ProteinFIXXStructuralMedicinesPhosphorylationClinically significantSimilarityTumorsGeneticSilicoMineralocorticoidNegativelyDomainTranscriptionDifferencesCatalyticAdultsGlucocorticoidsVivoSpeciesInsulinHomologousSequenceMultipleDistinctStudiesAberrantOutbreakDomainsPathologicalGlucoseEnzymeYeastGenesRegionSurvivalDisordersDemonstrateUniqueCellRolesBiologicalRoleImportantExposureProcessesComparativeLaboratoryRealHighLargeCommonGene expressionShowExpressionSurfaceStudyRequireInvolves
Protein12
- There is no known protein family with significant homology to the J chain. (wikipedia.org)
- Implementing REST to the entire ligand as opposed to solely the perturbed region, and also some important flexible protein residues (pREST region) in the ligand binding domain (LBD) has considerably improved the FEP+ results in most of the studied cases. (nature.com)
- However, to date FEP has typically been helpful mainly when (1) high-quality X-ray data is available and (2) the target protein does not undergo significant conformational changes. (nature.com)
- Detection of the most likely ligand binding mode, the presence of multiple stable binding conformations, insufficient equilibration, and determining an adequate sampling time (especially when significant protein side chain and backbone residue flexibility is possible) are the most critical aspects of FEP, and have been recently reviewed in detail 8 . (nature.com)
- The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
- Protein-protein interactions also resulted in significant variations in reduced macromolecular diffusion under crowded conditions, while metabolites exhibited significant two-dimensional surface diffusion and altered protein-ligand binding that may reduce the effective concentration of metabolites and ligands in vivo. (elifesciences.org)
- As part of a directed effort to discover novel G protein-coupled receptors through homology searching of expressed sequence tag databases, we identified a partial clone (GPCR97) that had significant homology to biogenic amine receptors. (aspetjournals.org)
- The GPCR97 clone was used to probe a human thalamus library, which resulted in the isolation of a full-length clone encoding a putative G protein-coupled receptor. (aspetjournals.org)
- A thesis is proposed here, based on rational argument that depletion of the cytoskeletal organizer protein shank3 may result in defective nNOS membrane localization, resulting in defective nitric oxide synthesis. (frontiersin.org)
- Based on the results of this analysis, we also predict that the budding yeast arsenate resistance protein Acr2 and the ORF Ygr203w encode protein phosphatases with catalytic properties similar to that of the Cdc25 family. (embl.de)
- Corn event 5307 was developed using recombinant DNA technology, resulting in the introduction of the engineered eCry3.1Ab gene and expression of the eCry3.1Ab insecticidal protein. (canada.ca)
- Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
FIXX2
- Oxford Biomedica plc (LSE:OXB) ("Oxford Biomedica" or "the Group"), a leading gene and cell therapy group, and Homology Medicines Inc. (Nasdaq: FIXX) ("Homology"), a genetic medicines company, announced today that the companies have agreed to establish a high-performing, full scope Adeno-Associated Virus (AAV) Manufacturing and Innovation Business in the US. (oxb.com)
- Homology Medicines, Inc. (Nasdaq: FIXX), a genetic medicines company, announced today the presentation of preclinical data that supports the targeted, prophylactic immunosuppression regimen in the ongoing pheEDIT gene editing clinical trial in adults with phenylketonuria (PKU) and juMPStart gene therapy trial in adults with Hunter syndrome (MPS II). (advfn.com)
Structural5
- Also, we employ x-ray crystallography and fluorescence light microscopy to provide complementary structural and dynamic information for challenging systems of significant biological importance. (emory.edu)
- The results imply that, in addition to PAL, other lignin-specific enzymes and/or tissue structural changes may have more significant roles in tissue toughening of broccoli branchlets. (scialert.net)
- The insulin receptor ortholog EmIR of the fox-tapeworm Echinococcus multilocularis displays significant structural homology to the human insulin receptor (HIR) and has been suggested to be involved in insulin sensing mechanisms of the parasite's metacestode larval stage. (uni-wuerzburg.de)
- This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. (cancer-genetics.org)
- Structural differences between glucocorticoid compounds result in different bioavailability, duration, onset of action, potency and metabolic profiles of each product. (medscape.com)
Medicines2
- Accessing Homology Medicines' unique AAV capabilities is a major advancement in Oxford Biomedica's goal to become an innovative global viral vector leader that provides solutions to Cell and Gene Therapy (C>) Biotech and Biopharma companies for their process development and manufacturing needs across key viral vectors. (oxb.com)
- We are pleased to share our work outlining the impact immunosuppression regimens had on outcomes following AAVHSC dosing in NHPs, as it contributes to a key area of research in the gene therapy and gene editing field," stated Albert Seymour, Ph.D., President and Chief Executive Officer of Homology Medicines. (advfn.com)
