Significantly cell survival. Medical search. Frequent questions

A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
adenocarcinoma: 0.66 vs 0.70, squamous cell carcinoma: 0.57 vs 0.56). (nih.gov)
Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma. (diva-portal.org)
Tumor TNM staging is the main basis for prognosis and treatment decision for head and neck squamous cell carcinoma (HNSCC) despite significant heterogeneity in terms of outcome among patients with the same clinical stage. (diva-portal.org)
This cancer is divided into two types: (1) squamous cell carcinoma, which appears in the middle or top of the esophagus and (2) adenocarcinoma, seen in the glandular cells of the esophagus [ 1 ]. (hindawi.com)
Esophageal squamous cell carcinoma affects the squamous cells and usually develops within the middle third of the esophagus. (medicinenet.com)
Squamous cell carcinoma ac- rate for 31 266 patients (74% men, 26% women) with counts for about 4% of cases of bladder cancer, adenocar- urinary bladder cancer diagnosed from 1997 to 2011 was cinoma for about 2% and all other types for about 4% of 72% (10) . (who.int)
Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). (medscape.com)
Cervical cancer has multiple histologic subtypes, with squamous cell carcinoma (SCC) accounting for approximately 75% of cases and invasive adenocarcinoma accounting for 10% to 15% of cases. (medscape.com)
[ 11-13 ] By contrast, we discovered, using laser capture microdissection and mass spectrometry, that keratin 17 (K17) could predict the overall survival of patients with cervical squamous cell carcinoma more accurately than grade, stage, or any other clinicopathologic features. (medscape.com)

This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
Deficiency of SAP results in sustained T-cell proliferation in response to EBV infection due to reduced ability to kill EBV-infected B cells. (medscape.com)
In preclinical studies, Nexavar has been shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. (worldpharmanews.com)
Findings showed THC treatment significantly reduced T-cell proliferation and decreased early stage rejection-indicator cytokines. (ibtimes.co.uk)
Cancer-preventing strategies of these beneficial bacteria such as binding to carcinogens and degrading them, stimulating anti-cancer enzymes, and preventing the conversion of procarcinogens to carcinogens, production of beneficial compounds that act as signaling molecules affecting the immune system, cell death, and proliferation, and interference with cell signaling pathways are reported [ 16 - 19 ]. (hindawi.com)
Cell Counting Kit‑8 assay and flow cytometry were undertaken to measure proliferation and apoptosis. (spandidos-publications.com)
shlncRNA XIST attenuated cell proliferation, invasion and migration, while increasing the apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
The miR‑320a mimic and PIK3CA inhibitor could recover the effect of oe‑lncRNA in terms of the proliferation, invasion, migration and apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
The bcr-abl oncoprotein has uncontrolled tyrosine kinase activity, which deregulates cellular proliferation, decreases adherence of leukemia cells to the bone marrow stroma, and protects leukemic cells from normal programmed cell death (apoptosis). (msdmanuals.com)

BUFFALO, N.Y. - Approximately one-third of patients with non-small-cell lung cancer (NSCLC) who were treated with the targeted therapy sotorasib (brand name Lumakras) survived for at least two years after enrolling in a large clinical trial that evaluated the drug - significantly longer than what can be expected from patients treated with standard chemotherapy. (roswellpark.org)
However, the identification of factors predicting a worse survival in stage II colon cancer led the American Society of Clinical Oncology (ASCO) [ 3 - 5 ], the Nationonal Comprehensive Cancer Network (NCCN) and the European Society for Medical Oncology (ESMO) to define a collective of high-risk patients who may benefit from adjuvant chemotherapy. (biomedcentral.com)
Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
This is largely due to improved chemotherapy protocols and stem cell transplantion, as well as improved monitoring and supportive care. (medscape.com)
THOUSAND OAKS, Calif.--(BUSINESS WIRE)--April 3, 2006--Amgen (Nasdaq:AMGN), the world's largest biotechnology company, today announced pivotal Phase 3 results demonstrating that panitumumab significantly improved progression-free survival and disease control (response rate and stable disease) compared to best supportive care (BSC) in metastatic colorectal cancer patients who had failed standard chemotherapy. (amgen.com)
A global study, led by UCL and UCLH and sponsored by Roche, has shown that the cancer immunotherapy atezolizumab significantly improved the overall survival of advanced stage non-small cell lung cancer patients who were not able to be treated with platinum-containing chemotherapy, when compared to single-agent chemotherapy. (news-medical.net)
The trial results, published today in The Lancet , are good news for non-small cell lung cancer patients who are not eligible for standard of care platinum-based chemotherapy, due to concerns about their ability to withstand the treatment. (news-medical.net)
The trial sought to establish the efficacy , safety and overall survival rate of first-line immunotherapy treatment with atezolizumab compared with single-agent chemotherapy in advanced stage NSCLC patients. (news-medical.net)
The study showed that atezolizumab significantly improved overall survival and resulted in a clinically meaningful long-term survival benefit, with twice as many patients (24%) who were treated with atezolizumab remaining alive at two years compared to those treated with chemotherapy (12%), despite over 50% of chemotherapy patients who were still alive at two years receiving subsequent immunotherapy. (news-medical.net)
IPSOS is the first randomised trial to show that immunotherapy treatment with first-line atezolizumab treatment significantly improves overall survival compared to single-agent chemotherapy for these poor prognosis patients, with twice as many remaining alive at two years. (news-medical.net)
New review article in Chinese Medical Journal details the potential mechanisms of resistance to the R-CHOP chemotherapy regimen in patients with diffuse large B-cell lymphoma. (news-medical.net)
In addition, results presented earlier this week at the AACR Annual Meeting 2018 , which were simultaneously published in The New England Journal of Medicine and highlighted on this blog , showed that a combination of ipilimumab and nivolumab significantly improved the overall response rate and median progression-free survival among certain patients with non-small cell lung carcinoma, compared with standard-of-care chemotherapy. (aacr.org)
NEW ORLEANS - For patients with resectable non-small cell lung cancer (NSCLC), further clinical data continue to show benefit from preoperative treatment with the immune checkpoint inhibitor nivolumab (Opdivo) with chemotherapy. (medscape.com)
The combination resulted in significantly longer event-free survival and a 14-fold greater chance of having a pathologic complete response compared with chemotherapy alone. (medscape.com)
Among 358 patients in the trial, the median event-free survival (EFS) was 31.6 months for patients randomly assigned to the combination of the immune checkpoint inhibitor nivolumab and platinum-base chemotherapy, compared with 20.8 months for patients assigned to chemotherapy alone. (medscape.com)
Neoadjuvant therapy may improve chances for complete resection and prevent or delay recurrence after surgery, but the absolute difference in 5-year recurrence-free survival and OS with neoadjuvant chemotherapy alone is only about 6%, they noted. (medscape.com)
In limited-stage SCLC, the overall survival rate has been significantly improved by adding dose-hyperfractionated thoracic radiotherapy and prophylactic cranial irradiation to systemic chemotherapy. (ersjournals.com)
If left untreated, patients with SCLC rarely survive longer than a few months 5 , but chemotherapy dramatically prolongs survival compared to the best supportive care 6 . (ersjournals.com)

