Significant role disease susceptibility. Medical search. Frequent questions

Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
Due to the highly contagious nature of pathogens and the susceptibility of every human the virus spread rapidly across China then Globally. (benthamscience.com)
Genomic technology is likely to play a significant role in infection control, although hospitals and other health providers will need to make individual decisions about which pathogens they sequence and when sequencing is needed. (phgfoundation.org)
They also play a crucial role in hospital infection control efforts by identifying common pathogens and providing drug susceptibility information. (phgfoundation.org)
This report reviews five viral, six bacterial, four fungal, and 19 parasitic pathogens, and two diseases of unknown cause that are known to or could potentially infect sockeye salmon. (cohencommission.ca)
4 , 13 Complement plays a crucial role in host defense against foreign bodies by promoting phagocyte-mediated clearance of cell debris through activation of an inflammatory response, opsonization of pathogens, and lysis of susceptible bacteria and cells. (jrheum.org)
The stress of infection by pathogens such as Cryphonectria parasitica, which causes sweet chestnut blight and which is present in the UK, might increase the susceptibility of European sweet chestnut. (forestresearch.gov.uk)

Hence, susceptibility to infection can be characterized by a construct that involves not only gene expression patterns of the host but also that of the microorganism, both of which continue to adapt in response to external stimuli. (hindawi.com)
A cell-based prion infection assay did not confirm the role of PARK2 in prion disease susceptibility. (bmj.com)
We hypothesised that common variants from TMPRSS2 and CD26 may play critical role in infection susceptibility of predisposed population or group of individuals. (ias.ac.in)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an emerging global public health crisis.Angiotensin converting enzyme 2 (ACE2) and trans-membrane protease serine 2 (TMPRSS2) are the two major host factors that contributeto the virulence of SARS-CoV-2 and pathogenesis of coronavirus disease-19 (COVID-19). (ias.ac.in)
As more is learned about infection by SARS-Co V-2 and the development of COVID19, it is clear that it has significant nutritional implications. (jdsupra.com)
Finally, throughout the world, the consequences of physical isolation and financial disruption by the threat of COVID-19 infection has led to significant increases in food insecurity and hunger, further increasing susceptibility to both infectious and diet-related chronic diseases. (jdsupra.com)
Infection control is the principal area where next generation sequencing (NGS) technologies could be used now for infectious disease management and surveillance, complemented by established techniques. (phgfoundation.org)
Paired sera, acute and convalescent, may be used to demonstrate seroconversion or a significant rise in antibody as an aid in the diagnosis of recent or current infection. (rapidtest.com)
In addition, the linkage between measles infection and premature delivery or spontaneous abortion supports screening pregnant mothers for susceptibility. (rapidtest.com)
The significance or role of measles virus infection in these disease states is unknown at the present time. (rapidtest.com)
7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
2 Invasive pneumococcal in the Africa-Eastern Mediterranean region, whereas disease (IPD), defined as infection of normally sterile serotypes 1 and 14 were prevalent in Europe and Latin sites of the body with S. pneumoniae , most frequently America. (who.int)

Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
It has long been believed that immune system dysfunction, in concert with genetic susceptibility and changes in the gut microbiome, plays a significant role in IBD. (newswise.com)

WHO will expand the Enhanced Gonococcal Antimicrobial Surveillance Programme (eGASP), a CDC and WHO initiative monitoring trends in antimicrobial susceptibility of Neisseria gonorrhoeae . (cdc.gov)

BOSTON - Researchers from the Center for Regenerative Medicine at Boston Medical Center and Boston University School of Medicine used variants of CRISPR to understand the functions of the genes that cause emphysema and chronic obstructive pulmonary disease (COPD). (bmc.org)
This is the first time that CRISPRi and CRISPRa have been applied in human induced pluripotent stem cells to understand the functional role of these genes," says Andrew Wilson, MD, a pulmonologist at Boston Medical Center and associate professor of medicine at Boston University School of Medicine. (bmc.org)
Emphysema is a complex genetic disease caused by a mutation or variant in a number of genes that contribute to making some individuals more susceptible to disease than others. (bmc.org)
So by understanding how GWAS genes affect type 2 cells, researchers can start to understand how these might contribute to diseases that affect these cells, like emphysema. (bmc.org)
rs13015258 a 50 UTR variant from CD26 have significant role in regulation of expression of key regulatory genes that could be involved in SARS-CoV-2 internalization. (ias.ac.in)
Almost every aspect of our health is influenced by our genes, including our physical appearance, susceptibility to diseases, mental health, and response to medicine. (reinholdweber.com)
With newer developments in science and technology, researchers can identify certain genes' mutations that increase disease risk in individuals. (reinholdweber.com)
Published in two separate papers in the journal New Phytologist , the researchers showed that by 'silencing' these genes, there was lower accumulation of callose and cellulose in the plant cell walls , and higher susceptibility of barley plants to the fungus. (phys.org)
In recent years there has been significant progress in identifying susceptibility genes and understanding the role of the immune system and host microbiota in the pathogenesis of IBDs. (worldhealth.net)

