• Women with BRCA- mutated ( BRCA m) advanced ovarian cancer treated first-line with LYNPARZA maintenance therapy had a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared to placebo. (merck.com)
  • Sean Bohen, executive vice president, global medicines development and chief medical officer at AstraZeneca, said, "For the first time, we see a significant and clinically impactful improvement in progression-free survival in the first-line maintenance setting for women with BRCA -mutated ovarian cancer treated with a PARP inhibitor. (merck.com)
  • A retrospective analysis 4 of 323 patients with advanced oropharyngeal squamous cell cancer enrolled in a randomized clinical trial found a 3-year overall survival rate of 82.4% for HPV-associated disease vs 57.1% for HPV-negative disease, and progression-free survival of 73.7% vs 43.4%, Dr. Agrawal reported. (ascopost.com)
  • Note that significantly more people who were treated with combined stereotactic radiosurgery and whole-brain radiation had a cognitive decline compared with those who had stereotactic radiosurgery alone, with no improvement in overall survival. (medpagetoday.com)
  • In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
  • CLDC-containing plasmid significantly improved survival, decreased systemic and liver viral loads, and reduced liver damage due to progression of viral infection. (usu.edu)
  • ESAs shortened overall survival and/or increased the risk of tumor progression or recurrence in clinical studies of patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
  • In vitro, miR-21 knockdown decreased survival in all BrCa subtypes in the presence of radiation. (jefferson.edu)
  • THOUSAND OAKS, Calif.--(BUSINESS WIRE)--April 3, 2006--Amgen (Nasdaq:AMGN), the world's largest biotechnology company, today announced pivotal Phase 3 results demonstrating that panitumumab significantly improved progression-free survival and disease control (response rate and stable disease) compared to best supportive care (BSC) in metastatic colorectal cancer patients who had failed standard chemotherapy. (amgen.com)
  • Panitumumab improved progression-free survival and response rate regardless of the measured level or intensity of EGFr staining. (amgen.com)
  • Improvements in progression-free survival and disease control also occurred regardless of age, sex, primary tumor location (colon versus rectum), or performance status. (amgen.com)
  • Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
  • It is well known that metastasis establishment, cell survival , and progression are affected by tumour-host cell interactions where changes in the host cellular compartments likely play an important role . (bvsalud.org)
  • A study comparing survival times among 341 epithelial ovarian cancer patients of whom 297 were non-diabetic, 28 were type II diabetics who did not use metformin, and 16 were type II diabetics who used metformin to find out if metformin use is associated with significantly longer progression free survival and overall survival in ovarian cancer patients. (naturalmedicinejournal.com)
  • Type II diabetes diagnosis and metformin usage were compared with progression-free survival (PFS), overall survival (OS), and chemotherapy resistance rate. (naturalmedicinejournal.com)
  • In this study Romero et al report that metformin use was associated with significantly longer progression-free survival and overall survival in ovarian cancer patients receiving standard treatments. (naturalmedicinejournal.com)
  • Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
  • On the one hand, it improves early post-MI survival by decreasing the occurrence of cardiac rupture. (springer.com)
  • Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
  • The overall survival rate at 3 mo was significantly higher in group A ( P = 0.05). (snmjournals.org)
  • The overall Kaplan-Meier survival rate and cumulative progression-free and cumulative event-free survival rates during the first 15 mo were significantly higher in patients receiving radionuclide therapy ( P = 0.019, P = 0.024, and P = 0.019, respectively). (snmjournals.org)
  • Meier survival methods to determine differences in time of progression from HIV to AIDS and death, by race/ethnicity, sex, age group, CD4+ T-cell count, metropolitan residence, and diagnosis year. (cdc.gov)
  • To improve survival of IDUs, HIV prevention efforts must ensure early access to HIV testing and care, as well as encourage adherence to antiretroviral treatment to slow disease progression. (cdc.gov)
