Significantly 3t3 cells. Medical search. Frequent questions

Studies with 3T3-L1 cells have shown chemerin expression is low in pre-differentiated adipocytes but its expression and secretion increases both during and after differentiation in vitro. (wikipedia.org)
Studies using mature human adipocytes, 3T3-L1 cells, and in vivo studies in mice showed chemerin stimulates the phosphorylation of the MAPKs, ERK1, and ERK2, which are involved in mediating lipolysis. (wikipedia.org)
This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Thus, in both differentiating and differentiated 3T3-L1 adipocytes, high concentrations of melatonin increased intracytoplasmic triglyceride accumulation, an indicator of adipogenic differentiation. (unican.es)
These findings suggest that, in human breast tumors, melatonin could stimulate the differentiation of fibroblasts and reduce the aromatase activity and expression in both fibroblasts and adipocytes, thereby reducing the number of estrogen-producing cells proximal to malignant cells. (unican.es)
TLK16998 alone had no effect on IR signaling in mouse 3T3-L1 adipocytes but, at concentrations as low as 3.2 μmol/l, enhanced the effects of insulin on the phosphorylation of the IR β-subunit and IR substrate 1, and on the amount of phosphatidylinositol 3-kinase that coimmunoprecipitated with IRS-1. (diabetesjournals.org)
TLK16998 also increased the potency of insulin in stimulating 2-deoxy- d -glucose uptake in 3T3-L1 adipocytes, with a detectable effect at 8 μmol/l and a 10-fold increase at 40 μmol/l. (diabetesjournals.org)
We investigated the role of S100B in the interaction between adipocytes and macrophages using a cell-culture model. (nih.gov)
3T3-L1 adipocytes (L1) were stimulated by TNF-α to examine S100B secretion. (nih.gov)
In mature adipocytes, G and GS individually caused apoptosis, but combination of G plus GS significantly increased apoptosis, more than either compound alone. (pcom.edu)
Further, ADP-1 beneficially affected lipid metabolism by enhancing lipid globule formation in mouse 3T3-L1 adipocytes. (phoenixpeptide.com)
KSS inhibited the accumulation of triglycerides in a dose-dependent manner in 3T3-L1 cells that were induced to differentiate into adipocytes. (elsevierpure.com)
The cells screen an exponential development stage until confluence can be reached, go through mitotic clonal enlargement (MCE) that allows a rise in the ultimate percentage of differentiated fats cells, and get into the terminal maturation procedure for acquiring all of the specific tools of adipocytes [7]. (euromedh2020.com)
The specialized plasma membrane structures termed caveolae and the caveolar-coat protein caveolin are highly expressed in insulin-sensitive cells such as adipocytes and muscle. (rupress.org)
Stimulation of 3T3-L1 adipocytes with insulin significantly increased the tyrosine phosphorylation of caveolin and a 29-kD caveolin-associated protein in caveolin-enriched Triton-insoluble complexes. (rupress.org)

Methods 3T3‐L1 preadipocytes were differentiated by using a mixture of adipogenic inducers, including a suboptimal concentration of insulin. (researchgate.net)
To compare the abilities of chicoric acid and its metabolites in scavenging free radicals and their effects on the viability of 3T3-L1 preadipocytes, an in vitro study of the metabolism of chicoric acid in rat liver microsomes was performed using liquid tandem mass spectrometry (HPLC-MS/MS). The results indicated that caffeic acid and caftaric acid were the hepatic phase I metabolites of chicoric acid. (rsc.org)
These three compounds had strong capacities for scavenging free radicals and had been demonstrated to increase intracellular ROS levels in 3T3-L1 preadipocytes, thereby reducing cell vitality. (rsc.org)
Here, we demonstrate the molecular mechanism underlying the effect of KSS on the differentiation of mouse preadipocytes (3T3-L1 cells). (elsevierpure.com)
jujubarepresses adipogenesis in 3T3-L1 preadipocytes [16]. (euromedh2020.com)

Conclusion: CAP treatment attenuates cell proliferation of OS cancer cells and fibroblasts in a treatment time-dependent manner, whereby U2-OS cells appeared more sensitive to CAP treatment as 3T3 fibroblasts after 10 sec of treatment. (iiarjournals.org)
In order to take a new approach to previous in vitro studies on the cytotoxicity of endodontic materials, it would be interesting to evaluate the response of fibroblasts and macrophages, which are cell lines involved in periapical inflammation and repair. (bvsalud.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

two main regulators of terminal adipogenesis, in 3T3-L1 cells. (unican.es)
In the present study, we investigated the effects of combinations of G plus GS on apoptosis and adipogenesis in 3T3-L1 cells. (pcom.edu)
3T3-L1 cells are utilized extensively like a cell tradition model to review the molecular control of adipogenesis [5]. (euromedh2020.com)
16] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
17, 18] TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and in primary adipocyte stem cells. (medscape.com)

Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Cell cycle analysis showed a significant increase in the accumulation of KSO-SFE-treated cells at sub-G1 phase, indicating the induction of apoptosis by KSO-SFE. (hindawi.com)
In addition to inducing necrosis and apoptosis, ROS induces autophagic cell death. (biomedcentral.com)
Every one of the above guidelines said those two flavonoids encourage apoptosis via equally exterior along with inbuilt precise hepatectomy apoptotic walkways in HL-60 cells. (pdgfrsignals.com)
Notwithstanding apoptosis, both of these flavonoids significantly inhibit fischer transcription element NF-kappa B along with STAT (Sign Transducer as well as Activator involving Transcription) signaling path, that happen to be highly depicted inside the leukemia disease. (pdgfrsignals.com)
Rigosertib was more potent than wortmannin and rapamycin in inducing sub-G1 and G2-M cell cycle arrest, as well as late apoptosis in the Inf-3T3 and MT-2 cells. (htlv.net)
Background/Aim: Cold atmospheric plasma (CAP) attenuates tumor cell proliferation and induces apoptosis in various cell lines. (iiarjournals.org)

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. (wikipedia.org)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
The presence of melatonin during differentiation also induced a parallel reduction in aromatase expression and activity and expression of the cells. (unican.es)
We also found that MC and PN were responsible for the anti-adipogenetic effect of KSS and significantly suppressed the expression of CCAAT/enhancer-binding proteins-δ (C/EBP-δ) mRNA 3 days after the induction of differentiation. (elsevierpure.com)
After inducing differentiation with medium containing retinoic acid and GSK 3-β inhibitor, SKPs formed polygonal corneal endothelial-like cells (sTECE). (elsevierpure.com)
In 3T3-L1 cells, daidzein enhanced adipocyte differentiation and PPARgamma expression in a dose-dependent manner. (oregonstate.edu)
In C3H10T1/2 cells, both daidzein and equol at 1 micromol/L and higher significantly increased adipocyte differentiation and insulin-stimulated glucose uptake. (oregonstate.edu)
Deletion of HP1β, but not HP1α, in ESCs provokes a loss of the morphological and proliferative characteristics of embryonic pluripotent cells, reduces expression of pluripotency factors and causes aberrant differentiation. (biomedcentral.com)
However, in differentiated cells, loss of HP1β has the opposite effect, perturbing maintenance of the differentiation state and facilitating reprogramming to an induced pluripotent state. (biomedcentral.com)
We demonstrate an unexpected duality in the role of HP1β: it is essential in ESCs for maintaining pluripotency, while it is required for proper differentiation in differentiated cells. (biomedcentral.com)
This unique duality makes them an attractive system for potential regenerative medicine and cell therapies, but also for differentiation studies in vitro and for modeling diseases. (biomedcentral.com)

Idescarparide significantly reduced lipid production in 3T3-L1 cells. (elsevierpure.com)

Alterations of cancer-related genes in tumor cell lines derived from cadmium -transformed BALB/c-3T3 cells. (cdc.gov)
BALB/c-3T3 cells were morphologically transformed with cadmium and the transformed cells were subcutaneously injected into nude mice to develop tumors. (cdc.gov)
Tumor cell lines showed a decrease in gene copy number and expression of p16 and erbB1 compared to the control BALB/c-3T3 cells. (cdc.gov)
The only murine cells tested not detectably expressing gp71 determinants were BALB/3T3 lines. (duke.edu)

Using viable cell membrane immunofluorescence, most established and early passage normal murine cell lines were significantly reactive with the antiserum, irrespective of neoplastic transformation, strain genotype, or whether they were of embryonic or adult tissue origin. (duke.edu)
Extraction from 9 parameters of KSO-SFE was screened for cytotoxicity towards human colorectal cancer cell lines (HT29) and mouse embryonic fibroblast (NIH/3T3) cell lines using MTS assay. (hindawi.com)
Human colorectal cancer (HT29) and mouse embryonic fibroblast (NIH/3T3) cell lines were purchased from the American Type Culture Collection (ATCC), USA. (hindawi.com)
Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. (biomedcentral.com)
Embryonic stem cells (ESCs), derived from the blastocyst-stage embryo, are capable of generating all cell types of the mammalian body (pluripotency) and of maintaining the capacity for indefinite self-renewal without compromising their genomic integrity. (biomedcentral.com)
Finally, the in vitro antiproliferative activity of all the complexes was evaluated against human cervical cancer (HeLa) and mouse embryonic fibroblast (NIH-3T3) cell lines by MTT assay and the results suggested that the complexes were significantly active compared to various clinically reported drugs. (uniss.it)