These studies lead to discoveries associating genetic variants to certain phenotypes as well as their implications in disease. (wikipedia.org)
These recently discovered structural variants are thought to play a very significant role in phenotypic diversity and disease susceptibility. (wikipedia.org)
Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile. (medlineplus.gov)

Two major AMD susceptibility loci have recently been identified as contributing significantly to the manifestation of AMD. (arvojournals.org)
This study confirms that in Northern Ireland, as has been reported in other populations, CFH and LOC387715 are major susceptibility loci associated with the manifestation of AMD. (arvojournals.org)

The aims of this study are to assess the levels of perceived threat (susceptibility, severity, impact), negative emotions (fear, worry), and self-efficacy of pregnant women in China related to COVID-19 and to examine their associations with mental health (depression and anxiety) and personal protective behavior (wearing a face mask). (jmir.org)
Fish are very closely tied to their environment, and thus water quality and other environmental parameters play an important role in their susceptibility and severity of diseases. (cohencommission.ca)
F v /F m showed a strong negative correlation with disease severity and can be an indicator for the early detection of gray mold on strawberry leaves. (frontiersin.org)

To address this key question, we used in vivo time-course analysis of OA development and murine interstrain variability in natural susceptibility to OA to examine changes in non-OA-prone CBA mice versus OA-prone STR/Ort mice, which develop disease that bears significant histologic resemblance to human OA. (bepress.com)
Our findings emphasize the importance of historical demographic events on hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence. (lu.se)

It gets us closer to understanding how inherited factors help contribute to susceptibility to emphysema. (bmc.org)
COPD and emphysema is the third leading cause of death worldwide, creating a significant burden of disease. (bmc.org)
There have been no new significant pharmacological agents developed to help treat the large number of patients afflicted with COPD or emphysema worldwide," says Rhiannon Werder, MD, a postdoctoral fellow at the Center for Regenerative Medicine at Boston Medical Center and Boston University School of Medicine. (bmc.org)
The current authors conducted a retrospective study of 61 patients with both emphysema of the upper zones and diffuse parenchymal lung disease with fibrosis of the lower zones of the lungs on chest computed tomography. (ersjournals.com)
We identified a novel gene, BICD1 , for emphysema susceptibility in COPD. (atsjournals.org)

Structural stability, binding affinity and level of expression of these threeinteracting proteins are key susceptibility factors for COVID-19. (ias.ac.in)
Nothing is known about the protein function of LOC387715 , its role in AMD disease manifestation or its interaction, if any, with additional unidentified proteins or environmental risk factors that lead to the progression of age-related ophthalmic disease such as AMD or cataract. (arvojournals.org)

Published in Science Advances , researchers discovered functional consequences by turning off the expression of the gene that contributes to the pathogenesis of these diseases. (bmc.org)
The exact pathogenesis of AS remains poorly understood but genetic factors play a key role in its development. (molvis.org)
Increasing evidence has suggested an important role for environmental factors such as exposure to pesticides in the pathogenesis of Parkinson's disease. (jneurosci.org)
The results of this study should advance our understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease. (jneurosci.org)
BACKGROUND: The role of single nucleotide polymorphisms (SNPs) in TP53 in the pathogenesis of glioma is still debated. (minervamedica.it)

The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. (hindawi.com)
COVID-19 is an emerging infectious disease that has created health care challenges worldwide. (jmir.org)
Genomics has the potential to influence every step of the infectious disease pathway. (phgfoundation.org)
monitoring antibiotic resistance and vaccine uptake and advising government on infectious disease policy. (phgfoundation.org)