  • There determinants of disease progression and survival. (cdc.gov)
  • Tumor progressed in 20 patients (24.7%) with the standard dose and in 19 (26%) with the decreased dose. (nih.gov)
  • Subgroup analysis by patient age, tumor status, number, size and T stage (T1G3 vs Tis) did not differ significantly. (nih.gov)
  • Thus, in tumor-bearing mice, 60% tumor reduction was observed, while in metastatic mice, the number of nodules decreased by 25% compared to the control group. (researchgate.net)
  • Although enhanced thymosin β4 (TMSB4X/Tβ4) expression is associated with tumor progression and metastasis, its tumor-promoting functions remain largely unknown. (aacrjournals.org)
  • Tβ4-knockout B16F1 (Tβ4 KO) clones show significantly diminished expression level of tumor-associated genes, which is regulated by the TGFβ/MRTFs pathway. (aacrjournals.org)
  • In conclusion, the TGFβ/Tβ4/MRTF/SRF pathway is critical for metastasis and tumor progression. (aacrjournals.org)
  • Dynamic cytoskeletal remodeling is critical to various morphogenetic and pathologic events, such as gastrulation, neural tube formation, tissue fibrosis, and tumor progression. (aacrjournals.org)
  • Factors predictive of tumor progression included age greater than 65 years (hazard ratio [HR] 2.36, 95% CI 1.30-4.29, p = 0.005), prior history of radiotherapy (HR 5.19, 95% CI 1.69-15.94, p = 0.004), and increasing tumor volume (HR 1.05, 95% CI 1.01-1.08, p = 0.005). (thejns.org)
  • Rarely, additional procedures may be required for hydrocephalus or tumor progression. (thejns.org)
  • And in vivo , PYCR1 interference also significantly inhibited tumor growth both in the tumor volume and weight. (jcancer.org)
  • We sought to determine the role of miR-21 in BrCa tumor initiation, progression and treatment response. (jefferson.edu)
  • An independent, central radiology review board assessed disease progression and tumor shrinkage. (amgen.com)
  • Patients who received panitumumab every two weeks showed a 46 percent decrease in tumor progression rate versus those who received best supportive care alone (p less than 0.000 000 001). (amgen.com)
  • Pejorative events were defined as side effects due to therapy, relapse in clinical symptoms, tumor progression, tumor laboratory marker increase, and death. (snmjournals.org)
  • Objectives To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). (bmj.com)
  • Fibrosis progression most often occurs in the long term, although the lung injury is initiated during the early stage with leakage of inflammatory cells and proteins from the circulation, into the lungs. (lu.se)
  • The groups did not differ in disease specific mortality, which was 12.2% in the standard dose arm and 16.4% in the decreased dose arm. (nih.gov)
  • A cohort study from the United Kingdom of Great Britain and Northern Ireland (UK) reported a significantly increased risk of mortality due to COVID-19 among PLWHs compared with people without HIV (14). (who.int)
  • [ii] It has been proposed that doubling global vitamin D levels could significantly reduce mortality. (baumancollege.org)
  • Previous studies explored baseline predictors for lung progression and mortality in SSc-ILD. (bmj.com)
  • Romero's findings are consistent with those of the Dutch ZODIAC trial that found a 57% decrease in cancer mortality for diabetics taking metformin. (naturalmedicinejournal.com)
  • ZODIAC also found a dose-dependent relationship, with a 42% decrease in cancer mortality for each 1-gram/day increase in dose. (naturalmedicinejournal.com)
  • Although mortality has decreased significantly and the progno- have been published. (cdc.gov)
  • However, data on people living with HIV (PLWHs) of Great Britain and Northern Ireland (UK) reported a were inconclusive ( 3 ) until a recent meta-analysis found a significantly increased risk of mortality due to COVID-19 higher incidence and more severe clinical outcomes than among PLWHs compared with people without HIV among persons without HIV. (who.int)
  • Disease recurred in 32 patients (39%) treated with the standard dose and in 33 (45%) treated with the decreased dose. (nih.gov)
  • The FDA has also approved the oral antiviral nirmatrelvir with ritonavir (Paxlovid) for the treatment of mild-to-moderate COVID-19 in adults who are at high risk for progression to severe disease. (cdc.gov)
  • There is an increasing need to provide quantitative measurements of gait, e.g. to provide detailed information about disease progression. (plos.org)
