Significance coronary stenosis. Medical search. Frequent questions

Risk stratification and management strategy of intermediate coronary lesions, defined as 50-70% diameter stenosis (DS) at coronary angiography [ 1 , 2 ], remain a challenging issue [ 3 , 4 ]. (hindawi.com)
Intravascular ultrasound (IVUS) is superior to coronary angiography in terms of accurate assessment of lumen area and plaque burden and thus is commonly applied to evaluate intermediate stenotic lesions and guide the decision about revascularization in real-world practice [ 4 , 7 ]. (hindawi.com)
This multicenter, multinational, prospective study included 381 patients with suspected CAD who had been referred for clinically indicated coronary angiography. (acc.org)
Noninvasive CT evaluation of coronary lesion severity (by CTA) + hemodynamic significance (by CTP using a 320-row detector CT) was compared to invasive angiography + single photon emission CT (SPECT) and analyzed on a per-patient and per-vessel basis. (acc.org)
Investigators reported results of CORE320 at ESC 2012 and found that combined CTA and CTP was capable of detecting hemodynamically significant stenoses (50% or 70%), as defined by invasive angiography with an associated SPECT perfusion defect. (acc.org)
Furthermore, combined CTA and CTP was superior to CTA alone for correctly identifying flow-limiting and functionally relevant obstructive CAD and predicted revascularization with accuracy similar to invasive coronary angiography + SPECT. (acc.org)
Overall, he said, "We found the addition of CT myocardial perfusion to CT angiography allows clinicians to distinguish between anatomic and flow limiting stenoses in patients with suspected coronary disease. (acc.org)
Coronary CT angiography was used to evaluate each coronary segment for the presence and composition of atherosclerotic plaque and the degree of coronary stenosis. (snmjournals.org)
To determine the best combination of parameters that would improve the diagnostic performance of exercise testing, coronary angiography plus exercise testing were done on 112 patients with angina pectoris and normal electrocardiogram. (who.int)
In patients with acute coronary syndrome (ACS), coronary computed tomographic angiography (CCTA) was used to capture adverse geometric characteristics (AGCs) of coronary plaques. (medpagetoday.com)
3 In patients with ACS and 2 or more significant lesions, the culprit lesion was defined using invasive coronary angiography and electrocardiography. (medpagetoday.com)
Study participants were assessed using computed tomography angiography (CTA) to look for any previously undiagnosed obstructive coronary atherosclerosis. (medicalnewstoday.com)
Recent advances in computer vision and machine learning technology have enabled the automated analysis of coronary angiography. (jmir.org)
The aim of this paper is to validate the performance of artificial intelligence-based quantitative coronary angiography (AI-QCA) in comparison with that of intravascular ultrasound (IVUS). (jmir.org)
INTRODUCTION: Transradial access (TRA) has rapidly emerged as the preferred vascular access site for coronary angiography and percutaneous coronary intervention. (bvsalud.org)
A total of 108 patients scheduled for coronary angiography because of chest pain or acute coronary syndromes were studied. (thoracickey.com)
However, it can be difficult to determine on angiography whether a stenosis causes ischemia or not. (thoracickey.com)
Other testing options are therefore important in the selection for coronary angiography and to distinguish functionally significant from nonsignificant coronary stenoses, with fractional flow reserve as a probable reference for the functional evaluation of a coronary stenosis. (thoracickey.com)
Coronary angiography is used to visualize these changes to the coronary arteries. (rsyd.dk)
Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. (rsyd.dk)
During the coronary angiography produce FFR, IFR and IMR will be measured as part of routine procedure. (rsyd.dk)
20% stenosis), nonobstructive CAD, and obstructive CAD (≥70% stenosis) on hospitalization for myocardial infarction (MI) at 1 year after angiography. (2minutemedicine.com)
The present diagnostic paradigm in patients with angina pectoris is focused on likelihood and subsequent identification of obstructive CAD PATHOPHYSIOLOGIC BASIS (3, 4), but most patients referred for assessment do not fulfill criteria for invasive coronary angiography (ICA), and in the Under resting conditions, the coronary blood flow is kept subset of patients ultimately examined with ICA, many patients, constant at varying coronary pressures. (readkong.com)
Diagnostic coronary angiography. (drkathiresan.com)
Coronary computed tomography angiography (CCTA) is a noninvasive method to image the coronary arteries. (medscape.com)
BACKGROUND Coronary computed tomography angiography (CTA) enables accurate anatomic evaluation of coronary artery stenosis but lacks information about hemodynamic significance. (kssg.ch)
PURPOSE To evaluate the accuracy and added diagnostic value of 3-dimensional (3D) image fusion of computed tomography coronary angiography (CTCA) and functional cardiac magnetic resonance (CMR) for assessing hemodynamically relevant coronary artery disease (CAD). (kssg.ch)
METHODS Twenty-seven patients with significant coronary stenoses on prospectively electrocardiography-gated dual-source CTCA, confirmed by catheter angiography. (kssg.ch)
age 64 ± 10) with suspected coronary artery disease (CAD) referred for catheter coronary angiography (CA) underwent CMR and computed tomography coronary angiography (CTCA). (kssg.ch)
MATERIALS AND METHODS Fifty-three patients with aortic regurgitation (AR) and 29 controls were examined with 64-multi-detector CT coronary angiography and transthoracic echocardiography (TTE). (kssg.ch)
However, in clinical practice, the visual assessment of the invasive coronary angiography is still the most common means for evaluating coronary disease. (unideb.hu)
The Society of Cardiac Angiography and Interventions (SCAI) released a focused update expert consensus statement in July 2018 for the use of invasive coronary physiological assessments. (dicardiology.com)
CT coronary angiography can detect coronary plaque with high resolution, estimate the degree of functional stenosis and characterise plaque features. (bmj.com)
Consequently, invasive coronary angiography (ICA) became the gold standard for diagnosis of CAD. (bmj.com)
This study was conducted on sixty patients who presented with symptoms of coronary artery disease and attended elective coronary angiography to rule out coronary artery disease. (springeropen.com)
Coronary artery anomalies in 126,595 patients undergoing coronary angiography. (scirp.org)
Coronary artery anomalies: Assessment with free-breathing three-dimensional coronary MR angiography. (scirp.org)
Angiography is the standard imaging approach for detecting fibromuscular dysplasia/arterial stenoses and aneurysms. (medscape.com)
The diagnostic and prognostic information available from captopril renography and the increasing availability of magnetic resonance angiography (MRA) have reduced the use of renal arteriography as a diagnostic tool, except in evaluating kidneys with intrarenal branch-artery stenoses and those with complex vascular anatomy, including multiple accessory arteries. (medscape.com)