Several studies ( 6 - 11 ) have associated norovirus susceptibility with the presence of an α1,2-linked fucose on histo-blood group antigens (HBGAs), which is determined by the FUT2 gene ( 12 , 13 ). (cdc.gov)
Genetic variations or mutations of a gene can make a person more susceptible to developing diseases like cancer, heart disease, diabetes, and more. (reinholdweber.com)
Individuals who inherit one copy of the sickle cell gene are carriers and may not show any symptoms of the disease. (reinholdweber.com)
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. (ox.ac.uk)
In this study, we provide evidence that the LARS2 gene may represent a novel type 2 diabetes susceptibility gene. (ox.ac.uk)
This is the first report of association between an aminoacyl tRNA synthetase gene and disease. (ox.ac.uk)
Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
Genomic tests, utilising somatic (prostate biopsy) tissue can also predict the risk of unfavourable pathology, biochemical recurrence and the likelihood of metastatic disease using gene expression. (amegroups.org)
The Ahl gene is also implicated in the susceptibility to noise -induced hearing loss (NIHL). (cdc.gov)
These genetic effects implicate the Ahl gene as contributing to NIHL susceptibility. (cdc.gov)
All of the available evidence supports a role for the Ahl gene in both AHL and NIHL among these strains of mice. (cdc.gov)

Prion diseases are a diverse group of neurodegenerative diseases, caused by prion protein misfolding. (bmj.com)

In conclusion, AI's role in OSH equity is vastly understudied. (cdc.gov)

The aim of our research is to identify toxic effects of metals, and[KB1] further, to understand causal relationships between metal exposure and various diseases, and how susceptibility factors influence these relationships. (ki.se)
Advancements in genetic technologies and genomics have reshaped healthcare, defining the transition from a 'one size fits all' approach to personalised medicine focused on preventing and treating various diseases utilising a patient's clinical and genetic characteristics. (bmj.com)
Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. (dovepress.com)

Enhanced susceptibility to a variety of infections and inflammation play a large role in early and prolonged lung disease following premature birth, although the mechanisms of susceptibility and immune dysregulation are active areas of research. (nih.gov)
The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)

This paper focuses on our increased, though by no means complete, understanding of the vitamin-D-dependent antimicrobial pathway and attempts to adjudicate published evidence regarding the vitamin's alleged role in altering host susceptibility to infections. (hindawi.com)
These parallel epidemics demonstrate the central role of nutrition and healthy dietary patterns in susceptibility to both infections and diet-related chronic diseases and these relationships should be further examined in future dietary guidelines. (jdsupra.com)
Special attention will be paid to prevention of cardio-vascular diseases, reduction of micronutrient insufficiency, stabilization of infectious diseases incidence rate including TB, malaria, helminthiasis, brucellosis, restriction of dissemination of HIV/AIDS and immunization-sensitive infections. (who.int)

Chronic obstructive pulmonary disease (COPD), characterized by airflow limitation, is a disorder with high phenotypic and genetic heterogeneity. (atsjournals.org)

A number of nontraditional roles are linked to adverse consequences of vitamin D deficiency. (hindawi.com)
Premature infants suffer significant respiratory morbidity during infancy with long-term negative consequences on health, quality of life, and health care costs. (nih.gov)
3216-3518 (78.7%-86.1%) agreed the disease would have various severe consequences. (jmir.org)

Differential susceptibility to copper in wild populations of three-spined stickleback. (exeter.ac.uk)

Significant linkage disequilibrium (LD) signature was observed in different populations. (ias.ac.in)
Development Goals including its contribution to the poverty cycle, disease concentration in vulnerable populations and those with poor access to services, and a detrimental impact on education through missed school days and cognitive effects of chronic anaemia. (who.int)

This is the largest genome-wide association study (GWAS) of a radiographic phenotype in lung disease and an important phenotype in COPD. (atsjournals.org)
Chronic obstructive pulmonary disease (COPD) is characterized by the progressive development of airflow limitation that is not fully reversible ( 1 ). (atsjournals.org)

Health beliefs are defined as a set of perceptions an individual holds about his/her susceptibility to a disease, the seriousness of that disease to his/her life and the benefits of taking action to reduce the threat of the disease [6]. (who.int)