Using these inhibitors also significantly boosted the expression of the pro-apoptotic genes, Bax/Bcl-2 ratio as well as the expression of the tumor suppressor gene p53 in the MT-2 and Inf-3T3cells. (htlv.net)

On days 3 and 7 of culture, islets were assessed for recovery, insulin content, viability, cellular composition, GLUT2 expression in beta cells, differentia‐ tion of pancreatic endocrine progenitor cells, function, and oxygen consumption rate. (crenolanibinhibitor.com)
Cytotoxicity was assessed using the MTT assay (cell viability) and Griess reagent (NO release). (bvsalud.org)

Low levels of ROS can promote cell proliferation but high levels induce cell death [ 13 ]. (biomedcentral.com)
Furthermore, the effects of rigosertib, wortmannin, and rapamycin on the PI3K/Akt/mTOR pathway to inhibit the proliferation of ATLL cells were examined. (htlv.net)
The aim of the study was to analyse the effects of different CAP sources and application times on osteosarcoma (OS) cells and non-malignant fibroblast cell proliferation. (iiarjournals.org)
Cell proliferation was determined by viable cell count at different time points after treatment. (iiarjournals.org)

It was found incubation of 3T3-L1 cells with recombinant human chemerin protein facilitated insulin-stimulated glucose uptake. (wikipedia.org)

Type I diabetes, that is called insulin-dependent diabetes mellitus (IDDM) or juvenile-onset diabetes develops when the body's immune system destroys pancreatic β-cells, the only cells in the body that produce the hormone insulin that regulates blood glucose. (gotomydoctor.com)
Of note, ADP-1 decreased blood glucose levels and enhanced insulin production in pancreatic β cells in db/db mice. (phoenixpeptide.com)
Finally, TCF7L2 polymorphisms have been associated with impaired insulin secretion, glucose production, and glucose tolerance via direct effects on pancreatic islet beta cells. (medscape.com)
Conclusion: This study underlines the importance of necroptosis in islet cell death after isolation and demonstrates the novel effects of Nec‐1 to increase islet insulin content, enhance pancreatic endocrine cell development, facilitate GLUT2 upregula‐ tion in beta cells, and augment insulin secretion. (crenolanibinhibitor.com)

In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
In vitro functional analysis of Na, K-ATPase pump activity revealed that sTECE had significantly high pump function compared to SKPs or control 3T3 cells. (elsevierpure.com)
The enhanced development of major endocrine cells and GLUT2 expression after Nec‐1 treatment subsequently led to a significant increase in the amount of insulin secreted in response to in vitro glucose challenge. (crenolanibinhibitor.com)
In spite of the advantages of the in vitro tests, they are not able to mimic the orchestrated role of cells present inperiradicular region and the long-term cytotoxicity presented by the sealers. (bvsalud.org)

One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
Previous study has shown that kenaf seed oil extracted by SFE (KSO-SFE) is cytotoxic towards human cervical cancer cell line [ 7 ]. (hindawi.com)
On the list of four separated metabolites both the flavonoids, MLF and also AIF were found to be the the richest cytotoxic broker together with IC50 of similar to twenty mu Meters within human being the leukemia disease HL-60 cells. (pdgfrsignals.com)

Chemerin was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. (wikipedia.org)
Macrophages are important immune cells that participate in both innate and adaptive immune responses, such as phagocytosis, recognition of molecular patterns, and activation of the immune response. (frontiersin.org)
Macrophages are immune cells widely distributed throughout the body and are components of innate immunity. (frontiersin.org)
Glycans are one of the four fundamental macromolecular components of all cells and are highly regulated in immune cells, including macrophages. (frontiersin.org)
Macrophages are the prevalent cells in inflammatory infiltrates that respond to sealers 12-13 . (bvsalud.org)