The promising data from that clinical trial, called CodeBreak 100, are shared in "Long-term outcomes and molecular correlates of sotorasib efficacy in patients with pretreated KRAS G12C mutated non-small-cell lung cancer: a 2-year analysis of CodeBreak 100," published this week in the Journal of Clinical Oncology . (roswellpark.org)
We also found that there were long-term benefits in nearly a quarter of patients, meaning these patients had progression-free survival greater than 12 months. (roswellpark.org)
While median progression-free survival (PFS) was 6.3 months, 40 patients (23%) experienced long-term clinical benefit - PFS of at least 12 months. (roswellpark.org)
The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, defined as cell deposits ≤ 0.2 mm) in loco-regional LN of stage I & II colon cancer patients. (biomedcentral.com)
This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. (biomedcentral.com)
Currently, the only definitive treatment available for XLP1 patients is allogeneic hematopoietic stem cell transplantation (HSCT). (medscape.com)
The study was designed to compare overall survival, time to progression, time to symptomatic progression, response as defined by RECIST criteria and safety in patients receiving Nexavar versus placebo. (worldpharmanews.com)
Median overall survival was 6.5 months in patients treated with Nexavar versus 4.2 months for those taking placebo. (worldpharmanews.com)
Nexavar demonstrated a clear survival benefit in Asia-Pacific patients and had comparable results to last year's international SHARP trial, despite these patients in the Asia-Pacific trial having poorer health status and more metastases. (worldpharmanews.com)
Nexavar has quickly become the systemic standard of care for liver cancer, and is the only systemic therapy that has been shown to improve overall survival in Asian patients with liver cancer. (worldpharmanews.com)
In Europe, Nexavar is approved for the treatment of hepatocellular carcinoma and for the treatment of patients with advanced renal cell carcinoma (RCC) who have failed prior interferon-alpha or interleukin-2 based therapy or are considered unsuitable for such therapy. (worldpharmanews.com)
RARITAN, N.J., February 8, 2021 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results from the final analysis of the Phase 3 TITAN study, which demonstrated the continued statistically significant benefit of the addition of ERLEADA ® (apalutamide) to androgen deprivation therapy (ADT) in overall survival (OS) in patients with metastatic castration-sensitive prostate cancer (mCSPC), regardless of extent of disease, when compared to placebo plus ADT. (jnj.com)
The TITAN final analysis further confirms that treatment with apalutamide can prolong overall survival and offer a clear long-term clinical benefit and established safety profile for patients with metastatic prostate cancer who are starting androgen deprivation therapy," said Dr. Kim Chi, Medical Oncologist at BC Cancer - Vancouver and principal investigator of the TITAN study. (jnj.com)
Initial results from the TITAN study presented at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) and simultaneously published in The New England Journal of Medicine showed the addition of ERLEADA ® (apalutamide) to ADT compared to placebo plus ADT significantly improved the dual primary endpoints of OS and radiographic progression-free survival (rPFS) in patients with mCSPC. (jnj.com)
With our partner Exelixis, we are very pleased that CABOSUN's primary endpoint of a statistically significant improvement of progression-free survival has been confirmed by the independent radiology review committee in patients with previously untreated advanced intermediate- or poor-risk RCC. (businesswire.com)
Eligible patients were required to have locally advanced or metastatic clear-cell RCC, ECOG performance status 0-2, and had to be intermediate or poor risk per the IMDC criteria (Heng, JCO, 2009). (businesswire.com)
for patients with advanced or late-stage metastatic RCC, however, the five-year survival rate is only 12 percent, with no identified cure for the disease. (businesswire.com)
A significantly higher proportion of patients were alive and free of disease progression on panitumumab at all of the scheduled time points through week 32. (amgen.com)
Objectives - We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. (ices.on.ca)
Conclusions - Patients undergoing sublobar/lobar resections had higher survival rate. (ices.on.ca)
Initiating antiretroviral therapy (ART) during tuberculosis therapy significantly reduced mortality rates by 56 percent in a randomized clinical trial of 642 patients co-infected with HIV and tuberculosis. (scienceblog.com)
Only patients with TB and HIV infection with a CD4+ cell count of less than 500 cells per cubic millimeter were included in the study. (scienceblog.com)
On World AIDS Day in 2009, President Zuma of South Africa announced the new policy, to provide ART to all TB patients with HIV infection and CD4 counts below 350 cells per cubic millimeter. (scienceblog.com)
Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. (cdc.gov)
The CFR for pediatric patients in this outbreak was lower than for adults ( 6 ), but the reasons for this increased survival were unknown. (cdc.gov)
The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with EVD. (cdc.gov)
In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (cdc.gov)
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP-the standard treatment regimen. (news-medical.net)
The five selected proteins (MKI67, EZH2, SLC2A1, CADM1, and NKX2-1 alias TTF1) were analyzed by immunohistochemistry on tissue microarrays including tissue from 326 non-small cell lung cancer patients. (nih.gov)
The best-performing model was subsequently validated in an independent cohort consisting of tissue from 345 non-small cell lung cancer patients. (nih.gov)
The January 10, 2002 issue of the New England Journal of Medicine noted that 20 years of clinical trials yielded survival improvement of only 2 months for patients with advanced lung cancer. (thehealthcareblog.com)