When we examine ACE genotype frequencies according to the clinical characteristics there was a statistically significant association between DD genotype and ocular involvement (p=0.04) also sacroiliac joint involvement (p=0.03). (molvis.org)
There were no statistically significant alterations in the burden of CNV duplications or deletions in any disease group or geographic region after correction for multiple testing. (bmj.com)
However, for SLE and MS there is less pronounced but statistically significant elevation in antibody levels. (rapidtest.com)

Genetics seems to play a significant role for metal susceptibility. (ki.se)
Host factors, diet, and lipopolysaccharide/TLR4 signaling pathways play a significant role in explaining how inhalant organic dust exposures impact bone health. (cdc.gov)
The aim of this study was to examine the role that low expression of caveolin-1 might play in susceptibility to ILD among African Americans. (nih.gov)
Lifestyle choices such as smoking, diet, and exercise can also play a role in the development of eye conditions. (reinholdweber.com)
These two polysaccharides play an important role in blocking the penetration of the plant cell wall by the powdery mildew fungus. (phys.org)
This is the first report demonstrating that microglia play a pivotal role in rotenone-induced degeneration of dopaminergic neurons. (jneurosci.org)
Microbiomes play an important role in determining the ecology and behaviour of their hosts. (lu.se)
OSH professionals can play a significant role in identifying strategies that ensure the benefits of AI in promoting workforce health and wellbeing are equitably distributed. (cdc.gov)

Laboratory diagnosis revealed a novel coronavirus named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), that causes coronavirus disease-19 (COVID- 19). (benthamscience.com)
Respiratory droplets of infected patients played a significant role in the transmission of COVID-19 from human to human. (benthamscience.com)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China and caused coronavirus disease of 2019 (COVID-19) 1 , 2 . (medrxiv.org)

Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not well known. (cdc.gov)
200 physicians dedicated to the study of rare (so-called "orphan") pulmonary diseases. (ersjournals.com)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Penicillin and macrolide are groups of empirical antibiotics used to eradicate toxigenic C. diphtheriae based on the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) guidelines for the treatment of diphtheria [ 9 , 10 ]. (biomedcentral.com)
With the same purpose, it is necessary to use mass media on a broader basis as well as disseminate published for population booklets and popular brochures on measures of control and prevention of cardio-vascular diseases, strengthening resistance of people to external negative impact and strengthening of protective factors. (who.int)
1 Discovering genomic and environmental determinants of health and disease and their interplay is essential for predicting personal susceptibility to various pathologies and individualised risk assessment, early disease detection, personalised treatment for better patient outcomes, and customising disease prevention strategies. (bmj.com)
Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
I'm Commander Ibad Khan, and I'm representing the Clinician Outreach and Communication Activity COCA with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)

Acquired mitral stenosis (MS), or mitral valve stenosis, is virtually synonymous with rheumatic heart disease. (medscape.com)
Therefore, rheumatic heart disease is a lifelong and sometimes progressive disease. (medscape.com)

Powdery mildew is a significant disease of barley wherever it is grown around the world, and resistance to the fungicide most commonly used to control it has been recently observed," says University of Adelaide Senior Research Scientist Dr Alan Little, with the ARC Centre of Excellence in Plant Cell Walls in the School of Agriculture, Food and Wine. (phys.org)
Gonorrhea is a sexually transmitted disease that can spread easily and has progressively developed resistance to the antibiotics used to treat it. (cdc.gov)

Our data provide new knowledge about susceptibility factors and NoV genotypes and suggest that additional studies of host genetic receptor factors and NoV are needed. (cdc.gov)
There are large individual differences in susceptibility to metal toxicity and we evaluate sensitivity factors such as gender, nutritional status, and genetics. (ki.se)
Although SSc-related ILD is more common and severe in African Americans than in Caucasians, little is known about factors underlying this significant health disparity. (nih.gov)
E2F1 is one of the transcription factors that cells enter the S phase and plays a key role in cell cycle. (hindawi.com)
Given that most men without risk factors have a low lifetime risk of developing lethal prostate cancer, much work is being done to further our knowledge of how we can best screen men in higher risk categories, such as those with a family history (FH) of the disease or those of African ancestry. (amegroups.org)
levels of pollutants in the environment, the levels of Finally, attributing health effects to specific pollutants is individual exposure to these pollutants, individual complicated by both the previously described factors susceptibility to the pollutants' toxic effects and the health affecting measurement and also the impact of effects attributable to the pollutants versus other influences. (cdc.gov)
Osteoporosis is a global health issue calcium intake and physical activity, two no risk factors for osteoporosis and along with heart disease, stroke, diabetes of the known variable factors preventing complications of this condition, were and cancer and takes up many financial osteoporosis [12]. (who.int)