Coronary flow reserve (CFR) is the maximum increase in blood flow through the coronary arteries above the normal resting volume. (wikipedia.org)
Its measurement is often used in medicine to assist in the treatment of conditions affecting the coronary arteries and to determine the efficacy of treatments used. (wikipedia.org)
When demand for oxygen in the myocardium is increased, the vascular resistance of the coronary arteries has the ability to reduce, and this can increase the volume of blood passing through the blood vessels. (wikipedia.org)
After stress testing, the perfusion imbalance between normal coronary arteries and those distal to a stenosis appears as a relative decrease in Tl-201 uptake in the areas perfused by the stenosed arteries. (msdmanuals.com)
Coronary atherosclerosis - also known as coronary artery disease - occurs when plaque from cholesterol deposits builds up inside the arteries that bring blood to the heart. (medicalnewstoday.com)
Normal coronary arteries display a predominant diastolic blood flow pattern, which is less marked in the distal right coronary artery (RCA), probably because of lower intramyocardial systolic contraction pressure in the right ventricle. (thoracickey.com)
Intracoronary physiology refers to the study of the functional status of coronary arteries within the heart. (drkathiresan.com)
There are three key intracoronary physiologic measures that are commonly used to assess the functional status of coronary arteries: FFR cardiology procedure, RFR, and IFR interventional cardiology. (drkathiresan.com)
The diagnosis of intracoronary physiology is used to determine the functional significance of stenoses (narrowings) in the coronary arteries, which can cause reduced blood flow to the heart and contribute to the development of chest pain (angina) or heart attacks. (drkathiresan.com)
A catheter is passed through the incision and into the coronary arteries. (drkathiresan.com)
The catheter is equipped with sensors and a pressure wire to measure blood pressure and flow within the coronary arteries . (drkathiresan.com)
The patient had drug-eluting stents placed to the mid-circumflex and right coronary arteries 13 months before the current presentation. (emguidewire.com)
The administration of sublingual nitroglycerin dilates the coronary arteries and increases side branch visualization. (medscape.com)
FFR-computed tomography (FFR-CT) has FDA clearance for imaging-only assessments or the coronary arteries, creating a computational-fluid dynamics algorithm derived FFR 3-D model for the entire coronary tree. (dicardiology.com)
3D reconstruction of coronary arteries from 2D angiographic projections using non-uniform rational basis splines (NURBS) for accurate modelling of coronary stenoses. (ox.ac.uk)
This study proposes a novel method to generate 3D models of stenotic coronary arteries, directly from 2D coronary images, and suitable for immediate assessment of the stenosis severity.From multiple 2D X-ray coronary arteriogram projections, 2D vessels were extracted. (ox.ac.uk)
Comparison of volume reduction due to a lesion with corresponding FFR measurement suggests that the method may help in estimating the physiological significance of a lesion.The algorithm accurately reconstructed 3D models of lesioned arteries and enabled quantitative assessment of stenoses. (ox.ac.uk)
This classification also included coronary arteries with severe diffuse irregularities or arteries in which the segment of a coronary artery between two severe obstructions also exhibited significant diffuse luminal irregularities. (wikidoc.org)
Ano- malous aortic origin of coronary arteries. (scirp.org)
Anomalies of the coronary arteries. (scirp.org)
Rapid identification of the course of anomalous coronary arteries in adults: The 'dot and eye' method. (scirp.org)
The clinical manifestations reflect the arteries involved and most commonly include hypertension caused by renal-artery stenosis (RAS) or strokes from carotid artery disease. (medscape.com)
CTA with maximum intensity projection (MIP) and quantitative measurement of stenosis is an accurate noninvasive technique for diagnosing fibromuscular dysplasia/stenosis of the visceral arteries, regardless of the etiology. (medscape.com)