For over the past 20 years, they relentlessly combined chemical agents in various regimens with ever-increasing dose intensity and the survival for patients is exactly the same, less than two years. (thehealthcareblog.com)
In this study, a possible role of plasma interleukin-2 (IL-2), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) as biomarkers for survival of HNSCC patients was investigated. (diva-portal.org)
Our findings indicate that CRP and TNF-α might be suitable as biomarkers in combination with tumor TNM staging for predicting survival and individualized treatment of HNSCC patients. (diva-portal.org)
The survival of HNC patients has only improved marginally during the last decade. (diva-portal.org)
The aim for this thesis was to investigate rapid and low cost blood based biomarkers which could indicate the risk of HNC, recurrence of the disease or the survival of HNC patients. (diva-portal.org)
In paper I, a possible role of plasma cytokines or proteins associated with immune response or inflammation, as biomarkers for the survival of HNC patients was investigated. (diva-portal.org)
Treatment with novel diazoxide choline extended-release tablets significantly improved hyperphagia in patients with Prader-Willi syndrome, Soleno Therapeutics announced. (medpagetoday.com)
We retrospectively analyzed clinical characteristics, response to treatment and survival of 282 patients with active newly-diagnosed multiple myeloma, comparing results between patients younger and older than 65 years. (scielo.br)
Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
Outcome and survival of myeloma patients diagnosed 2008-2015. (scielo.br)
The aims of the present study were to describe clinical features at diagnosis, response to treatment and survival in 282 patients with active newly-diagnosed MM (NDMM) and compare outcomes between patients younger and older than 65 years. (scielo.br)
Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
Recent advancements in stem cell research have given researchers new weapons in the fight against ALS and may also result in novel treatments for patients. (selfgrowth.com)
The use of mesenchymal stem cells (MSC) in ALS patients has been supported by the findings of preclinical investigations. (selfgrowth.com)
Small skin samples from people facing MND are all that are required for the creation of an endless supply of IPSCs in the laboratory, allowing for ongoing research on genetically similar cells to the patients. (selfgrowth.com)
Some ALS patients experience survival times that are significantly longer than the typical 3 to 5 years. (selfgrowth.com)
The findings could significantly delay tumor recurrence resulting from chemoresistance and prolong survival in glioblastoma patients, according to Sheng. (eurekalert.org)
Local recurrence-free survival rate was 80% over 26 months for R0-MPM patients. (businesswire.com)
Studies published today in Nature conclude that enrichment of B cells, a type of immune cell known for producing antibodies, in TLS was predictive of response to checkpoint blockade in patients with melanoma , soft-tissue sarcomas and renal cell carcinomas (RCC). (mdanderson.org)
Checkpoint inhibitors offer the potential for long-term survival to patients across many cancer types, but not all benefit equally. (mdanderson.org)
In a publication on 225 patients, primarily with Hb SS disease, data shows that even though 60% of patients were taking hydroxyurea, the median survival age was only 48 years. (nih.gov)
In another paper, the cumulative survival in 150 adults was followed from 2003 to 2016 and patients were screened for heart, lung, and kidney disease. (nih.gov)
Synovial sarcoma patients do not respond well to conventional treatment approaches, and therefore, like many other difficult-to-treat cancers, have low survival rates. (panarmenian.net)
Early this week, the U.S. Food and Drug Administration (FDA) approved a combination immunotherapy regimen for treating certain patients newly diagnosed with advanced renal cell carcinoma, the most common form of kidney cancer . (aacr.org)
One prediction model developed by the International Metastatic Renal-Cell Carcinoma Database Consortium classifies patients based on the presence or absence of six risk factors. (aacr.org)
In short, patients randomized to the combination had significantly improved overall survival rates compared with those randomized to sunitinib. (aacr.org)
With advancements in research on various surgical and drug treatments, the 5-year survival rate of hepatic carcinoma patients has increased ( 3 ). (spandidos-publications.com)
Event-free survival was improved in patients with a pathological complete response compared with those without, suggesting pCR is a surrogate endpoint for long-term outcomes in resectable non-small cell lung cancer, and this is the first time [this has been shown] in a randomized phase 3 study," he said. (medscape.com)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). (lu.se)
This study aimed to estimate the probability of survival in patients with bladder cancer in Jordan and identify fac- tors associated with survival. (who.int)
Better survival was observed in patients with early stage and well differentiated tumours at diagnosis. (who.int)
The survival of patients with bladder cancer in Jordan is comparable to that reported from developed coun- tries. (who.int)
Urothelial (transitional cell) carcinoma is the most patients younger than 50 years to 81.3% in patients older common histological type of bladder cancer, accounting than 50 years (9) . (who.int)
About 60% patients had lower survival rates. (who.int)
Although p16 INK4a has been well established as sensitive and accurate diagnostic biomarker for endocervical adenocarcinoma in situ and invasive adenocarcinoma in histologic sections and in cervical cytology specimens, clinical and diagnostic features alone have limited power to predict the survival of patients with endocervical adenocarcinoma. (medscape.com)
Thus, the goal of this study was to determine if K17 expression is a negative prognostic biomarker associated with decreased survival of patients with endocervical adenocarcinoma. (medscape.com)