Moreover, our blood-tissue combined study revealed a significant difference in SNPs between blood and tumoral samples, probably due to glioma heterogeneity and genomic instability. (minervamedica.it)

What we do know, is men with a family history (FH) of prostate cancer or those of Afro-Caribbean ancestry have a susceptibility to earlier onset and more aggressive disease making them an ideal group of men in whom to establish robust screening tools to improve survival by means of early diagnosis and treatment ( 6 ). (amegroups.org)

This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)
While the protein is involved in the normal functioning of the immune system, it plays a particular role in protecting the body against the development of autoimmune disorders and cancer. (medlineplus.gov)

While the relatively low incidence of frank type 2 diabetes in children may make recruitment for separate pediatric trials challenging, it could also open the door for an orphan disease designation that would significantly expedite approval of new therapies - this would of course require a consensus that the disease is fundamentally different in children vs. adults, which has not yet been established. (closeconcerns.com)
Targeted screening studies are currently under way in men with DNA repair mutations, men with a FH and those of Afro-Caribbean ethnicity which will greater inform our understanding of disease incidence and behaviour in these men, treatment outcomes and developing the most appropriate screening regime for such men. (amegroups.org)

The aim of our study was to investigate the role of several TP53 SNPs in the risk of glioma and their possible role as prognostic biomarkers of overall and progression-free survival. (minervamedica.it)
RESULTS: No association was observed with glioma susceptibility and overall survival. (minervamedica.it)
We observed a significant reduction in progression-free survival in patients with at least one exonic SNP. (minervamedica.it)
These men have been reported to carry upwards of a two-fold increased risk of developing the disease at an earlier age, with evidence suggesting poorer survival outcomes. (amegroups.org)
However, not all men are at equal risk for developing the lethal form of the disease, and the vast majority will have unaffected overall survival ( 3 ). (amegroups.org)

Kamal Niaz, Muhammad Farrukh Nisar , " Coronavirus Disease-19 (COVID-19): A Perspective of New Scenario ", Bentham Science Publishers (2021). (benthamscience.com)
At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. (ias.ac.in)

Age is a host factor that impacted bone disease with younger mice demonstrating increased susceptibility to bone loss following inhalant exposures as compared to older mice. (cdc.gov)
We found that the OA in STR/Ort mice exhibited a molecular phenotype resembling human OA, and we pinpointed a central role of NF-κB signaling and the emergence of an immune-related signature in OA cartilage over time. (bepress.com)
Genetic basis for susceptibility to noise -induced hearing loss in mice. (cdc.gov)

Similarly, individual susceptibility contaminated water supply (1). (cdc.gov)

Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)

Patients with connective tissue disease at the time of the diagnosis of CFPE were excluded from the study, as well as patients with a diagnosis of other interstitial lung diseases, such as drug-induced interstitial lung disease, pneumoconiosis, hypersensitivity pneumonitis, sarcoidosis, pulmonary histiocytosis, lymphangioleiomyomatosis and eosinophilic pneumonia 4 . (ersjournals.com)

Another important anomaly is that exposure to pathogenic organisms does not necessarily result in development of clinical disease. (hindawi.com)
even so, exposure alone does not necessarily result in development of clinical disease. (hindawi.com)
Specifically, the rate of progression to clinical disease in those with antibodies or antibodies and abnormal glucose tolerance is different, and the rate of C-peptide decline post-diagnosis varies significantly, with the rate of decline inversely proportional to age (i.e. younger children experience the fastest decline). (closeconcerns.com)