Treatment of coronary intermediate lesions remains a controversy, and the role of arterial remodeling patterns determined by intravascular ultrasound in intermediate lesion is still not well known. (hindawi.com)
The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
Quantitative flow ratio was assessed for evaluating the functional significance of intermediate lesions. (hindawi.com)
As a rule, percutaneous coronary intervention (PCI) with drug-eluting stent implantation for every intermediate lesion could increase the risk of stent thrombosis or restenosis, whereas deferral revascularization of high-risk intermediate lesions might be associated with a higher risk of long-term events [ 5 , 6 ]. (hindawi.com)
Accordingly, we sought to investigate the impact of arterial remodeling of intermediate lesions on long-term prognosis in patients with stable coronary artery disease. (hindawi.com)
The vFFR value indicates the significance of specific coronary lesions and shows where blood flow is limited. (siemens-healthineers.com)
CTA provides morphologic information of coronary anatomy and is capable of detecting the presence of atherosclerotic lesions. (acc.org)
In this study, cardiac CT was used to evaluate the prevalence of atherosclerotic lesions and the severity of coronary artery stenosis in patients with TID of the left ventricle with or without associated myocardial perfusion defects on SPECT MPI. (snmjournals.org)
A recent study characterized the prognostic value of adverse geometric characteristics of coronary lesions in predicting future acute coronary syndrome events. (medpagetoday.com)
We sought to characterize AGCs of coronary lesions capturing location and vessel geometry on baseline CCTA. (medpagetoday.com)
Culprit lesions were defined as single lesions with stenosis identified with the ROMICAT (Rule Out Myocardial Infraction by Computer Assister Tomography) definition. (medpagetoday.com)
All coronary lesions were qualitatively evaluated for adverse morphological features, including positive remodeling, low attenuation, spotty calcification, and napkin-ring sign. (medpagetoday.com)
Additionally, coronary lesions were identified for 3 AGCs: distance from ostium to lesion, location at vessel bifurcation, and vessel tortuosity, which was defined as the presence of 1 bend of greater than 90 degrees or 3 curves of 45 to 90 degrees. (medpagetoday.com)
The risk of future culprit lesions was adjusted for diameter stenosis, number of adverse plaque characteristics, and quantitative plaque characteristics. (medpagetoday.com)
Culprit lesions had a greater diameter stenosis, higher prevalence of adverse plaque characteristics, and higher median volumes and burdens of plaque. (medpagetoday.com)
An accurate quantitative analysis of coronary artery stenotic lesions is essential to make optimal clinical decisions. (jmir.org)
AI-QCA showed a moderate to strong correlation compared with IVUS in analyzing coronary lesions with significant stenosis. (jmir.org)
Functionally nonsignificant stenoses are common in the borderline stenosis group (diameter stenosis, 50%-75%) and may as well be found among high-grade stenoses (diameter stenosis, 76%-100%), with a recent study showing that 65% of lesions with diameter stenosis of 50% to 70% and 20% of lesions with diameter stenosis of 71% to 90% were without functional significance. (thoracickey.com)
The majority of atherosclerotic lesions responsible for the most serious CAD events (that is, the lesions that are most likely to rupture) are mild stenoses of inconsequential hemodynamic significance and are characterized by an abundance of lipid, numerous inflammatory cells, and a thin, fragile fibrous cap. (medscape.com)
This suggests that although measurements of coronary flow reserve (CFR) and fractional flow reserve (FFR), both of which are discussed below, may be useful in the assessment of the severity of stenoses and in the identification of lesions responsible for effort angina, they are not likely to identify the more dangerous plaques responsible for unstable angina, AMI, and sudden ischemic death. (medscape.com)
OBJECTIVES The aim of this study was to assess whether residual nonculprit (NC) lesions, defined as visual diameter stenosis after successful percutaneous coronary intervention, affect the rate of future events in patients with acute coronary syndromes. (eur.nl)
BACKGROUND In patients with acute coronary syndromes, approximately one-half of recurrent events after percutaneous coronary intervention arise from untreated lesions. (eur.nl)
The median diameter stenoses of the NC lesions in the latter 2 groups were 36.7% (interquartile range: 31.0% to 43.4%) and 37.4% (interquartile range: 32.0% to 46.5%), respectively (p = 0.22). (eur.nl)
NC les CONCLUSIONS Residual NC lesions are common after percutaneous coronary intervention for acute coronary syndromes and portend a higher rate of recurrent ischemic events within 3 years, especially when angiographically more severe. (eur.nl)
Further references and insights to this bifurcation campaign can be found by clicking here for the "Performing PCI in Coronary Bifurcation lesions in 2021" white paper and clicking here to view the "How to Perform PCI in Coronary Bifurcation Lesions in 2021" webinar. (radcliffecardiology.com)
Prof Gil has wide scientific and research interests including the evaluation of atherosclerotic plaque characteristic and distribution, coronary stenosis significance, treatment of complex lesions, notably bifurcation lesions using invasive diagnostic techniques that include IVUS, OCT or iFR/FFR. (radcliffecardiology.com)
The main aim of the registry is to compare the visual estimate of coronary lesions and the functional severity of the stenosis assessed by FFR, as well as the RFR pullback. (unideb.hu)
The use of invasive, pressure wire-based fractional flow reserve (FFR) in the cath lab is now considered the gold standard for assessing the hemodynamic significance of coronary lesions to determine if they should be revascularized or treated medically. (dicardiology.com)
In patients with multiple coronary lesions, FFR can be used to pinpoint which lesion is the main contributor to ischemia and may help reduce the number of stents implanted, leaving less severe lesions alone. (dicardiology.com)
It recommends either fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) technologies can be used to assess the hemodynamic significance of coronary lesions to determine if a stent is needed. (dicardiology.com)

