of both AMF and total fungi increased with plant species richness but was not significantly affected by drought. (ufz.de)
  • As a model organism, they chose bumblebees of the widespread species Bombus terrestris (buff-tailed bumblebee). (uni-bayreuth.de)
  • Futhermore, the rG4s that have analogues in many ortholog genes across different species show a preferential association with RNA processing and stability. (nih.gov)
  • Not only does dormancy create structure and memory that buffers populations against environmental fluctuations, it also modifies species interactions in ways that can feed back onto the eco-evolutionary dynamics of microbial communities. (nature.com)
  • Taking the density of regulatory sites in promoters as a measure of the potential and complexity of gene regulation, we found it to be quantitatively the same in all three environments, despite their different physico-chemical conditions and species composition. (biomedcentral.com)
  • Our collections are mainly used in taxonomic research to clarify species boundaries, relationships and which name should be used. (lu.se)
  • Increasingly, the collections are also used to extract DNA and thus enable studies of species' relationships, distribution history and population genetics, or to investigate the expression, variation or change of different genes over time. (lu.se)
  • Epigenetic alternations in genomic DNA include cytosine methylation in CpG islands, which usually extend throughout the promoters and the first exons of genes. (spandidos-publications.com)
  • DNA methylation, which is associated with gene silencing ( 12 ), is carried out by DNA methyltransferases (DNMTs). (spandidos-publications.com)
  • Recent studies have established that, similar to mutations, methylation-mediated silencing of tumor suppressor genes plays a major role in tumorigenesis. (spandidos-publications.com)
  • SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
  • The progression of hepatocellular carcinogenesis is thought to involve the deregulation of genes that are critical to cellular processes, such as cell cycle control, cell growth, apoptosis, cell migration and spreading. (spandidos-publications.com)
  • In agreement with GSS activity localization in vivo , we identified six genes encoding arylsulfatase-like enzymes with a predicted C-terminal transmembrane domain, of which five showed GSS activity upon heterologous expression in insect cells. (nature.com)
  • Analysis of the transcriptome - this is the totality of RNA molecules produced at a given time - revealed that the expression of 324 genes had changed. (uni-bayreuth.de)
  • There is much to suggest that the altered gene expression is a stress response that attacks and weakens the insects' energy resources. (uni-bayreuth.de)
  • specific rG4s have been shown to regulate gene expression, and are associated with human diseases. (nih.gov)
  • RNA extracted from mock-infected and WNV-infected cells was assessed for differential expression of genes using Affymetrix microarray. (molvis.org)
  • Low-level WNV infection of hRPE cells induced expression of genes that are typically associated with the host cell response to virus infection. (molvis.org)
  • Previous research showed that scavenger receptor class A member 5 (SCARA5) was one of the potential biomarkers of OSCC, and its expression is significantly low in OSCC. (degruyter.com)
  • But it is not known whether and how the regulation of gene expression also contributes to adaptation. (biomedcentral.com)
  • While the sequencing of metagenomes provides an overview of the genes present in specific environments that can potentially play a role in adaptation, the analysis of expression provides a more precise picture of what functions are expressed and active in a particular moment of the environment. (biomedcentral.com)
  • The high VGLL3 expression group had a significantly worse prognosis compared to the low expression group, as per both GEPIA (P = 0.0057) and ONCOLNC (P = 0.01). (researchgate.net)
  • In the present study, the expression of DBF4 and CDC7 and their relationship with clinical characteristics were comprehensively analyzed. (biomedcentral.com)
  • Detailly, compared with adjacent tissues, both mRNA and protein of DBF4 and CDC7 were significantly higher in HCC, and their expression was positively correlated with AJCC_T stage, clinical stage and G stage (grade) of liver cancer patients, and higher DBF4 or CDC7 expression predicted a worse prognosis in HCC patients with shorter overall survival (OS), recurrence-free survival (RFS), disease-specific survival (DSS) and progress-free survival (PFS). (biomedcentral.com)
  • In this present study, we comprehensively analyzed the expression of DDK complex members (DBF4 and CDC7) and the relationship between their expression and clinical features based on HCC from our hospital and public databases (TCGA, GEO). (biomedcentral.com)