Phosphorylation3
- Upon stress, phosphorylation of eukaryotic Initiation Factor 2α (eIF2α) decreases the available ternary complex, resulting in reduced translation initiation from the start codons of uORFs (uAUGs) and prolonged scanning of the preinitiation complex to translate the downstream main open reading frames (mORFs) to promote cell survival 12 - 15 . (biorxiv.org)
- Ang II caused a rapid tyrosine phosphorylation of Src homology and collagen (Shc), which was inhibited by quercetin. (aspetjournals.org)
- Binding of insulin to its receptor activates the insulin receptor tyrosine kinase, resulting in autophosphorylation and phosphorylation of several substrates, including insulin receptor substrate (IRS)-1 through -4. (diabetesjournals.org)
Clinically significant3
- The hemoglobinopathies represent the most common category of clinically significant inherited disorders, causing a huge burden on global health [ 1 ]. (biomedcentral.com)
- Proteus vulgaris , Morganella morganii , Serratia marcescens , Providencia species may also overproduce AmpC, but clinically significant expression is less common. (msdmanuals.com)
- These results may be highly clinically significant, because in the United States alone, f10,000 women are diagnosed annually with ERa-negative/ERh-positive breast carcinoma and may benefit from adjuvant tamoxifen. (lu.se)
Similarity3
- Homology analysis showed the highest similarity to M2 muscarinic acetylcholine receptors and overall low homology to all other biogenic amine receptors. (aspetjournals.org)
- All of these domains have a PH fold, but lack significant sequence similarity. (umbc.edu)
- The commercial results of the two French carmakers were published last week and, behind the facade homology represented by the similarity of volumes ( 3.75 million for Renault and 3.48 million for PSA ) and their decline (-3.4% for Renault and -10% for PSA), the figures underline the significant differences between the two manufacturers. (gerpisa.org)
Tumors1
- Furthermore, ECA39 is expressed in c-myc induced tumors and displays significant homology to the prokaryotic branched-chain amino acid aminotransferase (BCAT). (bdbiosciences.com)
Genetic2
- It has been estimated that 90% of genetic variations in humans are due to single nucleotide polymorphisms (SNPs) [ 1 ], most of which have minor allele frequencies exceeding 0.05 and will provide a significant proportion of common causal variants that will be mapped and identified in the future. (biomedcentral.com)
- These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. (cdc.gov)
Silico1
- In this work, several in silico models have been built with two classes of proteasome inhibitors (PIs) by using 3D-QSAR, homology modeling, molecular docking and molecular dynamics (MD) simulations. (fdocument.org)
Mineralocorticoid1
- Some glucocorticoids can have cross activity with mineralocorticoid receptor (MR) due to significant homology between GR and MR. (medscape.com)
Negatively1
- These results suggest that PTEN plays a significant role in regulating glucose metabolism in vivo by negatively regulating insulin signaling. (diabetesjournals.org)
Domain5
- To investigate the usefulness of mammalian Eps15 homology domain 1 (EHD1) as a prognostic marker for osteosarcoma, the expression of EHD1 in 57 osteosarcoma patients was measured using immunohistochemistry techniques and correlated with the clinicopathological features of patients. (biomedcentral.com)
- Mammalian Eps15 homology domain 1 (EHD1) is located in the chromosomal band 11q13 and is associated with lung, breast, head, neck, and small-cell lung cancer [ 4 ]. (biomedcentral.com)
- A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain. (embl.de)
- Pleckstrin homology-like domain. (umbc.edu)
- The resulting mutation was a 6-bp, in-frame deletion within a highly conserved region of the Src homology 2 (SH2) domain of SH2B3. (mcw.edu)
Transcription3
- 3 Given its homology and comparable transcription profile with known leukocyte protease inhibitors in the WFDC family of proteins, HE4 also presumably has a role in natural immunity. (nature.com)
- Binding of the glucocorticoid to GR results in several intracellular processes of gene transcription and translation that ultimately lead to several actions of glucocorticoids on tissues. (medscape.com)
- The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
Differences1
- These studies revealed significant differences between insulin signaling in Echinococcus and the related cestode parasite Taenia solium. (uni-wuerzburg.de)
Catalytic2
- PI3K is composed of two subunits: the p85 regulatory subunit, containing two Src homology-2 domains, and the p110 catalytic subunit ( 2 - 4 ). (diabetesjournals.org)
- IRS then binds to the regulatory subunit of PI3K through its Src homology domains, and this interaction activates the catalytic unit. (diabetesjournals.org)
Adults1
- This bleeding is painful and leads to long-term inflammation and deterioration of the joint (typically the ankles in children, and the ankles, knees, and elbows in adolescents and adults), resulting in permanent deformities, misalignment, loss of mobility, and extremities of unequal lengths. (medscape.com)
Glucocorticoids1
- Drugs that have been reported to result in hypercortisolism are glucocorticoids, megestrol acetate, and herbal preparations that contain glucocorticoids. (medscape.com)