The aim of this study was to determine whether poststenotic diastolic-to-systolic velocity ratio (DSVR) assessed by transthoracic Doppler echocardiography could accurately identify significant stenoses in the left coronary artery. (thoracickey.com)
Transthoracic pDSVR measurements in the distal to mid left anterior descending coronary artery and marginal branches of the left circumflex coronary artery had high accuracy for excluding functionally significant stenoses in the left coronary artery, as well as for identifying angiographic significant stenoses. (thoracickey.com)

The advancement in percutaneous transluminal coronary angioplasty (PTCA) has led to it becoming the predominant mode of revascularization. (hvt-journal.com)
The current study demonstrates that higher baseline and post procedural fibrinogen, is an independent predictor of 6 months major adverse cardiac and cerebrovascular events after elective percutaneous coronary intervention. (hvt-journal.com)
Traditionally, percutaneous coronary intervention (PCI) has become a common treatment of coronary artery disease (CAD). (hvt-journal.com)
Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). (bvsalud.org)
Stenosis and occlusion can be treated with percutaneous coronary intervention. (rsyd.dk)
Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. (rsyd.dk)
In brief, the ISCHEMIA trial was designed to study the impact of an initial invasive strategy (cardiac catheterisation and revascularisation with percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG] where feasible) compared with initial medical therapy in patients with stable CAD and moderate or severe ischaemia. (ecrjournal.com)
The statement said physiologically guided percutaneous coronary intervention (PCI) results in better clinical outcomes and saves resources compared to angiographic image guidance alone. (dicardiology.com)
Optimization of fractional flow reserve (FFR) after angiographically successful percutaneous coronary intervention (PCI) did not impact clinical outcomes but significantly reduced the proportion of patients leaving the cath lab with an FFR of 0.80 or less in a single-center randomized trial. (medscape.com)

A single test that could noninvasively calculate the severity of a lesion and its hemodynamic significance is desirable for the management of patients with symptomatic CAD. (acc.org)
Significance: Surgical decision based only on pressure measurements may miss some real hemodynamic problem due to the considered stenosis. (utc.fr)
Hemodynamic significance of coronary stenosis by vessel attenuation measurement on CT compared with adenosine perfusion MRI. (musc.edu)
The fractional flow reserve (FFR), the coronary flow reserve (CFR), and the resting full-cycle ratio (RFR) are established indices to determine the hemodynamic significance of a coronary stenosis. (unideb.hu)

CORE320 is the acronym for a study designed by investigators at Johns Hopkins University, Baltimore, Maryland: the combined coronary atherosclerosis and myocardial perfusion evaluation using 320-row detector CT. (acc.org)
When compared with the TID-negative control cohort, TID-positive patients had no significant differences in the presence and extent of atherosclerosis, the degree of coronary artery stenosis, or the calcium score at cardiac CT. (snmjournals.org)
Researchers from the University of Copenhagen in Denmark have found people without known cardiovascular disease that have undetected obstructive coronary atherosclerosis increase their risk for a heart attack eightfold. (medicalnewstoday.com)
Coronary atherosclerosis is the most common cause of heart attack. (medicalnewstoday.com)
According to Dr. Klaus Fuglsang Kofoed , clinical associate professor in the Department of Clinical Medicine at the University of Copenhagen in Denmark and corresponding author of this study, the research team decided to study how coronary atherosclerosis impacts a person's risk for a heart attack because it is the disease process responsible for heart attack and cardiac death. (medicalnewstoday.com)
Upon analysis, researchers found 54% of the study participants had no detectable coronary atherosclerosis. (medicalnewstoday.com)
Of the remaining 46% that were found to have previously undetected coronary atherosclerosis, 36% of participants had nonobstructive disease, and 10% had obstructive disease. (medicalnewstoday.com)
Additionally, scientists found among participants diagnosed with previously undetected coronary atherosclerosis, 61% were males, and 36% were females. (medicalnewstoday.com)
As it may play a role in coronary atherosclerosis in patients with diabetes, reducing EAT volume through physical exercise, improved diet and pharmaceutical interventions may improve future cardiovascular risk outcomes in this population. (researchsquare.com)
Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults. (cdc.gov)