In addition, consistent with the morphological changes of renal tissue, renal interstitial fibrosis in CKD rats after RC intervention was significantly improved, mainly manifested by a decrease in the positive expression of COL-1, FN, and a-SMA, and increased levels of E-cadherin protein. (bvsalud.org)
Evidence for GO induced autophagy includes increased levels of isoform B-II microtubule-associated protein 1 light chain 3 (LC3), aggregation of green fluorescence protein-tagged LC3, and increased numbers of autophagic vacuoles in cells. (biomedcentral.com)
The levels and subcellular distribution of the interferon-inducible double-stranded RNA-dependent protein kinase PKR have been measured in human Daudi cells and stably transfected mouse NIH 3T3 cells expressing the human protein kinase. (pasteur.fr)
in response to interferon treatment the protein kinase is induced severalfold in the cytoplasm whereas the level in the nucleus does not increase significantly. (pasteur.fr)
We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). (phoenixpeptide.com)
Expression of major corneal endothelial markers were confirmed by Reverse transcription polymerase chain reaction (RT-PCR) and quantitative Real time polymerase chain reaction (qRT-PCR).Western blots confirmed the expression of Na, K-ATPase protein, the major functional marker of corneal endothelial cells. (elsevierpure.com)
Epithelial Protein Lost in Neoplasm α is a novel cytoskeleton-associated tumor suppressor whose expression inversely correlates with cell growth, motility, invasion and cancer mortality. (biomedcentral.com)
HTLV-2 Encoded Antisense Protein APH-2 Suppresses HIV-1 Replication Abstract Antisense protein of Human T-cell. (htlv.net)
Global gene expression analysis identified thioredoxin-interacting protein (Txnip) as the only significantly upregulated gene (by 46%) under these conditions (P = 0.036), subsequently verified independently at mRNA and protein levels. (ox.ac.uk)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

In humans, chemerin levels are significantly different between individuals with normal glucose tolerance and individuals with type II diabetes and first degree relatives. (wikipedia.org)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
DIM, a major metabolite of indole-3-carbinol, which is naturally produced in broccoli and cabbage, enhances glucose uptake through the improvement of insulin sensitivity in 3T3-L1 cells [13] . (researchgate.net)

In humans, chemerin mRNA is highly expressed in white adipose tissue, liver and lung while its receptor, CMKLR1 is predominantly expressed in immune cells as well as adipose tissue. (wikipedia.org)

Although the cytotoxicity of endodontic sealers has been extensively investigated, most previous studies have used fibroblast cell lines. (bvsalud.org)

During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)

In epithelial cells, Eplin is required for formation of the F-actin adhesion belt by binding to the E-cadherin-catenin complex through α-catenin [ 6 ]. (biomedcentral.com)

We use RT-PCR reverse transcription system and the expand high fidelity PCR system to detect spliced XBP1 mRNA, and fraction cells to determine the location of the unconventional splicing of XBP1 mRNA. (mdpi.com)
Eplin-α mRNA is detected in various tissues and cell lines, but strikingly absent or downregulated in cancer cells [ 2 ]. (biomedcentral.com)
The results showed that mRNA expression of Akt/PI3K/mTOR was down-regulated in carrier, HAM/TSP, and ATLL patients, as well as MT-2, and Inf-3T3 cells, compared to the healthy individuals and untreated MT-2 and Inf-3T3 as controls. (htlv.net)
Treating the cells with rapamycin, wortmannin, and rigosertib decreased the phosphorylated forms of Akt and mTOR and restored their mRNA expression levels. (htlv.net)

Immunofluorescence of intact cells and quantitative immunoblotting of cell extracts indicate that PKR occurs in both the cytoplasm and the cell nucleus, with staining specifically in the nucleolus. (pasteur.fr)

The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
Autophagy usually serves as a survival mechanism in response to stress conditions, but excessive induction of autophagy results in cell death. (biomedcentral.com)
Background: Necroptosis has been demonstrated to be a primary mechanism of islet cell death. (crenolanibinhibitor.com)

Gene copy number and gene expression of c-fos and c-jun were significantly higher in the tumor cell lines compared to those of the control cells. (cdc.gov)
Neither the copy number nor the expression of c-myc exhibited any significant change in the tumor cell lines. (cdc.gov)

Melatonin inhibits aromatase activity and expression in human breast cancer cells, thus behaving as a selective estrogen enzyme modulator. (unican.es)
Our results suggest that overexpression of IRS-1 promotes cells growth, inhibits basal autophagy, reduces oxidative stress-induced autophagy, and diminishes oxidative stress-mediated autophagy-dependent cell death. (biomedcentral.com)

RARRES2 is thought to act as a cell surface receptor. (wikipedia.org)

We recommend blocking with 2-5% BSA as we have found that use of 5% milk significantly reduces the band intensity for beta actin. (abcam.com)

With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)
The combination of lunasin and cytokines (IL-12 plus IL-2) was capable of restoring IFNÎ³ production by NK cells from post-transplant lymphoma patients. (weeksmd.com)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