Currently, most treatment guidelines do not recommend immunotherapy treatment due to lack of randomized results to indicate that it is safe, well tolerated and increases overall survival for this poor prognosis population. (news-medical.net)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
These findings open up a whole new area ― that B cells are actually big drivers in cancer immunotherapy, specifically checkpoint blockade," said corresponding author Jennifer Wargo, M.D. , professor of Genomic Medicine and Surgical Oncology . (mdanderson.org)
NEW YORK - Researchers have identified new strategies for predicting response to immunotherapy, using approaches that integrate genomic and molecular signals, immune cell phenotypes, and other biological markers related to the body's anti-tumor immune response. (genomeweb.com)
After a median follow-up of 25.2 months, the 18-month survival rate was 77 percent for the immunotherapy combination arm compared with 60 percent for the sunitinib arm. (aacr.org)
In addition, at that time, it was not possible to estimate the median overall survival among those receiving the immunotherapy combination, whereas it was estimated to be 25.9 months among those who received sunitinib. (aacr.org)
instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)

RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
The PTEF also contains electrically charged particles, reactive oxygen species (ROS) and reactive nitrogen species (RNS) that permeate the cell's membrane leading to apoptosis (cell death). (businesswire.com)

Based on these data, we now know that KYPROLIS not only significantly extended progression-free survival compared to Velcade, but also overall survival, making it a clinically meaningful advance in the treatment of relapsed or refractory multiple myeloma. (amgen.com)

But a KRAS gene mutation called G12C, which represents 13% of NSCLC mutations, can cause cells to grow rapidly and uncontrollably, leading to tumor formation. (roswellpark.org)
Recent data suggest that the tumour, node, metastasis classification traditionally reserved for the staging of nonsmall cell lung cancer (NSCLC) can also be applied for the staging of SCLC 3 . (ersjournals.com)
in small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). (ersjournals.com)

This review describes current considerations in the use of hydroxyurea for the management of sickle cell disease in the context of clinical severity. (cdc.gov)
Dr. Keith Hoots, the Division Director at the Division of Blood Diseases and Resources (DBDR) opened the meeting by greeting the Sickle Cell Disease Advisory committee (SCDAC) members. (nih.gov)
In 1999 there were 2 major obstacles for curing adults with sickle cell disease. (nih.gov)

Combination of upregulated CRP and TNF-α in the patient plasma was significantly related to shorter patient survival, independent of clinical stage. (diva-portal.org)
High levels of K17 expression were significantly associated with decreased patient survival. (medscape.com)
K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. (medscape.com)
Elevated WNT5A expression has been significantly correlated with increased metastatic potential of melanoma cells as well as reduced patient survival. (lu.se)

Ipsen remains on track to submit the regulatory dossier for cabozantinib as a treatment for first-line advanced renal cell carcinoma in Europe in the third quarter of 2017. (businesswire.com)
Specifically, the FDA approved a combination of ipilimumab (Yervoy) and nivolumab (Opdivo) for the treatment of intermediate- or poor-risk, previously untreated advanced renal cell carcinoma. (aacr.org)
Renal cell carcinoma accounts for about 90 percent of kidney cancers. (aacr.org)
The approval of the ipilimumab and nivolumab combination for intermediate- or poor-risk, previously untreated advanced renal cell carcinoma was based on results from the CheckMate 214 phase III clinical trial, which were published recently in The New England Journal of Medicine . (aacr.org)
NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. (nih.gov)
Barrett's esophagus describes abnormal dysplasia and is thought to perhaps be a precursor to the development of further cell mutations and adenocarcinoma. (medicinenet.com)
Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)