Diamond et al found that resting wall motion abnormalities in patients with coronary artery diseases (CADs) improve after administration of an inotropic agent (dobutamine or epinephrine) or after coronary revascularization in some vascular territories with depressed contractile function, and that such territories eventually improve after revascularization. (medscape.com)
However, data regarding the long-term clinical outcomes of IVUS-guided deferral of coronary revascularization are limited. (hindawi.com)
That's important because the benefits of revascularization are highest in patients who have coronary stenoses that are flow-limiting and hemodynamically significant. (acc.org)
A further strategy would be to screen patients for existing evidence of coronary disease, with the intent of myocardial revascularization in those at greatest risk. (diabetesjournals.org)
Objective: In order to take a decision about the revascularization approach to be adopted, it is of fundamental importance to determine whether coronary artery stenoses induce ischemia or not. (utc.fr)
Ultimately, only a coronary blood flow is increased due to a simultaneous increase fraction of angina patients is treated with revascularization (5- in coronary perfusion pressure and a decrease in coronary 7). (readkong.com)
8,9 Studies have shown greater angina severity at the time of diagnosis to be associated with higher mortality rates, cardiovascular hospitalizations, coronary revascularization, and overall healthcare costs. (uscjournal.com)
The secondary endpoint of the study is a composite of major adverse cardiac events, including death, myocardial infarction, and repeat coronary revascularization at 1 year. (unideb.hu)

This multicenter, nested case-control study was a substudy of ICONIC (Incident Coronary Syndromes Identified by Computed Tomography) and included patients who had ACS with a culprit lesion precursor seen on CCTA. (medpagetoday.com)
001). The correlation was weaker for percent area stenosis and lesion length, although statistically significant (correlation coefficients of 0.29 and 0.33, respectively). (jmir.org)
Coronary flow velocity reserve (CFVR) assessed using Doppler transthoracic echocardiography (TTE) has recently been shown to be a noninvasive surrogate of fractional flow reserve, especially in the detection of a functionally nonsignificant lesion. (thoracickey.com)
FFR is a measure of the pressure difference across a stenotic (narrowed) coronary artery and is used to determine the functional significance of a lesion. (drkathiresan.com)
The IFR provides a continuous measure of the functional significance of a stenotic lesion, with values less than 0.89 indicating ischemia. (drkathiresan.com)
FFR offers quantifiable ratio measurement of the blood flow pressures before and after a lesion to determine physiological significance. (dicardiology.com)
Watch the VIDEO: iFR Equal to FFR Outcomes in Coronary Lesion Evaluation or read the article on the DEFINE-FLAIR and SWEDEHEART studies . (dicardiology.com)

Previous studies have suggested that TID in the context of reversible myocardial perfusion defects is associated with increased risk of severe, extensive multivessel coronary artery disease (CAD) ( 1 , 6 , 7 ). (snmjournals.org)
Noninvasive quantitative assessment of coronary vasodilator function with positron emission tomography is a powerful, independent predictor of cardiac mortality in patients with known or suspected coronary artery disease and provides meaningful incremental risk stratification over clinical and gated myocardial perfusion imaging variables. (qxmd.com)
Coronary artery disease can lead to stenosis and inadequate coronary perfusion causing stable angina, acute myocardial infarction or death. (rsyd.dk)
1] Coronary artery disease can lead to stenosis and occlusion of the vessel leading to inadequate coronary perfusion. (rsyd.dk)
Myocardial perfusion imaging (MPI) refers to the utilization of radiotracers to image regional myocardial perfusion from coronary artery blood flow to the heart muscle. (malvernlegacyproject.org)

Coronary flow reserve can be measured through a variety of methods, including digital subtraction cineangiography with coronary catheterization, doppler echocardiography, and positron emission tomography (PET). (wikipedia.org)
In nondiabetic patients, a number of factors may be used to stratify the level of risk of coronary disease, including clinical history, resting ventricular function, exercise capacity, the presence and extent of ischemia at single-photon emission-computed tomography (SPECT), or stress echo. (diabetesjournals.org)
Intravascular imaging, using ultrasound (IVUS) or optical coherence tomography, reveals that angiographic assessment of the coronary lumen grossly underestimates the presence, nature and extent of coronary artery plaque. (bmj.com)
Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography. (scirp.org)
A giant left circumflex coronary artery-right atrium arteriovenous fistula detected by multislice spiral computed tomography. (scirp.org)

Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. (qxmd.com)
It is unknown whether noninvasive assessment of coronary vasodilator function in patients with suspected or known coronary artery disease carries incremental prognostic significance. (qxmd.com)
In vitro assessment of DP and coronary artery SMCs yielded dose-dependent reduction in SMC migration and proliferation. (bvsalud.org)
Though is the visual assessment subjective and not always in accordance with the physiological importance of the stenosis. (rsyd.dk)
5] Martin K.C., Alan Yeung, William Fearon: Invasive Assessment of the Coronary Microcirkulation. (rsyd.dk)
REVIEW published: 29 October 2021 doi: 10.3389/fcvm.2021.723542 Doppler Echocardiography Assessment of Coronary Microvascular Function in Patients With Angina and No Obstructive Coronary Artery Disease Jakob Schroder* and Eva Prescott Department of Cardiology, Bispebjerg Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark Edited by: Echocardiographic evaluation is an essential part of the diagnostic work-up in Tim van de Hoef, Academic Medical patients with known or suspected cardiovascular disease. (readkong.com)
Association with symptoms and prognosis, Doppler Echocardiography comparison with alternative invasive and non-invasive imaging modalities, and possible Assessment of Coronary Microvascular Function in Patients interventions in angina patients with low CFVR were discussed, and key research With Angina and No Obstructive questions were proposed. (readkong.com)
Assessment of coronary stenosis severity is crucial in clinical practice. (ox.ac.uk)
Coronary artery disease risk assessment that incorporates clinical factors, plaque characteristics and perivascular inflammation offers a more comprehensive individualised approach to quantify and stratify coronary artery disease risk, with potential healthcare benefits for prevention, diagnosis and treatment recommendations. (bmj.com)
The TARGET-FFR trial involved 260 patients with coronary artery disease, including stable angina and non-ST-segment myocardial infarction, who were randomly assigned after angiographically successful PCI to blinded post-PCI coronary physiology assessment or to a physiology-guided incremental optimization strategy (PIOS). (medscape.com)