  • It was observed that GNG7 gene expression was downregulated in CCRCC tissue compared with healthy tissue, and high GNG7 predicted better prognosis for patients, and GNG7 also showed strong variability in clinical and TMN staging. (biomedcentral.com)
  • In general, microRNAs, a class of small (~21 nucleotide) non-coding RNAs, negatively regulate the expression of their target genes. (spandidos-publications.com)
  • miRNAs are highly conserved, small, non-coding RNAs that negatively regulate gene expression in vertebrates through multiple mechanisms, such as complimentary base pairing with the 3′-UTR of their target mRNAs, resulting in translational repression, mRNA cleavage and mRNA decay initiated by miRNA-guided rapid deadenylation ( 10 ). (spandidos-publications.com)
  • Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
  • mRNA expression data of energy-related genes were extracted from our whole retinal Affymetrix microarray data. (molvis.org)
  • The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)
  • Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)
  • Here, we compared gill-microbiota, gene expression and host-microorganism interactions in a group of deep sea mussels ( Gigantidas haimaensis ) parasitized by scale worm (PA group) and a no parasitic control group (NPA group). (frontiersin.org)
  • Together, our findings provide new insights into the effects of parasite scale worms on changes in symbiotic bacteria and gene expression in deep sea mussel hosts. (frontiersin.org)
  • Transcriptome sequencing on the roots, stems and leaves of cultivated ginseng and wild ginseng with different growth years was performed in this study, exploring the effect of growth years on gene expression in ginseng. (biomedcentral.com)
  • The result of weighted gene co-expression network analysis (WGCNA) showed that growth years significantly affected the gene expression of Mitogen-activated protein kinases (MAPK) signaling pathway and terpenoid backbone biosynthesis pathway in cultivated ginseng, but had no effects in wild ginseng. (biomedcentral.com)
  • However, it had little influence on the expression of genes related to ginsenoside synthesis in wild ginseng. (biomedcentral.com)
  • Growth years might affect the expression of genes for ginsenoside synthesis by influencing the expression of these transcription factors (TFs), like my elob lastosis (MYB), NAM, ATAF1 and 2, and CUC2 (NAC), APETALA2/ethylene-responsive factor (AP2/ERF), basic helix-loop-helix (bHLH) and WRKY, etc., thereby affecting the content of ginsenosides. (biomedcentral.com)
  • Concurrently, p62 gene expression is increased by oxidative stress through activation of the transcription factor NF-E2-related factor 2 ( 18 ). (spandidos-publications.com)
  • KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [ 3 ]. (medsci.org)
  • KLF6 downregulation enhances MDM2 gene expression that deregulates the p53 pathway [ 9 ]. (medsci.org)
  • We here explore the relationship between DRDs and Tfh cells, and analyse the relationship between DRD expression on Tfh cells and the course of SLE. (bmj.com)
  • Results The plasma dopamine concentration in patients with SLE was significantly increased, and abnormal mRNA expression of DRDs was observed in both PBMCs and CD4 + T cells. (bmj.com)
  • Results Circ_0000527 was highly expressed in both RB and RB cell lines, whose high expression level and degree Doripenem of differentiation were significantly correlated with the increase in cTNM staging level. (physiciansontherise.org)
  • 1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)
  • An ERh gene expression profile was identified and was markedly different from the ERa signature. (lu.se)
  • Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)
  • Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
  • The immune relevance of GNG7 and related genes was explored using renal cancer data from CCLE and TISIDB database. (biomedcentral.com)
  • A CCRCC prognostic model that involved 7 immune genes was further established to predict the survival probabilities of patients. (biomedcentral.com)
  • Our study proposed a novel panel of genes to predict CCRCC OS based on GNG7-related immune genes, which may help to accurately predict the prognosis of CCRCC patients and make better clinical decisions for individual treatment. (biomedcentral.com)
  • As a result, modern populations might differ for the amount of archaic genes incorporated in their gene pool, which are eventually expressed and may result in phenotypic differences affecting, for example, the immune response [ 8 ], or lipid catabolism [ 9 ]. (biorxiv.org)
  • immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)
  • We also found that the number of Bifidobacterium and Lactobacillus , and the Firmicutes to Bacteroidetes ratio correlated negatively and significantly with the plasma glucose level while the quantity of Clostridium correlated positively and significantly with the plasma glucose level in the diabetes group. (biomedcentral.com)
  • Microbial DNA was extracted from subgingival dental plaque (n=281) and V3-V4 regions of the 16S rRNA gene were sequenced to measure the relative abundances of 20 a priori - selected taxa with nitrate‐reducing capacity. (ahajournals.org)
  • according to morphological, physiological and its 16S rRNA gene sequence. (researchgate.net)
  • In an integrated analysis of the interactions between changes in the microbiota and host gene dysregulation, we found an agreement between the microbiota and transcriptomic responses to B. pettiboneaei parasitism. (frontiersin.org)
  • Researchers carried out an enzyme treatment at 50°C in the presence of 0.1M phosphate buffer (pH 7.0) for 3h where addition of commercial cellulases alone extensively removed protruding jute and cotton fibers from the fabric, whereas addition of commercial pectinases or xylanases mainly loosened the protruding long jute fiber bundle. (scialert.net)
  • Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)
  • Certain yeast that were somewhat ethanol-tolerant showed high activity in genes related to phosphate utilization. (mit.edu)
  • And further testing showed that the role of the phosphate, a natural pH buffer, was simply to reduce the acidity of the mixture. (mit.edu)
  • After characterizing allelic variation with pooled population sequencing, we found that seed banks retained twice as many host genes with mutations, whether phages were present or not. (nature.com)
  • Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells. (medsci.org)
  • The homeostatic regulation of cellular ATP is achieved by the coordinated activity of ATP utilization, synthesis, and buffering. (molvis.org)
  • New insights into cell-specific and compartmental ATP and GTP production, as well as utilization and buffering strategies and their relationship with known retinal and cellular functions, are discussed. (molvis.org)
  • RNA-seq was performed in blood Ly6C high and Ly6C low MC sorted by flow cytometry from control and HHcy cystathionine β-synthase gene-deficient ( Cbs -/- ) mice. (frontiersin.org)
  • In this context, drought was shown to have negative effects on ecosystems by disrupting ecological processes, which could be buffered in more biodiverse systems. (ufz.de)
  • After 9 years of summer droughts, bulk soil was sampled and used for Illumina sequencing of the ITS2 and SSU genes to characterize the total fungal and arbuscular mycorrhizal fungal (AMF) communities, respectively. (ufz.de)
  • With regard to glucose homeostasis, genetic variants in the IGF2R gene have been shown to be associated with both type 1 [ 5 ] and type 2 diabetes (T2DM) [ 6 ]. (hindawi.com)
  • RNA sequencing, shRNA knockdown, and chromatin Immunoprecipitation (ChIP) sequencing were performed to detect the target genes of ginsenoside Rg1-CNV that regulate angiogenesis. (cbinsights.com)
  • Meanwhile, the intervention of ginsenoside Rg1-CNV promoted the demethylation of H3K27me3 within the promoter region of VEGF-A and Jagged1 genes and reduced the H3K27me3 modification within this region. (cbinsights.com)
  • Furthermore, the growth years had significant effects on the genes related to ginsenoside synthesis in cultivated ginseng, and the effects were different in the roots, stems and leaves. (biomedcentral.com)
  • Subjects with R/R genotype had significantly higher FVIIc levels than Q353 heterozygote and homozygote subjects (96.36 versus 59.52). (who.int)
  • There were no significant difference between the genotype frequencies and chronic complications of diabetes, but the relationship between the Ff genotype and ketoacidosis was significant. (who.int)
  • Among the functions with highest regulatory potential in each niche, we found significant enrichment of processes related to sensing and buffering external variable factors specific to each environment, like for example, the availability of co-factors in deep sea, of oligosaccharides in soil and the regulation of pH in the acid mine. (biomedcentral.com)
  • Importantly, we demonstrate that the overexpression of miR-148a significantly inhibits HCC cell proliferation and cell cycle progression. (spandidos-publications.com)
  • Then, bioinformatic analysis was performed to investigate the mechanism of action of epigenetic modifying enzymes in regulating target genes. (cbinsights.com)