In spite of a significant increase in gene copy number of K-ras in tumor cells, no change was observed in its expression. (cdc.gov)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Scholars@Duke publication: Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. (duke.edu)
The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. (duke.edu)
Additionally, beta cells of Nec‐1‐treated islets had a significant upregulation in GLUT2 expression. (crenolanibinhibitor.com)

Cell lines established from these tumors were used in the present study. (cdc.gov)
Attenuation rates varied between cell lines, plasma sources and application times. (iiarjournals.org)

Human T lymphotropic virus type 1 (HTLV-1) infection can cause adult T-cell lymphoblastic leukemia (ATLL), an incurable, chemotherapy-resistant malignancy. (htlv.net)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)

J Cell Biol (1995) 129 (6): 1523-1531. (rupress.org)

These cells participate in pathogen recognition, apoptotic cell clearance, and antigen presentation ( 14 ). (frontiersin.org)

Finally, we note that the undifferentiated ESC nucleus itself shows less spatial organization than in differentiated cells. (biomedcentral.com)

consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Overexpression of IRS-1 resulted in inhibition of basal autophagy, and reduced oxidative stress-induced autophagy and cell death. (biomedcentral.com)

Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

Cancer cells produce greater levels of ROS than normal cells do because of increased metabolic stresses. (biomedcentral.com)
It is not fully understood how cancer cells grow rapidly and survive in the presence of high ROS levels. (biomedcentral.com)
In a quest for new therapeutic targets, our study sought to determine the levels of AKT, mTOR, and PI3K in ATLL MT-2 cells, HTLV-1 infected NIH/3T3 cells (Inf-3T3), and HTLV-1 infected patients (Carrier, HAM/TSP, and ATLL). (htlv.net)

Two-dimensional isoelectric focusing analysis of PKR in whole cell extracts reveals the presence of multiple forms with different pI values whereas similar analysis of the nuclear fraction indicates only one predominant species with a relatively basic pI. (pasteur.fr)
The minor fraction of HP1β that is chromatin-bound in ESCs is enriched within exons, unlike the situation in differentiated cells, where it binds heterochromatic satellite repeats and chromocenters. (biomedcentral.com)

we found that the IRS-1 overexpressing cells grow more rapidly than control cells do. (biomedcentral.com)
Results: Control exposed U2-OS and 3-T-3 cells exhibited characteristic cell growth. (iiarjournals.org)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

4,6,8,10-11 The behavior of other inflammatory cells present in the periapical region has not been widely assessed, although they also contribute to the intensity of the biological response to these materials. (bvsalud.org)

Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
While exerting marginal effects on non-neoplastic cells this unfolds promising applications in cancer therapy. (iiarjournals.org)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

Therefore, this study determined the cytotoxicity of KSO-SFE on colon cancer cells. (hindawi.com)

Lipofuscin consists of highly autofluorescent granules of oxidized proteins and lipids that build up in the lysosomes of aging cells in a variety of tissues. (biotium.com)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Similar results are observed whether cells expressing wild-type PKR or a catalytically inactive mutant form of the kinase are analyzed, but untransfected 3T3 cells are not stained by the antibody used. (pasteur.fr)
The response pattern varied depending on time and type of cell line used for analysis, although the results indicate a higher cytotoxicity for EPH in short-term tests. (bvsalud.org)
These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)

Skin-derived precursors (SKPs) are postnatal stem cells, which are self-renewing, multipotent precursors that can be isolated and expanded from the dermis. (elsevierpure.com)
Stem Cells Translational Medicine , 6 (3), 788-798. (elsevierpure.com)

Organisms2

Diseases1

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Health Care1

Adipocytes16

Preadipocytes5

Fibroblasts3

Adipogenesis5

Apoptosis7

Differentiation11

Lipid1

BALB4

Embryonic6

Inhibitors1

Viability2

Proliferation4

Insulin-stimulated glucose uptake1

Pancreatic4

Vitro4

Cytotoxic3

Macrophages5

Protein9

Recombinant1

Glucose3

Adipose tissue1

Fibroblast cell1

Innate and adaptive immune1

Epithelial cells1

MRNA4

Immunofluorescence1

Mechanism3

Tumor cell2

Inhibits2

Receptor1

Reduces1

Cytokines5

Expression5

Lines2

Human2

Pathways1

Biol1

Apoptotic1

Nucleus1

Inhibition2

Inflammation1

Levels3

Fraction2

Control3

Widely1

Effects2

Mice1

Study1

Tissues2

Results3

Stem cells2