Vivo2
- Homology also shared additional details of the optimized, in vivo gene therapy candidate HMI-204 for metachromatic leukodystrophy (MLD) during the 19th Annual WORLDSymposium™ Meeting. (advfn.com)
- Dr. Seymour continued, "Also at WORLD, we presented the details of our optimized gene therapy development candidate for MLD, which showed the ability to cross the blood-brain-barrier following a single I.V. administration in the murine disease model and resulted in levels of enzyme activity predicted to lead to efficacy in vivo. (advfn.com)
Species2
- A comparison of the anatomy of different species of animals reveals significant anatomical similarities, clearly indicating their evolution via divergence from one or more common ancestors. (tutorialspoint.com)
- Homology studies structures in different related species resulting from a shared ancestor, often expressed in a common embryological origin. (tutorialspoint.com)
Insulin3
- Increased insulin resistance (IR) and immune tolerance in pregnant women result in metabolic and immunological alterations, which may aggravate the development of gestational diabetes mellitus (GDM). (hindawi.com)
- These results clearly indicated that Echinococcus metacestode vesicles are able to sense exogenous host insulin which induces a mitogenic response. (uni-wuerzburg.de)
- These results indicated the capability of EmIR to sense and to transmit host insulin signals to the Echinococcus signaling machinery. (uni-wuerzburg.de)
Homologous2
- These structures, known as homologous organs, result from various evolution and allow organisms to perform distinct roles. (tutorialspoint.com)
- These organs, known as homologous organs, result from convergent evolution. (tutorialspoint.com)
Sequence3
- In his thesis and papers, Annala significantly extends a deep sequence of existing work on Chow theory, K-theory, and algebraic cobordism theory, including results of Voevodsky, Fulton-MacPherson, Levine-Morel, and Levine-Pandharipande. (math.ca)
- One of the key challenges motivating this sequence of investigations has been to define bivariant versions of Chow theory and K-theory on singular varieties that include both a homology and a cohomology, so that classes can be multiplied or intersected. (math.ca)
- Our results showed that the coding sequence of EZH2 was 2241 bp, encoding 746 amino acids. (hindawi.com)
Multiple2
- Alternative splicing results in multiple transcript variants encoding distinct isoforms. (cancerindex.org)
- This may involve significant role of "shank," named for SRC-homology (SH3) and multiple ankyrin repeat domains, in nitric oxide synthesis. (frontiersin.org)
Distinct1
- This system with the two main parts and their groups makes it possible to combine two (or more) distinct searches into one search result, while being flexible in removing results from the final list. (diva-portal.org)
Studies2
- Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of AMR have lacked a holistic view combining all aspects into one study. (europa.eu)
- Though human biopsy samples of functional bowel disorders are difficult to obtain for obvious reasons, animal studies have provided ambiguous results regarding concentrations of nNOS in nerve terminals in pathological states ( 9 , 10 ), which phenotypically manifest as either failure of relaxation of intestinal smooth muscles or varying degrees of impairment of gastrointestinal transit ( 11 , 12 ). (frontiersin.org)
Aberrant1
- These transcripts may result from aberrant rather than regulated splicing. (biomedcentral.com)
Outbreak1
- Laboratory results on the microbiologic, pathologic, and environmental conditions at the time of the 2015 outbreak suggested hemorrhagic septicemia caused by Pasteurella multocida serotype B and triggered by environmental conditions ( 3 , 6 ). (cdc.gov)
Domains1
Pathological1
- As a result, circRNAs exert important roles in numerous physiological and pathological processes [ 9 , 10 ]. (hindawi.com)
Glucose1
- Although the precise pathogenic mechanism of GDM has not been fully elucidated, it may occur as a result of abnormal glucose regulation and increased IR, inducing the disorders of glucose metabolism. (hindawi.com)
Enzyme1
- Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
Yeast1
- Disruption of the ECA39 gene in yeast results in an increased growth rate in comparison to wild type, such that G1 is shorter. (bdbiosciences.com)
Genes1
Region2
- We show that the cluster has formed de novo since the divergence of oats in a subtelomeric region of the genome that lacks homology with other grasses, and that gene order is approximately colinear with the biosynthetic pathway. (cas.cz)
- In his message to the meeting Dr Gezairy welcomed the participants and thanked them for their significant input in the efforts made by the laboratory network to ensure effective surveillance capable of properly directing the programme at this critical stage of polio eradication in the Region. (who.int)
Survival2
- A combination of surgery and chemotherapy results in the long-term survival of approximately 60-70% of osteosarcoma patients [ 3 ]. (biomedcentral.com)
- There was no significant difference in overall survival between patients with high and those with low CDK2AP1 mRNA levels after a median follow-up of 10 years (Kaplan-Meier analysis, p=0.872). (cancerindex.org)