  • Scientists from the Max Planck Institute for Heart and Lung Research and Giessen University have now succeeded for the first time in an animal model in not only halting the progression of the disease, but also in reversing it with the help of an inhalation therapy. (medicalnewstoday.com)
  • Not only was the disease progression halted, we were also able to observe a clear improvement in all areas,' explains Soni Pullamsetti, first author of the study. (medicalnewstoday.com)
  • Werner Seeger, Director of the Department of Lung Development and Remodelling at the MPI and Director of the Department of Internal Medicine at University Hospital Giessen sees the potential of the study as relating to the fact that 'for the first time, the progression of the disease was not only halted but the structural changes in the blood vessels were also reversed using a locally administered substance. (medicalnewstoday.com)
  • Subjects were included if they had a disease progression of at least -1dB/year for at least three years, despite controlled intraocular pressure (IOP). (nutritionaloutlook.com)
  • A recent study found that dental chews significantly reduced gum disease 2 in adult dogs. (mindbodygreen.com)
  • The study authors concluded that dental chews are a good option for slowing the development or progression of gum disease in dogs. (mindbodygreen.com)
  • Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. (globalrph.com)
  • Here, we assess if different DAPSA disease activity states are associated with different degrees of functional impairment and different extents of joint damage progression in patients with psoriatic arthritis (PsA). (bmj.com)
  • Breast cancer (BrCa) relies on specific microRNAs to drive disease progression. (jefferson.edu)
  • Panitumumab reduced the rate of disease progression by approximately half compared to best supportive care alone in these heavily pre-treated patients," said Marc Peeters, M.D., Ph.D., coordinator of Digestive Oncology Unit, University Hospital Ghent, and one of the study's lead investigators. (amgen.com)
  • A significantly higher proportion of patients were alive and free of disease progression on panitumumab at all of the scheduled time points through week 32. (amgen.com)
  • Study investigators also reported that panitumumab significantly improved disease control versus BSC alone (36 percent versus 10 percent, respectively), as measured by response rate and stable disease. (amgen.com)
  • Panitumumab treatment also showed a clinical benefit in the patients crossing over from the BSC arm, despite their disease progression. (amgen.com)
  • In the new data he presented, sorafenib halted disease progression in more than two-thirds of patients, some for as long as three years. (ecancer.org)
  • 4 It is unclear what proportion of the results are due to direct drug effects or to overall glycemic control, as insulin-dependence is a marker of disease progression in type II diabetics. (naturalmedicinejournal.com)
  • Our objective was to estimate the proportion of IDUs with a late HIV diagnosis (AIDS diagnosis within 12 months of HIV diagnosis) and determine the factors associated with disease progression after HIV diagnosis. (cdc.gov)
  • We measured the hypothalamic neuropeptide oxytocin in plasma and cerebrospinal fluid (CSF) in a cohort of HD gene expansion carriers (HDGECs), compared the levels to healthy HD family controls and correlated oxytocin levels to disease progression and social cognition. (lu.se)
  • All HIV-infected persons at risk for infection with M. tuberculosis must be carefully evaluated and, if indicated, administered therapy to prevent the progression of latent infection to active TB disease and avoid the complications associated with HIV-related TB. (cdc.gov)
  • The total lung volume increased significantly (p=0.001) and dose-dependently compared to Saline control, although the functional lung volume decreased due to development of lesions (oedema or fibrotic tissue formation). (lu.se)
  • We determined if a third of the dose of intravesical bacillus Calmette-Guerin (BCG) has the same efficacy than a standard dose for decreasing the risk of recurrence and progression after transurethral resection in patients with superficial high risk (stages T1G3 and carcinoma in situ) bladder cancer. (nih.gov)
  • Median time to recurrence was not attained in the standard dose arm and it was 63 months in the decreased dose arm. (nih.gov)
  • Although, the recurrence rate of NMIBC is significantly decreased by TUR in combination with intravesical chemotherapy, the rate of cancer progression is not diminished ( 7 - 12 ). (spandidos-publications.com)