  • Analysis of the genes for ribosomal large subunit (LSU) and whole small subunit (SSU) also help to elucidate phylogenetic relationships, since these genes are more conserved and less subject to evolutionary changes. (wikipedia.org)
  • A total of 7,928 SDE genes and 46 canonical pathways derived from it were identified. (frontiersin.org)
  • Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
  • Collectively, this late-model protocol provides a applicable and plain approach representing enabling characterization of the contribution of gene-modified T cell subsets in FAKE. (lekavi.ru)
  • Since the bacteria had first been measured in human populations in the early 1900s, its prevalence has decreased steadily and significantly. (reachmd.com)
  • The details of the dispersal routes, and the relationships between fossils and contemporary populations, are all but established. (biorxiv.org)
  • 11 , 12 Light-dependent gene silencing can be achieved through whole-organism irradiation or the targeted illumination of specific cell populations. (cdc.gov)
  • We also identified other genes, including IDO1 and BAMBI, that may influence the RPE and therefore outer blood-retinal barrier integrity during ocular infection and inflammation, or are associated with degeneration, as seen for example in aging. (molvis.org)
  • The ESBL genotypes were determined by polymerase chain reaction (PCR) using the bla(SHV), bla(TEM), and bla(CTX-M) gene sequences. (who.int)
  • Taken together, the genetic storage provided by seed banks can buffer lineages from extinction and contribute to the maintenance of diversity within a population [ 24 ]. (nature.com)
  • The symbiotic microorganism diversity of the PA group significantly decreased than NPA group, while the relative abundance of chemoautotrophic symbiotic bacteria that provide the host with organic carbon compounds significantly increased in PA. (frontiersin.org)
  • In conclusion, IGF2R gene polymorphism and circulating IGF2R are associated with T2DM. (hindawi.com)
  • The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
  • Additionally, immunohistochemistry results indicated that RSV treatment reduced the density of proliferating cell nuclear antigen-positive cells significantly in glomeruli of diabetic mice. (hindawi.com)
  • Immunohistochemical staining revealed that nuclear KLF6 level was significantly and inversely associated with tumor size and stages. (medsci.org)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Interestingly, RNA-seq revealed that G. haimaensis hosts responded to B. pettiboneaei parasitism through significant upregulation of protein and lipid anabolism related genes, and that this parasitism may enhance host mussel nutrient anabolism but inhibit the host's ability to absorb nutrients, thus potentially helping the parasite obtain nutrients from the host. (frontiersin.org)
  • The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
  • Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)
  • This study aimed to determine the genetic variation of the OLR1 gene affecting the fecundity traits of Awassi ewes. (researchsquare.com)
  • Additionally, there is a relationship between OLR1 gene genetic polymorphism and litter size in Xidu black pigs. (researchsquare.com)
  • The development of caged MOs (cMOs) has significantly extended the versatility of these reverse-genetic tools. (cdc.gov)
  • Gene set enrichment analysis (GSEA) was used to analyze the pathway enrichment of DBF4 and CDC7. (biomedcentral.com)
  • However, no transcriptome-wide method has been reported to map rG4s, limiting our understanding of the rG4 structure and its relationship with function and regulation. (nih.gov)
  • More recently, metagenomic studies have gone beyond the sequencing of DNA and the counting of genes, and have incorporated techniques and protocols to detect, measure and analyze their transcriptome. (biomedcentral.com)
  • This breakthrough research emphasized interactions as buffer against psychological and physical disorders. (securemulticast.org)
  • For both men and women the M genitalium prevalence was significantly higher in partners of M genitalium positive index patients than in M genitalium negative index patients with urethritis and/or cervicitis. (bmj.com)
  • Results: Analysis of the ONCOMINE and GEPIA databases showed that VGLL3 was significantly up-regulated in GC tissues (P = 0.003), and associated with the tumor TNM stage (P = 0.0163). (researchgate.net)
  • Enthesis development has historically been studied with lineage tracing of individual genes selected a priori, which does not allow for the determination of single-cell landscapes yielding mature cell types and tissues. (elifesciences.org)
  • In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)
  • The aim of this study is to investigate the insulin-like growth factor type 2 (IGF2R) gene and circulating soluble IGF2R in relation to type 2 diabetes (T2DM). (hindawi.com)