Disorders1
- Large repertoire of these disorders results from defective inhibitory neurotransmission that involves release of nitric oxide from prejunctional nerve terminals of motor neurons that traverse the smooth muscle layers of the gut ( 4 - 7 ). (frontiersin.org)
Demonstrate1
- Our results demonstrate that a layered mitigation strategy approach of administrative and engineering controls can reduce personal inhalation exposure to potentially infectious very fine respiratory droplets and aerosol particles within an indoor environment. (cdc.gov)
Unique1
- Metameric animals exhibit a unique sort of homology, such as arthropod appendages. (tutorialspoint.com)
Cell5
- In addition, transient overexpression of RanBPM in prostate cancer cell lines resulted in enhanced AR activity in a ligand-dependent fashion. (nih.gov)
- Despite the apparently simple Mendelian inheritance of α- and β-thalassemia and sickle cell disease (SCD), a significant variation in clinical severity is observed. (biomedcentral.com)
- As a result of the agreement, which is immediately accretive to the Group's revenue growth with contribution from Homology and future customer pipeline, Oxford Biomedica will establish a presence in the US and will offer global pharmaceutical and biotechnology clients innovative manufacturing expertise in AAV and lentiviral-based cell and gene therapies. (oxb.com)
- Angiotensin II (Ang II) induces vascular smooth muscle cell (VSMC) hypertrophy, which results in various cardiovascular diseases. (aspetjournals.org)
- 3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)
Roles1
- These results validated a different transcript in pigs and characterized its expression profile in fetal tissues of different gestation stages, which indicated that EZH2 played important roles during porcine embryonic development. (hindawi.com)
Biological1
- How biomolecules efficiently function in real biological environments with crowding and significant chemical and physical heterogeneity remains a fundamental question in biology ( Minton, 2001 ). (elifesciences.org)
Role2
- Non-random gene organization in eukaryotes plays a significant role in genome evolution. (cas.cz)
- We discuss the implications of our results in terms of the potential role for HE4 in histopathologic diagnosis, as a serum tumor biomarker, and as a therapeutic target. (nature.com)
Important2
- These results could be particularly important in helping to improve drug design. (elifesciences.org)
- Although the dissertation will be the most important criterion (the impact of the results, the creativity of the work, the quality of exposition, etc.) it will not be the only one. (math.ca)
Exposure1
- Our results show DIY air filtration units can be an effective means of reducing aerosol exposure. (cdc.gov)
Processes1
- Spontaneous mutation and acquired immunologic processes can result in this disorder, as well. (medscape.com)
Comparative1
- Studying vestigial or rudimentary organs is another significant component of comparative anatomy. (tutorialspoint.com)
Laboratory1
- However, whether a second unknown infectious agent had predisposed the animals to infection with P. multocida was unclear from the laboratory results. (cdc.gov)
Real1
- This set of rules proved to be robust for most cases and gives high fidelity separation between real homologies and spurious matches. (aaai.org)
High2
Large1
- When confronted with the task of finding homology to large numbers of sequences, database searching tools such as Blast and Fasta generate prohibitively large amounts of information. (aaai.org)
Common1
- Homology results from adaptive radiation from a common ancestor, allowing organisms to adapt effectively to varied ecological niches. (tutorialspoint.com)
Gene expression1
- The result showed that the bacterium expression system was suitable for the virus gene expression. (scirp.org)
Show2
- Recent AIV isolates (2002-2006) show significant molecular drifts when compared with the H5N2 vaccine-strain or other field isolates (1994-2000). (biomedcentral.com)
- The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
Expression1
- There were no significant associations between CDK2AP1 expression and estrogen receptor status, tumour grade and tumour type. (cancerindex.org)
Surface1
- Rotavirus infects the proximal small intestine, where it elaborates an enterotoxin and destroys the epithelial surface, resulting in blunted villi, extensive damage, and shedding of massive quantities of virus in stool ( 13 ). (cdc.gov)
Study1
- The study resulted in two types of satisfactory 3D-QSAR models, i.e. , the CoMFA model (Q 2 = 0.462, R 2 pred = 0.820) for epoxyketone inhibitors (EPK) and the CoMSIA model (Q 2 = 0.622, R 2 pred = 0.821) for tyropeptin-boronic acid derivatives (TBA). (fdocument.org)
Require1
- Additionally, at any time following the three-year anniversary of the agreement, the Group will have a call option to purchase, and Homology will have a put option to require the Group to purchase, Homology's ownership interest in Oxford Biomedica Solutions. (oxb.com)
Involves1
- Failure of nitric oxide synthesis, the major inhibitory neurotransmitter, results in a phenotype that involves complete failure of gut smooth muscle relaxation ( 8 ). (frontiersin.org)