  • Bladder intracavitary hyperthermic perfusion chemotherapy (BHPC), the combination of local hyperthermia with chemotherapy, can significantly improve the effect of intracavity chemotherapy, and is reported to have an additive or supra-additive effect, preventing NMIBC recurrence post-TUR ( 13 - 16 , 18 - 20 ). (spandidos-publications.com)
  • Has a 3-fold decreased dose of bacillus Calmette-Guerin the same efficacy against recurrences and progression of T1G3 and Tis bladder tumors than the standard dose? (nih.gov)
  • [iv] In both in vitro and in vivo studies, results showed that mice with induced testicular cancer treated with the Cordyceps sinensis mushroom had significantly smaller and fewer tumors than the control group. (greenmedinfo.com)
  • The global ablation of miR-21 significantly decreased the tumorigenesis and metastases of BrCa, while sensitizing tumors to radio-and chemotherapeutic agents via Fas/FasL-dependent apoptosis. (jefferson.edu)
  • Kaplan-Meier estimates for time to progression did not differ significantly (p = 0.7997). (nih.gov)
  • Our data suggest that neonatal S. pneumoniae pneumonia induce serum vitamin A deficiency and long-time lung vitamin A reduction, vitamin A supplement after neonatal S. pneumoniae pneumonia inhibit the progression of asthma by altering CD4 + T cell subsets. (nature.com)
  • The risk of developing COPD is particularly high among individuals who start smoking at a young age, as tobacco smoke significantly slows lung development. (who.int)
  • Diffuse cutaneous subset, presence of antitopoisomerase-I antibodies, decreased baseline forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) were reported to be significantly associated with lung progression in patients with SSc, while positive anticentromere antibody (ACA) was protective. (bmj.com)
  • 5 In March 2012, a Taiwanese study, looking at 1 million participants, reported that the use of hypoglycemic medications was associated with a 40% decreased risk of lung cancer. (naturalmedicinejournal.com)
  • Bleomycin induced plasma leakage in the lungs, showing significantly increased immune cells as well as proteins found in the lung lumen (assessed in BALF). (lu.se)
  • Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
  • 3 A large case-control study found that long-term metformin use was associated with a decreased risk of ovarian cancer, while long-term insulin use increased risk. (naturalmedicinejournal.com)
  • Several cohort studies have found an association between metformin use and decreased cancer incidence in general. (naturalmedicinejournal.com)
  • In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)
  • Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes. (bvsalud.org)
  • Our results suggest that a 3-fold decreased dose of intravesical BCG is as effective as the standard dose against progression in patients with high risk stages T1G3 and Tis superficial bladder carcinoma but with significantly less toxicity. (nih.gov)
  • Median time to progression was not attained in either arm. (nih.gov)
  • 1-3 Risk factors for high myopia at adult age are a young age of onset and a fast progression rate during childhood. (bmj.com)
  • Those who live on into adulthood continue to suffer the health consequences of second-hand smoke exposure, as frequent lower respiratory infections in early childhood significantly increase risk of developing COPD in adulthood. (who.int)
  • Some patients with mild to moderate COVID-19 may be at increased risk for progression to severe COVID-19. (cdc.gov)
  • For these patients, therapeutics, such as antivirals, have been shown to significantly decrease the risk of hospitalization and death, and outcomes are improved if therapeutics are started within the first days of illness. (cdc.gov)
  • Decreased risk of atrial fibrillation and stroke upon usage of left atrial appendage closure device to complement market expansion. (pharmiweb.com)
  • This risk is increased with progression of HIV and uncontrolled infection (4). (who.int)
  • The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined. (globalrph.com)
  • To decrease these risks, as well as the risk of serious cardiovascular and thromboembolic reactions, use the lowest dose needed to avoid RBC transfusions [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
  • For IDUs, the risk for progression from HIV to AIDS 3 years after HIV diagnosis was greater for nonwhites, males and older persons. (cdc.gov)
  • the risk of a coronary event is thought to increase 2% for every 1% decrease in HDL cholesterol. (medscape.com)