This non-invasive imaging algorithm should replace the current standard of using a vascular pressure wire to measure the Fractional Flow Reserve (FFR) - a measure for the physiologic significance of a coronary obstruction on the basis of which the interventional cardiologist decides whether an obstruction needs to be treated with stent placement, or otherwise should be left untreated. (europa.eu)
The ability to reliably detect coronary artery disease based on the acoustic noises produced by a stenosis can provide a simple, non-invasive technique for diagnosis. (global-sci.com)
This distinction is important, because anatomically significant but functionally nonsignificant stenoses have a good prognosis without invasive treatment. (thoracickey.com)
The recently published International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial has shed further light on the importance of pharmacotherapy in the management of stable coronary artery disease (CAD). (ecrjournal.com)
European *Correspondence: Jakob Schroder Society of Cardiology guidelines recommend TTDE CFVR evaluation only following jakob.arnborg.schroeder.01@ preceding anatomic invasive or non-invasive coronary imaging excluding obstructive regionh.dk CAD. (readkong.com)
Schroder and Prescott CFVR in Non-obstructive Angina INTRODUCTION and prognosis, comparison with alternative invasive and non- invasive imaging modalities, and possible interventions in angina Coronary artery disease remains one of the leading causes of patients with low CFVR were discussed. (readkong.com)
The proposed method has the potential to allow immediate analysis of the stenoses in clinical practice, thereby providing incremental diagnostic and prognostic information to guide treatments in real time and without the need for invasive techniques. (ox.ac.uk)

It is, however, limited in its ability to detect myocardial ischemia as morphologic information alone is not enough to predict the physiological significance of coronary luminal stenosis. (acc.org)
RFR is used to assess the physiological significance of stenoses in patients with stable angina or in those undergoing cardiac stress testing. (drkathiresan.com)