Physical findings are important to provide criteria for diagnosis and to detect abnormalities suggestive of alternative etiologies, as well as to indicate disease subtypes. (medscape.com)
When only a single joint is affected, radiography is important to exclude other diseases. (medscape.com)
In addition, a growing body of evidence suggests vitamin D has an important contributory role in the antimicrobial pathway. (hindawi.com)
This condition might add a more significant role for antibiotics as an important treatment for diphtheria. (biomedcentral.com)
The detailed and high-resolution information obtained by sequencing a pathogen from a patient can be used to make a diagnosis and inform treatment, but is also important in a public health context for understanding how diseases spread in the community. (phgfoundation.org)
Our results further highlight the important role of mitochondria in glucose homeostasis. (ox.ac.uk)
In her opening remarks, Dr. Diane Wherrett provided a definition of "disease modifying therapies" for type 1 diabetes (those that preserve beta cell function) and set the stage for a critically important concept: that the development of the disease has a very different pathophysiology in children compared to adults. (closeconcerns.com)
2 , 4 - 6 Early recognition is important because TMA is associated with significant mortality and morbidity, including end-stage kidney disease, although prompt initiation of supportive and specific management can transform disease outcomes. (jrheum.org)
The lungNENomics project aims to address these important questions, and will continue to improve the biological understanding of this exceedingly rare and understudied disease. (who.int)

Our hope is that this study will help in the understanding of the genetics of the disease, improve our understanding of how the disease occurs at a cellular level, and support the development of new therapies to treat these conditions. (bmc.org)
Ultimately, genetics plays a significant role in our health and well-being, but by taking proactive steps, we can improve our overall health and potentially overcome some of the challenges of our genetic makeup. (reinholdweber.com)

In an article published by Boston University, Andrew Thurston sheds light on a groundbreaking study that establishes a strong correlation between experiencing racism and an increased risk of heart disease among Black women. (stanford.edu)
This study aims to evaluate the first-line antibiotic susceptibility pattern of toxigenic Corynebacterium diphtheriae isolates. (biomedcentral.com)
This study demonstrates significant harmful effects of Allura Red on gut health and identifies gut serotonin as a critical factor mediating these effects. (worldhealth.net)

This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Parkinson's disease (PD) is characterized by a progressive and selective loss of dopaminergic neurons in the substantia nigra (SN), resulting in movement disorders ( Olanow and Tatton, 1999 ). (jneurosci.org)

Juvenile rheumatoid arthritis (JRA) is the most common chronic rheumatologic disease in children and is one of the most common chronic diseases of childhood (see the image below). (medscape.com)
These parallel epidemics, one noninfectious ( obesity and diet-related chronic diseases) and one infectious (COVID-19), appear to be synergistic. (jdsupra.com)
Those at most risk for the most serious outcomes of COVID-19, including hospitalization and death, are people afflicted by diet-related chronic diseases (obesity, type 2 diabetes, and cardiovascular disease). (jdsupra.com)
Thus, these interrelationships between chronic diseases, COVID-19, and social determinants of health, emphasize the critical importance of improving dietary patterns. (jdsupra.com)
Chronic diseases microbial-non-susceptibility of pneumococcus. (bvsalud.org)

With a cohort of over 59,000 Black women from across the United States, the BWHS has made significant strides in understanding the health disparities faced by this demographic. (stanford.edu)
It played a significant role in determining our overall health and well-being. (reinholdweber.com)
But, they also influence more complex health issues like the risk of developing certain diseases. (reinholdweber.com)
Findings showed that the health belief parameters (perceived susceptibility to breast cancer, benefits of and barriers to practising breast self-examination) were influenced differently by the film. (who.int)
BSE has been defined as a preventive health behaviour, i.e. "an activity undertaken by a person, who believes [herself] to be healthy, for the purpose of preventing disease or detecting disease in an asymptomatic state" [4]. (who.int)
The elements of the Health Belief Model related to breast cancer can thus be translated as the perception of: one's own susceptibility to breast cancer, the benefits of BSE to one's life, and possible barriers to the implementation of BSE. (who.int)
The quality of the environment has historically played a spends a great deal of time indoors may be less affected by significant role in public health (1). (cdc.gov)
Streptococcus pneumoniae poses a serious public At present, more than 94 different pneumococcal health concern because it causes a wide range serotypes have been classified based on the unique poly- of diseases including otitis media, septicaemia, saccharide characteristics and composition expressed meningitis and pneumonia. (who.int)
5 a significant role in the treatment of patients and in a Research Institute for Tropical Medicine, Department of Health, Manila, Philippines. (who.int)
The objectives were to present literature that updates the framework and related topics and increases awareness of the role of climate change in occupational safety and health. (cdc.gov)
There is a significant difference in health beliefs and behaviour [14]. (who.int)

1 - 3 Acute kidney injury is a common prominent feature of the disease, owing to the susceptibility of the glomerular circulation to endothelial damage. (jrheum.org)