  • There is strong evidence that quitting smoking can decrease the risk of developing kidney cancer. (who.int)
  • Brain metastases were significantly reduced following miR-146a-5p knockdown. (bvsalud.org)
  • The primary outcome was cognitive progression, defined as a decline, 3 months after the radiation, of more than 1 standard deviation from baseline on any of six standard cognitive tests that measured such things as memory and verbal skills. (medpagetoday.com)
  • When dividing the HDGECs into groups with or without cognitive impairment, we found the oxytocin level to be significantly lower by 30.3% in the HDGECs with cognitive symptoms (p = 0.046). (lu.se)
  • Among factors that play direct role in initiation and progression of fibrotic process are epithelial-mesenchymal transition and myofibroblasts recruitment/differentiation, mediated by the transforming growth factor-beta1 (TGF-beta1). (cdc.gov)
  • The contribution of miR-21 to progression and metastases was tested by crossing miR-21−/− mice with mice that spontaneously develop BrCa. (jefferson.edu)
  • Four patients (6.1%) with Tis had local extension into the prostatic urethra and ducts, including 3 (8.3%) treated with the standard dose and 1 (3.4%) treated with the decreased dose. (nih.gov)
  • Deferred cystectomy for progression was performed in 7 patients (8.4%) treated with the standard dose and in 7 (9.5%) of those treated with the decreased dose. (nih.gov)
  • Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls. (lww.com)
  • Results A total of 25/98 and 25/117 patients with SSc showed ILD progression in the derivation cohort and the validation cohort, respectively. (bmj.com)
  • For example, after six months (week 24) approximately four times as many panitumumab-treated patients were alive and progression-free (18 percent versus five percent with BSC alone). (amgen.com)
  • Twice as many panitumumab-treated patients were alive and progression-free at week 32 (10 percent versus four percent with BSC alone). (amgen.com)
  • In a randomized pilot study of 26 nondiabetic patients with biopsy-proven ACF, metformin 250 mg daily for 1 month significantly decreased the number of ACF and the cellular proliferation index. (naturalmedicinejournal.com)
  • Radionuclide therapy is feasible and safe and significantly defers the occurrence of fatal and nonfatal events in patients clinically uncontrolled by conventional therapy. (snmjournals.org)
  • Conclusion Treatment with high daily doses of cholecalciferol in patients with CKD Stages 3-4 halts the progression of SHPT and does not cause hypercalcaemia or other side effects. (medscape.com)
  • In this single-institution retrospective study, we investigate the patient characteristics and treatment outcomes, including pseudo-progression (PsP), for LGG patients selected for PT. (lu.se)
  • The PT patients had a significantly better PFS and OS than the XRT patients (p =.025 and.035), but in multivariate analysis radiation modality was non-significant. (lu.se)
  • Higher DAPSA scores were significantly and independently associated with probability of structural progression in multiple analyses. (bmj.com)
  • Early smoking cessation is the most effective treatment for slowing the progression of COPD and improving asthma symptoms. (who.int)
  • A basic difference between HD pathology in human and tgHD51 rats is in the rate of NDP progression that originates primarily from slow neuronal degeneration consequently resulting in lesser extent of concomitant reactive gliosis in the brain of tgHD51 rats. (hindawi.com)
  • Although larger amount of striatal neurons displays only gradual decrease in their size, their number is significantly reduced in the oldest tgHD51 rats. (hindawi.com)
  • Our quantitative analysis proved that the end of the first year represents the turn in the development of morphological changes related to the progression of NDP in tgHD51 rats. (hindawi.com)
  • In cultured anterior pituitary cells from ovariectomized rats, L-DOPA (10-5 M, 6h) decreased the apoptotic index (determined by TUNEL assay. (conicet.gov.ar)
  • Researchers have shown that treating precancerous anal growths called high-grade squamous intraepithelial lesions (HSILs) in persons living with HIV significantly decreased the progression to anal cancer. (sciencedaily.com)
  • PsP was defined as new or growing lesions followed by either decrease or stabilization during a 12 month-period with no treatment. (lu.se)