Coronary flow reserve is used in diagnostics and treatment of patients with conditions such as coronary artery disease and syndrome X. In the treatment of these conditions, vasodilators are used to allow sufficient blood to flow past a stenosis, for example, and the measurement of CFR enables the efficacy of such interventions to be measured. (wikipedia.org)
Consecutive patients with stable coronary heart disease who received IVUS examination between January 2011 and January 2014 were retrospectively screened. (hindawi.com)
Other clinical scenarios requiring IVUS examination (restenosis, acute coronary syndrome, left main disease, and chronic total occlusion) were excluded. (hindawi.com)
Medis medical imaging systems BV (MEDIS), with 25 years of experience in medical imaging, will introduce a novel imaging-based biomarker as an accurate proxy for functional stenosis severity, creating a breakthrough in the treatment of ischemic heart disease (IHD). (europa.eu)
The presence of TID with an otherwise normal SPECT MPI study does not translate into a greater extent of coronary artery disease as assessed by cardiac CT or increased risk for future major adverse cardiac events. (snmjournals.org)
The exercise electrocardiogram (ECG) is used in the evaluation of symptomatic patients to predict the presence and extent of coronary artery disease (CAD) [1,2]. (who.int)
Approximately 50% of mortality in diabetic patients is related to coronary disease ( 1 ), and diabetes has a significant impact on outcome in patients with established coronary disease ( 2 ). (diabetesjournals.org)
However, resting ST segment changes may be false positive responses for epicardial coronary disease ( 5 ), and false positive ST segment changes and poor exercise capacity may reduce the utility of standard exercise electrocardiogram testing. (diabetesjournals.org)
Hypertension, carotid stenosis, chronic kidney disease and metabolic syndrome all showed a strong association with SBI. (biomedcentral.com)
Heart failure, coronary artery disease, hyperhomocysteinemia and obstructive sleep apnea are also likely of significance. (biomedcentral.com)
Impaired vasodilator function is an early manifestation of coronary artery disease and may precede angiographic stenosis. (qxmd.com)
Although there is no cure for coronary artery disease, the condition can be managed through lifestyle changes and medications . (medicalnewstoday.com)
The objective of this work is to compute simultaneously pressures and flow rates in the coronary network of patients with three-vessel disease, in order to study more precisely the relationship between these two quantities. (utc.fr)
The existence of disease in the microcirculation is likely to influence the measurement and importance of a stenosis or occlusion. (rsyd.dk)
Pharmacotherapy in Stable Coronary Artery Disease: Historical Perspectives and New Insights from the. (ecrjournal.com)
Of note, the relative outcomes of the primary endpoint were similar between the two treatment arms in patients with and without high-risk characteristics, such as multivessel disease, severe ischaemia, diabetes or proximal left anterior descending artery (LAD) stenosis. (ecrjournal.com)
In the absence of obstructive coronary artery disease, Andreas Seitz, Robert Bosch Hospital, Germany low TTDE-derived coronary flow velocity reserve (CFVR) is considered a marker of Gaetano Antonio Lanza, coronary microvascular dysfunction (CMD). (readkong.com)
development of coronary artery disease (CAD) (1, 2). (readkong.com)
This is important for the diagnosis and management of coronary artery disease, which is a leading cause of death worldwide. (drkathiresan.com)
The diagnosis of intracoronary physiology involves the measurement of Fractional Flow Reserve (FFR), Instantaneous Wave-Free Ratio (IFR), and Resting Flow Reserve (RFR) in patients with suspected or known coronary artery disease. (drkathiresan.com)
A 56-year-old man with a medical history of schizophrenia, tobacco abuse, and coronary artery disease presented to our emergency department for chest pain. (emguidewire.com)
New guidelines on screening for cardiovascular risk, released in late 2013 by the American Heart Association/American College of Cardiology (AHA/ACC), recommend use of a revised calculator for estimating the 10-year risk of developing a first atherosclerotic CVD event, which is defined as nonfatal myocardial infarction, death from coronary heart disease, or stroke (fatal or nonfatal) in a person who was initially free from atherosclerotic CVD. (medscape.com)
Coronary artery disease (CAD) affects more than 20.1 million adults in the US and remains the leading cause of mortality and morbidity. (uscjournal.com)
The CAC score assesses the volume of coronary calcifications located in atherosclerotic plaques and provides a summary measure of atherosclerotic disease, reflecting the cumulative lifetime effect of risk factors and genetic and environmental factors [7]. (researchsquare.com)
Characterizations of the coronary vessel for predominantly focal, diffuse, or mixed type disease according to visual vs. RFR pullback determination will be compared. (unideb.hu)
Treatment for coronary artery disease usually involves lifestyle changes and, if necessary, drugs and certain medical procedures. (malvernlegacyproject.org)
Cardiac imaging is central to the diagnosis and risk stratification of coronary artery disease, beyond symptoms and clinical risk factors, by providing objective evidence of myocardial ischaemia and characterisation of coronary artery plaque. (bmj.com)
However, coronary artery disease risk is also driven by biological processes, such as inflammation, that are not fully reflected by severity of stenosis, myocardial ischaemia or by coronary plaque features. (bmj.com)
Cardiac CT (CCT) imaging has transformed the detection, characterisation and stratification of coronary artery disease (CAD) risk in individuals. (bmj.com)
Our study aimed to determine the association between non-alcoholic fatty liver and increased epicardial adipose tissue mass with coronary artery disease severity. (springeropen.com)
0.001) while regarding the non-alcoholic fatty liver disease fibrosis score and Fibrosis-4 for non-alcoholic fatty liver disease diagnosis, there was no significance between both groups. (springeropen.com)
High epicardial adipose tissue thickness may represent a marker of severity of non-alcoholic fatty liver disease as well as an independent predictor of coronary artery disease risk. (springeropen.com)
One of the main concerns of the cardiology studies is how to prevent coronary artery disease development and how to estimate the risk of the disease before it becomes clinically symptomatic [ 1 ]. (springeropen.com)
Haramati LB, Glickstein JS, Issenberg H Haramati N, Crooke GA. MR imaging and CT of vascular anomalies and connections in patients with congenital heart disease: Significance in surgical planning. (scirp.org)
Familial hypercholesterolemia is a common genetic condition affecting 1 in 310 people, resulting in premature coronary artery disease due to elevated cholesterol levels from birth If a parent has familial hypercholesterolemia, there is a 50% chance their child will inherit the condition. (cdc.gov)
5) Behavior Questionnaire elicited data on behavior which may be associated with coronary heart disease for examined persons ages 25-74. (cdc.gov)

vFFR is an angiographic method used to assess coronary physiology and calculate fractional flow reserve (FFR) values. (siemens-healthineers.com)

Recent reports have indicated that findings of reduced DSVR measured by TTE in the distal left anterior descending coronary artery (LAD) may be a simple, noninvasive method for the detection of high-grade coronary stenoses located more proximally in the LAD. (thoracickey.com)
Both iFR and FFR are deemed "definitely beneficial" for assessing the functional significance of intermediate coronary stenoses when noninvasive stress imaging is not available or does not provide a definitive answer. (dicardiology.com)