The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
The majority of clear cell RCC tumors have lower than normal levels of a protein called von Hippel-Lindau, which leads to higher levels of MET, AXL and VEGF. (businesswire.com)
An MD Anderson-led study found that B-cell markers were the most differentially expressed genes in responders relative to non-responders, and B cells in the tumors of responders appeared to be more mature and specialized. (mdanderson.org)
Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas . (aao.org)
There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
Ovarian clear cell carcinomas (OCCCs) are rare, aggressive and chemoresistant tumors . (bvsalud.org)

People with low triiodothyronine (T3) syndrome had significantly less survival time after diagnosis with multiple myeloma. (medpagetoday.com)
Black and Hispanic U.S. men who have sex with men have higher rates of HIV diagnosis than whites, and they are more likely than whites to develop AIDS within three years after learning that they are infected with HIV.1 The study that produced these findings also revealed that blacks have the lowest survival rate three years after receiving an AIDS diagnosis. (guttmacher.org)
The survival rate fell as men's CD4+ T-cell count six months after AIDS diagnosis declined. (guttmacher.org)
Finally, whereas progression from HIV to AIDS declined only slightly over time, survival after an AIDS diagnosis improved markedly: Some 86% of men who received an AIDS diagnosis in 2001 were still alive three years later, compared with 79% of those who had learned of their illness in 1996. (guttmacher.org)
Parametric survival models have not previously been applied to survival following a diagnosis of HIV/AIDS in Australia. (who.int)
Using likelihood based goodness-of-fit criteria the Weibull model was found to be the best-fitted model for predicting survival following a diagnosis of HIV infection without and with a diagnosis of AIDS. (who.int)
New treatments are needed in order to improve the prognosis of ES-SCLC, as median survival with current standard treatment is still only 9-10 months from diagnosis. (ersjournals.com)
Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases. (medscape.com)

Treatment is with tyrosine kinase inhibitors (TKI) such as imatinib , dasatinib , nilotinib , bosutinib , and ponatinib , which significantly improve response and prolong survival. (msdmanuals.com)

Their article describes in detail various aspects of tumor biology, including molecular pathways, tumor microenvironment, clonal evolution (selective growth of particular cells) and cell of origin that can help identify potential mechanisms and predictive biomarkers of drug resistance. (news-medical.net)
Molecular signaling pathways control the intracellular decisions of cell growth. (news-medical.net)
Alterations in the B-cell receptor, PI3K-Akt, NF-kB, and JAK-STAT3 pathways can also cause drug resistance. (news-medical.net)
Investigators reanalyzed this data using a standardized bioinformatics pipeline to identify various signatures that captured cancer cell states, tumor immune inflammation, and immune inhibitory pathways. (genomeweb.com)

p = 0.001) and higher in those who received autologous hematopoietic stem cell transplantation. (scielo.br)
Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)

While uncertainty persists regarding the explanation of the high recurrence-rate in node negative colon cancer, there is emerging evidence that the appearance of isolated tumor cells (ITC) and micro-metastases in LN could be associated with worse prognosis [ 8 - 14 ]. (biomedcentral.com)
The regimen has demonstrated significant improvement of patient prognosis and overall survival. (news-medical.net)

Nexavar® targets both the tumor cell and tumor vasculature. (worldpharmanews.com)
Glioblastoma often resists front-line chemotherapies, including temozolomide, a drug that damages DNA and triggers tumor cell death. (eurekalert.org)
Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). (lu.se)

There was no statistically significant difference between the arms for progression-free survival. (aacr.org)

Secondary endpoints included overall survival and objective response rate. (businesswire.com)
The published results show a significant improvement in the two primary co-endpoints ― event-free survival and pathologic complete response. (medscape.com)

The healthcare system can promote tailored strategies to reduce barriers and increase TCD screening and hydroxyurea use among children with sickle cell anemia. (cdc.gov)
Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). (cdc.gov)
Hydroxyurea has proven clinical efficacy for SCA - treatment significantly reduces disease manifestations and prolongs survival. (cdc.gov)
Myelosuppressive drugs (eg, hydroxyurea ), stem cell transplantation, and interferon alfa are also sometimes used. (msdmanuals.com)

The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)

A survival benefit has rarely been demonstrated in relapsed or refractory multiple myeloma. (amgen.com)

Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)
AG treatment did not affect the mRNA and protein levels of GHS-R1a and GHS-R1b in both control and Cis-treated cells. (hindawi.com)
In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
The rate (75 percent) and timing (median 7.0 weeks) of crossover from the BSC alone arm to receiving panitumumab, and the anti-tumor activity observed after crossover, likely confounded the ability to demonstrate a treatment effect on overall survival (Hazard ratio = 0.93). (amgen.com)
Methods - We investigated the trends in survival based on treatment modality. (ices.on.ca)
In this podcast, members of the Cancer.Net Editorial Board discuss new research in molecular testing, also known as biomarker testing or tumor marker testing, to help guide treatment for people with early-stage non-small cell lung cancer. (cancer.net)
The FDA placed a clinical hold on Vertex's investigational diabetes cell therapy VX-880 , saying the company didn't have enough evidence to support a treatment dose increase. (medpagetoday.com)
In numerous clinical settings, mesenchymal stem cell treatment has already demonstrated significant therapeutic potential. (selfgrowth.com)
Mesenchymal stem cells (MSCs) may be a promising treatment option for ALS, as evidenced by clinical models. (selfgrowth.com)
This makes stem cell therapy an appealing treatment option for ALS since it takes on the disease's intricate evolution through a number of processes. (selfgrowth.com)
CHCP opens a new and promising treatment for addressing the challenges of eradicating microscopic residual cancer cells following surgical tumor resection. (businesswire.com)
The CHCP treatment takes advantage of this regulation to target rapidly dividing cancer cells without harming normal cells, as cancer cells tend to undergo this growth phase more often. (businesswire.com)
Several covariates-age, sex, combined HIV exposure category, CD4 cell counts, antiretroviral treatment and AIDS-defining illnesses-were included in the parametric model to predict factors associated with future mortality. (who.int)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
In contrast, little progress has been made in the treatment of extensive-stage SCLC (ES-SCLC), apart from the recently documented survival gain by the addition of prophylactic cranial irradiation. (ersjournals.com)
On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
cancer is the 10th most common cancer in the world, Significant differences in survival rates among age with an estimated 549 393 new cases and 7.2/100 100 groups and treatment types were also found. (who.int)
Successful use of allogeneic stem cell transplantation for treatment-refractory mycosis fungoides]. (medscape.com)
Rook AH, Yoo EK, Grossman DJ, Kao DM, Fox FE, Niu Z. Use of biological response modifiers in the treatment of cutaneous T-cell lymphoma. (medscape.com)
Novel treatment approaches for cutaneous T-cell lymphoma. (medscape.com)
Herrmann JJ, Roenigk HH Jr, Hönigsmann H. Ultraviolet radiation for treatment of cutaneous T-cell lymphoma. (medscape.com)
Cutaneous T cell lymphoma: update of treatment. (medscape.com)
Topical treatment of early cutaneous T-cell lymphoma. (medscape.com)
Although highly curable if detected early, once the melanoma has metastasized there are few treatment options and a median survival rate of only 6-9 months. (lu.se)

Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)

Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)

The combination of a prognostic biomarker panel with clinicopathological parameters did not improve survival prediction in non-small cell lung cancer, questioning the potential of immunohistochemistry-based assessment of protein biomarkers for prognostication in clinical practice. (nih.gov)

The KRAS gene produces a protein called K-Ras, which regulates cell growth. (roswellpark.org)
mRNA of ghrelin receptors(GHS-R1a and GHS-R1b), as well as, protein levels of GHS-R1a, were expressed abundantly in A2780 cells. (hindawi.com)
Ataxia telangiectasia and Rad3-related protein (ATR), the apical kinase of the intra-S-phase DNA damage response, plays a central role in safeguarding cells from replication stress and can therefore limit the efficacy of antimetabolite drug therapies. (nih.gov)
Numerous protein biomarkers have been analyzed to improve prognostication in non-small cell lung cancer, but have not yet demonstrated sufficient value to be introduced into clinical practice. (nih.gov)
To me, the most novel finding in this study is that we discovered connexin 43 selectively binds to the PIK3CB/p110beta protein, enabling certain glioblastoma cells to gain chemoresistant traits," Sheng said. (eurekalert.org)
Sheng's team applied two molecules that blocked downstream chemical reactions, curbing the production of Akt - a key protein kinase that the cancer cells need to metabolize food, move, proliferate, and survive. (eurekalert.org)
Recent studies indicate that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells beyond the capacity for folding of nascent polypeptides within the endoplasmic reticulum (ER) lumen, thereby disrupting ER homeostasis and triggering the unfolded protein response (UPR). (jci.org)
Using state-of-the-art CRISPR genome screening technology, the scientists first identified the a protein (BRD9) as essential for the survival of synovial sarcoma tumours. (panarmenian.net)
Significantly, they found a protein (BRD9) that is essential for the survival of synovial sarcoma cells. (panarmenian.net)
They confirmed through biochemical studies in synovial sarcoma cells that BRD9 partners with the disease-causing SS18-SSX protein, and thus supports it in driving cancer development. (panarmenian.net)
Commenting on the breakthrough, Dr. Gerard Brien said: 'As the term degrader suggests, the drug we created 'degrades' the BRD9 protein, removing it from cancer cells. (panarmenian.net)
It essentially 'tricks' the cells into eliminating this protein on which they rely, which in turn leads to their death. (panarmenian.net)
MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. (lu.se)

Mechanistically, in vitro data support these findings, as co-culture of hESC-MSCs with lipopolysaccharide (LPS)-stimulated BWF1 lymphocytes decreased lymphocyte secretion of TNFα and IL-6 and enhanced the percentage of putative regulatory T cells. (nature.com)
In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)

Here, we aimed to develop and validate a prognostic model for surgically resected non-small cell lung cancer. (nih.gov)
Survival is variable, depending on the different prognostic factors, ranging from months to more than 10 years. (scielo.br)

The median overall survival (OS) was not significantly different between the cohorts. (bvsalud.org)