  • We stated that serum vitamin A levels in neonatal S. pneumoniae pneumonia mice were lower than 0.7µmol/L from day 2-7 post infection, while pulmonary vitamin A productions were significantly lower than those in the control mice from day 7-28 post infection. (nature.com)
  • Interestingly, I. obliquus intake decreased body weight in middle-aged mice and increased body temperature in response to light-dark switching in mature adult mice. (researchgate.net)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • Histological examination revealed marked decrease in granulomas formation and less collagen deposition in the lungs of OPN-KO mice compared to WT. (cdc.gov)
  • Spearman's correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised score, or progression rate. (lww.com)
  • In Hong Kong SAR, one study demonstrated the TB rate decreased in those under 60, remained unchanged in those between 60 and 69 and increased in those more than 70 years of age from 1989 to 1998. (who.int)
  • The normal function of the endothelium was thus restored, cell proliferation in the blood vessel walls decreased significantly and the narrowing of the blood vessels reversed. (medicalnewstoday.com)
  • The engagement of CTLA4 by costimulatory molecules results in decreased T-cell receptor signaling, interleukin 2 transcription ( 3 ), and cell cycle arrest at the G1 stage, with the final result of inducing T-cell anergy ( 4 , 5 ). (snmjournals.org)
  • 0.01, Student t test), whereas no significant changes were observed in the cell cycle progression. (conicet.gov.ar)
  • L-DOPA: 30.30, ×2) In addition, we analyzed the effects of L-DOPA on anterior pituitary cell cycle progression. (conicet.gov.ar)
  • Early detection and treatment of primary tumours is crucial to limit progression and local invasion of deep tissues. (unav.edu)
  • The chews decreased plaque and calcified plaque (calculus), as well as sulfur compounds in the dogs' mouths, which is a marker of bad breath. (mindbodygreen.com)
  • Vitamin A supplement after neonatal S. pneumoniae pneumonia significantly promoted Foxp3 + Treg and Th1 productions, decreased Th2 and Th17 cells expressions, alleviated airway hyperresponsiveness (AHR) and inflammatory cells infiltration during AAD. (nature.com)
  • In 2010, the Journal of Biomedical Sciences reported that cardiovascular risks are significantly lower in individuals who excrete higher levels of magneiusm, indicating its protective role. (baumancollege.org)
  • RAW 264.7 and MLE-15 cells exposed to SWCNT and bleomycin had significantly less TGF-beta1 released in the presence of OPN-blocking antibody. (cdc.gov)
  • Also, confounding factors related to HIV infection, progression of HIV and uncontrolled infection ( 4 ). (who.int)
  • Japanese researchers are assessing the use of metformin for colorectal cancer prevention, investigating whether use will prevent progression of dysplastic aberrant crypt foci (ACF). (naturalmedicinejournal.com)
  • serum creatine kinase levels were decreased at the second blood test, which was sampled at least 6 months after the first blood test. (lww.com)
  • 9-12 The strongest progression of eye growth is observed in early childhood, while stabilisation may not occur until late adolescence. (bmj.com)
  • Haematological toxic effects did not differ significantly between two groups. (researchgate.net)
  • The proportion of subjects reaching a 30% decrease in PTH did not differ. (medscape.com)
  • The aim of this study is to investigate myopia progression in Europeans as a function of age and degree of myopia from first prescription to final refractive error. (bmj.com)
  • The sudden development of hearing loss can be devastating, and often more consequential than the slow progression of age-related hearing loss," they point out. (medscape.com)
  • Researchers associated citicoline supplementation with a significant slow down of glaucoma progression. (nutritionaloutlook.com)
  • But they did state that supplementation with citicoline might significantly slow down glaucoma rates of progression. (nutritionaloutlook.com)
  • Despite the equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had a significantly lower proteinuria and less severe renal histological abnormalities. (hindawi.com)
  • The rates in older people were significantly higher than younger groups in both males and females. (who.int)
  • Studies demonstrated that pneumonia can decrease vitamin A productions and vitamin A reduction/deficiency may promote asthma development. (nature.com)
  • COVID-19 infection was significantly associated with younger age. (who.int)