At the end of the day, the consensus seemed to be that simply extrapolating clinical trial results from adults to children is not ideal (or possible) given the fundamental differences in disease pathophysiology between the two groups. (closeconcerns.com)
Notably, and this is new news from our view, the clinical course of the disease appears different between those diagnosed as children compared to those diagnosed as adults. (closeconcerns.com)
Fascinatingly, the efficacy of disease-modifying therapy may be different in those diagnosed as children compared to adults. (closeconcerns.com)

The susceptibility pattern of C. diphtheriae to erythromycin was better than that to penicillin. (biomedcentral.com)

Even the recommended sufficient range of 25-80 ng/mL, which was extracted from previous data that did not account for sun exposure, race, age, and geographic latitude, may not necessarily apply to the noncalcemic effects for which the vitamin purportedly has a biological role. (hindawi.com)

This list includes subacute sclerosing panencephalitis (SSPE), systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Patients with SSPE, a chronic degenerative neurologic disease, have documented high levels of antibody to measles virus. (rapidtest.com)
We also now have more life-prolonging systemic and hormonal therapies for men with advanced disease at our disposal than ever before. (amegroups.org)

Burden of Disease report. (who.int)

Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). (cdc.gov)

Background: Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). (bvsalud.org)

Colorized scanning electron micrograph of a T cell, a type of lymphocyte that plays a central role in the immune response. (scitechdaily.com)
Obesity-related diseases including heart disease, stroke, type 2 diabetes, and cancer are a leading cause of preventable death. (cshlpress.com)
The ADA in collaboration with JDRF, T1D Exchange, Benaroya Research Institute, the International Society of Pediatric and Adolescent Diabetes (ISPAD), TrialNet, and the Immune Tolerance Network hosted a Consensus Conference last week in Alexandria, VA titled "Defining Pathways for Development of Disease Modifying Therapies in Children with Type 1 Diabetes. (closeconcerns.com)

It is the commonest cancer in UK with Caucasian males having a lifetime risk of 13.2-15% of developing the disease ( 2 ). (amegroups.org)

We attempted to determine the role of the Rv3143 "orphan" response regulator in the physiology of Mycobacterium tuberculosis and its orthologue Msmeg_2064 in Mycobacterium smegmatis. (bvsalud.org)

The dye directly disrupts gut barrier function and increases the production of serotonin, a hormone/neurotransmitter found in the gut, which subsequently alters gut microbiota composition, leading to increased susceptibility to colitis. (worldhealth.net)
Furthermore, bacterial community composition showed significant variation between the two geographical clusters and between specific MHC alleles/supertypes. (lu.se)

Pregnant women are particularly affected by this disease. (jmir.org)

Supplemental dietary vitamin D was shown to prevent organic dust-induced bone loss, but not lung disease, in animals. (cdc.gov)

APOE plays multiple roles in the regulation of lipid and lipoprotein levels in the blood. (dovepress.com)

With the inclusion of PCV13 in the National Immunization Program, continued monitoring of the prevailing serotypes of S. pneumoniae isolates in the Philippines is needed to guide disease and AMR control measures. (who.int)

Anatomy12

Organisms26

Diseases28

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology3

Phenomena and Processes81

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Information Science8

Named Groups4

Health Care21

Geographicals4

Pathogens7

Infection12

Genetic susceptibility2

Antimicrobial susceptibility1

Genes9

Variants3

Loci2

Severity3

Variability2

Emphysema5

Proteins2

Pathogenesis5

Infectious disease4

Gene11

Neurodegenerative diseases1

Conclusion1

Various diseases3

Dysregulation2

Infections3

Phenotypic1

Consequences3

Differential1

Populations2

COPD2

Threat1

Statistically significant3

Play8

Respiratory3

Pulmonary diseases2

Prevention8

Rheumatic heart d2

Resistance2

Factors7

Genomic1

Onset1

Autoimmune3

Incidence2

Survival5

Coronavirus2

Mice3

Similarly1

Metastatic disease1

Interstitial1

Clinical disease3

Important9

Genetics2

Study3

Parkinson's3

Chronic diseases5

Health11

Endothelial1

Adults3

Pattern1

Geographic1

Systemic2

Burden of dise1

Symptomatic1

Pneumococcal1

Type3

Commonest1

Orphan1

Composition2

Pregnant1

Lung disease1

Multiple roles1

Isolates1