Chest pain is one of the most common presenting concerns of patients seeking care in the emergency department, and the underlying etiology can range from acute coronary syndrome to various other non-cardiac causes. (uscjournal.com)
OBJECTIVE To prospectively examine coronary artery plaques as predictors of myocardial ischaemia using cardiac magnetic resonance (CMR). (kssg.ch)
New cardiac CT techniques can assess coronary artery inflammation by imaging perivascular fat, and this may represent an important step forward in identifying the 'residual risk' that is not detected by plaque or ischaemia imaging. (bmj.com)
Retinal arterial occlusive events caused by cholesterol, fibrinoplatelet or calcific emboli are known to occur in individuals with atheromatous vessels and aortic valves especially during or after interventional procedures such as cardiac catheterisation and coronary artery bypass graft procedures. (bmj.com)
Previous studies have shown the risk of retinal embolisation to be as high as 55% to 100% after coronary bypass surgery, 1 2 about 1.25% to 13.2% after carotid stenting 3 4 and about 6.3% after cardiac catheterisation. (bmj.com)
Taylor AJ, Rogan KM, Virmani R. Sudden cardiac death associated with isolated congenital coronary artery ano- malies. (scirp.org)

Systolic wall thickening after coronary artery occlusion and subsequent reperfusion in normal and ischemic zones. (medscape.com)
Regional myocardial function and electrophysiological alteration after coronary artery occlusion. (medscape.com)
Heyndrickx et al observed that after 5 minutes of occlusion in the left anterior descending coronary artery, surface electrocardiogram (ECG) findings and regional contraction (with reperfusion) rapidly normalized. (medscape.com)
Main Results: For patients with stenoses on LAD, LCx, LMCA and occlusion of the RCA, the flow rate delivered to the right territory is of course a function of the aortic pressure, the left stenoses severity, and the pressure distal to the thrombosis. (utc.fr)
Plaque rupture can subsequently lead to coronary artery occlusion, often without warning or with angina. (uscjournal.com)

Introduction: Patients undergoing coronary stent implantation incur a 2% annual rate of adverse events, largely driven by in-stent restenosis (ISR) due to neointimal (NI) tissue proliferation, a process in which smooth muscle cell (SMC) biology may play a central role. (bvsalud.org)
In these videos, Prof Robert Gil and Dr Tomasz Pawlowski perform three cases, incorporating the treatment of OM-CX with bifurcation - dedicated stent, Bifurcation stenting and Complex PCI in distal LM stenosis. (radcliffecardiology.com)

IVUS-derived negative remodeling is associated with adverse long-term clinical outcome in stable patients with intermediate coronary artery stenosis. (hindawi.com)
70%, is common but its clinical significance is controversial. (2minutemedicine.com)
N. Söylemez, R. Demirbağ, T. Hazırolan and O. AkpınarP, "Anomalous Origin of the Right Coronary Artery from the Left Sinus Valsalva with Coronary Ectasia," International Journal of Clinical Medicine , Vol. 2 No. 3, 2011, pp. 269-271. (scirp.org)

Objectives Transcatheter aortic valve implantation (TAVI) is an established treatment for patients with severe symptomatic aortic stenosis. (bmj.com)
5 For patients with severe symptomatic aortic stenosis (AS), valvular replacement has been increasingly performed via a femoral catheter technique called transcatheter aortic valve implantation (TAVI). (bmj.com)

The success rates of peak DSVR (pDSVR) measurements in the distal to mid left anterior descending coronary artery and marginal branches of the left circumflex coronary artery were 85% and 32%, respectively. (thoracickey.com)

Fractional flow reserve (FFR) is a more objective measurement of the significance of the stenosis. (rsyd.dk)
Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR). (rsyd.dk)

IFR provides information on the severity of stenoses and their impact on blood flow. (drkathiresan.com)

4 The pathophysiology of ACS involves disruption of coronary atherosclerotic plaque, leading to activation of platelets and the coagulation cascade. (uscjournal.com)

Early recoil, alteration in blood vessels, release of vasoactive and thrombogenic factors and neo-intimal proliferation have been suggested as significant contributors to the restenosis after coronary angioplasty (1, 2). (hvt-journal.com)
Intravascular ultrasound (IVUS) offers detailed 3D tomographic views of coronary plaques and reference vessels. (jmir.org)

First, two-dimensional imaging cannot assess haemodynamic consequences of stenoses, in terms of myocardial ischaemia. (bmj.com)

This retrospective study included patients who underwent IVUS-guided coronary intervention at a single tertiary center in Korea. (jmir.org)
The next day, he underwent multivessel coronary artery bypass grafting . (emguidewire.com)

1.68 to be the optimal cutoff value for identifying both functionally significant stenoses and diameter stenoses ≥ 50%, with sensitivity of 86% and 90%, specificity of 74% and 84%, positive predictive value of 51% and 71%, and negative predictive value of 94% and 95%, respectively. (thoracickey.com)

Anatomy25

Organisms3

Diseases73

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment96

Phenomena and Processes25

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care36

Geographicals4

Angiography39

Arteries23

Lesions30

Left corona2

Percutaneous9

Hemodynamic4

Atherosclerosis10

Revascularization8

Lesion7

Perfusion5

Tomography5

Assessment10

Invasive7

Physiological2

Disease36

Angiographic1

Noninvasive2

Cardiac6

Occlusion5

Stent2

Clinical3

Symptomatic2

Distal1

Fractional2

Severity of stenoses1

Atherosclerotic1

Vessels2

Myocardial ischaemia1

Underwent2

Diameter stenoses1