  • RNA structures are of crucial importance for biological function and gene regulation. (nih.gov)
  • Because of its Serologic surveys and detection of OPV DNA by PCR have relationship to variola virus and immunologic cross- indicated that wild rodents and shrews are likely reservoir reaction, cowpox virus was used to protect humans against hosts of cowpox virus in western Europe ( 19 - 23 ), although smallpox ( 1 ). (cdc.gov)
  • This reaction continues to move to the left as long as CO 2 is constantly eliminated or until HCO 3 - is significantly depleted, making less HCO 3 - available to bind H + . That HCO 3 - and PaCO 2 can be managed independently (by kidneys and lungs, respectively) makes this a very effective buffering system. (medscape.com)
  • On the upside, mask compliance on the Hill improved significantly and steadily over the course of the semester. (colorado.edu)
  • A. strictum has been shown to be involved in some myoparasitic relationships, as well as a wide range of plant endophytic and parasitic relationships, and further studies are required to determine A. strictum's use as a biological control agent and role as a parasite that reduces crop yields. (wikipedia.org)
  • The climbing index in GSO-treated Drosophila was significantly higher than that in the tert-butyl-hydroperoxide-treated flies. (sdbonline.org)
  • The frequencies of 3 genotypes ( Aa, FF and Bb ) were significantly higher in the patient group. (who.int)
  • However, whether circulating IGF2R is determined by IGF2R gene variants and how soluble IGR2R is related to diabetes in adults are currently unknown. (hindawi.com)
  • Our aim was to quantify and evaluate the difference in the composition of gut microbiota between children with type 1 diabetes and healthy children and to determine the possible relationship of the gut microbiota of children with type 1 diabetes with the glycemic level. (biomedcentral.com)
  • In the children with diabetes, the bacterial number of Actinobacteria and Firmicutes, and the Firmicutes to Bacteroidetes ratio were all significantly decreased, with the quantity of Bacteroidetes significantly increased with respect to healthy children. (biomedcentral.com)
  • Moreover, the quantity of bacteria essential to maintain gut integrity was significantly lower in the children with diabetes than the healthy children. (biomedcentral.com)
  • People know that it's not one gene that says you'll be susceptible to diabetes or not. (mit.edu)
  • Altering a single gene has not prevented diabetes-or made yeast more ethanol-tolerant. (mit.edu)
  • CONCLUSIONS: In nursing homes, universal decolonization with chlorhexidine and nasal iodophor led to a significantly lower risk of transfer to a hospital due to infection than routine care. (cdc.gov)
  • Conventional MOs are typically used to constitutively disrupt targeted genes in an organism-wide manner. (cdc.gov)
  • Quantitative real-time PCR analysis of 23 genes was used to validate the microarray results. (molvis.org)
  • OBJECTIVES: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). (surrey.ac.uk)
  • Definition of the homologous of bovine subunit VII of ubiquinol-cytochrome C reductaseshould facilitate further analysis of structure/function relationships of silkworm cytochrome bcl complex. (researchgate.net)
  • Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. (cdc.gov)
  • We and others have synthesized light-activatable cMOs that allow spatiotemporal control of RNA splicing or translation, complementing the use of conditional knockouts to study stage- and tissue-specific differences in gene function. (cdc.gov)
  • 18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • The cells were stained according to the proportion of 10?L Annexin V-fluorescein isothiocyanate (Annexin V-FITC) and 5?L propidium iodide (PI) kit (BD Biosciences, San Diego, CA, USA) per 1?ml cell suspension and incubated in dark at room temperature for 15?min, followed by the addiditon of 400?L binding buffer. (physiciansontherise.org)
  • This prospective study was conducted with 96 spent CM from patients undergoing IVF cycle, in order to determine relationships of Cell-free DNA levels in embryo CM with embryo cleavage quality on day 3. (who.int)
  • Total excess fat mass was significantly lower in the OLETF-tadalafil group versus the OLETF-vehicle group. (thetechnoant.info)
  • Twenty-five strains (40.3%) harbored the CTX-M group 1 gene. (who.int)
  • In mRNAs, rG4s are enriched in untranslated regions, and are significantly correlated with microRNA target sites and polyadenylation signals. (nih.gov)
  • It was observed that NRA, growth and fibre yield decreased significantly with the reduction in light intensity. (scialert.net)