The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
Esophageal cancer describes the disease where cells that line the esophagus change or mutate and become malignant . (medicinenet.com)
There are more rare forms of cancer that affect the esophagus, including lymphoma , malignant melanoma , sarcoma, choriocarcinoma, and small cell cancer. (medicinenet.com)
In adenocarcinomas, K17 staining was detected in a mean of 33.9% of malignant cells. (medscape.com)
Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. (msdmanuals.com)

They note that previous research has shown the activation of cannabinoid receptors on immune cells triggers potent immunosuppression - but the role of cannabinoids in transplantation to prevent rejection has not been investigated. (ibtimes.co.uk)

Human embryonic stem cell (hESC)-derived MSCs are an alternative to adult MSCs that can circumvent issues regarding scalability and consistent quality due to their derivation from a renewable starting material. (nature.com)
Stem cell transplant for ALS: Can the curse be changed to a boon? (selfgrowth.com)
Numerous investigational therapies, many of which are currently in clinical trials like stem cell transplant for ALS , have been developed in response to recent advancements in our knowledge of the disease pathogenesis processes that underlie ALS. (selfgrowth.com)
The development of the disease condition might be slowed down by stem cell therapy. (selfgrowth.com)
Mesenchymal stem cells (MSCs) in general may act by differentiating toward a particular cell type or by secreting various growth and trophic substances. (selfgrowth.com)
In order to ameliorate the unfavourable settings for sick motor neurons, stem cells take on a supporting function by establishing a fostering and neuroprotective milieu. (selfgrowth.com)
In this role, transplanted stem cells release neurotrophic factors, give rise to non-neuronal, non-sick cells like astrocytes and microglia, or develop into modulatory neurons that connect to damaged motor neurons. (selfgrowth.com)
Preclinical research has shown that stem cells may be used to treat ALS, which is hopeful. (selfgrowth.com)
Transplanted stem cells release neurotrophic factors and develop into accessory cells like astrocytes and microglia, creating a neuroprotective environment that can delay the degeneration of motor neurons. (selfgrowth.com)
Fortunately, ALS-affected neurons can be accurately mimicked by a type of stem cell termed an Induced Pluripotent Stem Cell (IPSC). (selfgrowth.com)
In clinical trials, stem cells are being utilised to treat ALS effectively. (selfgrowth.com)
Stem cells have the ability to locate injury in the body and repair any type of cell. (selfgrowth.com)
Because of this, stem cell transplants are currently employed to preserve a patient's healthy neurons while also offering the possibility of producing new cells to replace the deceased ones. (selfgrowth.com)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
Normal stem cells are retained and can emerge after drug suppression of the CML clone. (msdmanuals.com)

The presence of ITC was associated with a significantly worse disease-free survival (hazard ratio = 4.73, p = 0.005). (biomedcentral.com)
Similarly, ITC were associated with significantly worse overall survival (hazard ratio = 3.50, p = 0.043). (biomedcentral.com)
Cox proportional hazard regression was used to identify independent factors associated with survival. (who.int)

The overall survival rate (OS) was 50.8% after one year and 32.5% after two years. (roswellpark.org)
Study investigators also reported that panitumumab significantly improved disease control versus BSC alone (36 percent versus 10 percent, respectively), as measured by response rate and stable disease. (amgen.com)
Panitumumab improved progression-free survival and response rate regardless of the measured level or intensity of EGFr staining. (amgen.com)
the five-year relative survival rate for this form of the disease is just 11.6 percent. (aacr.org)
The survival rate was significantly lower in the highly expressed lncRNA XIST group. (spandidos-publications.com)
Hormonally nonfunctional parathyroid cancer has a lower survival rate because it is often found at a later stage, as it does not have early signs such as increased calcium and parathyroid hormone levels. (medlineplus.gov)
Individuals with CDC73 gene mutations are also at a higher risk of recurrence of the cancer and have a decreased survival rate compared to those without CDC73 gene mutations. (medlineplus.gov)

By affecting the Histone RNA, CHCP causes cell death in microscopic cancerous cells at the surgical margins while sparing normal healthy cells. (businesswire.com)
To date, diverse immunotherapeutic modalities have been accepted as viable strategies for eliminating cancerous cells. (frontiersin.org)

Evidence shows that MSCs home to sites of inflammation where they inhibit immune and inflammatory responses by influencing the behavior of local innate and adaptive immune cells (reviewed in 20 ). (nature.com)
However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)

This type of cancer arises from the glandular cells found in that area of the esophagus. (medicinenet.com)

In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Similar survival rates were found for leukocytes (88%) and epithelial cells (10%) after rinsing with Listerine mouthwash. (cdc.gov)
Hepatoma cell lines (SUN449), hepatoblastoma cell line (HepG2, Huh‑6), liver cancer cell line (HepG2) and transformed human liver epithelial‑2 cells (THLE‑2) were used in the present study. (spandidos-publications.com)
K17 was not detected in the epithelial cells of benign glandular lesions, but groups of cuboidal cells, residing beneath the epithelial layer of benign glands, were frequently positive for K17, especially in cases of microglandular hyperplasia. (medscape.com)

It is believed that mutations in the deoxyribonucleic acid (DNA) signal the cells related to the esophagus to multiply abnormally [ 4 , 5 ]. (hindawi.com)
Somatic mutations in many different genes have been found in parathyroid cancer cells. (medlineplus.gov)

Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
Most data regarding the impact of age on survival mainly come from clinical trials developed before the current therapy choices were in use. (scielo.br)

The likelihood of a patient responding to immune checkpoint blockade may depend on B cells in the tumor, located within specialized immune-cell clusters known as tertiary lymphoid structures (TLS), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)

RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)

In spite of the big improvement in the clinical field for OC therapy, an overlall low survival and high recurrence rates still exist and were attributed to the poor screening approach, inadequate therapeutic options, and development of drug resistance [ 3 , 4 ]. (hindawi.com)
We observed more than 20% increase in five-year survival rates for all surgical groups over time. (ices.on.ca)
In the March 15, 2004 issue of the Journal of Clinical Oncology, an editorial stated that a review of all the large, prospective, randomized trials published comparing the newer taxane-based regimens, none of these regimens have increased either complete response rates or overall survival, with median survivals remaining at two years or less. (thehealthcareblog.com)
It is estimated that 65% of solid tumor resections result in residual microscopic tumor cells at the surgical margin, which contributes to LRR and poor survival rates. (businesswire.com)
rates among men 55 and older did not change significantly during the study period. (guttmacher.org)
The 5-year, 10-year and 15-year survival rates common malignancy of the urinary system. (who.int)
Survival three main types of bladder cancer: transitional cell car- rates varies significantly among age groups. (who.int)

However, the presence of nevus cells contiguous with a choroidal melanoma on histologic examination provides evidence that melanomas may arise from choroidal nevi. (aao.org)
Histologically, posterior uveal melanomas are composed of spindle cells and/or epithelioid melanoma cells (Figs 12-17, 12-18, 12-19). (aao.org)
Spindle cell melanoma consists primarily of spindle-B melanoma cells (see Fig 12-18). (aao.org)
Spindle-A melanoma cells have slender, elongated nuclei with small nucleoli. (aao.org)
In spindle-B melanoma cells, coarse, granular chromatin and plump, large nuclei are seen. (aao.org)
Epithelioid melanoma cells resemble epithelium because of their abundant eosinophilic cytoplasm and enlarged round to oval nuclei. (aao.org)
The cytoplasmic melanin content in melanoma cells can vary considerably. (aao.org)
In this thesis we investigate the possibility of impairing melanoma cell motility by targeting WNT5A signaling. (lu.se)
Our results demonstrate that TGFβ is an unsuitable target for blocking WNT5A signaling since it mediates unpredictable effects on melanoma cell invasion. (lu.se)
Instead, we show that the t-butyloxycarbonyl-modified WNT5A-derived hexapeptide Box5 functions a potent antagonist of WNT5A-induced signaling, migration and invasion in melanoma cells. (lu.se)
Moreover, we demonstrate that IL-6 can drive melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression and that targeting IL-6, in contrast to TGFβ, reduces melanoma cell invasion. (lu.se)
We furthermore reveal the existence of a WNT5A-IL-6 positive feedback loop in melanoma cells that augments their invasive capacity. (lu.se)
Concomitantly, we show that combined targeting of IL-6 and WNT5A within this loop more effectively impairs melanoma cell invasion. (lu.se)

We investigated the ability of the ATR inhibitor, AZD6738, to prevent the gemcitabine-induced intra-S-phase checkpoint activation and evaluated the antitumor potential of this combination in vitro and in vivo In PDAC cell lines, AZD6738 inhibited gemcitabine-induced Chk1 activation, prevented cell-cycle arrest, and restrained RRM2 accumulation, leading to the strong induction of replication stress markers only with the combination. (nih.gov)
The results collected from the clinical trial combined with the JCRI in-vitro and clinical research data generated over the last 10 years, demonstrated that the Canady Helios™ Cold Plasma (CHCP) combined with complete surgical resection of the tumor, causes cancer cell death at the surgical margin, without harming non-cancerous tissue. (businesswire.com)
Therefore, A. vitis cells surviving in cuttings appear to be more heat-tolerant than cells grown in vitro . (ajevonline.org)

Genomic landscapes of ovarian clear cell carcinoma from latin countries reveal aberrations linked to survival and progression. (bvsalud.org)

The impact of ITC on survival was assessed using Cox regression analyses. (biomedcentral.com)

Anatomy19

Organisms8

Diseases34

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes58

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care21

Squamous cell carc10

Proliferation14

Chemotherapy18

Patients70

Immunotherapy9

Apoptosis3

Progression-free survival com1

NSCLC3

Sickle cell di3

Patient survival4

Renal5

Adenocarcinoma3

Tumors7

Diagnosis8

Prolong survival1

Pathways4

Hematopoietic4

Prognosis2

Tumor cell3

Statistically significant1

Endpoints2

Hydroxyurea4

Pembrolizumab1

Multiple myeloma1

Treatment25

Cytokines2

Cancers1

Biomarker1

Protein13

Findings3

Prognostic2

Median overall1

Malignant5

Transplantation1

Stem17

Hazard3

Rate7

Cancerous cells2

Immune cells5

Glandular cells1

Dendritic cells2

Epithelial3

Mutations2

Clinical trials2

Lymphoid2

Outcomes1

Rates7

Melanoma13

Vitro3

Genomic1

Regression1